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    PROCESS FOR PRODUCING LOW ENDOTOXIN CHITOSAN
    7.
    发明申请
    PROCESS FOR PRODUCING LOW ENDOTOXIN CHITOSAN 审中-公开
    生产低内毒素壳聚糖的方法

    公开(公告)号：WO2013140190A1

    公开(公告)日：2013-09-26

    申请号：PCT/GB2013/050775

    申请日：2013-03-25

    申请人： MEDTRADE PRODUCTS LIMITED

    发明人： GLADMAN, June ,  HARDY, Craig ,  HOGGARTH, Andrew

    IPC分类号： C08B37/08 ,  C08L5/08

    CPC分类号： C08B37/003 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L2300/232 ,  A61L2300/404 ,  A61L2300/418 ,  A61L2400/04 ,  C08L5/08

    摘要： The present invention relates to a process for producing a low endotoxin alkali chitosan, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products.

    摘要翻译： 本发明涉及一种生产低内毒素碱性壳聚糖的方法，还涉及一种生产低内毒素中性壳聚糖，壳聚糖盐和壳聚糖衍生物的方法及其制备方法。 该方法包括使壳聚糖与碱溶液接触以形成混合物并将混合物离开至少约12小时。 低内毒素碱性壳聚糖可用于制造其他有用的基于壳聚糖的产品。

    PROCOAGULANT PEPTIDES AND THEIR DERIVATIVES AND USES THEREFOR
    8.
    发明申请
    PROCOAGULANT PEPTIDES AND THEIR DERIVATIVES AND USES THEREFOR 审中-公开
    顺铂肽及其衍生物及其用途

    公开(公告)号：WO2013003045A3

    公开(公告)日：2013-04-25

    申请号：PCT/US2012042346

    申请日：2012-06-14

    申请人： ETHICON INC ,  WANG YI-LAN ,  ZHANG GUANGHUI

    发明人： WANG YI-LAN ,  ZHANG GUANGHUI

    IPC分类号： A61L15/32

    CPC分类号： A61L26/0052 ,  A61K38/39 ,  A61L24/0015 ,  A61L24/108 ,  A61L26/009 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2400/04

    摘要： The present invention is directed to a hemostatic or tissue sealing material having (a) a peptide having a sequence SEQ ID NO: 1 or an amino acid analog sequence thereof, and (b) a scaffold for said peptide or amino acid analogue sequence. The scaffold is preferably hemostatic, such as a natural or genetically engineered absorbable polymer, a synthetic absorbable polymer, or combinations thereof. The natural or genetically engineered absorbable polymers can be selected from the group consisting of a protein, a polysaccharide, or combinations thereof.

    摘要翻译： 本发明涉及一种止血或组织密封材料，其具有（a）具有序列SEQ ID NO：1或其氨基酸类似物序列的肽，和（b）所述肽或氨基酸类似物序列的支架。 支架优选为止血剂，例如天然或遗传工程可吸收聚合物，合成可吸收聚合物或其组合。 天然或遗传工程可吸收聚合物可以选自蛋白质，多糖或其组合。

    BIOABSORBABLE POLYMERIC COMPOSITIONS AND MEDICAL DEVICES
    9.
    发明申请
    BIOABSORBABLE POLYMERIC COMPOSITIONS AND MEDICAL DEVICES 审中-公开
    生物可溶性聚合物组合物和医疗器械

    公开(公告)号：WO2010042952A1

    公开(公告)日：2010-04-15

    申请号：PCT/US2009/060544

    申请日：2009-10-13

    申请人： ORBUSNEICH MEDICAL, INC. ,  THATCHER, G., Lawrence ,  COTTONE, Robert, J.

    发明人： THATCHER, G., Lawrence ,  COTTONE, Robert, J.

    IPC分类号： A61F2/00

    CPC分类号： A61L31/041 ,  A61L17/12 ,  A61L24/0042 ,  A61L24/043 ,  A61L26/0052 ,  A61L26/009 ,  A61L27/26 ,  A61L27/58 ,  A61L28/0026 ,  A61L28/0057 ,  A61L29/049 ,  A61L29/148 ,  A61L31/148 ,  C08L67/04 ,  C08L2205/02 ,  C08L2666/18

    摘要： The bioabsorbable polymers and compositions of the present invention may be formed into medical devices such as stents that can be crimped onto a catheter system for delivery into a blood vessel. The properties of the bioabsorbable polymers allow for both crimping and expansion of the stent. The crystal properties of the bioabsorbable polymers may change during crimping and/or expansion allowing for improved mechanical properties such as tensile strength and slower degradation kinetics. Typically, bioabsorbable polymers comprise aliphatic polyesters based on lactide backbone such as poly L-lactide, poly D-lactide, poly D,L-lactide, mesolactide, glycolides, lactones, as homopolymers or copolymers, as well as formed in copolymer moieties with co-monomers such as, trimethylene carbonate (TMC) or ε-caprolactone (ECL).

    摘要翻译： 本发明的生物可吸收聚合物和组合物可以形成医疗装置，例如可以卷曲到导管系统上用于输送到血管中的支架。 生物可吸收聚合物的性质允许支架的卷曲和膨胀。 生物可吸收聚合物的结晶特性可以在卷曲和/或膨胀期间改变，从而允许改进的机械性能如拉伸强度和较慢的降解动力学。 通常，生物可吸收聚合物包括基于丙交酯骨架的脂肪族聚酯，例如聚L-丙交酯，聚D-丙交酯，聚D，L-丙交酯，乳酰胺，乙交酯，内酯作为均聚物或共聚物，以及在共聚物部分中与共聚物形成 单体如三亚甲基碳酸酯（TMC）或ε-己内酯（ECL）。