公开(公告)号：WO2004069054A2

公开(公告)日：2004-08-19

申请号：PCT/US2004/001585

申请日：2004-01-20

Applicant: INTEGRATED VASCULAR SYSTEMS INC. ,  PALERMO, Thomas ,  BELEF, William, M. ,  CARLEY, Michael, T. ,  GINN, Richard, S. ,  JABBA, Ronald, J ,  PANTAGES, Anthony

Inventor： PALERMO, Thomas ,  BELEF, William, M. ,  CARLEY, Michael, T. ,  GINN, Richard, S. ,  JABBA, Ronald, J ,  PANTAGES, Anthony

IPC: A61B17/00

CPC classification number: A61B17/064 ,  A61B17/0057 ,  A61B17/0643 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/1227 ,  A61B17/1285 ,  A61B2017/00637 ,  A61B2017/00672

Abstract: An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. The closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.

Abstract translation: 一种用于将闭合元件输送到形成在血管或其他体腔中的开口中的装置及其制造和使用方法。 该装置构造成保持封闭元件，使得封闭元件基本上设置在该装置内。 该装置还可以将封闭件基本上邻近开口附近的血管壁接合并定位。 在封闭元件的展开过程中，该装置将闭合元件膨胀超过封闭元件的自然横截面，使得封闭元件在展开时构造成与大量的血管壁和/或组织接合。 闭合元件进一步构造成返回到自然横截面，从而将所接合的血管壁和/或组织基本上闭合和/或密封，使得开口内止血增强。

公开(公告)号：WO2003071956A3

公开(公告)日：2003-09-04

申请号：PCT/US2003/005059

申请日：2003-02-18

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： BELEF, Martin, W. ,  ALDRICH, William, N ,  CARLEY, Michael, T ,  JABBA, Ronald, J ,  SALMON, Stephen, M ,  PANTAGES, Anthony ,  SAGASTEGUI, Javier

IPC: A61B17/00

Abstract: An apparatus for delivering a clip to close an opening through tissue includes a sheath and a carrier assembly including a clip therein that is slidable on the sheath. An actuator assembly is connectable to the sheath, and telescoping actuator members extend from the handle that are connectable to the carrier assembly for advancing the carrier assembly along the sheath. An obturator on the actuator assembly includes splines that may be deployed beyond a distal end of the sheath, and expanded to a transverse expanded configuration for positioning the sheath before deploying the clip. The actuator members include cooperating detents that selectively release the actuator members as the carrier assembly reaches predetermined positions along the sheath for deploying the clip from the carrier assembly, and that collapse the splines to allow removal of the apparatus after deploying the clip.

公开(公告)号：WO2003071955A3

公开(公告)日：2003-09-04

申请号：PCT/US2003/004906

申请日：2003-02-18

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： CARLEY, Michael, T. ,  GINN, Richard, S. ,  SAGASTEGUI, Javier ,  JABBA, Ronald, J. ,  ALDRICH, William, N. ,  BELEF, Martin, W.

IPC: A61B17/064

Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

公开(公告)号：WO2002062234A2

公开(公告)日：2002-08-15

申请号：PCT/US2001/048843

申请日：2001-12-11

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： GINN, Richard, S. ,  SALMON, Stephen, M. ,  JABBA, Ronald, J.

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B2010/0003 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00898

Abstract: An apparatus for sealing a passage through tissue includes an elongate shaft and a cylindrical plug disposed on a distal end of the shaft, the plug including a helical thread on its outer surface. Intestinal submucosa may be secured to the plus, e.g., in a cavity in its distal end, that may be delivered into the passage. Alternatively, the plug may be formed from a bioabsorbable material and may be released from the shaft within the passage. The plug is threaded into the passage, thereby engaging the tissue to seal the passage. The shaft is rotated until it engages a blood vessel within the tissue while monitoring blood flow through the vessel. The shaft is rotated to thread the plug into the passage until blood flow ceases through the vessel, whereupon rotation of the shaft is reversed to back the plug until blood flow through the vessel resumes.

Abstract translation: 用于密封通过组织的通道的装置包括细长轴和设置在轴的远端上的圆柱塞，该塞在其外表面上包括螺旋形螺纹。 肠粘膜下层可以固定到加上，例如在其远端的空腔中，其可以被输送到通道中。 或者，塞子可以由生物可吸收材料形成并且可以在通道内从轴释放。 塞子被拧入通道中，从而接合组织以密封通道。 旋转轴直到其与组织内的血管接合，同时监测通过血管的血流。 轴被旋转以将塞子螺纹连接到通道中，直到血流停止通过血管，由此轴的旋转被反向以回到塞子，直到通过血管的血液流动恢复。

公开(公告)号：WO2002045594A3

公开(公告)日：2002-06-13

申请号：PCT/US2001/046916

申请日：2001-11-30

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： ROE, Steven, N. ,  GINN, Richard, S. ,  BELEF, W., Martin

IPC: A61B17/00

Abstract: An apparatus (10) for delivering a closure element into a puncture communicating with a blood vessel (90) includes an introducer sheath (12), and a locator member (14) disposed within the sheath, the locator member (14) having a distal portion extending distally beyond the distal end of the sheath. A plurality of splines (64) are provided on the distal portion of the locator member (14), the splines (64) being selectively expandable between an axial collapsed configuration and a transverse expanded configuration. An actuator (70) is coupled to the locator member (14) for controllably expanding the splines (64). A housing (24) is slidably disposed on the sheath for deploying a closure element, such as a vascular clip (26). The locator actuator (70) may automatically collapse the splines (64) upon advancement of the housing (24). Alternatively, the distal portion includes a helically wound wire (444) and a tether (450) coupled to the wire that is movable for causing the wire to buckle instead of the splines.

公开(公告)号：WO2004060169A3

公开(公告)日：2004-07-22

申请号：PCT/US2003/040812

申请日：2003-12-17

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： CARLEY, Michael, T. ,  GINN, Richard, S.

IPC: A61B17/00

Abstract: The present invention relates to a method of making clips which can be used to engage body tissue for the purpose of closing wounds. Such clips are generally annular in shape and have radially inwardly extending tines. The present invention first forms a precursor which, in one embodiment, has the tines extending radially outwardly from the annular body and then forms the clip by inverting the precursor such that the tines extend radially inwardly. In an alternate embodiment, the precursor is formed with an over-sized lateral dimension and then compressed inwardly to bring the tines closer together and to reduce the lateral dimension of the precursor. It is preferred to manufacture such clips from a superelastic alloy such as nickel-titanium, in which case the inverted or compressed precursor must be heated and quenched to heat set the clip in its final shape.

公开(公告)号：WO2003071957A2

公开(公告)日：2003-09-04

申请号：PCT/US2003/005109

申请日：2003-02-20

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： PANTAGES, Anthony ,  JABBA, Ronald, J. ,  GINN, Richard, S.

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/064 ,  A61B17/08 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00659 ,  A61B2017/00668 ,  A61B2017/00672 ,  A61B2017/0641

Abstract: An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end. A skin overlies the outer surface of the sheath and the carrier assembly that is separable from the outer surface as the carrier assembly is advanced from the proximal end towards the distal end of the sheath. During use, the distal end of the sheath is inserted into an opening through tissue, e.g., into a puncture communicating with a blood vessel. The carrier assembly is advanced towards the distal end of the sheath, causing the skin to separate from the outer surface of the elongate member, and the clip is deployed from the carrier to seal the opening.

Abstract translation: 用于递送夹子的设备包括导引器鞘，导引器鞘包括在其近端和远端之间延伸的外表面。 夹子被承载在外表面上，例如在可从近端朝向远端沿外表面滑动的载体组件上。 皮肤覆盖在护套的外表面上，并且当载体组件从护套的近端向远端推进时，载体组件从外表面可分离。 在使用期间，护套的远端插入穿过组织的开口中，例如插入与血管连通的穿刺中。 载体组件朝着护套的远端前进，使得皮肤与细长构件的外表面分离，并且夹子从载体展开以密封开口。

公开(公告)号：WO2003071957A3

公开(公告)日：2003-09-04

申请号：PCT/US2003/005109

申请日：2003-02-20

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： PANTAGES, Anthony ,  JABBA, Ronald, J. ,  GINN, Richard, S.

IPC: A61B17/00

Abstract: An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end. A skin overlies the outer surface of the sheath and the carrier assembly that is separable from the outer surface as the carrier assembly is advanced from the proximal end towards the distal end of the sheath. During use, the distal end of the sheath is inserted into an opening through tissue, e.g., into a puncture communicating with a blood vessel. The carrier assembly is advanced towards the distal end of the sheath, causing the skin to separate from the outer surface of the elongate member, and the clip is deployed from the carrier to seal the opening.

公开(公告)号：WO2003071955A2

公开(公告)日：2003-09-04

申请号：PCT/US2003/004906

申请日：2003-02-18

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： CARLEY, Michael, T. ,  GINN, Richard, S. ,  SAGASTEGUI, Javier ,  JABBA, Ronald, J. ,  ALDRICH, William, N. ,  BELEF, Martin, W.

IPC: A61B17/00

CPC classification number: A61B17/08 ,  A61B17/0057 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/083 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00668 ,  A61B2017/00672 ,  A61B2017/00867 ,  A61B2017/0641 ,  A61B2017/081 ,  H03K3/356139 ,  H03K3/356156

Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

Abstract translation: 用于接合组织的夹具包括限定平面并围绕垂直于平面延伸的中心轴设置的大致环形的主体。 主体包括交替的内部和外部弯曲区域，围绕夹子的周边限定Z字形图案。 身体偏向平面构型，该平面构型位于平面内，并可朝向延伸出平面的横向构型偏转。 齿从内部弯曲区域延伸，尖齿在平面构型中朝向中心轴线定向，并且在横向构型中平行于中心轴线。 尖齿可以包括比主尖齿短的主要尖齿和次要尖齿。 主尖齿可以设置在相对的内部弯曲区域上并且朝向彼此定向，使得它们在平面构造中重叠。

公开(公告)号：WO2003047434A1

公开(公告)日：2003-06-12

申请号：PCT/US2002/037698

申请日：2002-11-22

Applicant: INTEGRATED VASCULAR SYSTEMS, INC.

Inventor： GINN, Richard

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/064 ,  A61B34/76 ,  A61B2017/00367 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00663 ,  A61B2017/00668 ,  A61B2017/00672 ,  A61B2017/081

Abstract: An apparatus for sealing a passage through tissue includes a tubular member, a plug (412), and a locator member (416). The plug is disposed on a distal end of the tubular member and includes an external thread (418). The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.

Abstract translation: 用于密封通过组织的通道的装置包括管状构件，插头（412）和定位构件（416）。 塞子设置在管状构件的远端上并且包括外螺纹（418）。 定位器构件插入到管状构件的内腔中，直到远端部分设置在塞子之外。 远侧部分包括螺旋缠绕的线和联接到线的系绳，其可移动以使线扣合。 为了密封与血管连通的通道，定位器构件的远端部分插入通道中，并且将塞子拧入通道中，直到远端部分延伸到血管内。 系绳被拉动以扣紧线，并且插头是无螺纹的，直到带扣的线接触到容器的壁，然后释放插头以密封通道。