公开(公告)号：WO2002020090A3

公开(公告)日：2002-03-14

申请号：PCT/EP2001/010448

申请日：2001-09-10

Applicant: NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  BATEMAN, Simon, David ,  GIMONA, Alberto ,  HOLINEJ, Jurij ,  HUELS, Jasper ,  JAYAWARDENE, Sumedha ,  KARABELAS, Argeris, Jerry ,  KHALED, Maha, Y. ,  KARNACHI, Anees, Abdulquadar ,  NIC LOCHLAINN, Eimear, Mairin ,  MACERATA, Richard ,  SLOAN, Victor

Inventor： BATEMAN, Simon, David ,  GIMONA, Alberto ,  HOLINEJ, Jurij ,  HUELS, Jasper ,  JAYAWARDENE, Sumedha ,  KARABELAS, Argeris, Jerry ,  KHALED, Maha, Y. ,  KARNACHI, Anees, Abdulquadar ,  NIC LOCHLAINN, Eimear, Mairin ,  MACERATA, Richard ,  SLOAN, Victor

IPC: A61P5/00

Abstract: A composition for treating a cyclooxygenase-2 dependent disorder or condition comprising: 5-methyl-2(2'-chloro-6'-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt thereof, which composition is an immediate release pharmaceutical composition for treatment of said disorder or condition for about 24 hours.

公开(公告)号：WO2004080451A1

公开(公告)日：2004-09-23

申请号：PCT/EP2004/002528

申请日：2004-03-11

Applicant: NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  FORENZO, Patrick ,  KHALED, Maha, Y. ,  WANG, Barbara ,  ZIELINSKI, Joseph, Lawrence

Inventor： FORENZO, Patrick ,  KHALED, Maha, Y. ,  WANG, Barbara ,  ZIELINSKI, Joseph, Lawrence

IPC: A61K31/195

CPC classification number: A61K9/0095 ,  A61K31/195

Abstract: Provided are compositions comprising aqueous suspensions of 5-methyl-2-(2’-chloro-6’-fluoroanilino)phenylacetic acid suitable for oral administration. Methods for making such compositions and methods for their stabilization are provided.

Abstract translation: 提供了包含适合于口服给药的5-甲基-2-（2'-氯-6'-氟苯胺基）苯乙酸的水悬浮液的组合物。 提供制备这些组合物的方法及其稳定化方法。

公开(公告)号：WO2003074041A1

公开(公告)日：2003-09-12

申请号：PCT/EP2003/002322

申请日：2003-03-06

Applicant: NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  KARNACHI, Anees Abdulquadar ,  KHALED, Maha, Y. ,  HOLINEJ, Jurij ,  JOSHI, Yatindra

Inventor： KARNACHI, Anees Abdulquadar ,  KHALED, Maha, Y. ,  HOLINEJ, Jurij ,  JOSHI, Yatindra

IPC: A61K31/196

CPC classification number: A61K9/2095 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/195 ,  A61K31/196

Abstract: A method of treating a cyclooxygenase-2 dependent disorder or condition comprising administering 5-methyl-2-(2'-chloro-6'-fluoroanilino)phenylacetic acid in an amount effective to treat such a disorder or condition for about 24 hours, comprising administering orally once a day to a human in need of such treatment one or more immediate release pharmaceutical compositions comprising 5-methyl-2-(2'-chloro-6'-fluoroanilino)phenylacetic acid , and compositions suitable for use in such methods.

Abstract translation: 一种治疗环加氧酶-2依赖性病症或病症的方法，包括以有效治疗这种病症或病症的量施用5-甲基-2-（2'-氯-6'-氟苯胺基）苯乙酸约24小时，包括 每天口服一次给予需要这种治疗的人一种或多种包含5-甲基-2-（2'-氯-6'-氟苯胺基）苯乙酸的立即释放药物组合物，以及适用于这些方法的组合物。

公开(公告)号：WO0220090A2

公开(公告)日：2002-03-14

申请号：PCT/EP0110448

申请日：2001-09-10

Applicant: NOVARTIS AG ,  NOVARTIS ERFIND VERWALT GMBH ,  BATEMAN SIMON DAVID ,  GIMONA ALBERTO ,  HOLINEJ JURIJ ,  HUELS JASPER ,  JAYAWARDENE SUMEDHA ,  KARABELAS ARGERIS JERRY ,  KHALED MAHA Y ,  KARNACHI ANEES ABDULQUADAR ,  NIC LOCHLAINN EIMEAR MAIRIN ,  MACERATA RICHARD ,  SLOAN VICTOR

Inventor： BATEMAN SIMON DAVID ,  GIMONA ALBERTO ,  HOLINEJ JURIJ ,  HUELS JASPER ,  JAYAWARDENE SUMEDHA ,  KARABELAS ARGERIS JERRY ,  KHALED MAHA Y ,  KARNACHI ANEES ABDULQUADAR ,  NIC LOCHLAINN EIMEAR MAIRIN ,  MACERATA RICHARD ,  SLOAN VICTOR

IPC: A61K47/02 ,  A61K9/20 ,  A61K9/28 ,  A61K31/195 ,  A61K31/196 ,  A61K47/12 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61P5/00 ,  A61P29/00 ,  A61P43/00

CPC classification number: A61K31/195 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2866 ,  A61K31/196

Abstract: A composition for treating a cyclooxygenase-2 dependent disorder or condition comprising: 5-methyl-2(2'-chloro-6'-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt thereof, which composition is an immediate release pharmaceutical composition for treatment of said disorder or condition for about 24 hours.

Abstract translation: 一种用于治疗环氧合酶-2依赖性病症或病症的组合物，其包含：5-甲基-2（2'-氯-6'-氟苯胺基）苯乙酸或其药学上可接受的盐，该组合物是用于治疗 所述疾病或病症约24小时。

公开(公告)号：WO2005037266A1

公开(公告)日：2005-04-28

申请号：PCT/EP2004/011223

申请日：2004-10-07

Applicant: NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  DANNENFELSER, Rose-Marie ,  GEORGOUSIS, Vivian, Christine ,  KHALED, Maha, Y. ,  PATEL, Tarun, S. ,  SIKORA, Joseph ,  WANG, Barbara

Inventor： DANNENFELSER, Rose-Marie ,  GEORGOUSIS, Vivian, Christine ,  KHALED, Maha, Y. ,  PATEL, Tarun, S. ,  SIKORA, Joseph ,  WANG, Barbara

IPC: A61K31/196

CPC classification number: A61K31/135 ,  A61K9/0019 ,  A61K31/196 ,  A61K47/10 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26 ,  A61K47/44

Abstract: The invention relates to a composition for the treatment of a cyclooxygenase-2-mediated disorder or condition comprising 5-methyl-2-(2’-chloro-6’-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof suitable for parenteral administration, and to a method for the treatment of a cyclooxygenase-2-mediated disorder or condition in a human or animal in need of such treatment by parenteral administration of 5-methyl-2-(2’-chloro-6’-fluroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof.

Abstract translation: 本发明涉及用于治疗环氧合酶-2介导的病症或病症的组合物，其包含5-甲基-2-（2'-氯-6'-氟苯胺基）苯乙酸或其药学上可接受的盐，优选钾盐， 以及用于治疗需要这种治疗的人或动物中环氧合酶-2介导的病症或病症的方法，通过肠胃外给药5-甲基-2-（2'-氯-6 芴丙基）苯乙酸或其药学上可接受的盐，优选其钾盐。

公开(公告)号：WO0220090A9

公开(公告)日：2003-10-30

申请号：PCT/EP0110448

申请日：2001-09-10

Applicant: NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  BATEMAN SIMON DAVID ,  GIMONA ALBERTO ,  HOLINEJ JURIJ ,  HUELS JASPER ,  JAYAWARDENE SUMEDHA ,  KARABELAS ARGERIS JERRY ,  KHALED MAHA Y ,  KARNACHI ANEES ABDULQUADAR ,  NIC LOCHLAINN EIMEAR MAIRIN ,  MACERATA RICHARD ,  SLOAN VICTOR

Inventor： BATEMAN SIMON DAVID ,  GIMONA ALBERTO ,  HOLINEJ JURIJ ,  HUELS JASPER ,  JAYAWARDENE SUMEDHA ,  KARABELAS ARGERIS JERRY ,  KHALED MAHA Y ,  KARNACHI ANEES ABDULQUADAR ,  NIC LOCHLAINN EIMEAR MAIRIN ,  MACERATA RICHARD ,  SLOAN VICTOR

IPC: A61K47/02 ,  A61K9/20 ,  A61K9/28 ,  A61K31/195 ,  A61K31/196 ,  A61K47/12 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61P5/00 ,  A61P29/00 ,  A61P43/00

CPC classification number: A61K31/195 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2866 ,  A61K31/196

Abstract: A composition for treating a cyclooxygenase-2 dependent disorder or condition comprising: 5-methyl-2(2'-chloro-6'-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt thereof, which composition is an immediate release pharmaceutical composition for treatment of said disorder or condition for about 24 hours.

Abstract translation: 一种用于治疗环氧合酶-2依赖性病症或病症的组合物，其包含：5-甲基-2（2'-氯-6'-氟苯胺基）苯乙酸或其药学上可接受的盐，该组合物是用于治疗 所述疾病或病症约24小时。