Abstract:
The present disclosure relates generally to tissue, including organ, transplantation. Taught herein is a genetic-based diagnostic assay to ascertain the status of a tissue transplantation procedure in a recipient based on a characterization of circulating or other cell free nucleic acid material. The instant disclosure enables kits, primers and protocols for ascertaining the status of a transplantation procedure.
Abstract:
A halogen incandescent burner comprising a quartz body comprising a light emitting chamber, a filament positioned within the light emitting chamber, and a multilayer optical coating on at least a portion of the chamber. The coating may include a plurality of layers of a low refractive index material and a high refractive index material having a total thickness of at least nine microns, wherein the gain of the burner is at least 1.7. The high refractive index material may comprise tantala and the low refractive index material may comprise silica.
Abstract:
Systems (100) and methods for recovering manganese nodules from the seabed are disclosed. A buoyant body (220) is generated by freezing water, forming a clathrate ice, or using a liquid that is less dense than seawater. Nodules that have been collected from the seabed are incorporated into or otherwise coupled to the buoyant body. The buoyant body is then released to make a free or tethered ascent to the surface.
Abstract:
The present invention relates generally to a method for identifying or distinguishing one type of cell from other cells within a population of cells. The present invention further provides the detection, monitoring and isolation of sub- populations cell types within a population of cells including a biological entity comprising such cell types. Kits, diagnostic agents and panels of nucleic acid probes for identifying and distinguishing cell types also form part of the present invention. The detection of particular cell types is based upon the use of a labelled probe that hybridizes to chromosomal DNA at the flanking sequences of a deletion. Alternatively two probes with distinguishable reporter molecules are used wherein only one probe is capable of hybridizing to chromosomal DNA in one cell type whereas both are capable of hybridizing to chromosomal DNA in another cell type. The methods are useful in the identification of cells with copy number variations, chromosomal deletions, additions or aberrations.
Abstract:
Compounds of formula (I) or a salt thereof are provided wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , X, n, p and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
Abstract:
Described herein are applicator systems and applicators for nasal devices, and methods of applying nasal devices. In general, an applicator system includes a nasal device and one or more of: an inserter from which the nasal device is released, a handle that is releasably connected to the nasal device, or an applicator liner that can be removed after positioning the device relative to the nasal cavity.
Abstract:
A floating-point number is encoded into a binary string. A left-to-right comparison of the binary string determines relative magnitude of the floating-point number. If the floating-point number is negative, then take an absolute value of the floating-point number. The resulting binary string conversion is then complemented. If the floating-point number is zero, then a value for the binary string is assigned. The value is a "1" followed by a plurality of "0"s. A portion of each byte of the binary string determines whether another byte follows in the binary string. A value of a bit of each byte of the binary string determines whether another byte follows. In another aspect, the floating-point number encodes to a binary string having a length as a function of the mantissa and exponent of the floating-point number.
Abstract:
The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I) wherein R 1 is a group selected from: Formulas (A), (B), (C)
Abstract:
The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
Abstract:
A portable power supply for electrical appliances is disclosed that comprising of a wearable frame, a power generation unit, a fuel supply container, and an electrical appliance which is supplied electrical power from the electrical power generation unit and may be attached to the frame. Also disclosed is a method of using a portable electrical power unit with an appliance by storing a fuel supply in a container, converting the fuel to electrical power using an electrical power generator, operating an electrical appliance, the operator carrying the container and the electrical power generator while using the appliance.