公开(公告)号：WO2013085502A1

公开(公告)日：2013-06-13

申请号：PCT/US2011/063667

申请日：2011-12-07

Applicant: BIOLIFE, L.L.C. ,  HEN, John ,  THOMPSON, John A. (deceased) ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

Inventor： HEN, John ,  THOMPSON, John A. (deceased) ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

IPC: A61K9/14 ,  A61L15/00

CPC classification number: A61K9/7007 ,  A61K9/0014 ,  A61K9/146 ,  A61K47/32 ,  A61L26/0014 ,  A61L26/009 ,  A61L2300/404 ,  A61L2400/04 ,  C08L25/06

Abstract: A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.

Abstract translation: 用于促进出血性伤口部位愈合的组合物和方法。 该组合物优选包括基本上无水的阳离子交换树脂形式，其当在血液上施用时，提供对伤口中浮游微生物和生物膜的抗微生物剂。 当应用足量时，树脂还能够通过与存在于​​血液和其它体液中的阳离子进行脱水和离子交换来提供对浮游微生物和生物膜的持续和持续的抗微生物。 当树脂的浓度至少为26mg / ml时，提供MRSA，MRSE和绿脓假单胞菌生物活性降低> 3log。

公开(公告)号：WO2010068509A1

公开(公告)日：2010-06-17

申请号：PCT/US2009/065990

申请日：2009-11-25

Applicant: BIOLIFE, L.L.C. ,  HEN, John ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

Inventor： HEN, John ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

IPC: A61F13/00 ,  A61F15/00

CPC classification number: A61L15/60 ,  A61L15/24 ,  A61L15/28 ,  A61L2400/04 ,  C08L29/04 ,  C08L39/06

Abstract: Hemostatic wound dressings for substantially arresting the flow of severe, life threatening bleeding from a wound by rapidly adhering to the wound site, absorbing and concentrating and thickening the blood at the dressing blood interface and accelerating the natural clot formation beneath the dressing and finally, forming a strong seal that will substantially prohibits further flow of blood out of the wound site. These hemostatic wound dressings are formed of unique combinations of hemostatic dressing aspects which achieve wound seal strengths that are significantly higher than the sum of seal strengths expected from the individual aspects alone. Some embodiments also achieve these synergistic seal strengths by combining one hemostatic dressing with a non-hemostatic device.

Abstract translation: 止血伤口敷料，用于通过快速粘附到伤口部位，大大地阻止严重的威胁生命的出血流，在敷料血液界面吸收和浓缩血液并加速敷料下方的天然凝块形成，最后形成 强烈的印章将大大禁止血液进一步流出伤口部位。 这些止血伤口敷料由止血敷料方面的独特组合形成，其实现了伤口密封强度，其显着高于单个方面预期的密封强度的总和。 一些实施方案还通过将一种止血敷料与非止血装置组合来实现这些协同的密封强度。

公开(公告)号：WO2008127287A2

公开(公告)日：2008-10-23

申请号：PCT/US2007/021782

申请日：2007-10-11

Applicant: BIOLIFE, L.L.C. ,  HEN, John ,  THOMPSON, John, Alfred ,  KEENE, Talmadge, Kelly ,  TOLLON, Michael, H. ,  TRAVI, Mark ,  THOMAS, Roger

Inventor： HEN, John ,  THOMPSON, John, Alfred ,  KEENE, Talmadge, Kelly ,  TOLLON, Michael, H. ,  TRAVI, Mark ,  THOMAS, Roger

IPC: A61K31/74

CPC classification number: A61L15/44 ,  A61L15/60 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/602

Abstract: The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound, hi an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.

Abstract translation: 本发明涉及用于阻止或减少来自开放伤口或医疗或外科手术的血流量的材料和方法。 本发明的组合物包含交联聚丙烯酸的盐形式。 在一个实施方案中，组合物包含聚丙烯酸的钠盐。 本发明的组合物还可以任选地包含一种或多种不同的盐高铁酸盐和/或阳离子交换树脂和/或银化合物。在例举的实施方案中，本发明的组合物包含以干粉形式提供的聚丙烯酸钠。 本发明的聚丙烯酸酯组合物可以直接施用于伤口或治疗部位，或者它们可以掺入伤口敷料例如绷带中。 在用本发明处理的伤口或治疗部位形成的凝块或痂状物是非常有弹性的，并且在拉伸到断裂点时显示出相当大的拉伸强度。 本发明还涉及伤口和手术部位敷料和覆盖物，以及使用本发明组合物来阻止来自开放伤口或治疗部位的血流的方法。

公开(公告)号：WO2008127287A9

公开(公告)日：2008-12-18

申请号：PCT/US2007021782

申请日：2007-10-11

Applicant: BIOLIFE LLC ,  HEN JOHN ,  THOMPSON JOHN ALFRED ,  KEENE TALMADGE KELLY ,  TOLLON MICHAEL H ,  TRAVI MARK ,  THOMAS ROGER

Inventor： HEN JOHN ,  THOMPSON JOHN ALFRED ,  KEENE TALMADGE KELLY ,  TOLLON MICHAEL H ,  TRAVI MARK ,  THOMAS ROGER

IPC: A61K31/74

CPC classification number: A61L15/44 ,  A61L15/60 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/602

Abstract: The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound, hi an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.

Abstract translation: 本发明涉及用于从开放的伤口或医疗或外科手术中停止或减少血液流动的材料和方法。 本发明的组合物包含交联聚丙烯酸的盐形式。 在一个实施方案中，组合物包含聚丙烯酸的钠盐。 本发明的组合物还可任选地包含一种或多种不同的高铁酸盐，和/或阳离子交换树脂和/或银化合物。在示例性实施方案中，本发明的组合物包含以干粉状形式提供的聚丙烯酸钠。 本发明的聚丙烯酸酯组合物可以直接施用到伤口或治疗部位，或者它们可以并入伤口敷料如绷带中。 在用本发明处理的伤口或治疗部位处形成的凝块或痂是非常有弹性的，并且当拉伸到断裂点时显示出显着的拉伸强度。 本发明还涉及伤口和手术部位敷料和覆盖物，以及使用本发明的组合物来阻止来自开放伤口或治疗部位的血液流动的方法。

公开(公告)号：WO2008127287A3

公开(公告)日：2009-02-12

申请号：PCT/US2007021782

申请日：2007-10-11

Applicant: BIOLIFE LLC ,  HEN JOHN ,  THOMPSON JOHN ALFRED ,  KEENE TALMADGE KELLY ,  TOLLON MICHAEL H ,  TRAVI MARK ,  THOMAS ROGER

Inventor： HEN JOHN ,  THOMPSON JOHN ALFRED ,  KEENE TALMADGE KELLY ,  TOLLON MICHAEL H ,  TRAVI MARK ,  THOMAS ROGER

IPC: A61K31/74

CPC classification number: A61L15/44 ,  A61L15/60 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/602

Abstract: The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound, hi an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.

Abstract translation: 本发明涉及用于从开放的伤口或医疗或外科手术中停止或减少血液流动的材料和方法。 本发明的组合物包含交联聚丙烯酸的盐形式。 在一个实施方案中，组合物包含聚丙烯酸的钠盐。 本发明的组合物还可任选地包含一种或多种不同的高铁酸盐，和/或阳离子交换树脂和/或银化合物。在示例性实施方案中，本发明的组合物包含以干粉状形式提供的聚丙烯酸钠。 本发明的聚丙烯酸酯组合物可以直接施用到伤口或治疗部位，或者它们可以并入伤口敷料如绷带中。 在用本发明处理的伤口或治疗部位处形成的凝块或痂是非常有弹性的，并且当拉伸到断裂点时显示出显着的拉伸强度。 本发明还涉及伤口和手术部位敷料和覆盖物，以及使用本发明的组合物来阻止来自开放伤口或治疗部位的血液流动的方法。

公开(公告)号：WO2007127390A3

公开(公告)日：2007-11-08

申请号：PCT/US2007/010278

申请日：2007-04-27

Applicant: BIOLIFE, L.L.C. ,  HEN, John ,  THOMPSON, John, Alfred ,  KEENE, Talmadge, Kelly

Inventor： HEN, John ,  THOMPSON, John, Alfred ,  KEENE, Talmadge, Kelly

IPC: A61K33/26 ,  A61P17/02

Abstract: The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and/or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form.

公开(公告)号：WO2007127390A2

公开(公告)日：2007-11-08

申请号：PCT/US2007010278

申请日：2007-04-27

Applicant: BIOLIFE LLC ,  HEN JOHN ,  THOMPSON JOHN ALFRED ,  KEENE TALMADGE KELLY

Inventor： HEN JOHN ,  THOMPSON JOHN ALFRED ,  KEENE TALMADGE KELLY

CPC classification number: A61K33/26 ,  A61K31/715 ,  A61K31/717 ,  A61K31/718 ,  A61K31/722 ,  A61K31/729 ,  A61K31/731 ,  A61K31/734 ,  A61K31/74 ,  A61K31/79 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404

Abstract: The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and/or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form.

Abstract translation: 本发明涉及用于伤口处理的方法和组合物。 该方法和组合物用于促进和加速伤口愈合; 提供抑制微生物感染; 在伤口上提供保护性结痂样覆盖物; 和/或用于阻止来自开放伤口的血液或体液的流动。 该方法和组合物可以用于增加伤口中的肉芽和上皮形成。 在一个实施方案中，提供了高铁酸盐和阳离子交换材料的基本上无水的化合物。 本发明的组合物还可以包含银化合物。 在使用中，本发明的组合物优选作为干燥敷料应用于渗出的慢性伤口部位。 如果慢性伤口部位干燥，则可以在施用干燥形式的敷料之前用合适的液体或水性介质润湿伤口部位。

公开(公告)号：WO2014153566A3

公开(公告)日：2014-11-13

申请号：PCT/US2014036313

申请日：2014-05-01

Applicant: BIOLIFE LLC ,  HEN JOHN ,  KEENE TALMADGE KELLY ,  TRAVI MARK

Inventor： HEN JOHN ,  KEENE TALMADGE KELLY ,  TRAVI MARK

IPC: A61K33/26 ,  A61L15/16 ,  A61L15/18

CPC classification number: A61B17/12159 ,  A61B17/0057 ,  A61B17/12163 ,  A61B2017/00004 ,  A61B2017/12004 ,  A61B2017/12054 ,  A61F13/00 ,  A61F13/36 ,  A61F2013/00412 ,  A61F2013/00472 ,  A61L15/18 ,  A61L15/60 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/06 ,  A61L2300/102 ,  A61L2300/418 ,  A61L2400/04 ,  A61M25/02 ,  A61M35/00 ,  A61M35/003 ,  A61M35/006 ,  C08L25/18

Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up simple.

Abstract translation: 止血片优选包括高铁酸钾和形成片剂的阳离子离子交换树脂压力，用于递送至出血的伤口。 与片状的止血粉末的薄层相比，片剂改善了与出血的伤口表面的粘附速度，并且通过手动压片片剂可以显着地提高和更均匀的压力。 在由血液或渗出物与片剂的直接接触表面的相互作用形成密封件之后，大部分未使用的片剂容易地从密封层剥离，从而使清洁变得简单。

公开(公告)号：WO2014153566A2

公开(公告)日：2014-09-25

申请号：PCT/US2014/036313

申请日：2014-05-01

Applicant: BIOLIFE, L.L.C. ,  HEN, John ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

Inventor： HEN, John ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

IPC: A61M35/00

CPC classification number: A61B17/12159 ,  A61B17/0057 ,  A61B17/12163 ,  A61B2017/00004 ,  A61B2017/12004 ,  A61B2017/12054 ,  A61F13/00 ,  A61F13/36 ,  A61F2013/00412 ,  A61F2013/00472 ,  A61L15/18 ,  A61L15/60 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/06 ,  A61L2300/102 ,  A61L2300/418 ,  A61L2400/04 ,  A61M25/02 ,  A61M35/00 ,  A61M35/003 ,  A61M35/006 ,  C08L25/18

Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.

Abstract translation: 止血片优选包括高铁酸钾和形成片剂的阳离子离子交换树脂压力，用于递送至出血的伤口。 与片状的止血粉末的薄层相比，该片剂改善了与出血的伤口表面的粘合速度，并且通过手动压片片剂可以显着地提高和更均匀的压力。 在由血液或渗出物与片剂的直接接触表面的相互作用形成密封之后，大部分未使用的片剂容易从密封层剥离，从而使清洁容易。 如果片剂的未使用部分没有从伤口部位移除，则止血敷料的储存器停止进一步渗血并提供抗微生物保护和愈合。 片剂可以应用于任何表面取向并且可以具有任何形状和厚度。

公开(公告)号：WO2011123112A1

公开(公告)日：2011-10-06

申请号：PCT/US2010/029412

申请日：2010-03-31

Applicant: BIOLIFE, L.L.C. ,  HEN, John ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

Inventor： HEN, John ,  KEENE, Talmadge Kelly ,  TRAVI, Mark

IPC: C01C1/00

CPC classification number: A61K33/26 ,  A61K31/79 ,  A61K2300/00

Abstract: A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.

Abstract translation: 一种阻止血液从出血伤口流出的组合物和方法。 该组合物优选包括与有效量的不溶性阳离子交换材料和有效量的无机混合的无水高铁酸盐化合物。 可以加入聚维酮碘以增强抗菌性能。 在该方法中，将一定量的组合物磁性地附着在磁体的表面上，然后通过将粉末状化合物覆盖的表面压在伤口上足以使血液凝结的时间将粉末混合物施加到伤口上 阻止伤口进一步的血液流动。