公开(公告)号：WO2019116337A1

公开(公告)日：2019-06-20

申请号：PCT/IB2018/060095

申请日：2018-12-14

Applicant: POLITECNICO DI MILANO

Inventor： BERTACCO, Riccardo ,  MELLONI, Andrea Ivano ,  SHARMA, Parikshit Pratim ,  PESERICO, Nicola

IPC: G01N21/17

CPC classification number: G01N21/1717 ,  G01N2021/1727

Abstract: It is described an opto-magnetic device sensible to the presence of an analyte in a sample, comprising: an integrated optical circuit (101) having an input (IN) for an input optical radiation and at least one output (OU) for an output optical radiation; said optical circuit defining an area (102) sensible to the variations of a local refraction index probed by the optical radiation, destined to come in contact with the sample; a plurality of probe molecules (105) such to anchor to at least said sensible area (102); a plurality of magnetic particles (107) such to anchor to molecules (106) of the analyte, bound to the probe molecules (105) upon a molecular recognition; a magnetic actuator (108) configured to generate a variable magnetic field and move in an oscillating way said magnetic particles (107) in order to cause a variation of the refraction index probed by the optical radiation in the sensible area (102) of the optical circuit (101), and a variation of at least one characteristic parameter of the output optical radiation correlated to a concentration of the molecules (106) of the analyte in the sample.

公开(公告)号：WO2019045871A1

公开(公告)日：2019-03-07

申请号：PCT/US2018/040299

申请日：2018-06-29

Applicant: SIEMENS ENERGY, INC.

Inventor： WILLIAMS, Jason E.

IPC: G01N25/72 ,  G01N29/24 ,  G01N21/17

CPC classification number: G01N29/2418 ,  G01H9/008 ,  G01N21/1717 ,  G01N25/72 ,  G01N29/0654 ,  G01N29/228 ,  G01N2291/0231 ,  G01N2291/02881 ,  G01N2291/2693 ,  G01S5/16

Abstract: A non-destructive method for the condition assessment of a turbine component is provided. A pulsed laser is used to excite a desired surface of the turbine component by directing the pulsed laser at the desired surface to couple ultrasonic energy into the surface of the turbine component. A thermographic image of the desired surface under the influence of the ultrasonic is captured by an image receiver. A system for the non-destructive detection of defects in a material utilizing acoustic thermography is also provided. The system includes a pulsed laser to couple ultrasonic energy into the material, an infrared camera to capture the thermographic image, and a processor communicatively coupled to the infrared camera to receive, store, and analyze the thermographic image.

公开(公告)号：WO2016156622A1

公开(公告)日：2016-10-06

申请号：PCT/EP2016/057382

申请日：2016-04-04

Applicant: GASPOROX AB

Inventor： LUNDIN, Patrik ,  KARLSSON, Daniel ,  LEWANDER XU, Märta ,  SWARTLING, Johannes ,  DILLNER, Joachim

IPC: G01L11/02 ,  G01M3/22 ,  G01M3/32 ,  G01M3/38 ,  G01N21/90

CPC classification number: G01M3/229 ,  G01L11/02 ,  G01M3/3281 ,  G01M3/38 ,  G01N21/1717 ,  G01N21/3504 ,  G01N21/359 ,  G01N21/39 ,  G01N21/65 ,  G01N21/718 ,  G01N21/90 ,  G01N2021/399

Abstract: A method and system is disclosed for determining the integrity of a closed container. The method and system includes the steps of positioning the container in a surrounding, changing a gas pressure, a gas composition, a gas concentration, or any combination of gas pressure, gas concentration and gas composition, in the surrounding. Thereafter subjecting the container to an optical sensor, non-intrusively, the sensor being sensitive to at least one gas, and the sensor is configured for detecting the at least one gas inside the container. Reading a signal from the optical sensor related to a gas pressure, a gas concentration, a gas composition, or any combination of gas pressure, gas concentration, and gas composition, inside the container. The behaviour of the signal being indicative of breach in integrity of the container.

Abstract translation: 公开了一种用于确定密闭容器的完整性的方法和系统。 该方法和系统包括以下步骤：将周围的容器定位在周围，改变气体压力，气体成分，气体浓度或气体压力，气体浓度和气体组成的任何组合。 此后，对容器进行非侵入式的光学传感器，所述传感器对至少一种气体敏感，并且所述传感器构造成用于检测所述容器内的至少一种气体。 在容器内读取与光学传感器有关的气体压力，气体浓度，气体组成或气体压力，气体浓度和气体组成的任何组合的信号。 信号的行为表示容器完整性的违反。

公开(公告)号：WO2016026005A1

公开(公告)日：2016-02-25

申请号：PCT/AU2015/050479

申请日：2015-08-20

Applicant: RMIT UNIVERSITY

Inventor： GRACIOSO MARTINS, Ana Maria ,  HARRISON, Sally ,  REZK, Amgad R. ,  PORTER, Nichola Anne ,  CARPENTER, Peter David ,  DU PLESSIS, Johan ,  FRIEND, James R. ,  YEO, Leslie Y.

IPC: B81B7/02 ,  B01F11/02 ,  G01N21/62 ,  B06B1/06

CPC classification number: B81B7/02 ,  B01F11/02 ,  B01F11/0266 ,  B01L3/5027 ,  B01L2300/0867 ,  B01L2400/0436 ,  B06B1/06 ,  G01H9/00 ,  G01N21/1717 ,  G01N21/62 ,  G01N21/645 ,  G01N21/76 ,  G01N21/763 ,  G01N2021/1729 ,  H01J43/04

Abstract: A chemical, biochemical or biological analysis system and method including: a surface acoustic wave (SAW) actuator (6) including a piezoelectric substrate (9) and at least one interdigital electrode (17) located on a working surface (11) of the piezoelectric substrate (9), the SAW actuator generating travelling SAWs in the working surface when an electrical signal is applied to the interdigital electrode; at least one reaction chamber (19) located on the working surface of the piezoelectric substrate; a light detector (16) for detecting luminescent, fluorescent or phosphorescent emissions within the reaction chamber; a reagent flow line (29) for providing a flow of reagent through the reaction chamber; a test sample supply line (29) for supplying a test sample to the reaction chamber; wherein the SAW actuator can generate travelling SAWs within the working surface to thereby induce chaotic micromixing, convective transport, concentration or combinations thereof of the test sample and the reagent contained within the reaction chamber.

Abstract translation: 一种化学，生物化学或生物分析系统和方法，包括：表面声波（SAW）致动器（6），包括压电基片（9）和至少一个叉指电极（17），位于所述压电 基板（9），当将电信号施加到叉指电极时，SAW致动器在工作表面中产生行进的SAW; 位于所述压电基板的工作表面上的至少一个反应室（19）; 光检测器（16），用于检测反应室内的发光，荧光或磷光发射; 用于提供通过反应室的试剂流的试剂流动管线（29）; 用于将测试样品供应到所述反应室的测试样品供应管线（29） 其中所述SAW致动器可以在所述工作表面内产生行进的SAW，从而导致所述测试样品和所述反应室中包含的试剂的混沌微混合，对流传输，浓缩或其组合。

公开(公告)号：WO2014090748A1

公开(公告)日：2014-06-19

申请号：PCT/EP2013/075954

申请日：2013-12-09

Applicant: NEXCIS ,  UNIVERSITE D'AIX-MARSEILLE

Inventor： MOREAU, Antonin ,  BERMUDEZ, Véronica ,  ESCOUBAS, Ludovic ,  SIMON, Jean-Jacques

IPC: G01N21/17

CPC classification number: G01B11/303 ,  G01N21/1717 ,  G01N2021/1725 ,  G01N2201/065

Abstract: L'invention concerne un dispositif de photoréflectance (1) pour la caractérisation d'une surface rugueuse comportant : - Des moyens d'émission (2) d'un faisceau pompe (3); - Des moyens d'émission (8) d'un faisceau sonde (11); - Des moyens de détection (14) du faisceau sonde réfléchi par la surface; - Une sphère intégrante (13) apte à collecter le faisceau sonde réfléchi par la surface, la sphère intégrante comportant : - une première sortie (15) reliée aux moyens de détection (14), et disposée de façon à recevoir une majorité du faisceau sonde (11) réfléchi par la surface (4); - une deuxième sortie (16) agencée de façon à recevoir une majorité du faisceau pompe (3) réfléchi par la surface.

Abstract translation: 本发明涉及用于表征粗糙表面的光反射装置（1），包括： - 用于发射泵浦光束（3）的装置（2）; - 用于发射探测光束（11）的装置（8）; - 用于检测由所述表面反射的探测光束的装置（14）; - 集成球（13），其能够收集由所述表面反射的探测光束，所述积分球包括： - 连接到所述检测装置（14）的第一输出（15），并且设置成接收所述探针的大部分 由表面（4）反射的光束（11）; - 布置成接收由表面反射的泵浦光束（3）的大部分的第二输出（16）。

公开(公告)号：WO2013141326A1

公开(公告)日：2013-09-26

申请号：PCT/JP2013/058175

申请日：2013-03-13

Applicant: CANON KABUSHIKI KAISHA

Inventor： KUBOTA, Oichi

IPC: G01N29/06 ,  G01H9/00 ,  G01N29/07 ,  G01N29/11 ,  G01N29/24 ,  G01N29/34 ,  G01N21/17 ,  G01N21/35

CPC classification number: G01N21/3586 ,  G01H9/00 ,  G01N21/1717 ,  G01N21/4795 ,  G01N29/069 ,  G01N29/07 ,  G01N29/075 ,  G01N29/11 ,  G01N29/2418 ,  G01N29/343 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/0697 ,  G01N2291/011 ,  G01N2291/023 ,  G01N2291/10

Abstract: An electromagnetic wave pulse measuring device, includes an elastic vibration wave generating section which irradiates a predetermined area of a sample with an elastic vibration wave, an electromagnetic wave pulse generating section which irradiates the predetermined area, which is irradiated with the elastic vibration wave, with an electromagnetic wave pulse, and an electromagnetic wave pulse detecting section which measures a waveform of the electromagnetic wave pulse modulated in the predetermined area by the elastic vibration wave. The timing at which the electromagnetic wave pulse detecting section measures the waveform of the electromagnetic wave pulse is a timing at which a phase angle of the elastic vibration wave has a predetermined value when the elastic vibration wave generating section generates the elastic vibration wave.

Abstract translation: 一种电磁波脉冲测量装置，包括用弹性振动波照射样品的预定区域的弹性振动波产生部分，照射弹性振动波的预定区域的电磁波脉冲发生部分， 电磁波脉冲和电磁波脉冲检测部，其通过弹性振动波测量在规定区域中调制的电磁波脉冲的波形。 电磁波脉冲检测部测量电磁波脉冲的波形的定时是当弹性振动波产生部产生弹性振动波时弹性振动波的相位角具有预定值的定时。

公开(公告)号：WO2013009911A3

公开(公告)日：2013-07-11

申请号：PCT/US2012046305

申请日：2012-07-11

Applicant: UNIV PRINCETON ,  MILES RICHARD B ,  DOGARIU ARTHUR ,  MICHAEL JAMES B

Inventor： MILES RICHARD B ,  DOGARIU ARTHUR ,  MICHAEL JAMES B

IPC: H01S3/22 ,  G01N21/17 ,  G01N21/65 ,  H01S3/00 ,  H01S3/094 ,  H01S3/23

CPC classification number: H01S3/097 ,  G01N21/1717 ,  G01N21/65 ,  G01N2021/1725 ,  G01N2021/1793 ,  G01N2021/655 ,  H01S3/0014 ,  H01S3/094092 ,  H01S3/22 ,  H01S3/2391

Abstract: Systems and methods for lasing molecular gases, and systems and methods of detecting molecular species are provided. The systems and methods can include the use of an excitation laser (820) tuned to a wavelength associated with oxygen or nitrogen. The lasing-can occur in both the forward and reverse directions relative to the excitation laser beam (822). Reverse lasing can provide a laser beam (824) that propagates back toward the excitation laser source (820), and can provide a method for remote sampling of molecular species contained in the air with a dichroic beam splitter (835) and detector (830). For example, systems and methods of detecting a molecular species of interest can be achieved by using the properties of the backward or forward propagating air laser to indicate a change in a pulse from the source of laser pulses caused by a modulation laser (810) tuned to interact with the molecular species of interest by changing the properties of the air by heating or multi-photon ionization of a Raman interaction.

Abstract translation: 提供了用于激发分子气体的系统和方法，以及检测分子种类的系统和方法。 系统和方法可以包括使用调谐到与氧或氮相关的波长的激发激光器（820）。 激光可以相对于激发激光束（822）在正向和反向方向上发生。 反向激光可以提供朝向激发激光源（820）传播的激光束（824），并且可以提供用二色性分束器（835）和检测器（830）远程采样包含在空气中的分子种类的方法， 。 例如，可以通过使用反向或正向传播的空气激光器的特性来指示从由调制激光器（810）调谐的激光脉冲源引起的脉冲的变化来实现检测感兴趣的分子种类的系统和方法 通过改变拉曼相互作用的加热或多光子电离来改变空气的性质来与感兴趣的分子物质相互作用。

公开(公告)号：WO2013041856A1

公开(公告)日：2013-03-28

申请号：PCT/GB2012/052310

申请日：2012-09-19

Applicant: ISIS INNOVATION LIMITED

Inventor： EDWARDS, David John ,  VACHIRIMON, Pithawat

IPC: G01S15/89 ,  G01H9/00 ,  A61B5/05 ,  A61B5/00 ,  G01N21/47 ,  G01N21/17

CPC classification number: G01N21/47 ,  A61B5/0048 ,  A61B5/0051 ,  A61B5/0059 ,  A61B5/05 ,  A61B5/0507 ,  A61B5/7228 ,  G01N21/1702 ,  G01N21/1717 ,  G01N21/3581 ,  G01N29/0654 ,  G01N2291/017 ,  G01S13/50 ,  G01S13/862 ,  G01S13/89 ,  G01S15/899

Abstract: An imaging system for an object such as human or animal tissue applies acoustic vibrations localised in two or three dimensions and simultaneously illuminates the object with an illuminating electromagnetic wave. The acoustic vibration comprises a carrier wave that is amplitude modulated by an AM waveform. The carrier wave is selected to provide the localization of the acoustic vibration, whereas the AM waveform includes a frequency component selected to provide a vibration of the object of greater magnitude than the carrier wave. To detect a Doppler component shifted by the frequency of said frequency component of the AM waveform, a signal processing apparatus comprises a phase locked-loop locked to the EM frequency, producing a frequency-demodulated signal comprising the set of the Doppler components, and a lock-in amplifier configured to extract a signal at a reference frequency equal to the frequency of a frequency component of the AM waveform.

Abstract translation: 用于诸如人或动物组织的物体的成像系统施加局限于两维或三维的声振动并且同时用照射电磁波照射物体。 声振动包括由AM波形幅度调制的载波。 选择载波以提供声振动的定位，而AM波形包括被选择为提供比载波更大幅度的物体的振动的频率分量。 为了检测偏移了AM波形的所述频率分量的频率的多普勒分量，信号处理装置包括锁定到EM频率的锁相环，产生包括多普勒分量集合的频率解调信号，以及 锁定放大器被配置为以等于AM波形的频率分量的频率的参考频率提取信号。

公开(公告)号：WO2012141605A4

公开(公告)日：2012-12-20

申请号：PCT/RO2012000003

申请日：2012-02-16

Applicant: CT INTERNAT DE BIODINAMICA ,  GHEORGHIU EUGEN ,  BRATU DUMITRU ,  DAVID MIHAI SORIN ,  POLONSCHII CRISTINA

Inventor： GHEORGHIU EUGEN ,  BRATU DUMITRU ,  DAVID MIHAI SORIN ,  POLONSCHII CRISTINA

IPC: G01N27/06 ,  G01N21/55 ,  G01N27/02 ,  G01N33/543

CPC classification number: C12Q1/6825 ,  G01N21/1717 ,  G01N21/553 ,  G01N21/645 ,  G01N27/02 ,  G01N27/745 ,  G01N33/5308 ,  G01N33/5438 ,  G01N35/0098 ,  Y10T436/143333 ,  C12Q2563/116 ,  C12Q2563/143

Abstract: Method and a system for detecting the presence and/or determining the concentration of certain analytes. The method consists of receiving in a measurement chamber a sample comprising a target analyte, wherein the measurement chamber includes an electrode pair (42a-b), in which at least one of the electrodes (42a) is compatible with optical measurements, acting as a light sensitive sensor connected to an optical analyzer (32); applying an oscillating actuation field (e.g. magnetic, electromagnetic, mechanic) to the measurement chamber (12), the applied field oscillating with a first frequency; measuring a target electrical impedance of the electrode pair (42a-b), the impedance indicative of a change of position of the target analyte (60) in response to applying the oscillating actuation field, wherein measuring the target electrical impedance comprises applying an electrical signal to the electrode pair (42a-b), the electrical signal oscillating with a second frequency distinct from the first frequency; measuring a target optical parameter, e.g. the intensity of the emitted light of the target analyte in response to applying the oscillating actuation field, wherein measuring the target, the intensity of the emitted light comprises applying an electromagnetic signal to the target analyte, the electromagnetic signal (e.g. light); determining a frequency component of the target electrical or/and optical parameter of the electrode pair at the first frequency; and determining a concentration of the target analyte according to the frequency component of the target electrical or/and optical parameter.

Abstract translation: 用于检测某些分析物的存在和/或确定浓度的方法和系统。 该方法包括在测量室中接收包含目标分析物的样品，其中测量室包括电极对（42a-b），其中至少一个电极（42a）与光学测量相兼容，其作为 光敏传感器连接到光学分析器（32）; 将振荡致动场（例如磁，电磁，机械）施加到测量室（12），所施加的场以第一频率振荡; 测量电极对（42a-b）的目标电阻抗，响应于施加振荡致动场而指示目标分析物（60）的位置变化的阻抗，其中测量目标电阻抗包括施加电信号 电极对（42a-b），电信号以与第一频率不同的第二频率振荡; 测量目标光学参数，例如， 响应于施加振荡致动场的目标分析物的发射光的强度，其中测量目标，发射光的强度包括向目标分析物施加电磁信号，电磁信号（例如光）; 以所述第一频率确定所述电极对的目标电或/和光参数的频率分量; 以及根据目标电或/和光学参数的频率分量确定目标分析物的浓度。

公开(公告)号：WO2012063795A3

公开(公告)日：2012-07-26

申请号：PCT/JP2011075663

申请日：2011-11-08

Applicant: UNIV TOKYO ,  QFACTOR LTD ,  TOMY CO LTD ,  ITO SEIGO ,  TAKIGUCHI KIYOAKI

Inventor： ITO SEIGO ,  TAKIGUCHI KIYOAKI

IPC: G01N21/63

CPC classification number: G01N21/21 ,  G01N21/1717 ,  G01N2021/1721

Abstract: Proposed is a detection device capable of improving detection sensitivity. The detection device (1) is provided with: an conferral means (10) which confers the local site of a sample (SPL) with oscillating waves; an augmentation means (20) which applies a quasi-electrostatic field to all or a part of the sample (SPL) and augments the oscillation energy of the carrier obtained by the sample (SPL) by polarization at the local site; and a detection means (30) for detecting the carrier of which the oscillation energy is augmented by the augmentation means (20). The wider induction of polarization at the locality of the sample (SPL) by the augmentation means (20) in this detection device (1) enables the detection of the carrier without strengthening the output of the oscillating waves.

Abstract translation: 提出能够提高检测灵敏度的检测装置。 检测装置（1）具有：赋予样品（SPL）的局部位置具有振荡波的赋予装置（10）; 对所述样品（SPL）的全部或一部分施加准静电场的增强装置（20），并通过所述局部位置的极化增强由所述样品（SPL）获得的所述载体的振荡能量; 以及检测装置（30），用于检测由所述增加装置（20）增加所述振荡能量的载波。 通过该检测装置（1）中的增强装置（20）在样本（SPL）的位置处的更大的极化感应使得能够检测载波而不强化振荡波的输出。