公开(公告)号：WO2009044201A1

公开(公告)日：2009-04-09

申请号：PCT/GB2008/050891

申请日：2008-10-02

申请人： HUTCHINSON, Philip James ,  HUTCHINSON, Rosemary Guinevere ,  HUTCHINSON, James Andrew ,  HUTCHINSON, Louise Jane ,  ROBINSON, Andrew

发明人： ROBINSON, Andrew

IPC分类号： A47C27/08 ,  A61G7/10

CPC分类号： A61G7/05776 ,  A61G2203/34 ,  A61G2203/44

摘要： A mattress pump apparatus controller, wherein the controller is arranged to monitor pressure of a fluid in at least some parts of the mattress; detect a change in the pressure due to placement of a load on the mattress; measure a load pressure of the fluid; and determine a weight of the load from the load pressure.

摘要翻译： 一种床垫泵装置控制器，其中所述控制器设置成监测所述床垫的至少一些部分中的流体的压力; 检测由于将负载放置在床垫上而导致的压力变化; 测量流体的载荷压力; 并从负载压力确定负载的重量。

公开(公告)号：WO1992019527A1

公开(公告)日：1992-11-12

申请号：PCT/EP1992000898

申请日：1992-04-23

申请人： HUTCHINSON INDUSTRIES LIMITED ,  HOPPERUS-BUMA, Peter ,  HUTCHINSON, Thomas, James ,  MERLER, Crellin

发明人： HUTCHINSON INDUSTRIES LIMITED

IPC分类号： B66F03/24

CPC分类号： B65D90/143 ,  B60P1/6445

摘要： The invention comprises a method of loading or unloading a transportable container onto or from a transporting vehicle. The method involves engaging each of the four corner regions of the container (3) with an apparatus (1, 43) having a powered extendable and retractable leg (2). To unload the container from the transporting vehicle shown in Fig. 5, each leg (2) is synchronously lowered so that they engage the ground surface and accordingly lift the container (3). The transporting vehicle is then moved from under the container (3). Alternatively, if the container (3) is to be loaded onto the transporting vehicle shown in Fig 5, the deck of the transporting vehicle is positioned under the container (3) once the legs (2) have been lowered. Then, synchronously each of the legs (2) is raised so as to lower the container (3) onto the ground or to lower the container (3) onto the deck of the transporting vehicle. Each apparatus (1, 43) is then disengaged from the corner regions of the container (3). The invention also relates to the apparatus for loading or unloading a container (3) onto or from a transporting vehicle. Four lifting devices (1, 43) are provided each having an extendable leg (2) formed by a piston and cylinder assembly. Each lifting device (1, 43) has a peg (4) which engages an upper aperture in a container (3), a second locating means (20) is provided for engaging the lower part of the container (3) and a foot (31) for contacting the ground surface. The apparatus can be used to relocate containers (3).

摘要翻译： 本发明包括一种将运输容器装载到运输车辆上或从运输车辆卸载的方法。 该方法包括将容器（3）的四个角区域中的每一个与具有动力可伸缩和伸缩腿（2）的装置（1，43）接合。 从图1所示的运输车辆卸下容器。 如图5所示，每个腿部（2）同步下降，使得它们接合地面并相应地提升容器（3）。 然后，运送车辆从容器（3）下方移动。 或者，如果要将容器（3）装载到图5所示的运输车辆上，一旦腿部（2）已经下降，则运输车辆的甲板位于容器（3）下方。 然后，同步地将每个腿部（2）升起以将容器（3）下降到地面上或将容器（3）下降到运输车辆的甲板上。 然后，每个装置（1,2,3）从容器（3）的角部区域脱开。 本发明还涉及用于将容器（3）装载或卸载到运输车辆上或从运输车辆卸载的装置。 提供四个提升装置（1，43），每个起重装置具有由活塞和气缸组件形成的可伸长腿部（2）。 每个提升装置（1,2,3）具有与容器（3）中的上孔接合的钉（4），设置有用于与容器（3）的下部接合的第二定位装置（20） 31）用于接触地面。 该装置可用于搬运容器（3）。

公开(公告)号：WO2005082346A1

公开(公告)日：2005-09-09

申请号：PCT/US2005/005683

申请日：2005-02-24

申请人： MERCK & CO., INC. ,  MERCK FROSST CANADA & CO. ,  EVANS, Jilly ,  FORD-HUTCHINSON, Anthony ,  HUTCHINSON, John, H. ,  YOUNG, Robert

发明人： EVANS, Jilly ,  FORD-HUTCHINSON, Anthony ,  HUTCHINSON, John, H. ,  YOUNG, Robert

IPC分类号： A61K31/16

CPC分类号： A61K31/00 ,  A61K31/196 ,  A61K31/47

摘要： The instant invention provides a method for treating and/or reducing the risk for atherosclerosis, pulmonary fibrosis and stroke, comprising administering an effective amount of a cysteinyl leukotriene 2 receptor antagonist, including a selective cysteinyl leukotriene 2 receptor antagonist and a dual cysteinyl leukotriene 1 receptor and cysteinyl leukotriene 2 receptor antagonist to a patient in need of such treatment.

摘要翻译： 本发明提供了治疗和/或降低动脉粥样硬化，肺纤维化和中风风险的方法，包括给予有效量的半胱氨酰白三烯2受体拮抗剂，包括选择性半胱氨酰白三烯2受体拮抗剂和双半胱氨酰白三烯1受体 和半胱氨酰白三烯2受体拮抗剂给需要这种治疗的患者。

公开(公告)号：WO2023039548A1

公开(公告)日：2023-03-16

申请号：PCT/US2022/076237

申请日：2022-09-09

申请人： FRED HUTCHINSON CANCER CENTER

发明人： GUJRAL, Taranjit ,  BELLO, Thomas ,  CHAN, Marina

IPC分类号： A61K31/519 ,  C07D403/06 ,  C07D487/04 ,  A61P35/00

摘要： Treatment for prostate cancer, including castration-resistant prostate cancer, by utilizing a protein kinase inhibitor selected from an SC-1 compound, a PP121 compound, a PD166285 dihydrochloride (diHCI) compound, an NCGC00348110 compound, a Dasatinib compound, a PDK1/Akt/Fit DPI compound, a Staurosporine compound, and/or a Cdk 1/2 Inhibitor III compound, optionally in combination with an androgen receptor signaling inhibitor are described. Assays to predict in vivo effectiveness of potential therapeutics against prostate cancer are also provided.

公开(公告)号：WO2022178326A1

公开(公告)日：2022-08-25

申请号：PCT/US2022/017100

申请日：2022-02-18

申请人： HUTCHINSON TECHNOLOGY INCORPORATED

发明人： RUZICKA, Ryan N. ,  SAKAMOTO, Yasushi ,  MILLER, Mark A.

IPC分类号： G02B27/64 ,  G03B13/36

摘要： SMA actuators and related methods are described. One embodiment of an actuator includes a base; a plurality of buckle arms; and at least a first shape memory alloy wire coupled with a pair of buckle arms of the plurality of buckle arms. Another embodiment of an actuator includes a base and at least one bimorph actuator including a shape memory alloy material. The bimorph actuator attached to the base.

公开(公告)号：WO2022136781A1

公开(公告)日：2022-06-30

申请号：PCT/FR2021/052390

申请日：2021-12-17

申请人： HUTCHINSON ,  SAFT

发明人： DE FRANCQUEVILLE, Loïc ,  FLORENTZ, Bertrand ,  CHOPARD, Fabrice ,  CAPILLO, Andrea ,  BRIAND, Axel ,  BOREL, Philippe ,  PHILIPPE, Sébastien

IPC分类号： H01M10/613 ,  H01M10/615 ,  H01M10/625 ,  H01M10/6554 ,  H01M10/6567 ,  H01M50/204

摘要： L’invention concerne un dispositif de régulation thermique (1) comportant un organe (2) à chauffer ou à refroidir, une conduite (3) de circulation de fluide comprenant au moins une partie souple (6) apte à se déformer en fonction de la pression du fluide au sein de la conduite (3), et au moins une zone de contact (5) venant en contact avec ledit organe (2) lorsque la pression du fluide dans la conduite (3) est supérieur à une pression déterminée et qui est écartée dudit organe (2) lorsque la pression du fluide dans la conduite (3) est inférieure à la pression déterminée, le dispositif de régulation thermique (1) comportant des moyens de régulation aptes à faire varier la pression du fluide au sein de la conduite (3).

公开(公告)号：WO2022115715A1

公开(公告)日：2022-06-02

申请号：PCT/US2021/061035

申请日：2021-11-29

申请人： FRED HUTCHINSON CANCER RESEARCH CENTER ,  BLAZE BIOSCIENCE, INC. ,  CROOK, Zachary ,  OLSON, James ,  STRONG, Roland K. ,  NAIRN, Natalie Winblade ,  TAPSCOTT, Stephen ,  GRABSTEIN, Kenneth

发明人： CROOK, Zachary ,  OLSON, James ,  STRONG, Roland K. ,  NAIRN, Natalie Winblade ,  TAPSCOTT, Stephen ,  GRABSTEIN, Kenneth

IPC分类号： A61K9/00 ,  A61K38/00 ,  A61K38/03 ,  A61K47/00 ,  A61K47/64 ,  C07K14/00

摘要： Described herein are compositions and methods for selective depletion of target molecules using a recyclable CDP- receptor-binding mediated complex to elicit endocytosis and cellular degradation of the target. Exemplary compositions containing a peptide, such as a CDP peptide, that bind a transferrin receptor can be linked to a peptide that binds a target molecule. Such compositions can be used to selectively recruit the target molecule to endosomes via transferrin receptor-mediated endocytosis of the composition and the bound target molecule. Once inside the endosome, the acidic pH can lead to release of the target molecule from the composition due to pH-dependent binding of the composition for the target molecule, and the transferrin receptor portion is recycled back to the cell surface for "reloading". The target molecule can then be trafficked into lysosomes wherein it is degraded.

公开(公告)号：WO2022066965A2

公开(公告)日：2022-03-31

申请号：PCT/US2021/051832

申请日：2021-09-23

申请人： FRED HUTCHINSON CANCER RESEARCH CENTER

发明人： MARTINOV, Tijana

IPC分类号： C07K16/18 ,  A61P35/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/725 ,  A61K35/17 ,  A61K2039/505 ,  C07K14/4702 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70539 ,  C07K2317/73

摘要： The present disclosure provides compositions and methods for targeting SOX2 antigen to, for example, treat or manage cancer. Provided compositions include binding proteins that are capable of binding to a SOX2 antigen:HLA complex. Also provided are polynucleotides and transgene constructs encoding binding proteins, such as a T cell receptor or a chimeric antigen receptor, that specifically bind to a SOX2 antigen. Such polynucleotides and transgene constructs can be introduced into an immune cell, such as a T cell, and used in immunotherapy in a subject having or at risk for a cancer associated with SOX2 expression or activity. The present disclosure also provides immunogenic compositions comprising SOX2 antigens, and related uses.

公开(公告)号：WO2021236718A1

公开(公告)日：2021-11-25

申请号：PCT/US2021/033080

申请日：2021-05-19

申请人： FRED HUTCHINSON CANCER RESEARCH CENTER

发明人： CHAN, Marina ,  GUJRAL, Taranjit

IPC分类号： A61K38/17 ,  A61P1/16 ,  A61P1/18

摘要： The present disclosure is based on the discovery that a clinical grade compound of Formula (I) potently blocks TGF-β activity and significantly reverse the activated phenotypes of myofibroblast in vitro. The compound of Formula (I) can be used in the treatment of fibrotic conditions in general, such as non-alcoholic steatohepatitis (NASH), cirrhosis, HBV infection, any liver disease, pulmonary fibrosis, interstitial lung disease, idiopathic pulmonary fibrosis (IPF), renal fibrosis, cardiac fibrosis, or any combination thereof.

公开(公告)号：WO2021224378A1

公开(公告)日：2021-11-11

申请号：PCT/EP2021/061965

申请日：2021-05-06

申请人： HUTCHINSON

发明人： NOE, Mathieu

IPC分类号： B23B29/02 ,  F16F7/10 ,  F16F7/104

摘要： Barre d'alésage munie d'actionneurs électrodynamiques pour contrer les vibrations et machine-outil munie d'une telle barre. La barre d'alésage (BF) est munie d'une paroi (P), d'un logement interne (Ll) et d'un axe longitudinal (Z), ladite barre d'alésage (BF) comportant, dans son logement interne (Ll) : • un premier actionneur (100) électrodynamique muni de bobinages (101, 102) associés à une masse mobile (110) et un ensemble de ressorts (120, 121) agencés pour définir une première direction d'actionnement (X) perpendiculaire à l'axe longitudinal (Z) de la barre d'alésage; • un deuxième actionneur (200) électrodynamique muni de bobinages (201, 202) associés à une masse mobile (210) et un ensemble de ressorts (220, 221) agencés pour définir une deuxième direction d'actionnement (Y) à la fois perpendiculaire à la première direction d'actionnement (X) et à l'axe longitudinal (Z) de la barre d'alésage. Les actionneurs permettent ainsi de contrer les vibrations dans les directions (X, Y) perpendiculaires à l'axe longitudinal (Z) de la barre, lequel axe longitudinal définit également la direction d'alésage.