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    NOVEL ORGANIC SEMICONDUCTOR COMPOUND, METHOD FOR PREPARING SAME, AND ORGANIC SEMICONDUCTOR COMPOSITION, AND ORGANIC SEMICONDUCTOR THIN FILM AND ELEMENT CONTAINING SAME
    3.
    发明申请
    NOVEL ORGANIC SEMICONDUCTOR COMPOUND, METHOD FOR PREPARING SAME, AND ORGANIC SEMICONDUCTOR COMPOSITION, AND ORGANIC SEMICONDUCTOR THIN FILM AND ELEMENT CONTAINING SAME 审中-公开
    新型有机半导体化合物，其制备方法和有机半导体组合物，以及有机半导体薄膜和含有该元件的元件

    公开(公告)号：WO2010074520A3

    公开(公告)日：2010-11-04

    申请号：PCT/KR2009007749

    申请日：2009-12-23

    Applicant: LUMINANO CO LTD ,  HAN SUNG-HWAN ,  CHO CHEON-GYU

    Inventor： HAN SUNG-HWAN ,  CHO CHEON-GYU

    IPC: C07D209/04 ,  C07D209/02

    CPC classification number: C07D209/02 ,  C07D209/04 ,  C07D209/08 ,  C07D209/26 ,  C07D209/86 ,  C07D209/88 ,  C07D471/22 ,  C07D487/04 ,  C07D487/14 ,  H01L51/0072 ,  Y02E10/549

    Abstract: The present invention relates to a novel polycyclic aromatic organic semiconductor compound and a method for preparing the same, and an organic semiconductor composition, organic semiconductor thin film, and electronic, optical, or electro-optical element containing the compound. The novel organic semiconductor compound according to the present invention has high crystallinity and control capability, and facilitates control of doping conditions in the manufacture of organic semiconductor element so that it can be used for diverse applications. The compound can be mass-produced at low cost and has high solubility in organic solvents so that a liquid phase process can be applied to the manufacture of semiconductor elements and the like, thus enabling the mass-production of semiconductor elements and solar cells at low cost.

    Abstract translation: 本发明涉及新型多环芳香族有机半导体化合物及其制备方法，以及含有该化合物的有机半导体组合物，有机半导体薄膜以及电子，光学或电光学元件。 根据本发明的新型有机半导体化合物具有高结晶度和控制能力，并且有利于在制造有机半导体元件时控制掺杂条件，使得其可以用于多种应用。 该化合物可以以低成本大量生产并且在有机溶剂中具有高溶解度，从而可以将液相工艺应用于半导体元件等的制造，从而使得半导体元件和太阳能电池的批量生产处于低 成本。

    NOVEL BIPHENYL COMPOUNDS AND THEIR USE
    6.
    发明申请
    NOVEL BIPHENYL COMPOUNDS AND THEIR USE 审中-公开
    新型联烯化合物及其用途

    公开(公告)号：WO2006020358A3

    公开(公告)日：2006-12-28

    申请号：PCT/US2005026214

    申请日：2005-07-27

    Applicant: SMITHKLINE BEECHAM CORP ,  CYTOKINETICS ,  CHAUDHARI AMITA M ,  DHANAK DASHYANT ,  KNIGHT STEVEN DAVID ,  MORGANS DAVID J JR ,  PARRISH CYNTHIA A

    Inventor： CHAUDHARI AMITA M ,  DHANAK DASHYANT ,  KNIGHT STEVEN DAVID ,  MORGANS DAVID J JR ,  PARRISH CYNTHIA A

    IPC: A61K31/335 ,  A61K31/167 ,  A61K31/17 ,  C07C233/15 ,  C07C275/28 ,  C07C275/32 ,  C07C275/40 ,  C07C335/16 ,  C07C335/20 ,  C07D319/06

    CPC classification number: C07C275/28 ,  C07C233/15 ,  C07C233/43 ,  C07C259/06 ,  C07C275/30 ,  C07C275/40 ,  C07C275/42 ,  C07C275/64 ,  C07C317/24 ,  C07C317/42 ,  C07C323/44 ,  C07C335/16 ,  C07D209/02 ,  C07D307/79 ,  C07D317/66 ,  C07D319/18

    Abstract: The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. In an additional aspect, the invention provides methods of screening for compounds that will bind to a KSP kinesin, for example compounds that will displace or compete with the binding of the compounds of the invention. The methods comprise combining a labeled compound of the invention, a KSP kinesin, and at least one candidate agent and determining the binding of the candidate bioactive agent to the KSP kinesin. In a further aspect, the invention provides methods of screening for modulators of KSP kinesin activity. The methods comprise combining a compound of the invention, a KSP kinesin, and at least one candidate agent and determining the effect of the candidate bioactive agent on the KSP kinesin activity.

    Abstract translation: 本发明涉及某些联苯化合物。 具体而言，本发明涉及式（I）的化合物及其药学上可接受的盐：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和Y如下定义。 本发明的化合物是KSP抑制剂，特别是人KSP抑制剂，并且可用于治疗各种疾病和病症，例如癌症，增生，再狭窄，心脏肥大，免疫病症，真菌病症和炎症。 因此，本发明还涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物抑制KSP和治疗与其相关的病症的方法。 另一方面，本发明提供了筛选结合KSP驱动蛋白的化合物的方法，例如将取代或与本发明化合物的结合竞争的化合物。 该方法包括将标记的本发明化合物，KSP驱动蛋白和至少一种候选试剂组合并确定候选生物活性剂与KSP驱动蛋白的结合。 另一方面，本发明提供了筛选KSP驱动蛋白活性调节剂的方法。 该方法包括将本发明化合物，KSP驱动蛋白和至少一种候选试剂组合，并确定候选生物活性剂对KSP驱动蛋白活性的影响。

    NOVEL BIPHENYL COMPOUNDS AND THEIR USE
    7.
    发明申请
    NOVEL BIPHENYL COMPOUNDS AND THEIR USE 审中-公开
    新颖的联苯化合物及其用途

    公开(公告)号：WO2006020358A2

    公开(公告)日：2006-02-23

    申请号：PCT/US2005/026214

    申请日：2005-07-27

    Applicant: SMITHKLINE BEECHAM CORPORATION ,  CYTOKINETICS ,  CHAUDHARI, Amita, M. ,  DHANAK, Dashyant ,  KNIGHT, Steven, David ,  MORGANS, David, J., Jr. ,  PARRISH, Cynthia, A.

    Inventor： CHAUDHARI, Amita, M. ,  DHANAK, Dashyant ,  KNIGHT, Steven, David ,  MORGANS, David, J., Jr. ,  PARRISH, Cynthia, A.

    IPC: A61K31/704

    CPC classification number: C07C275/28 ,  C07C233/15 ,  C07C233/43 ,  C07C259/06 ,  C07C275/30 ,  C07C275/40 ,  C07C275/42 ,  C07C275/64 ,  C07C317/24 ,  C07C317/42 ,  C07C323/44 ,  C07C335/16 ,  C07D209/02 ,  C07D307/79 ,  C07D317/66 ,  C07D319/18

    Abstract: The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. In an additional aspect, the invention provides methods of screening for compounds that will bind to a KSP kinesin, for example compounds that will displace or compete with the binding of the compounds of the invention. The methods comprise combining a labeled compound of the invention, a KSP kinesin, and at least one candidate agent and determining the binding of the candidate bioactive agent to the KSP kinesin. In a further aspect, the invention provides methods of screening for modulators of KSP kinesin activity. The methods comprise combining a compound of the invention, a KSP kinesin, and at least one candidate agent and determining the effect of the candidate bioactive agent on the KSP kinesin activity.

    Abstract translation: 本发明涉及某些联苯化合物。 具体地说，本发明涉及式（I）化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和Y定义如下，及其药学上可接受的盐。 本发明的化合物是KSP抑制剂，特别是人KSP抑制剂，并且可用于治疗各种疾病和病症，例如癌症，增生，再狭窄，心脏肥大，免疫疾病，真菌病症和炎症。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物抑制KSP和治疗与其相关的病症的方法。 在另一方面，本发明提供筛选将结合KSP驱动蛋白的化合物的方法，例如将取代或与本发明化合物结合竞争的化合物。 所述方法包括组合本发明的标记化合物，KSP驱动蛋白和至少一种候选试剂，并确定候选生物活性剂与KSP驱动蛋白的结合。 另一方面，本发明提供筛选KSP驱动蛋白活性调节剂的方法。 所述方法包括组合本发明的化合物，KSP驱动蛋白和至少一种候选试剂，并确定候选生物活性剂对KSP驱动蛋白活性的影响。

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