公开(公告)号：WO2014144885A2

公开(公告)日：2014-09-18

申请号：PCT/US2014/029479

申请日：2014-03-14

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WEINER, David ,  MUTHUMANI, Karuppiah ,  WALTERS, Jewell ,  YAN, Jian

发明人： WEINER, David ,  MUTHUMANI, Karuppiah ,  WALTERS, Jewell ,  YAN, Jian

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/575 ,  C12N9/0071 ,  C12N2710/20034 ,  C12N2730/10111 ,  C12N2770/24234 ,  C12Y114/18001

摘要： Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.

摘要翻译： 本文公开了治疗癌症的组合物和方法，特别是治疗和提供针对肿瘤生长的保护的疫苗。

公开(公告)号：WO2021092019A1

公开(公告)日：2021-05-14

申请号：PCT/US2020/058891

申请日：2020-11-04

申请人： INOVIO PHARMACEUTICALS, INC. ,  REGENERON PHARMACEUTICALS, INC. ,  YAN, Jian ,  FERRARO, Bernadette ,  WALTERS, Jewell

发明人： BREDLAU, Amy-Lee ,  LOWY, Israel ,  SKOLNIK, Jeffrey

IPC分类号： C07K14/47 ,  A61K39/00 ,  C07K16/30

摘要： Provided herein are nucleic acid molecules, proteins, compositions and methods for treating brain cancer in a subject. In some embodiments, the compositions comprise cancer antigens hTERT, WT-1, and PSMA. In some embodiments, the compositions also comprise an adjuvant. The methods comprise administering to a subject in need thereof the cancer antigens. According to certain embodiments, the methods further involve administering the adjuvant and an anti-PD-1 antibody. In certain embodiments, the methods further comprise administering radiation therapy and/or a chemotherapeutic agent. In certain embodiments, the methods are clinically proven safe, clinically proven effective, or both.

公开(公告)号：WO2014144885A3

公开(公告)日：2014-12-04

申请号：PCT/US2014029479

申请日：2014-03-14

申请人： UNIV PENNSYLVANIA ,  WEINER DAVID ,  MUTHUMANI KARUPPIAH ,  WALTERS JEWELL ,  YAN JIAN

发明人： WEINER DAVID ,  MUTHUMANI KARUPPIAH ,  WALTERS JEWELL ,  YAN JIAN

IPC分类号： A61K48/00 ,  A61K38/00 ,  C07H21/04 ,  C07K14/00

CPC分类号： A61K39/0011 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/575 ,  C12N9/0071 ,  C12N2710/20034 ,  C12N2730/10111 ,  C12N2770/24234 ,  C12Y114/18001

摘要： Disclosed are vaccine compositions comprising one or more nucleic acid encoding one or more amino acid sequence(s) selected from the group consisting of amino acid sequences of tyrosinase (Tyr), tyrosinase-related protein 1 (TYRP1 ), tyrosinase-related protein 2 (TYRP2), melanoma-associated antigen 4 protein (MAGEA4), growth hormone release hormone (GHRH), MART-1/melan-A antigen, cancer testis antigen NY-ESO-1, cancer testis antigen NY-ESO-2, preferentially expressed antigen in melanoma (PRAME), Wilms' tumor 1 (WT1), and human telomerase reverse transcriptase (hTERT). The vaccine compositions can further comprise a nucleic acid encoding one or more other antigens including prostate specific antigen (PSA). Further disclosed are methods of preventing or treating cancer in a subject in need comprising administering to the subject a vaccine composition comprising a particular number of cancer antigens for treating or preventing a particular cancer.

摘要翻译： 公开了包含编码一种或多种选自由酪氨酸酶（Tyr）的氨基酸序列，酪氨酸酶相关蛋白1（TYRP1），酪氨酸酶相关蛋白2（TYRP1） TYRP2），黑素瘤相关抗原4蛋白（MAGEA4），生长激素释放激素（GHRH），MART-1 / melan-A抗原，癌睾丸抗原NY-ESO-1，癌睾丸抗原NY-ESO-2，优先表达 黑素瘤抗原（PRAME），Wilms肿瘤1（WT1）和人端粒酶逆转录酶（hTERT）。 疫苗组合物还可包含编码一种或多种其它抗原（包括前列腺特异性抗原（PSA））的核酸。 进一步公开的是在需要的受试者中预防或治疗癌症的方法，包括向受试者施用包含特定数量的癌抗原的疫苗组合物，用于治疗或预防特定的癌症。

公开(公告)号：WO2014093886A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/075127

申请日：2013-12-13

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  INOVIO PHARMACEUTICALS, INC. ,  WEINER, David, B. ,  YAN, Jian ,  WALTERS, Jewell

发明人： WEINER, David, B. ,  YAN, Jian ,  WALTERS, Jewell

IPC分类号： A61K39/00 ,  A61K39/38 ,  C12N15/64 ,  C12P19/34

CPC分类号： A61K39/0011 ,  A61K2039/53 ,  C07K14/4748

摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.

摘要翻译： 本文公开了包含编码突变的WT1抗原的一个或多个核酸序列的核酸分子。 公开了包含编码突变的WT1抗原的一个或多个核酸序列的载体，组合物和疫苗。 公开了治疗具有WT1表达肿瘤的个体的方法和预防表达WT1的肿瘤的方法。 公开了突变的WT1抗原。

公开(公告)号：WO2014093897A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/075141

申请日：2013-12-13

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  INOVIO PHARMACEUTICALS, INC. ,  WEINER, David B. ,  YAN, Jian ,  WALTERS, Jewell

发明人： WEINER, David B. ,  YAN, Jian ,  WALTERS, Jewell

IPC分类号： A61K39/00 ,  A61K39/38 ,  C12N15/64 ,  C12P19/34

CPC分类号： A61K39/0011 ,  A61K2039/53 ,  C07K14/4748

摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.

摘要翻译： 本文公开了包含一个或多个编码突变的WT1抗原的核酸序列的核酸分子。 公开了包含一个或多个编码突变的WT1抗原的核酸序列的载体，组合物和疫苗。 公开了治疗具有表达WT1的肿瘤的个体的方法以及预防表达WT1的肿瘤的方法。 公开了突变的WT1抗原。