公开(公告)号：WO2016040575A1

公开(公告)日：2016-03-17

申请号：PCT/US2015/049349

申请日：2015-09-10

Applicant: FONTEM HOLDINGS 1 B.V. ,  WENSLEY, Martin ,  HUFFORD, Michael ,  LLOYD, Peter

Inventor： WENSLEY, Martin ,  HUFFORD, Michael ,  LLOYD, Peter

IPC: A61M15/06 ,  A61M11/04 ,  A24F47/00

CPC classification number: A61M11/001 ,  A24F47/008 ,  A61M11/002 ,  A61M11/042 ,  A61M15/002 ,  A61M15/0086 ,  A61M15/06 ,  A61M16/1085 ,  A61M2205/3334 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2206/11 ,  A61M2230/40

Abstract: A device for generating a condensation aerosol includes (a) vaporization chamber having an upstream first inlet and a downstream outlet; (b) a heater element in the vaporization chamber between the upstream first inlet and the downstream outlet; (c) an airflow path in fluid communication with the vaporization chamber, wherein the airflow path comprises a second inlet configured to permit a substantially laminar flow of air into the airflow path, wherein the second inlet is downstream of the heater element; and (d) the device having components or apparatus on or in the device for changing air flow in the vaporization chamber. Changing the air flow in the vaporization chamber may be used to change the particle size of a condensation aerosol produced in the vaporization chamber, and/or to change the amount of visible vapor emitted from the device.

Abstract translation: 一种用于产生冷凝气溶胶的装置包括（a）具有上游第一入口和下游出口的蒸发室; （b）在上游第一入口和下游出口之间的蒸发室中的加热器元件; （c）与所述蒸发室流体连通的气流路径，其中所述气流路径包括构造成允许空气基本上层流到所述气流路径中的第二入口，其中所述第二入口在所述加热器元件的下游; 和（d）该装置具有用于改变蒸发室中的气流的装置中或装置中的部件或装置。 改变蒸发室中的空气流可以用于改变在蒸发室中产生的冷凝气溶胶的粒度，和/或改变从装置发射的可见蒸汽的量。

公开(公告)号：WO2007079442A1

公开(公告)日：2007-07-12

申请号：PCT/US2007/000115

申请日：2007-01-03

Applicant: INVIVODATA, INC. ,  SHIFFMAN, Saul ,  HUFFORD, Michael, R. ,  PATY, Jean, A.

Inventor： SHIFFMAN, Saul ,  HUFFORD, Michael, R. ,  PATY, Jean, A.

IPC: G06F19/00

CPC classification number: G06Q90/00 ,  G06F19/00 ,  G06Q10/04 ,  G16H10/20 ,  G16H40/20

Abstract: A system for developing and implementing empirically derived algorithms to generate decision rules to determine participant noncompliance and fraud with research protocols in clinical trials allows for the identification of complex patterns of variables that detect or predict participant noncompliance and fraud with research protocol, including performance and enrollment goals, in the clinical trial. The data may be used to overall predict the performance of any participant in a clinical trial, allowing selection of participants that tend to produce useful, high-quality results. The present invention can also be used to monitor participant compliance with the research protocol and goals to determine preferred actions to be performed. Optionally, the invention may provide a spectrum of noncompliance, from minor noncompliance needing only corrective feedback, to significant noncompliance requiring participant removal from the clinical trial or from future clinical trials. The algorithms and decision rules can also be domain- specific, such as detecting non-compliance or fraud among subjects in a cardiovascular drug trial, or demographically specific, such as taking into account gender, age or location, which provides for algorithms and decision rules to be optimized for the specific sample of participants being studied.

Abstract translation: 用于开发和实施经验派生算法以生成决策规则以确定临床试验中的研究协议的参与者违规和欺诈的系统允许通过研究方案来识别检测或预测参与者违规和欺诈的复杂变量模式，包括绩效和注册 目标，在临床试验。 数据可用于总体预测临床试验中任何参与者的表现，允许选择倾向于产生有用的高质量结果的参与者。 本发明还可以用于监视参与者遵守研究协议和目标以确定要执行的优选动作。 任选地，本发明可以从仅需要纠正反馈的轻微不合规性到要求参与者从临床试验或未来临床试验中移除的重大不合规提供一系列不合规。 算法和决策规则也可以是域特异性的，例如在心血管药物试验中检测受试者的不合规或欺诈，或人口统计特异性，例如考虑性别，年龄或位置，其提供算法和决策规则 针对正在研究的参与者的具体样本进行优化。

公开(公告)号：WO2016118645A1

公开(公告)日：2016-07-28

申请号：PCT/US2016/014158

申请日：2016-01-20

Applicant: FONTEM HOLDINGS 1 B.V. ,  WENSLEY, Martin ,  HUFFORD, Michael ,  LLOYD, Peter

Inventor： WENSLEY, Martin ,  HUFFORD, Michael ,  LLOYD, Peter

IPC: A24F47/00 ,  A24D1/14 ,  A61M15/06

CPC classification number: A24F47/008 ,  H05B1/0244 ,  H05B3/16 ,  H05B3/46

Abstract: A device for generating a condensation aerosol includes vaporization chamber having an upstream first inlet and a downstream outlet. A tube supplies liquid to a heater in the vaporization chamber. The liquid is pumped out of the tube and onto the heater, which vaporizes the liquid. Air flows from inlets through the vaporization chamber, and generally perpendicular to the tube. The vaporized liquid is entrained in the air, forming a condensation aerosol having a particle size in a selected range. A second inlet provides a substantially laminar flow of air into the airflow path, wherein the second inlet is downstream of the heater; and the device capable of changing air flow in the vaporization chamber to change the particle size of the condensation aerosol and/or to change the amount of visible vapor emitted from the device.

Abstract translation: 用于产生冷凝气雾剂的装置包括具有上游第一入口和下游出口的蒸发室。 管将液体供应到蒸发室中的加热器。 将液体从管中泵送到加热器上，该加热器使液体蒸发。 空气从入口流过蒸发室，并且通常垂直于管。 蒸发的液体被夹带在空气中，形成粒度在选定范围内的凝结气溶胶。 第二入口提供基本上层流的空气进入气流路径，其中第二入口在加热器的下游; 以及能够改变蒸发室中的空气流动以改变冷凝气溶胶的粒度和/或改变从装置发射的可见蒸汽的量的装置。