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    COMBINATION OF NOVEL VACCINES AGAINST ZIKA VIRUS AND DNA ANTIBODY CONSTRUCTS FOR USE AGAINST ZIKA VIRUS
    1.
    发明申请
    COMBINATION OF NOVEL VACCINES AGAINST ZIKA VIRUS AND DNA ANTIBODY CONSTRUCTS FOR USE AGAINST ZIKA VIRUS 审中-公开
    新型疫苗与ZIKA病毒的组合以及用于ZIKA病毒的DNA抗体构建体

    公开(公告)号：WO2018053478A1

    公开(公告)日：2018-03-22

    申请号：PCT/US2017/052203

    申请日：2017-09-19

    申请人： WEINER, David ,  MUTHUMANI, Karuppiah ,  YAN, Jian

    发明人： MUTHUMANI, Karuppiah ,  YAN, Jian

    IPC分类号： A61K39/12 ,  A61P31/14 ,  C07K14/18 ,  C12N15/40

    摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV -Envelope (anti-ZIKV E) Protein antibody.

    摘要翻译： 本文公开了包含编码针对寨卡病毒抗原的抗体的重组核酸序列及其功能片段的组合物。 本发明还涉及一种组合物，其包含在哺乳动物中引起针对zika病毒的免疫应答的第一组合物和包含编码抗体，其片段，其变体或组合的组合的重组核酸序列的组合 它们。 在一些情况下，核酸分子包含编码抗ZIKV-包膜（抗ZIKV E）蛋白抗体的核苷酸序列。

    GENETIC CONSTRUCTS AND COMPOSITIONS COMPRISING RRE AND CTE AND USES THEREOF
    4.
    发明申请
    GENETIC CONSTRUCTS AND COMPOSITIONS COMPRISING RRE AND CTE AND USES THEREOF 审中-公开

    公开(公告)号：WO2004045548A3

    公开(公告)日：2004-06-03

    申请号：PCT/US2003/036924

    申请日：2003-11-19

    申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WEINER, David, B. ,  MUTHUMANI, Karuppiah

    发明人： WEINER, David, B. ,  MUTHUMANI, Karuppiah

    IPC分类号： C12N5/00

    摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.

    HUMAN RESPIRATORY SYNCYTIAL VIRUS CONSENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING SAME
    9.
    发明申请
    HUMAN RESPIRATORY SYNCYTIAL VIRUS CONSENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING SAME 审中-公开
    人呼吸综合征病毒共同抗原，核酸构建物及其制备的疫苗及其使用方法

    公开(公告)号：WO2013155205A9

    公开(公告)日：2013-12-05

    申请号：PCT/US2013036008

    申请日：2013-04-10

    申请人： UNIV PENNSYLVANIA ,  WEINER DAVID B ,  CHOO DANIEL ,  MUTHUMANI KARUPPIAH ,  OBENG-ADJEI NYAMEKYE ,  SCOTT VERONICA

    发明人： WEINER DAVID B ,  CHOO DANIEL ,  MUTHUMANI KARUPPIAH ,  OBENG-ADJEI NYAMEKYE ,  SCOTT VERONICA

    IPC分类号： C07K14/135

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/57 ,  A61K2039/70 ,  C12N2760/18522 ,  C12N2760/18534

    摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that encodes consensus RSV F protein or immunogenic fragment thereof, sequences that encodes an RSV G(A) protein or immunogenic fragment thereof and sequences that encodes an RSV G(B) protein or immunogenic fragment thereof. Compositions comprising one, combinations of two or all three sequences are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Nucleic acid molecules and compositions comprising the chemokine CC20 and/or a consensus RSV M2-1 protein or immunogenic fragment thereof are also disclosed. Immunomodulatory methods and methods of inducing an immune response against RSV are disclosed. Method of preventing RSV infection and methods of treating individuals infected with RSV are disclosed.

    摘要翻译： 公开了包含编码RSV免疫原的一个或多个核酸序列的核酸分子和组合物。 公开了包含编码共有RSV F蛋白或其免疫原性片段的序列的编码RSV G（A）蛋白或其免疫原性片段的序列和编码RSV G（B）蛋白或其免疫原性片段的序列的核酸。 公开了包含一个，两个或所有三个序列的组合的组合物。 编码序列任选地包括编码信号肽的可操作的连锁编码序列。 还公开了包含趋化因子CC20和/或共有RSV M2-1蛋白或其免疫原性片段的核酸分子和组合物。 公开了诱导针对RSV的免疫应答的免疫调节方法和方法。 公开了预防RSV感染的方法和治疗感染RSV的个体的方法。

    HUMAN RESPIRATORY SYNCYTIAL VIRUS CONCENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFORM, AND METHODS OF USING SAME
    10.
    发明申请
    HUMAN RESPIRATORY SYNCYTIAL VIRUS CONCENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFORM, AND METHODS OF USING SAME 审中-公开
    人呼吸综合病毒凝血酶抗原，核酸结构及其制备的疫苗及其使用方法

    公开(公告)号：WO2013155205A1

    公开(公告)日：2013-10-17

    申请号：PCT/US2013/036008

    申请日：2013-04-10

    申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WEINER, David B. ,  CHOO, Daniel ,  MUTHUMANI, Karuppiah ,  OBENG-ADJEI, Nyamekye ,  SCOTT, Veronica

    发明人： WEINER, David B. ,  CHOO, Daniel ,  MUTHUMANI, Karuppiah ,  OBENG-ADJEI, Nyamekye ,  SCOTT, Veronica

    IPC分类号： C07K14/135

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/57 ,  A61K2039/70 ,  C12N2760/18522 ,  C12N2760/18534

    摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that encodes consensus RSV F protein or immunogenic fragment thereof, sequences that encodes an RSV G(A) protein or immunogenic fragment thereof and sequences that encodes an RSV G(B) protein or immunogenic fragment thereof. Compositions comprising one, combinations of two or all three sequences are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Nucleic acid molecules and compositions comprising the chemokine CC20 and/or a consensus RSV M2-1 protein or immunogenic fragment thereof are also disclosed. Immunomodulatory methods and methods of inducing an immune response against RSV are disclosed. Method of preventing RSV infection and methods of treating individuals infected with RSV are disclosed.

    摘要翻译： 公开了包含编码RSV免疫原的一个或多个核酸序列的核酸分子和组合物。 公开了包含编码共有RSV F蛋白或其免疫原性片段的序列的编码RSV G（A）蛋白或其免疫原性片段的序列和编码RSV G（B）蛋白或其免疫原性片段的序列的核酸。 公开了包含一个，两个或所有三个序列的组合的组合物。 编码序列任选地包括编码信号肽的可操作的连锁编码序列。 还公开了包含趋化因子CC20和/或共有RSV M2-1蛋白或其免疫原性片段的核酸分子和组合物。 公开了诱导针对RSV的免疫应答的免疫调节方法和方法。 公开了预防RSV感染的方法和治疗感染RSV的个体的方法。