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    CANCER VACCINES TARGETING SURVIVIN AND USES THEREOF
    3.
    发明申请
    CANCER VACCINES TARGETING SURVIVIN AND USES THEREOF 审中-公开

    公开(公告)号：WO2019118766A2

    公开(公告)日：2019-06-20

    申请号：PCT/US2018/065529

    申请日：2018-12-13

    申请人： INOVIO PHARMACEUTICALS, INC.

    发明人： YAN, Jian ,  SLAGER, Anna ,  GARMAN, Bradley ,  COOCH, Neil

    IPC分类号： A61K39/00 ,  C12N15/62

    摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens are disclosed. Methods of treating a subject with a Survivin-expressing tumor and methods of preventing a Survivin-expressing tumor are disclosed. Synthetic consensus Survivin antigens are disclosed.

    CANCER VACCINES TARGETING MUC16 AND USES THEREOF
    4.
    发明申请
    CANCER VACCINES TARGETING MUC16 AND USES THEREOF 审中-公开

    公开(公告)号：WO2019118764A1

    公开(公告)日：2019-06-20

    申请号：PCT/US2018/065524

    申请日：2018-12-13

    申请人： INOVIO PHARMACEUTICALS, INC.

    发明人： YAN, Jian ,  SLAGER, Anna ,  GARMAN, Bradley ,  COOCH, Neil

    IPC分类号： A61K48/00 ,  A61K48/14

    摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen are disclosed. Methods of treating a subject with a MUC16-expressing tumor and methods of preventing a MUC16-expressing tumor are disclosed. Modified consensus MUC16 antigen is disclosed.

    THE IN VIVO USE OF CHONDROITINASE AND/OR HYALURONIDASE TO ENHANCE DELIVERY OF AN AGENT
    6.
    发明申请
    THE IN VIVO USE OF CHONDROITINASE AND/OR HYALURONIDASE TO ENHANCE DELIVERY OF AN AGENT 审中-公开
    体内驱虫和/或透明质酸酶用于增强代谢物的体内使用

    公开(公告)号：WO2017190147A1

    公开(公告)日：2017-11-02

    申请号：PCT/US2017/030447

    申请日：2017-05-01

    申请人： INOVIO PHARMACEUTICALS, INC.

    发明人： SMITH, Trevor ,  SCHOMMER, Nina ,  BRODERICK, Kate ,  YUNG, Bryan ,  SCHULTHEIS, Katherine

    IPC分类号： C12N9/88 ,  A61K35/30 ,  A61K38/51

    摘要： Disclosed herein are methods of delivering an agent to a subject. Further disclosed herein are methods of treating a disease or disorder in a subject. The methods may include administering to the subject a chondroitinase polypeptide or a polynucleotide encoding a chondroitinase polypeptide in an amount sufficient to degrade glycosaminoglycans, and administering to the subject the agent. The methods may further include administering a hyaluronidase polypeptide or a polynucleotide encoding a hyaluronidase.

    摘要翻译： 本文公开了将药剂递送至受试者的方法。 本文进一步公开了治疗受试者的疾病或病症的方法。 所述方法可以包括向受试者施用足以降解糖胺聚糖的量的软骨素酶多肽或编码软骨素酶多肽的多核苷酸，并且向受试者施用药剂。 该方法可以进一步包括施用透明质酸酶多肽或编码透明质酸酶的多核苷酸。

    COMPOUNDS HAVING IMMUNOMODULATOR ACTIVITY
    9.
    发明申请
    COMPOUNDS HAVING IMMUNOMODULATOR ACTIVITY 审中-公开
    具有免疫调节剂活性的化合物

    公开(公告)号：WO2013158792A1

    公开(公告)日：2013-10-24

    申请号：PCT/US2013/037020

    申请日：2013-04-17

    申请人： INOVIO PHARMACEUTICALS, INC. ,  SARDESAI, Niranjan ,  KIM, J. Joseph

    发明人： SARDESAI, Niranjan ,  KIM, J. Joseph

    IPC分类号： A61K31/42 ,  A61P37/06

    CPC分类号： C07D261/08 ,  A61K31/42

    摘要： The present invention is directed to methods of suppressing an immune response in a subject in need thereof comprising administering a therapeutically effective amount of a compound having the following formula: 3-phenyl-4,5-dihydro-5-isoxazoleacetic acid to the subject in need thereof, wherein R1-5 represents from one to five substituents independently selected from hydrogen, nitro, cyano, C1-C3-alkyl, halogen, carboxy, amino, trifluoromethyl, hydroxy, C1-C3-alkoxy groups, X is hydrogen, halo, N3, SH, =O, =CH2, an aromatic, preferably phenyl, ring optionally substituted by R1-5 groups as defined above, amino, mono- or disubstituted amino groups wherein the substituents are selected from C1-C4 alkyl, phenyl or benzyl groups optionally substituted by R1-5 groups as defined above Y is hydrogen, allyl C1-C4, amino, or a group of formula --(CH2)0-1A wherein A is an aromatic, preferably phenyl, ring optionally substituted by R1-5 groups as defined above with the proviso that when X and Y are hydrogen, R1-5 cannot represent a 4-hydroxy or 4-alkoxy groups.

    摘要翻译： 本发明涉及在有需要的受试者中抑制免疫应答的方法，包括向受试者施用治疗有效量的具有下式的化合物：3-苯基-4,5-二氢-5-异恶唑乙酸 其中R1-5表示一至五个独立地选自氢，硝基，氰基，C 1 -C 3 - 烷基，卤素，羧基，氨基，三氟甲基，羟基，C 1 -C 3 - 烷氧基，X是氢，卤素 ，N 3，SH，= O，= CH 2，任选被如上定义的R 1〜5基团取代的芳基，优选苯基，氨基，单取代或二取代的氨基，其中取代基选自C 1 -C 4烷基，苯基或 任选被如上所定义的R 1〜5基团取代的苄基是氢，烯丙基C 1 -C 4，氨基或式 - （CH 2）0-1A基团，其中A是任选被R 1取代的芳基，优选苯基， -5个基团，条件是当X和Y为 e氢，R1-5不能代表4-羟基或4-烷氧基。