中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

59 records (took 0.025 seconds)

    SAMPLE ENCAPSULATION SYSTEM
    1.
    发明申请
    SAMPLE ENCAPSULATION SYSTEM 审中-公开

    公开(公告)号：WO2023023076A1

    公开(公告)日：2023-02-23

    申请号：PCT/US2022/040492

    申请日：2022-08-16

    Applicant: JOHNSON, Bruce

    Inventor： JOHNSON, Bruce

    IPC: B32B27/02 ,  B30B11/02 ,  G01N35/02 ,  G01N1/36

    Abstract: A method for sample encapsulation. A first sampling swab is provided that includes an absorbent portion and a fluid control portion that extends from the absorbent portion. The absorbent portion is proximate a proximal end of the first sampling swab. The fluid control portion is proximate a distal end of the first sampling swab. A sample is collected with the absorbent portion. At least a portion of the sample is liquid. An encapsulation material is provided that includes a first web and a second web. The first sampling swab is positioned between the first web and the second web. The first web is urged into contact with the second web proximate the absorbent portion. The urging of the first web into contact with the second web proximate the absorbent portion causes liquid to move from the absorbent portion towards the fluid control portion. The urging of the first web into contact with the second web proximate the absorbent portion is discontinued which causes the liquid to be drawn into the absorbent portion. The first web is urged into contact with the second web proximate the distal end of the first sampling swab to encapsulate the liquid in the encapsulation material.

    INTRAVAGINAL INCONTINENCE DEVICE
    2.
    发明申请
    INTRAVAGINAL INCONTINENCE DEVICE 审中-公开

    公开(公告)号：WO2011079124A1

    公开(公告)日：2011-06-30

    申请号：PCT/US2010/061566

    申请日：2010-12-21

    Applicant: MCNEIL-PPC, INC. ,  HULL, Raymond, J. ,  JOHNSON, Bruce, C. ,  MAVINKURVE, Pramod ,  ROSENFELD, Leonard

    Inventor： HULL, Raymond, J. ,  JOHNSON, Bruce, C. ,  MAVINKURVE, Pramod ,  ROSENFELD, Leonard

    IPC: A61F2/82

    CPC classification number: A61F2/005

    Abstract: An intravaginal urinary incontinence device has an insertion end and an opposed withdrawal end. The device has a resilient frame including a working portion disposed proximate the withdrawal end and an anchoring portion disposed proximate the insertion end. The working portion has a resilient structure having a plurality of connected elongate elements for providing support to an associated urinary system. The anchoring portion has a plurality of connected elongate elements arranged to expand laterally within a user's vagina. The elongate elements are formed of a high modulus polymer having an elastic modulus of at least 2 or 3 GPa. Additionally, the polymer may have an Initial Stress @ 3% Strain of at least about 30 MPa, an elongation at yield of at least 3%, a Stress Ratio of at least about 0.5, and/or an Aged Stress (t=50 hrs @ 40° C) @ 3% Strain is greater than about 35 MPa.

    Abstract translation: 阴道内尿失禁装置具有插入端和相对的取出端。 该装置具有弹性框架，该框架包括靠近抽出端设置的工作部分和靠近插入端设置的锚固部分。 工作部分具有弹性结构，其具有多个连接的细长元件，用于向相关的泌尿系统提供支撑。 锚定部分具有多个连接的细长元件，其布置成在使用者的阴道内横向膨胀。 细长元件由具有至少2或3GPa的弹性模量的高模量聚合物形成。 此外，聚合物可具有至少约30MPa的初始应力@ 3％应变，至少3％的屈服伸长率，至少约0.5的应力比和/或老化应力（t = 50小时） @ 40℃）@ 3％应变大于约35MPa。

    FLUOROALKYL TETRABENAZINE CARBINOL COMPOUNDS AS IMAGING AGENTS AND PROBES
    5.
    发明申请
    FLUOROALKYL TETRABENAZINE CARBINOL COMPOUNDS AS IMAGING AGENTS AND PROBES 审中-公开
    作为成像剂和探针的氟代苄基四氢萘酚化合物

    公开(公告)号：WO2009073677A1

    公开(公告)日：2009-06-11

    申请号：PCT/US2008/085304

    申请日：2008-12-03

    Applicant: GENERAL ELECTRIC COMPANY ,  AMARASINGHE, Kande Kankananamalage Dayarathna ,  RISHEL, Michael James ,  DINN, Sean Richard ,  JOHNSON, Bruce Fletcher

    Inventor： AMARASINGHE, Kande Kankananamalage Dayarathna ,  RISHEL, Michael James ,  DINN, Sean Richard ,  JOHNSON, Bruce Fletcher

    IPC: C07D471/04 ,  C07D455/06 ,  A61K31/4353

    CPC classification number: C07D455/06

    Abstract: The present invention provides novel fluoroalkyl tetrabenazine carbinol compounds. The fluoroalkyl tetrabenazine carbinol compounds are provided in both racemic and enantiomerically enriched forms and may comprise either or both of fluorine-18 and fluorine 19. The fluoroalkyl tetrabenazine carbinol compounds are shown to possess high affinity for VMAT-2, a biomarker implicated in human diabetes. The fluoroalkyl tetrabenazine carbinol compounds comprising a fluorine-18 group are useful as PET imaging agents targeting the VMAT-2 biomarker. The non-radiolabled fluoroalkyl tetrabenazine carbinol compounds are useful as probes for the discovery of PET imaging agents.

    Abstract translation: 本发明提供新的氟代烷基四苯并嗪甲醇化合物。 氟烷基四苯并嗪甲醇化合物以外消旋和对映异构体富集的形式提供，并且可以包含氟-18和氟19中的一种或两种。氟烷基丁苯那嗪甲醇化合物显示对VMAT-2具有高亲和力，VMAT-2是涉及人类糖尿病的生物标记 。 包含氟-18基团的氟代烷基四苯并嗪甲醇化合物可用作靶向VMAT-2生物标志物的PET显像剂。 非放射性氟烷基丁苯那嗪甲醇化合物可用作发现PET成像剂的探针。

    METHOD FOR MAKING TETRABENAZINE COMPOUNDS
    7.
    发明申请
    METHOD FOR MAKING TETRABENAZINE COMPOUNDS 审中-公开
    制备四羧酸化合物的方法

    公开(公告)号：WO2008154243A1

    公开(公告)日：2008-12-18

    申请号：PCT/US2008/065738

    申请日：2008-06-04

    Applicant: GENERAL ELECTRIC COMPANY ,  RISHEL, Michael James ,  AMARASINGHE, Kande Kankananamalage Dayarathna ,  DINN, Sean Richard ,  JOHNSON, Bruce Fletcher

    Inventor： RISHEL, Michael James ,  AMARASINGHE, Kande Kankananamalage Dayarathna ,  DINN, Sean Richard ,  JOHNSON, Bruce Fletcher

    IPC: C07D217/00 ,  C07D217/24 ,  C07D455/00

    CPC classification number: C07D455/06 ,  C07D217/16 ,  C07D217/18 ,  Y02P20/55

    Abstract: A method of preparing a tetrabenazine compound (TBZ compound) having structure I comprising the steps of reacting a nucleophilic alkenyl species with aldehyde compound II and oxidizing the resultant allylic alcohol to provide enone III. The protecting group P 1 on the tetrahydroisoquinoline nitrogen is removed and the resultant deprotected intermediate is induced to undergo an amino cyclization reaction to provide a product TBZ compound having structure I. The method may be used to prepare either enantiomeric form of tetrabenazine; (+)-tetrabenazine or (-)-tetrabenazine. Alternatively the method may be adapted to provide a mixture enriched in one tetrabenazine enantiomer, a racemic mixture, or a diastereomeric mixture of tetrabenazine compounds. In addition, the present invention provides novel synthetic intermediate compositions which may be used to prepare either or both enantiomers of tetrabenazine, derivatives of tetrabenazine, and analogs of tetrabenazine.

    Abstract translation: 制备具有结构I的丁苯那嗪化合物（TBZ化合物）的方法包括以下步骤：使亲核烯基物质与醛化合物II反应并氧化得到的烯丙基醇以提供烯酮III。 除去四氢异喹啉氮上的保护基P1，将所得脱保护的中间体诱导进行氨基环化反应，得到具有结构I的产物TBZ化合物。该方法可用于制备对映体形式的丁苯那嗪; （+） - 丁苯那嗪或（ - ） - 丁苯那嗪。 或者，该方法可以适于提供富集一种四苯并嗪对映异构体，外消旋混合物或丁苯那嗪化合物的非对映体混合物的混合物。 此外，本发明提供了新的合成中间体组合物，其可用于制备丁苯那嗪，丁苯那敏衍生物和丁苯那嗪类似物的任一种或两种对映异构体。

    LAMINAR FLOW WATER JET WITH ENERGETIC PULSE WAVE SEGMENTATION AND CONTROLLER
    9.
    发明申请
    LAMINAR FLOW WATER JET WITH ENERGETIC PULSE WAVE SEGMENTATION AND CONTROLLER 审中-公开
    层流水喷射器与能量脉冲波分段和控制器

    公开(公告)号：WO2006055759A3

    公开(公告)日：2007-02-01

    申请号：PCT/US2005041778

    申请日：2005-11-17

    Applicant: JOHNSON BRUCE

    Inventor： JOHNSON BRUCE

    IPC: B05B17/08 ,  A01G27/00 ,  B05B1/14 ,  B05B17/04 ,  F21S8/00

    CPC classification number: B05B12/06 ,  B05B1/34 ,  B05B17/08 ,  F21S8/00 ,  F21W2121/02 ,  F21Y2103/00 ,  F21Y2115/10

    Abstract: An apparatus for producing and controlling an energetic pulse wave in a laminar flow having an at least one water input and a housing with a water channel flowing therethrough. At least one jetting element for jetting a laminar flow tube from a laminar flow passing through the water channel. With at least one energetic pulse wave generating element generating an energetic pulse in a controlled fashion that travels into the laminar flow and selectively interrupts the laminarity therein.

    Abstract translation: 一种用于生产和控制具有至少一个水输入的层流中的能量脉冲波的装置和具有流过其中的水通道的壳体。 至少一个喷射元件，用于从穿过水通道的层流喷射层流管。 具有至少一个能量脉冲波产生元件，其以受控的方式产生能量脉冲，其以行进到层流中并选择性地中断其中的层流。

    NETWORK COMMERCIAL TRANSACTIONS
    10.
    发明申请
    NETWORK COMMERCIAL TRANSACTIONS 审中-公开
    网络商业交易

    公开(公告)号：WO2006113834A2

    公开(公告)日：2006-10-26

    申请号：PCT/US2006/014801

    申请日：2006-04-19

    Applicant: MICROSOFT CORPORATION ,  JOHNSON, Bruce, E. ,  WEBSTER-LAM, Chung

    Inventor： JOHNSON, Bruce, E. ,  WEBSTER-LAM, Chung

    IPC: G06Q30/00

    CPC classification number: G06F21/10 ,  G06F21/34 ,  G06F2221/2135 ,  G06F2221/2137 ,  G06Q20/02 ,  G06Q20/12 ,  G06Q20/32 ,  G06Q20/3223 ,  G06Q20/4014 ,  G06Q20/407 ,  G06Q30/00 ,  H04L63/08 ,  H04W12/06

    Abstract: Current embodiments provide for authorization and payment of an online commercial transaction between a purchaser and a merchant including verification of an identity of the purchaser and verification of an ability of the purchaser to pay for the transaction, where the identity provider and the payment provider are often different network entities. Other embodiments also provide for protocols, computing systems, and other mechanisms that allow for identity and payment authentication using a mobile module, which establishes single or multilevel security over an untrusted network (e.g., the Internet). Still other embodiments also provide for a three-way secure communication between a merchant, consumer, and payment provider such that sensitive account information is opaque to the merchant, yet the merchant is sufficiently confident of the consumer's ability to pay for requested purchases. In yet another embodiment, electronic billing information is used for authorization, auditing, payment federation, and other purposes.

    Abstract translation: 当前的实施例规定了购买者和商家之间的在线商业交易的授权和支付，包括验证购买者的身份以及验证购买者支付交易的能力，其中身份提供者和支付提供者经常是 不同的网络实体。 其他实施例还提供协议，计算系统和允许使用移动模块进行身份和支付认证的其他机制，该移动模块通过不可信网络（例如因特网）建立单一或多级安全性。 其他实施例还提供商家，消费者和支付提供商之间的三向安全通信，使得敏感的帐户信息对于商家是不透明的，但是商家对消费者支付所请求的购买的能力充满信心。 在另一个实施例中，电子账单信息用于授权，审计，支付联合等目的。

Patent Agency Ranking