公开(公告)号：WO2009061367A2

公开(公告)日：2009-05-14

申请号：PCT/US2008/012349

申请日：2008-10-31

Applicant: BIOSENSOR, INC. ,  SCHULTZ, Peter ,  AMOSOV, Arkady ,  IZVARINA, Natalia ,  KRAVETZ, Sergey

Inventor： SCHULTZ, Peter ,  AMOSOV, Arkady ,  IZVARINA, Natalia ,  KRAVETZ, Sergey

IPC: A61B5/00 ,  G01N21/49

CPC classification number: G01N21/49 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7239 ,  G01N21/1717 ,  G01N2021/1725

Abstract: A method and apparatus for non-invasively determining a concentration of glucose in a subject using optical excitation and detection is provided. The method includes emitting an exciter beam to irradiate a portion of tissue of the subject, causing physical and chemical changes in the surface, and causing an initial back scattering of light. The method further includes periodically emitting a probe beam which irradiates the portion of tissue and causes periodic back scatterings of light. The initial and periodic back scatterings are detected and converted into electrical signals of at least the amplitude, frequency or decay time of the physical and chemical changes, the back scatterings being modulated by the physical and chemical changes. By differentiating over time at least one of the amplitude, frequency or decay time of the physical and chemical changes, the concentration of glucose may be determined.

Abstract translation: 提供了使用光学激发和检测非侵入性地确定受试者中葡萄糖浓度的方法和装置。 该方法包括发射激光束以照射被摄体的一部分组织，引起表面的物理和化学变化，并引起光的初始反向散射。 该方法还包括周期性地发射照射组织部分并引起光的周期性后向散射的探针束。 初始和周期性后向散射被检测并转换成至少物理和化学变化的振幅，频率或衰减时间的电信号，后向散射由物理和化学变化调制。 通过随时间推移物理和化学变化的幅度，频率或衰减时间中的至少一个，可以确定葡萄糖的浓度。

公开(公告)号：WO2009061367A3

公开(公告)日：2009-08-13

申请号：PCT/US2008012349

申请日：2008-10-31

Applicant: BIOSENSOR INC ,  SCHULTZ PETER ,  AMOSOV ARKADY ,  IZVARINA NATALIA ,  KRAVETZ SERGEY

Inventor： SCHULTZ PETER ,  AMOSOV ARKADY ,  IZVARINA NATALIA ,  KRAVETZ SERGEY

IPC: A61B5/00 ,  G01N21/49

CPC classification number: G01N21/49 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7239 ,  G01N21/1717 ,  G01N2021/1725

Abstract: A method and apparatus for non-invasively determining a concentration of glucose in a subject using optical excitation and detection is provided. The method includes emitting an exciter beam (Bl) to irradiate a portion (130) of tissue of the subject, causing physical and chemical changes in the surface, and causing an initial back scattering (Dl) of light. The method further includes periodically emitting a probe beam (B2) which irradiates the portion of tissue and causes periodic back scatterings (D2) of light. The initial and periodic back scatterings are detected and converted into electrical signals of at least the amplitude, frequency or decay time of the physical and chemical changes, the back scatterings being modulated by the physical and chemical changes. By differentiating over time at least one of the amplitude, frequency or decay time of the physical and chemical changes, the concentration of glucose may be determined.

Abstract translation: 提供了使用光学激发和检测非侵入性地确定受试者中葡萄糖浓度的方法和装置。 该方法包括发射激光束（B1）以照射受试者的组织的一部分（130），引起表面的物理和化学变化，并引起光的初始反向散射（D1）。 该方法还包括周期性地发射照射组织部分并产生光的周期性后向散射（D2）的探针束（B2）。 初始和周期性后向散射被检测并转换成至少物理和化学变化的振幅，频率或衰减时间的电信号，后向散射由物理和化学变化调制。 通过随时间推移物理和化学变化的幅度，频率或衰减时间中的至少一个，可以确定葡萄糖的浓度。