公开(公告)号：WO2009040782A3

公开(公告)日：2009-06-04

申请号：PCT/IE2008000092

申请日：2008-09-26

Applicant: ROYAL COLLEGE OF SURGEONS IE ,  KIJANKA GREGOR ,  KENNY DERMOT ,  KAY ELAINE

Inventor： KIJANKA GREGOR ,  KENNY DERMOT ,  KAY ELAINE

IPC: G01N33/574

CPC classification number: G01N33/57419

Abstract: The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a biological sample from the individual for a combination of a plurality of biomarkers selected from SEQUENCE ID NO's: 1 to 12, where the combination of biomarkers is chosen such that detection of all biomarkers in the patient correlates to at least a 50% risk of the patient being positive for colorectal cancer. Detection of all of the combination of biomarkers indicates that the patient should undergo a colonoscopy. Kits for performing the method of the invention are also provided.

Abstract translation: 本发明涉及一种筛选患者以鉴定和定量结肠直肠癌风险的方法，并由此鉴定适合进一步侵入性研究的患者，例如结肠镜检查。 该方法采用显示与结肠直肠癌风险方法相关的自身抗体，并涉及测定来自个体的生物样品中选自SEQUENCE ID NO：1至12的多种生物标记的组合，其中生物标记的组合是 选择为使得患者中所有生物标志物的检测与患者对结肠直肠癌为阳性的至少50％的风险相关。 所有生物标记组合的检测表明患者应该接受结肠镜检查。 还提供了用于执行本发明的方法的试剂盒。

公开(公告)号：WO2010040851A3

公开(公告)日：2010-04-15

申请号：PCT/EP2009/063229

申请日：2009-10-09

Applicant: DUBLIN CITY UNIVERSITY ,  DIMOV, Ivan ,  DUCREE, Jens ,  LEE, Luke ,  KIJANKA, Gregor

Inventor： DIMOV, Ivan ,  DUCREE, Jens ,  LEE, Luke ,  KIJANKA, Gregor

IPC: B01L3/00 ,  C12M1/00 ,  C12Q1/00 ,  G01N33/483

Abstract: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

公开(公告)号：WO2010040851A2

公开(公告)日：2010-04-15

申请号：PCT/EP2009063229

申请日：2009-10-09

Applicant: UNIV DUBLIN CITY ,  DIMOV IVAN ,  DUCREE JENS ,  LEE LUKE ,  KIJANKA GREGOR

Inventor： DIMOV IVAN ,  DUCREE JENS ,  LEE LUKE ,  KIJANKA GREGOR

IPC: B01L3/00 ,  C12M1/00 ,  C12Q1/00 ,  G01N33/483

CPC classification number: B01L3/50273 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2400/0457 ,  B01L2400/0472 ,  Y10T436/25

Abstract: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

Abstract translation: 描述了包括具有在输入和输出之间的衬底内限定的流体路径的微型三向器件的顺序流分析工具。 该装置包括设置在流体路径内但偏离流体路径的俘获室，俘获室在基本上垂直于流体路径的方向上延伸到衬底中，使得设置在流体路径内流动的流体内的可操作地颗粒将优先收集在俘获 室。

公开(公告)号：WO2009040782A2

公开(公告)日：2009-04-02

申请号：PCT/IE2008/000092

申请日：2008-09-26

Applicant: ROYAL COLLEGE OF SURGEONS IN IRELAND ,  KIJANKA, Gregor ,  KENNY, Dermot ,  KAY, Elaine

Inventor： KIJANKA, Gregor ,  KENNY, Dermot ,  KAY, Elaine

IPC: G01N33/574

CPC classification number: G01N33/57419

Abstract: The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a biological sample from the individual for a combination of a plurality of biomarkers selected from SEQUENCE ID NO's: 1 to 12, where the combination of biomarkers is chosen such that detection of all biomarkers in the patient correlates to at least a 50% risk of the patient being positive for colorectal cancer. Detection of all of the combination of biomarkers indicates that the patient should undergo a colonoscopy. Kits for performing the method of the invention are also provided.

Abstract translation: 本发明涉及筛选患者以识别和定量结肠直肠癌风险的方法，从而鉴定适合进一步侵入性研究的患者，例如结肠镜检查。 该方法使用显示与结肠直肠癌风险方法相关的自身抗体，并涉及从个体中检测生物标志物组合的多个生物标志物的组合中选择SEQ ID NO：1至12的生物标志物，其中生物标志物的组合为 选择使得患者中所有生物标志物的检测与患有结肠直肠癌阳性的至少50％的风险相关。 检测生物标志物的所有组合表明患者应进行结肠镜检查。 还提供了用于执行本发明的方法的套件。