公开(公告)号：WO2008097829A2

公开(公告)日：2008-08-14

申请号：PCT/US2008/052766

申请日：2008-02-01

Applicant: NEOSE TECHNOLOGIES, INC. ,  JOHNSON, Karl, F. ,  SCHWARTZ, Marc, F. ,  WU, Bingyuan

Inventor： JOHNSON, Karl, F. ,  SCHWARTZ, Marc, F. ,  WU, Bingyuan

IPC: C12P21/06

CPC classification number: C12N9/1051

Abstract: The present invention provides large scale methods of producing eukaryotic N -acetylglucosaminyltransferase I in bacterial cells.

Abstract translation: 本发明提供了在细菌细胞中生产真核生物N-乙酰葡糖胺基转移酶I的大规模方法。

公开(公告)号：WO2007089923A2

公开(公告)日：2007-08-09

申请号：PCT/US2007002878

申请日：2007-02-01

Applicant: NEOSE TECHNOLOGIES INC ,  JOHNSON KARL F ,  MOBASSERI ALIAKBAR ,  BAI XIAOMEI ,  KINEALY KYLE

Inventor： JOHNSON KARL F ,  MOBASSERI ALIAKBAR ,  BAI XIAOMEI ,  KINEALY KYLE

IPC: A61K38/16

CPC classification number: C12N9/1081 ,  C07K14/505

Abstract: The present invention provides modified Campylobacter sialyltransferase proteins that exhibit enhanced expression as compared to its unmodified form. Nucleic acids that encode the sialyltransferase proteins are also included, as are methods to produce and use the sialyltransferase proteins.

Abstract translation: 本发明提供了与其未修饰形式相比表现出增强的表达的修饰的弯曲杆菌唾液酸转移酶蛋白。 还包括编码唾液酸转移酶蛋白的核酸，以及产生和使用唾液酸转移酶蛋白的方法。

公开(公告)号：WO2005121331A9

公开(公告)日：2006-06-01

申请号：PCT/US2005019442

申请日：2005-06-03

Applicant: NEOSE TECHNOLOGIES INC ,  JOHNSON KARL F ,  CHEN XI ,  TAUDTE SUSANN ,  SARIBAS SAMI

Inventor： JOHNSON KARL F ,  CHEN XI ,  TAUDTE SUSANN ,  SARIBAS SAMI

IPC: C12P19/18 ,  C12N1/20 ,  C12N5/10 ,  C12N9/10 ,  C12N15/00 ,  C12P21/06

CPC classification number: C12N9/1051

Abstract: The present invention features compositions and methods related to truncated mutants of GalNAcT2. In particular, the invention features truncated human GalNAcT2 polypeptides. The invention also features nucleic acids encoding such truncated polypeptides, as well as vectors, host cells, expression systems, and methods of expressing and using such polypeptides.

Abstract translation: 本发明的特征在于与GalNAcT2的截短突变体相关的组合物和方法。 特别地，本发明特征在于截短的人GalNAcT2多肽。 本发明还包括编码这种截短的多肽的核酸，以及载体，宿主细胞，表达系统以及表达和使用这些多肽的方法。

公开(公告)号：WO2005121332A2

公开(公告)日：2005-12-22

申请号：PCT/US2005/019583

申请日：2005-06-03

Applicant: NEOSE TECHNOLOGIES, INC. ,  JOHNSON, Karl F. ,  HAKES, David ,  WEI, Ge ,  LIU, Li ,  SARIBAS, Sami ,  SJOBERG, Eric ,  CLAUSEN, Henrik ,  BENNETT, Eric, Paul ,  MOBASSERI, Aliakbar

Inventor： JOHNSON, Karl F. ,  HAKES, David ,  WEI, Ge ,  LIU, Li ,  SARIBAS, Sami ,  SJOBERG, Eric ,  CLAUSEN, Henrik ,  BENNETT, Eric, Paul ,  MOBASSERI, Aliakbar

IPC: C12N9/10

CPC classification number: C12N9/1081 ,  C07K2319/20 ,  C07K2319/40

Abstract: The present invention features compositions and methods related to truncated mutants of ST6GalNAcI. In particular, the invention features truncated human, mouse, and chicken ST6GalNAcI polypeptides. The invention also features nucleic acids encoding such truncated polyeptides, as well as vectors, host cells, expression systems, and methods of expressing and using such polypeptides.

Abstract translation: 本发明涉及与ST6GalNAcI的截短突变体有关的组合物和方法。 特别地，本发明的特征在于截短的人，小鼠和鸡ST6GalNAcI多肽。 本发明还包括编码这种截短多肽的核酸，以及载体，宿主细胞，表达系统以及表达和使用这些多肽的方法。

公开(公告)号：WO2005121331A2

公开(公告)日：2005-12-22

申请号：PCT/US2005/019442

申请日：2005-06-03

Applicant: NEOSE TECHNOLOGIES, INC. ,  JOHNSON, Karl, F. ,  CHEN, Xi ,  TAUDTE, Susann ,  SARIBAS, Sami

Inventor： JOHNSON, Karl, F. ,  CHEN, Xi ,  TAUDTE, Susann ,  SARIBAS, Sami

IPC: C12N9/10

CPC classification number: C12N9/1051

Abstract: The present invention features compositions and methods related to truncated mutants of GalNAcT2. In particular, the invention features truncated human GalNAcT2 polypeptides. The invention also features nucleic acids encoding such truncated polypeptides, as well as vectors, host cells, expression systems, and methods of expressing and using such polypeptides.

Abstract translation: 本发明的特征在于与GalNAcT2的截短突变体相关的组合物和方法。 特别地，本发明特征在于截短的人GalNAcT2多肽。 本发明还包括编码这种截短的多肽的核酸，以及载体，宿主细胞，表达系统以及表达和使用这些多肽的方法。

公开(公告)号：WO2005069921A2

公开(公告)日：2005-08-04

申请号：PCT/US2005001614

申请日：2005-01-21

Applicant: NEOSE TECHNOLOGIES INC ,  UNIV ALBERTA ,  SIMALA-GRANT JOANNE ,  TAYLOR DIANE ,  JOHNSON KARL F ,  BEZILA DANIEL JAMES

Inventor： SIMALA-GRANT JOANNE ,  TAYLOR DIANE ,  JOHNSON KARL F ,  BEZILA DANIEL JAMES

IPC: C12N9/10 ,  C12P21/00 ,  C12P21/06

CPC classification number: C12P21/005 ,  C12N9/1051

Abstract: This invention provides nucleic acid and amino acid sequences of fucosyltransferases from Helicobactor pylori. The invention also provides methods to use the fucosyltransferases to synthesize oligosaccharides, glycoproteins, and glycolipids.

Abstract translation: 本发明提供了来自幽门螺杆菌幽门螺杆菌的岩藻糖基转移酶的核酸和氨基酸序列。 本发明还提供了使用岩藻糖基转移酶合成低聚糖，糖蛋白和糖脂的方法。

公开(公告)号：WO2004009793A2

公开(公告)日：2004-01-29

申请号：PCT/US2003/023155

申请日：2003-07-23

Applicant: NEOSE TECHNOLOGIES, INC. ,  JOHNSON, Karl, F. ,  BEZILA, Daniel, James

Inventor： JOHNSON, Karl, F. ,  BEZILA, Daniel, James

IPC: C12N

CPC classification number: C12P21/005 ,  C12N9/1051

Abstract: This invention provides nucleic acid and amino acid sequences of fucosyltransferases from Helicobactor pylori. The invention also provides methods to use the fucosyltransferases to synthesize oligosaccharides, glycoproteins, and glycolipids.

Abstract translation: 本发明提供了来自Helicobactor pylori的岩藻糖基转移酶的核酸和氨基酸序列。 本发明还提供了使用岩藻糖基转移酶来合成寡糖，糖蛋白和糖脂的方法。

公开(公告)号：WO2008097829A3

公开(公告)日：2008-12-18

申请号：PCT/US2008052766

申请日：2008-02-01

Applicant: NEOSE TECHNOLOGIES INC ,  JOHNSON KARL F ,  SCHWARTZ MARC F ,  WU BINGYUAN

Inventor： JOHNSON KARL F ,  SCHWARTZ MARC F ,  WU BINGYUAN

IPC: C12P21/04 ,  C12P21/06

CPC classification number: C12N9/1051

Abstract: The present invention provides large scale methods of producing eukaryoticN-acetylglucosaminyltransferase I in bacterial cells.

Abstract translation: 本发明提供了在细菌细胞中产生真核N-乙酰葡糖胺基转移酶I的大规模方法。

公开(公告)号：WO2007089923A3

公开(公告)日：2007-08-09

申请号：PCT/US2007/002878

申请日：2007-02-01

Applicant: NEOSE TECHNOLOGIES, INC. ,  JOHNSON, Karl, F. ,  MOBASSERI, Aliakbar ,  BAI, Xiaomei ,  KINEALY, Kyle

Inventor： JOHNSON, Karl, F. ,  MOBASSERI, Aliakbar ,  BAI, Xiaomei ,  KINEALY, Kyle

IPC: C12P21/02

Abstract: The present invention provides modified Campylobacter sialyltransferase proteins that exhibit enhanced expression as compared to its unmodified form. Nucleic acids that encode the sialyltransferase proteins are also included, as are methods to produce and use the sialyltransferase proteins.

公开(公告)号：WO2004009838A3

公开(公告)日：2006-04-06

申请号：PCT/US0323057

申请日：2003-07-23

Applicant: NEOSE TECHNOLOGIES INC ,  UNIV ALBERTA ,  RASKO DAVID ,  SIMLA-GRANT JOANNE ,  TAYLOR DIANE ,  JOHNSON KARL F ,  BEZILA DANIEL JAMES

Inventor： RASKO DAVID ,  SIMLA-GRANT JOANNE ,  TAYLOR DIANE ,  JOHNSON KARL F ,  BEZILA DANIEL JAMES

IPC: C12P21/02 ,  C12N9/10 ,  C12P21/00 ,  C07H21/04 ,  C07K1/00 ,  C12N1/20 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C12P21/06 ,  C12Q1/48

CPC classification number: C12P21/005 ,  C12N9/1051

Abstract: This invention provides nucleic acid and amino acid sequences of fucosyltransferases from Helicobactor pylori. The invention also provides methods to use the fucosyltransferases to synthesize oligosaccharides, and glycolipids.

Abstract translation: 本发明提供了来自幽门螺杆菌幽门螺杆菌的岩藻糖基转移酶的核酸和氨基酸序列。 本发明还提供了使用岩藻糖基转移酶合成低聚糖和糖脂的方法。