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公开(公告)号：WO2013090701A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069716
申请日：2012-12-14
Applicant: SEMPRUS BIOSCIENCES CORP. , BOUCHARD, Michael , ZHANG, Zheng , LI, Jun , SKINNER, Matt , ROTH, Laurence , WEAVER, Douglas , MARCHESE, Eric, W. , REED, Robert , HUVAL, Chad , LOOSE, Christopher, R.
Inventor： BOUCHARD, Michael , ZHANG, Zheng , LI, Jun , SKINNER, Matt , ROTH, Laurence , WEAVER, Douglas , MARCHESE, Eric, W. , REED, Robert , HUVAL, Chad , LOOSE, Christopher, R.
CPC classification number: A61M25/0026 , A61L29/085 , A61L29/14 , A61L33/0088 , A61M25/0108 , A61M2025/0019 , A61M2025/0047 , B05D3/02 , B05D7/22 , Y10T428/1393
Abstract: Catheters and a method of preparation thereof, the catheter comprising a catheter body, a juncture hub, extension lines and connectors, the catheter body having a proximal end, a distal end, an exterior surface, a tip region having a length of 10 cm measured from the distal end of the catheter body, and at least two lumen, each of the catheter body lumen having a proximal end, a distal end, a Lumen Aspect Ratio of at least 3:1, and an intraluminal surface, the distal ends of the at least two catheter body lumen being (i) non-coterminus or (ii) laser-cut, the exterior surface of the catheter body in the tip region or the intraluminal surface of the two catheter body lumen comprising a hydrophilic polymer layer having an Average Dry Thickness of at least about 50 nanometers.
Abstract translation: 导管及其制备方法，所述导管包括导管主体，接合毂，延伸线和连接器，所述导管主体具有近端，远端，外表面，测量长度为10cm的尖端区域 从导管主体的远端和至少两个内腔，每个导管体腔具有近端，远端，至少3:1的流明长宽比和管腔内表面， 所述至少两个导管体腔是（i）非子母体或（ii）激光切割，所述导管体在所述前导区域或所述两个导管体腔的管腔内表面的外表面包含亲水性聚合物层，所述亲水性聚合物层具有 平均干燥厚度至少约50纳米。
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2.发明申请
公开(公告)号：WO2011156589A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039790
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP. , LI, Jun , ZHANG, Zheng , HUVAL, Chad , BOUCHARD, Michael , COURY, Arthur, J. , LOOSE, Christopher, R.
Inventor： LI, Jun , ZHANG, Zheng , HUVAL, Chad , BOUCHARD, Michael , COURY, Arthur, J. , LOOSE, Christopher, R.
CPC classification number: C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
Abstract: A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37 C in 70 µg/mL fibrinogen derived from human plasma containing 1.4 µg/mL I-125 radiolabeled fibrinogen
Abstract translation: 一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有 在纤维蛋白原结合测定中，纤维蛋白原吸附小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟
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公开(公告)号：WO2008005217A3
公开(公告)日：2008-02-21
申请号：PCT/US2007014688
申请日：2007-06-25
Applicant: GENZYME CORP , HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
Inventor： HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
IPC: A61K31/295 , A61K9/14 , A61K33/26
CPC classification number: A61K33/26 , A61K9/145 , A61K9/146 , A61K31/295 , A61K31/785 , A61K45/06 , A61K2300/00
Abstract: A pharmaceutical composition comprises a pharmaceutically acceptable ferrous iron compound; an amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Alternatively, a pharmaceutica composition comprises a pharmaceutically acceptable ferrous iron compound and pharmaceutically acceptable carrier, wherein the ferrous iron compound is selecte from the group consisting of iron(II) acetate, iron(II) citrate, iron(II) ascorbate, iron(II) oxalate, iron(II) oxide, iron(II) carbonate, iron(II) carbonate saccharated, iron(II) formate, iron(II) sulfate, iron(II) chloride, iron(II) acetylacetonate and combinations thereof. A method of treating a subject with hyperphosphatemia comprises administering to the subject an effective amount of a pharmaceutical composition as described above.
Abstract translation: 药物组合物包含药学上可接受的亚铁化合物; 胺聚合物或其药学上可接受的盐和药学上可接受的载体。 或者，药物组合物包含药学上可接受的亚铁化合物和药学上可接受的载体，其中亚铁化合物选自乙酸铁（II），柠檬酸铁（II），抗坏血酸铁（II），抗坏血酸铁（II） ）草酸盐，氧化铁（II），碳酸铁（II），糖化的碳酸铁（II），甲酸铁（II），硫酸铁（II），氯化铁（II），乙酰丙酮铁（II）及其组合。 治疗高磷血症患者的方法包括给予患者有效量的上述药物组合物。
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公开(公告)号：WO2007130463A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010650
申请日：2007-05-02
Applicant: GENZYME CORPORATION , HUVAL, Chad, C. , DHAL, Pradeep, K. , HOLMES-FARLEY, Stephen, Randall
Inventor： HUVAL, Chad, C. , DHAL, Pradeep, K. , HOLMES-FARLEY, Stephen, Randall
IPC: C08G73/02
CPC classification number: A61K31/785 , C08G73/02 , C08G73/0206
Abstract: Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a -CH 2 CH 2 - group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.
Abstract translation: 公开了一种聚合物或其生理上可接受的盐。 聚合物包含聚合的多官能胺单体。 胺单体包含至少两个胺基团和至少两个通过-CH 2 CH 2 - 基团连接的无环氮原子，条件是胺单体不是 乙二胺或二亚乙基三胺。 所公开的聚合物可用于结合需要这种治疗的受试者中的阴离子。
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公开(公告)号：WO2007027566A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/033437
申请日：2006-08-25
Applicant: GENZYME CORPORATION , HUVAL, Chad, C. , HOLMES-FARLEY, Stephen, Randall , DHAL, Pradeep, K.
Inventor： HUVAL, Chad, C. , HOLMES-FARLEY, Stephen, Randall , DHAL, Pradeep, K.
CPC classification number: A61K31/785 , A61K31/77 , A61K31/787 , C08F226/02 , C08F226/04 , C08F226/06
Abstract: Polymers and compositions utilizing such polymers are disclosed for treating hyperphosphatemia and other illnesses associated with elevated serum phosphate levels. Phosphate binding polymers, or a pharmaceutically acceptable salt of the polymers, comprise pendent groups extending from a backbone of the polymer. Each pendent group comprises at least two nitrogen-bearing functional groups which bind phosphate. Variations of such polymer and compositions are disclosed.
Abstract translation: 公开了使用这种聚合物的聚合物和组合物用于治疗与高血清磷酸盐水平升高相关的高磷酸盐血症和其它疾病。 磷酸酯结合聚合物或聚合物的药学上可接受的盐包括从聚合物主链延伸的侧基。 每个侧基包含至少两个结合磷酸盐的含氮官能团。 公开了这种聚合物和组合物的变化。
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Patent Agency Ranking
公开(公告)号：WO2013090695A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069705
申请日：2012-12-14
Applicant: SEMPRUS BIOSCIENCES CORP. , LI, Jun , ZHANG, Zheng , WEAVER, Douglas , MARCHESE, Eric W. , DELEAULT, Abby N. , NGUYEN, Phu C. , ELIAS, Kobe , HUVAL, Chad , LOOSE, Christopher R.
Inventor： LI, Jun , ZHANG, Zheng , WEAVER, Douglas , MARCHESE, Eric W. , DELEAULT, Abby N. , NGUYEN, Phu C. , ELIAS, Kobe , HUVAL, Chad , LOOSE, Christopher R.
CPC classification number: A61M25/0045 , A61L29/049 , A61L29/085 , A61L29/14 , A61L29/18 , A61L33/0023 , A61L33/064 , A61L2400/12 , A61M25/00 , A61M25/0012 , A61M2025/0019 , A61M2025/0042 , A61M2025/0046 , A61M2025/0047 , A61M2025/0062 , Y10T428/1393 , C08L75/04 , C08L33/04 , C08L33/14
Abstract: Catheters and a method for preparation thereof, the catheter comprising as component parts thereof a catheter body, a juncture hub, at least one extension line and at least one connector, each of said component parts comprising an exterior surface, at least one lumen having an intraluminal surface and a bulk polymer, wherein the intraluminal or external surface of a first of said component parts and the exterior or intraluminal surface of a second of said component parts comprise a hydrophilic polymer layer thereon having an Average Dry Thickness of at least about 50 nanometers and the first and second component parts comprise bulk polymers having different chemical compositions.
Abstract translation: 导管及其制备方法，所述导管包括导管主体，接合毂，至少一个延伸线和至少一个连接器的组成部分，每个所述部件包括外表面，至少一个内腔具有 管腔内表面和本体聚合物，其中所述组分部分中的第一个的管腔或外表面以及所述组分第二部分的外部或管腔内表面包含其上的亲水性聚合物层，其平均干燥厚度为至少约50纳米 并且第一和第二组分部分包括具有不同化学组成的本体聚合物。
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7.发明申请ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 审中-公开具有非浮选表面的制品及其制备方法，不改变物理性质
公开(公告)号：WO2011156603A3
公开(公告)日：2012-04-26
申请号：PCT/US2011039806
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP , WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
Inventor： WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
CPC classification number: A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface
Abstract translation: 本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 该方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理性能，然后在经处理的基材表面上形成接枝聚合物层
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8.发明申请ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME INCLUDING PRETREATMENT OF SUBSTRATES 审中-公开具有非污染表面的制品及其制备方法，包括预处理基质
公开(公告)号：WO2011156596A3
公开(公告)日：2012-04-26
申请号：PCT/US2011039799
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP , ROTH LAURENCE A , ZHANG ZHENG , HUVAL CHAD C , BOUCHARD MICHAEL A , LOOSE CHRISTOPHER R
Inventor： ROTH LAURENCE A , ZHANG ZHENG , HUVAL CHAD C , BOUCHARD MICHAEL A , LOOSE CHRISTOPHER R
CPC classification number: A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
Abstract translation: 本文描述了用于制备在包含聚合物表面的基底上具有低污垢表面的医疗装置和其他制品的方法。 聚合物表面材料可具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容且不结垢的表面。 该方法涉及处理基材以降低基材表面上或基材中的化学物质的浓度，而不改变装置或制品的整体物理性质，并且此后在处理过的基材表面上形成接枝聚合物层。
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9.发明申请ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 审中-公开具有非浮选表面的制品及其制备方法，不改变物理性质
公开(公告)号：WO2011156603A2
公开(公告)日：2011-12-15
申请号：PCT/US2011039806
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP , WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
Inventor： WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
CPC classification number: A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface
Abstract translation: 本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 该方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理性能，然后在经处理的基材表面上形成接枝聚合物层
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公开(公告)号：WO2008042222A3
公开(公告)日：2008-12-18
申请号：PCT/US2007020852
申请日：2007-09-26
Applicant: GENZYME CORP , DHAL PRADEEP K , HARRIS DAVID J , HOLMES-FARLEY STEPHEN RANDALL , HUVAL CHAD C , NIVOROZHKIN VITALY , SHUTTS BRUCE
Inventor： DHAL PRADEEP K , HARRIS DAVID J , HOLMES-FARLEY STEPHEN RANDALL , HUVAL CHAD C , NIVOROZHKIN VITALY , SHUTTS BRUCE
IPC: A61K8/72
CPC classification number: C08G69/40 , A61K8/72 , A61K31/785 , C07C235/08 , C07C237/10 , C08G83/003 , C08L101/00
Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.
Abstract translation: 酰胺化合物，酰胺聚合物，包括酰胺化合物和酰胺聚合物的组合物可用于结合目标离子，例如动物胃肠道中的含磷化合物。 在一些情况下，酰胺化合物和酰胺聚合物可以包括衍生自酰胺多元醇和有机多元酸或酯的核。
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