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    METHOD FOR REDOX REACTION USING AN OLD YELLOW ENZYME
    2.
    发明申请
    METHOD FOR REDOX REACTION USING AN OLD YELLOW ENZYME 审中-公开
    使用老的黄色酶的氧化还原反应的方法

    公开(公告)号：WO2008143956A1

    公开(公告)日：2008-11-27

    申请号：PCT/US2008/006263

    申请日：2008-05-15

    Applicant: CODEXIS, INC. ,  GLIEDER, Anton ,  SCHITTMAYER, Matthias ,  KAMBOURAKIS, Spiros ,  ZACH, Simone

    Inventor： GLIEDER, Anton ,  SCHITTMAYER, Matthias ,  KAMBOURAKIS, Spiros ,  ZACH, Simone

    IPC: C12P1/00

    CPC classification number: C12P33/06 ,  C12P7/26

    Abstract: A method of selective biooxidation to non activated carbon-hydrogen bonds of substances using a Geobacillus kaustophilus 'Old Yellow Enzyme1 is provided". It is shown that OYEs can be used to facilitate the biooxydation of substances, such as testosterone. It is also shown that OYE can introduce double bonds to form alpha, betaalpha, beta desaturated ketones. Furthermore, it is also shown that the use of OYEs allows for the production of oxidized substances in one step reactions, which are otherwise not accessible or only accessible after complex and inefficient multi-step reactions. In addition, the OYE used shows high stability (e.g. at high temperature, or in long lasting bioconversions). An exemplary embodiment is provided showing the use of an OYE to convert testosterone to 6α- hydroxytestosterone.

    Abstract translation: 提供了一种利用土壤杆菌“老黄酶1”对物质的非活性碳氢键进行选择性生物氧化的方法“，表明OYE可用于促进物质如睾酮的生物氧化，还显示 OYE可以引入双键形成α，βalpha，β去饱和酮，此外，还表明，使用OYE允许在一步反应中生产氧化物质，否则它们不可接近或仅在复杂和低效后才能进入 此外，所用的OYE显示出高稳定性（例如在高温或长期生物转化中）。提供了示例性实施方案，其显示使用OYE将睾酮转化为6a-羟基睾酮。

    METHOD OF MAKING(+)-SITOPHILURE
    5.
    发明申请
    METHOD OF MAKING(+)-SITOPHILURE 审中-公开
    制作（+） - SITOPHILURE的方法

    公开(公告)号：WO2007076109A2

    公开(公告)日：2007-07-05

    申请号：PCT/US2006/049225

    申请日：2006-12-22

    Applicant: BIOCATALYTICS, INC. ,  KALAITZAKIS, Dimitris ,  ROZZELL, J., David ,  KAMBOURAKIS, Spiros ,  SMONOU, Ioulia

    Inventor： KALAITZAKIS, Dimitris ,  ROZZELL, J., David ,  KAMBOURAKIS, Spiros ,  SMONOU, Ioulia

    IPC: C12P7/26

    CPC classification number: C12P7/26 ,  Y02P20/582

    Abstract: (+)-Sitophilure, the aggregation pheromone of the pests rice weevil and maize weevil, is synthesized in high yield and diestereomeric excess by contacting 4-methyl-3,5heptadione with a reduced nicotinamide cofactor and a ketoreductase enzyme capable of catalyzing the reduction of 4-methyl-3,5-heptadione to produce (4 R , 5 S )-5-hydroxy-4-methyl-3-heptanone to the substantial exclusion of other diastereomers.

    Abstract translation: （+） - Sitophilure是通过使4-甲基-3,5-庚二酮与还原型烟酰胺辅因子和能够催化还原的酮还原酶的酮还原酶接触，合成高产量和二异构体过量的害虫稻象鼻虫和玉米象鼻虫的聚集信息素 （4R，5S）-5-羟基-4-甲基-3-庚酮，以实质排除其它非对映异构体。

    METHOD OF MAKING(+)-SITOPHILURE
    7.
    发明申请
    METHOD OF MAKING(+)-SITOPHILURE 审中-公开
    （+） - SITOPHILURE的制造方法

    公开(公告)号：WO2007076109A3

    公开(公告)日：2007-12-27

    申请号：PCT/US2006049225

    申请日：2006-12-22

    Applicant: BIOCATALYTICS INC ,  KALAITZAKIS DIMITRIS ,  ROZZELL J DAVID ,  KAMBOURAKIS SPIROS ,  SMONOU IOULIA

    Inventor： KALAITZAKIS DIMITRIS ,  ROZZELL J DAVID ,  KAMBOURAKIS SPIROS ,  SMONOU IOULIA

    IPC: A01N25/00

    CPC classification number: C12P7/26 ,  Y02P20/582

    Abstract: (+)-Sitophilure, the aggregation pheromone of the pests rice weevil and maize weevil, is synthesized in high yield and diestereomeric excess by contacting 4-methyl-3,5heptadione with a reduced nicotinamide cofactor and a ketoreductase enzyme capable of catalyzing the reduction of 4-methyl-3,5-heptadione to produce (4R, 5S)-5-hydroxy-4-methyl-3-heptanone to the substantial exclusion of other diastereomers.

    Abstract translation: （+） - Sitophilure是害虫水稻象鼻虫和玉米象甲的聚集信息素，通过使4-甲基-3,5-庚二酮与还原的烟酰胺辅因子和能够催化还原的酮还原酶接触而以高产率和双对异构体过量合成 （4R，5S）-5-羟基-4-甲基-3-庚酮基本排除其它非对映异构体。

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