-
公开(公告)号：WO2022232937A1
公开(公告)日：2022-11-10
申请号：PCT/CA2022/050705
申请日：2022-05-05
Inventor： JEFFERIES, Wilfred , RIBECA, Paolo
IPC: A61K39/12 , A61K9/51 , A61K39/00 , A61K39/215 , A61P31/00 , A61P31/14 , A61P37/04 , C07K14/005 , C07K14/165 , C12N7/00 , C12N15/50
Abstract: The present invention provides multi-epitope vaccines comprising or capable of expressing one or more concatemers of epitopes from a viral pathogen, namely, SARS-CoV-2. wherein at least a portion of the epitopes are from conserved viral proteins and wherein the vaccine comprises or expresses epitopes for all MHC I and MHC II alleles with a frequency > 1 % in the target population.
-
公开(公告)号：WO2018220386A1
公开(公告)日：2018-12-06
申请号：PCT/GB2018/051495
申请日：2018-05-31
Applicant: THE JAMES HUTTON INSTITUTE
IPC: C07K14/315 , A61K39/00 , A61K39/385 , C07K19/00 , C12N7/04
Abstract: The present invention relates to macromolecular complexes comprising micron-scale networks which include binding motifs thereon which allow the covalent bonding of the micron-scale networks to particles which provide nanoscale display surfaces. In particular the present invention relates to micron-scale networks of TMV coat proteins comprising a peptide tag (e.g. SpyTag) and particles providing a nanoscale display surface comprising GFP and a corresponding binding protein (e.g. SpyCatcher) wherein the peptide tag and binding protein pair are capable of spontaneously forming a covalent bond.
-
公开(公告)号：WO2016156878A1
公开(公告)日：2016-10-06
申请号：PCT/GB2016/050944
申请日：2016-04-01
Applicant: JAMES HUTTON INSTITUTE , CELLUCOMP LIMITED
Inventor： TALIANSKI, Mikhail , LOVE, Andrew , WHALE, Eric , HEPWORTH, David , PETUKHOVA, Natalia , SHAW, Jane
CPC classification number: C12R1/91 , B82Y30/00 , B82Y40/00 , C04B18/022 , C04B28/02 , C04B2111/00482 , C07K14/005 , C07K2319/20 , C07K2319/735 , C08L1/02 , C09D101/02 , C09K8/467 , C12N7/00 , C12N2710/00023 , C12N2710/10031 , C12N2720/00023 , C12N2720/00031 , C12N2770/00023 , C12N2770/00031 , C12P19/04 , Y02W30/97 , C04B20/008 , C04B24/2641 , C04B24/383 , C04B14/026 , C04B14/386 , C04B14/42 , C04B16/0608 , C04B16/0691 , C04B18/24 , C04B18/248 , C04B18/26
Abstract: The present invention relates to nanoparticles and their use to form nanocomposite material, in particular bionanocomposite material, specifically wherein the nanoparticles are formed using plant virus attached to a scaffold of cellulosic material and / or cellulose derived materials, in particular wherein said cellulosic material further comprises plant cell components, for example hemicellulose, pectin, protein or combinations thereof.
Abstract translation: 本发明涉及纳米颗粒及其用于形成纳米复合材料，特别是复合材料的用途，具体地，其中使用连接到纤维素材料和/或纤维素衍生材料的支架上的植物病毒形成纳米颗粒，特别是其中所述纤维素材料还包含 植物细胞成分，例如半纤维素，果胶，蛋白质或其组合。
-
公开(公告)号：WO2023001911A1
公开(公告)日：2023-01-26
申请号：PCT/EP2022/070401
申请日：2022-07-20
Applicant: CELLUCOMP LIMITED , THE JAMES HUTTON INSTITUTE
IPC: A01N25/10 , A01N25/34 , A01N59/16 , A01N65/00 , A01N65/08 , A01P1/00 , A61F13/00 , A61L15/28 , B01D46/00 , A01N25/24 , C08L5/06 , C08L97/02 , C08L99/00
Abstract: The present invention relates to a process for preparing an antimicrobial cellulose-containing microporous superabsorbent composition from an herbaceous plant material, the process comprising the step of comminuting dry granulated herbaceous plant material to form microparticles having an average particle diameter of from 100 μm to 800 μm; to obtain the cellulose -containing microporous superabsorbent composition.
-
Patent Agency Ranking5.发明申请
公开(公告)号：WO2022246559A1
公开(公告)日：2022-12-01
申请号：PCT/CA2022/050841
申请日：2022-05-26
Inventor： JEFFERIES, Wilfred A. , RIBECA, Paolo
IPC: C12N15/85 , A61K31/713 , A61K31/7088 , A61K39/12 , A61K48/00 , A61K49/00 , A61P31/00 , A61P31/12 , A61P37/04 , C07K14/08 , C07K14/18 , C07K14/19 , C07K14/165 , C12N15/40 , C12N15/50 , C12N15/63 , C12N15/113
Abstract: The present invention relates to an expression vector that encodes all or a portion of replicon proteins from a positive stranded virus, wherein expression of the replicon proteins is under the control of CMV and T7 promoters, and wherein expression of a payload is under the control of a sub-genomic promoter. Also provided are methods of using the vector in therapeutics and vaccines.
-
公开(公告)号：WO2022109726A1
公开(公告)日：2022-06-02
申请号：PCT/CA2021/051666
申请日：2021-11-23
Inventor： JEFFERIES, Wilfred , RIBECA, Paolo
Abstract: The present invention provides a method of epitope-based vaccine design. The method comprising: a) providing one or more target amino acid sequence(s); b) optionally discarding peptides based on one or more predetermined features; c) parsing and selecting MHC I and/or MHC II binding peptides from said sequences; and d) assembling the MHC I and/or MHC II binding peptides optionally with linkers to produce an assembly of peptides.
-
公开(公告)号：WO2017046607A1
公开(公告)日：2017-03-23
申请号：PCT/GB2016/052900
申请日：2016-09-16
Applicant: THE JAMES HUTTON INSTITUTE
Inventor： GASKIN, Graham , HILLIER, Stephen John
CPC classification number: B05B17/0676 , B05B17/0623 , B05B17/0653 , B05B17/0669 , B06B1/0238 , B06B2201/77
Abstract: A compact apparatus for atomisation of fluid samples comprises a sonotrode (11), placed so that an ultrasonic wave emitted by the sonotrode is directed through a channel (25) in a separate channel device (21) and reflected by from the interface (26) in a high-low impedance transition zone (Tz), so that a standing wave is formed within the channel. A positive air flow through the channel, driven by a pressure differential at each end of the channel, interacts with the working fluid or slurry being delivered by a fluid delivery device (30) to atomise it. The speed of the air flow and the dispersal, homogeneity, and size of particles in the slurry sample can be controlled by varying the shape of the channel outlet.
Abstract translation: 用于雾化流体样品的紧凑装置包括超声波发生器（11），放置使得由超声波发射器发射的超声波被引导通过分离的通道装置（21）中的通道（25）并由界面（26）反射， 在高低阻抗过渡区（Tz）中，使得在通道内形成驻波。 由通道的每个端部处的压差驱动的通过通道的正空气流与由流体输送装置（30）输送的工作流体或浆料相互作用以使其雾化。 可以通过改变通道出口的形状来控制气流的速度以及浆料样品中的颗粒的分散，均匀性和尺寸。
-
公开(公告)号：WO2015044678A1
公开(公告)日：2015-04-02
申请号：PCT/GB2014/052926
申请日：2014-09-26
Applicant: THE JAMES HUTTON INSTITUTE
Inventor： TAYLOR, Mark , DUCREUX, Laurence , MORRIS, Wayne , USMAN, Muhammad , HANCOCK, Robert
IPC: C12N15/82 , C07K14/415
CPC classification number: C12N15/8271 , C07K14/415 , C12N15/8218 , C12N15/8226 , C12N15/8261 , C12N15/8273 , Y02A40/146
Abstract: Methods of using a homologue of TOC1a, preferably to TOC1a with a polynucleotide sequence SEQ ID NO: 1, to modulate the tuberization process in a plant and cells and plants provided by the same.
Abstract translation: 使用具有多核苷酸序列SEQ ID NO：1的TOC1a同源物优选TOC1a的方法来调节由其提供的植物和细胞和植物中的结块化过程。
-
公开(公告)号：WO2014045055A1
公开(公告)日：2014-03-27
申请号：PCT/GB2013/052473
申请日：2013-09-20
Applicant: THE JAMES HUTTON INSTITUTE
Inventor： LOVE, Andrew John , TALIANSKI, Mikhail Emmanuilovich , CHAPMAN, Sean Nicholas , SHAW, Jane
IPC: C12N7/00
CPC classification number: C12N7/00 , A61K9/5123 , B82Y5/00 , C12N2710/20023 , C12N2710/20031 , C12N2770/00023 , C12N2770/00031 , C12N2770/18023 , C12N2770/18031 , C12N2770/34023 , C12N2770/34031 , C12N2770/40023 , C12N2770/40031
Abstract: There is described a process for production of metal-coated virus particles or metallic nanoparticles, said process comprising admixing virus particles with plant material with reducing power and a metal salt, wherein the process can be provided in planta or ex planta and the virus particles aid the production of the metal-coated virus particles or metallic nanoparticles.
Abstract translation: 描述了金属包覆的病毒颗粒或金属纳米颗粒的生产方法，所述方法包括将病毒颗粒与具有还原力的植物材料和金属盐混合，其中该方法可以在植物或外植物中提供，并且病毒颗粒有助于 金属包覆病毒颗粒或金属纳米粒子的生产。
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.016 seconds)
