公开(公告)号：WO2012007537A1

公开(公告)日：2012-01-19

申请号：PCT/EP2011/062015

申请日：2011-07-13

Applicant: DUBLIN CITY UNIVERSITY ,  LEONARD, Paul ,  DIMOV, Ivan ,  O'KENNEDY, Richard ,  FITZGERALD, Valerie

Inventor： LEONARD, Paul ,  DIMOV, Ivan ,  O'KENNEDY, Richard ,  FITZGERALD, Valerie

IPC: B01L3/00

CPC classification number: G01N33/54306 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/12 ,  B01L2300/16 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/545 ,  G01N33/569 ,  G01N33/68

Abstract: The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e. millions-billions) but with greater efficiency and shorter time.

Abstract translation: 本发明描述了使用非常高密度微孔阵列进行生物相互作用的高通量筛选的空间寻址技术。 讨论了能够识别，选择和表征特定蛋白质蛋白质，蛋白质DNA和/或蛋白质 - 碳水化合物相互作用的治疗，诊断和药物发现影响，从数百万（至数十亿）细胞的异质群体。 重要的是，这种技术具有当前基于显示屏的筛选系统（即数百万亿）的筛选和选择能力，但具有更高的效率和更短的时间。

公开(公告)号：WO2011051405A1

公开(公告)日：2011-05-05

申请号：PCT/EP2010/066402

申请日：2010-10-28

Applicant: Dublin City University ,  Dimov, Ivan ,  GARCÍA-CORDERO, José L ,  Basabe-Desmonts, Lourdes

Inventor： Dimov, Ivan ,  GARCÍA-CORDERO, José L ,  Basabe-Desmonts, Lourdes

IPC: B01L3/00 ,  F04B19/00

CPC classification number: B01L3/50273 ,  B01L3/502753 ,  B01L2200/0631 ,  B01L2300/10 ,  B01L2300/14 ,  B01L2400/049 ,  F04B19/006 ,  Y10T29/494

Abstract: A device for blood-plasma separation and plasma-based blood analysis is described. The device uses blood samples smaller than 5 μL (directly from the finger) and flow is achieved with a degassing-driven flow technique that causes blood to flow spontaneously into air-filled dead-end channels without external pumping mechanisms.

Abstract translation: 描述了血浆 - 血浆分离和基于血浆的血液分析装置。 该装置使用小于5μL（直接从手指）的血液样品，并且通过脱气驱动的流动技术实现流动，其使血液自发地流入充满空气的死端通道而没有外部泵送机构。

公开(公告)号：WO2010040851A3

公开(公告)日：2010-04-15

申请号：PCT/EP2009/063229

申请日：2009-10-09

Applicant: DUBLIN CITY UNIVERSITY ,  DIMOV, Ivan ,  DUCREE, Jens ,  LEE, Luke ,  KIJANKA, Gregor

Inventor： DIMOV, Ivan ,  DUCREE, Jens ,  LEE, Luke ,  KIJANKA, Gregor

IPC: B01L3/00 ,  C12M1/00 ,  C12Q1/00 ,  G01N33/483

Abstract: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

公开(公告)号：WO2010146153A1

公开(公告)日：2010-12-23

申请号：PCT/EP2010/058631

申请日：2010-06-18

Applicant: DUBLIN CITY UNIVERSITY ,  GANDHIRAMAN, Ram Prasad ,  BASABE-DESMONTS, Lourdes ,  RIAZ, Asif ,  LEE, Luke ,  DIMOV, Ivan ,  DUCREE, Jens ,  DANIELS, Stephen Michael

Inventor： GANDHIRAMAN, Ram Prasad ,  BASABE-DESMONTS, Lourdes ,  RIAZ, Asif ,  LEE, Luke ,  DIMOV, Ivan ,  DUCREE, Jens ,  DANIELS, Stephen Michael

IPC: B01L3/00 ,  B05D7/22 ,  C23C16/04 ,  C23C16/505

CPC classification number: C23C16/045 ,  B01L3/502707 ,  B01L2300/161 ,  B05D1/62 ,  B05D5/08 ,  B05D7/22 ,  B05D2201/00 ,  C23C16/505

Abstract: The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment.

Abstract translation: 描述了在微流体装置的各个通道或空腔内形成阻挡层。 阻挡层通过气相沉积工艺实现，期望地在等离子体环境中实现。

公开(公告)号：WO2010040851A2

公开(公告)日：2010-04-15

申请号：PCT/EP2009063229

申请日：2009-10-09

Applicant: UNIV DUBLIN CITY ,  DIMOV IVAN ,  DUCREE JENS ,  LEE LUKE ,  KIJANKA GREGOR

Inventor： DIMOV IVAN ,  DUCREE JENS ,  LEE LUKE ,  KIJANKA GREGOR

IPC: B01L3/00 ,  C12M1/00 ,  C12Q1/00 ,  G01N33/483

CPC classification number: B01L3/50273 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2400/0457 ,  B01L2400/0472 ,  Y10T436/25

Abstract: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

Abstract translation: 描述了包括具有在输入和输出之间的衬底内限定的流体路径的微型三向器件的顺序流分析工具。 该装置包括设置在流体路径内但偏离流体路径的俘获室，俘获室在基本上垂直于流体路径的方向上延伸到衬底中，使得设置在流体路径内流动的流体内的可操作地颗粒将优先收集在俘获 室。

公开(公告)号：WO1994025778A1

公开(公告)日：1994-11-10

申请号：PCT/BG1994000004

申请日：1994-04-28

Applicant: DIMOV, Ivan, Ivanov

IPC: F16H01/20

CPC classification number: F16H1/22 ,  F16H57/023 ,  F16H57/033 ,  F16H2057/005 ,  F16H2057/0335 ,  Y10T74/19665 ,  Y10T74/2186

Abstract: The gear is intended for use in toothed reduction gear systems in machine tool transmissions and other machinery. It is characterized by the fact that assembly slots (13, 30) are provided in apertures in partitions in the housing (1, 20) below the radial roller bearing with two flanges on the outer ring (8, 16, 29) of the intermediate shaft-pinions (6, 15, 24). Thanks to this arrangement, subassemblies put together outside the housing can be mounted in the one-piece housings (1, 20, 35); those subassemblies comprise the intermediate shaft-pinions (6, 15, 24), the toothed wheels (5, 7, 25) and the inner rings of the roller bearings (8, 16, 29) in the following construction: multi-stage, single-flow gears; gears with stages divided between two symmetrically configured pairs of spiral gear wheels whose teeth are inclined at opposing angles; multi-flow gears in which the assembly slots (30) are formed by machining a cylindrical surface (31) in the one-piece housing (in the two-stage gears the said surface is machined on the outer partition (20) of the housing, in the four-stage gears on the intermediate partition (36) of the housing). The four-stage multi-flow gears consist of two two-stage gears connected by a shaft-pinion (37) running without any radial support through the intermediate partition (36) of the one-piece housing (35).

Abstract translation: 该齿轮适用于机床传动装置和其他机械的齿形减速齿轮系统。 其特征在于，组装槽（13,30）设置在径向滚子轴承下方的壳体（1,20）中的隔板中的孔中，在中间件的外圈（8,16,29）上具有两个凸缘 轴小齿轮（6,15,24）。 由于这种布置，放置在壳体外部的子组件可以安装在一体式壳体（1,20,35）中; 这些组件包括中间轴小齿轮（6,15,24），齿轮（5,7,25）和滚柱轴承（8,16,29）的内圈，具有以下结构：多级， 单流齿轮; 齿轮具有在两个对称配置的螺旋齿轮对之间划分的齿，其齿以相对的角度倾斜; 多流动齿轮，其中组装槽（30）通过机械加工一体式壳体中的圆柱形表面（31）而形成，所述圆柱形表面（31）在所述两级齿轮中，所述表面被加工在所述壳体的外隔板（20）上 在壳体的中间隔板（36）上的四级齿轮中）。 四级多流量齿轮包括两个两级齿轮，通过轴 - 小齿轮（37）连接，轴 - 小齿轮（37）不通过一体式壳体（35）的中间分隔件（36）而没有任何径向支撑。