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1.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 审中-公开多肽和多核苷酸，以及作为药物和生物学药物目标的用途
公开(公告)号：WO2010067308A2
公开(公告)日：2010-06-17
申请号：PCT/IB2009055585
申请日：2009-12-08
申请人： COMPUGEN LTD , LEVINE ZURIT , ROSENBERG AVI YESHAH , ROTMAN GALIT , TOPORIK AMIR , KINAR YARON , NEMZAR SERGEY , COHEN-DAYAG ANAT , WALACH SHIRA , SAMEACH-GREENWALD SHIRLEY , DASSA LIAT , BEIMAN MERAV , MONTIA EVE , NOVIK AMIT , LEVY OFER
发明人： LEVINE ZURIT , ROSENBERG AVI YESHAH , ROTMAN GALIT , TOPORIK AMIR , KINAR YARON , NEMZAR SERGEY , COHEN-DAYAG ANAT , WALACH SHIRA , SAMEACH-GREENWALD SHIRLEY , DASSA LIAT , BEIMAN MERAV , MONTIA EVE , LEVY OFER
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/28 , A61K38/00 , A61K39/39558 , A61K2039/505 , C07K14/47 , C07K16/30 , C07K16/3015 , C07K16/3038 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12Q1/6886 , C12Q2600/136 , G01N33/57484 , G01N33/577 , G01N2333/47
摘要： This invention relates to a novel target for production of immune and non¬ immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTC AP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.
摘要翻译： 本发明涉及用于产生基于免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供针对在癌症中差异表达的KRTCAP3，FAM26F，MGC52498，FAM70A或TMEM154抗原以及诊断和治疗用途的治疗性抗体。 本发明还涉及KRTC AP3，FAM26F，MGC52498，FAM70A和TMEM154蛋白质和变体的细胞外结构域及其治疗用途。
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2.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 审中-公开多肽和多核苷酸，以及作为药物和生物学药物目标的用途
公开(公告)号：WO2009032845A2
公开(公告)日：2009-03-12
申请号：PCT/US2008/075122
申请日：2008-09-03
申请人： COPUGEN, LTD. , COMPUGEN USA, INC. , LEVINE, Zurit , ROSENBERG, Avi , ROTMAN, Galit , NOVIK, Amit , TOPORIK, Amir , KINAR, Yaron , NEMZER, Sergey , KOIFMAN, Cynthia , BEIMAN, Merav , DASSA, Liat , WALACH, Shira , MONTIA, Eve , SAMEACH-GREENWALD, Shirley , PERGAM, Tania , MILO, Dalit , COHEN-DAYAG, Anat , LEVY, Ofer , BUBIS, Marina
发明人： LEVINE, Zurit , ROSENBERG, Avi , ROTMAN, Galit , NOVIK, Amit , TOPORIK, Amir , KINAR, Yaron , NEMZER, Sergey , KOIFMAN, Cynthia , BEIMAN, Merav , DASSA, Liat , WALACH, Shira , MONTIA, Eve , SAMEACH-GREENWALD, Shirley , PERGAM, Tania , MILO, Dalit , COHEN-DAYAG, Anat , LEVY, Ofer , BUBIS, Marina
IPC分类号： A61K38/17
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants awhich are suitable targets for immunotherapy, cancer therapy, and drug development.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对VSIG1，ILDR1，LOC253012，AI216611，C1ORF32或FXYD3抗原的治疗性抗体，其是预测的共刺激家族成员，并且在包括肺癌，卵巢癌和结肠癌在内的癌症中差异表达， 诊断和治疗用途。 还提供了这些抗体用于调节B7共刺激和相关疗法（例如治疗自身免疫）的用途。 本发明还涉及发现VSIG1及其变体FXYD3及其变体，ILDR1及其变体，LOC253012及其变体，AI216611及其变体和C1ORF32及其变体的细胞外结构域，其是免疫治疗，癌症治疗的合适靶标 ，药物开发。
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公开(公告)号：WO2009016486A3
公开(公告)日：2009-12-30
申请号：PCT/IB2008002002
申请日：2008-07-31
申请人： COMPUGEN LTD , TIRAN ZOHAR , DIBER ALEX , NEMZER SERGEY , KINAR YARON , COJOCARU GAD S , COHEN YOSSI
发明人： TIRAN ZOHAR , DIBER ALEX , NEMZER SERGEY , KINAR YARON , COJOCARU GAD S , COHEN YOSSI
IPC分类号： G01N33/574
CPC分类号： A61K45/06 , A61K31/13 , A61K31/282 , A61K31/35 , A61K31/451 , A61K31/65 , A61K31/7068 , A61K33/24 , A61K2300/00
摘要： A method for treating a subject for urologic cancer or a urologic cancer related disorder comprises administering an NMDA receptor antagonist such as memantine to the subject.
摘要翻译： 用于治疗患有泌尿系统癌症或泌尿系癌症相关疾病的受试者的方法包括向受试者施用NMDA受体拮抗剂如美金刚。
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公开(公告)号：WO2009083950A2
公开(公告)日：2009-07-09
申请号：PCT/IL2008/001561
申请日：2008-12-01
申请人： COMPUGEN LTD. , KINAR, Yaron , BEIMAN, Merav , MONTIA, Eve , WALLACH, Shira , PERGAM, Tania , NOVIK, Amit , SAMEAH-GREENWALD, Shirley , COJOCARU, Gad S. , COHEN-DAYAG, Anat , FURMAN, Yael
发明人： KINAR, Yaron , BEIMAN, Merav , MONTIA, Eve , WALLACH, Shira , PERGAM, Tania , NOVIK, Amit , SAMEAH-GREENWALD, Shirley , COJOCARU, Gad S. , COHEN-DAYAG, Anat , FURMAN, Yael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/347 , G01N2800/60
摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucelotides and proteins, and to kits utilizing same.
摘要翻译： 本发明涉及用于基于测量多核苷酸和蛋白质的表达，特别是测量各种新的以及已知的多核苷酸和蛋白质的表达来预测肾损伤发作的手段和方法， 并使用相同的工具包。
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5.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 审中-公开多肽和多核苷酸及其用作生产药物和生物制品的药物目标
公开(公告)号：WO2009032845A3
公开(公告)日：2009-05-28
申请号：PCT/US2008075122
申请日：2008-09-03
申请人： COPUGEN LTD , COMPUGEN USA INC , LEVINE ZURIT , ROSENBERG AVI , ROTMAN GALIT , NOVIK AMIT , TOPORIK AMIR , KINAR YARON , NEMZER SERGEY , KOIFMAN CYNTHIA , BEIMAN MERAV , DASSA LIAT , WALACH SHIRA , MONTIA EVE , SAMEACH-GREENWALD SHIRLEY , PERGAM TANIA , MILO DALIT , COHEN-DAYAG ANAT , LEVY OFER , BUBIS MARINA
发明人： LEVINE ZURIT , ROSENBERG AVI , ROTMAN GALIT , NOVIK AMIT , TOPORIK AMIR , KINAR YARON , NEMZER SERGEY , KOIFMAN CYNTHIA , BEIMAN MERAV , DASSA LIAT , WALACH SHIRA , MONTIA EVE , SAMEACH-GREENWALD SHIRLEY , PERGAM TANIA , MILO DALIT , COHEN-DAYAG ANAT , LEVY OFER , BUBIS MARINA
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants awhich are suitable targets for immunotherapy, cancer therapy, and drug development.
摘要翻译： 本发明涉及用于生产基于免疫和非免疫的治疗剂和用于疾病诊断的新型靶。 更具体地说，本发明提供了针对VSIG1，ILDR1，LOC253012，AI216611，C1ORF32或FXYD3抗原的治疗性抗体，其是预测的共刺激家族成员并且在癌症包括肺癌，卵巢癌和结肠癌中差异表达，以及 诊断和治疗用法。 还提供了这些抗体用于调节B7共刺激和相关疗法如治疗自身免疫的用途。 本发明进一步涉及VSIG1及其变体，FXYD3及其变体，ILDR1及其变体，LOC253012及其变体，AI216611及其变体，以及C1ORF32及其变体的细胞外结构域的发现，它们是免疫治疗，癌症治疗 和药物开发。
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公开(公告)号：WO2010100633A1
公开(公告)日：2010-09-10
申请号：PCT/IL2009/000235
申请日：2009-03-01
申请人： COMPUGEN LTD. , KINAR, Yaron , BEIMAN, Merav , MONTIA, Eve , WALLACH, Shira , PERGAM, Tania , NOVIK, Amit , SAMEAH-GREENWALD, Shirley , COJOCARU, Gad S. , COHEN-DAYAG, Anat , FURMAN, Yael
发明人： KINAR, Yaron , BEIMAN, Merav , MONTIA, Eve , WALLACH, Shira , PERGAM, Tania , NOVIK, Amit , SAMEAH-GREENWALD, Shirley , COJOCARU, Gad S. , COHEN-DAYAG, Anat , FURMAN, Yael
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158 , C12Q2600/16 , G01N33/6893 , G01N2800/347 , G01N2800/52 , Y10T436/143333
摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of polynucelotides and/or proteins, and to kits utilizing same. The present invention discloses novel polynucleotide varinats and proteins encoded therefrom, and sets comprising the novel polynucleotides, and known genes the expression of which is indicative of renal injury.
摘要翻译： 本发明涉及用于基于测量多核苷酸和蛋白质的表达来预测肾损伤发作的方法和方法，特别是关于测量多聚核苷酸和/或蛋白质组的表达，以及使用它们的试剂盒。 本发明公开了新颖的多核苷酸变种蛋白和由其编码的蛋白质，以及包含新型多核苷酸的组以及其表达指示肾损伤的已知基因。
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7.发明申请
公开(公告)号：WO2010067308A3
公开(公告)日：2010-06-17
申请号：PCT/IB2009/055585
申请日：2009-12-08
申请人： COMPUGEN LTD. , LEVINE, Zurit , ROSENBERG, Avi Yeshah , ROTMAN, Galit , TOPORIK, Amir , KINAR, Yaron , NEMZAR, Sergey , COHEN-DAYAG, Anat , WALACH, Shira , SAMEACH-GREENWALD, Shirley , DASSA, Liat , BEIMAN, Merav , MONTIA, Eve , NOVIK, Amit , LEVY, Ofer
发明人： LEVINE, Zurit , ROSENBERG, Avi Yeshah , ROTMAN, Galit , TOPORIK, Amir , KINAR, Yaron , NEMZAR, Sergey , COHEN-DAYAG, Anat , WALACH, Shira , SAMEACH-GREENWALD, Shirley , DASSA, Liat , BEIMAN, Merav , MONTIA, Eve , LEVY, Ofer
IPC分类号： C07K16/28 , C07K14/705
摘要： This invention relates to a novel target for production of immune and non¬ immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTC AP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.
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公开(公告)号：WO2009083950A3
公开(公告)日：2009-09-03
申请号：PCT/IL2008001561
申请日：2008-12-01
申请人： COMPUGEN LTD , KINAR YARON , BEIMAN MERAV , MONTIA EVE , WALLACH SHIRA , PERGAM TANIA , NOVIK AMIT , SAMEAH-GREENWALD SHIRLEY , COJOCARU GAD S , COHEN-DAYAG ANAT , FURMAN YAEL
发明人： KINAR YARON , BEIMAN MERAV , MONTIA EVE , WALLACH SHIRA , PERGAM TANIA , NOVIK AMIT , SAMEAH-GREENWALD SHIRLEY , COJOCARU GAD S , COHEN-DAYAG ANAT , FURMAN YAEL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/347 , G01N2800/60
摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucelotides and proteins, and to kits utilizing same.
摘要翻译： 本发明涉及用于通过测量多核苷酸和蛋白质的表达来预测肾损伤发作的方法和方法，特别是关于测量新颖和已知的多肽酶和蛋白质的组合的表达，以及使用它们的试剂盒。
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9.发明申请
公开(公告)号：WO2009016486A2
公开(公告)日：2009-02-05
申请号：PCT/IB2008/002002
申请日：2008-07-31
申请人： COMPUGEN, LTD , TIRAN, Zohar , DIBER, Alex , NEMZER, Sergey , KINAR, Yaron , COJOCARU, Gad S. , COHEN, Yossi
发明人： TIRAN, Zohar , DIBER, Alex , NEMZER, Sergey , KINAR, Yaron , COJOCARU, Gad S. , COHEN, Yossi
IPC分类号： A61K33/24
CPC分类号： A61K45/06 , A61K31/13 , A61K31/282 , A61K31/35 , A61K31/451 , A61K31/65 , A61K31/7068 , A61K33/24 , A61K2300/00
摘要： A method for treating a subject for urologic cancer or a urologic cancer related disorder comprises administering an NMDA receptor antagonist such as memantine to the subject.
摘要翻译： 治疗对象患有泌尿系统癌症或泌尿系统癌症相关疾病的方法包括向所述对象施用NMDA受体拮抗剂例如美金刚。
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10.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 审中-公开多肽和多核苷酸，以及作为药物和生物学药物目标的用途
公开(公告)号：WO2009095925A3
公开(公告)日：2010-04-15
申请号：PCT/IL2009000123
申请日：2009-02-01
申请人： COMPUGEN LTD , LEVIN ZURIT , ROSENBERG AVI YESHAH , ROTMAN GALIT , TOPORIK AMIR , DASSA LIAT , BEIMAN MERAV , LEVY OFER , NEMZAR SERGEY , WALACH SHIRA , SAMEACH-GREENWALD SHIRLEY , MONTIA EVE , KINAR YARON , COHEN-DAYAG ANAT
发明人： LEVIN ZURIT , ROSENBERG AVI YESHAH , ROTMAN GALIT , TOPORIK AMIR , DASSA LIAT , BEIMAN MERAV , LEVY OFER , NEMZAR SERGEY , WALACH SHIRA , SAMEACH-GREENWALD SHIRLEY , MONTIA EVE , KINAR YARON , COHEN-DAYAG ANAT
IPC分类号： C07K14/47
CPC分类号： A61K39/3955 , C07K14/47 , C07K16/28 , C07K16/2887 , C07K16/2896 , C07K2317/21 , C07K2317/34
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KIAA0746, CD20 or CD55 antigens, which are differentially expressed in cancer and in specific blood cells, and diagnostic and therapeutic usages. This invention further relates to the discovery of extracellular domains of KIAA0746 and its variants, CD20 and its variants, CD55 and its variants, which are suitable targets for immunotherapy, cancer therapy, treatment of inflammatory, allergic and autoimmune disorders, and drug development.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对KIAA0746，CD20或CD55抗原的治疗性抗体，其在癌症和特异性血细胞中差异表达，以及诊断和治疗用途。 本发明还涉及KIAA0746及其变体CD20及其变体CD55及其变体的细胞外结构域的发现，其是免疫治疗，癌症治疗，炎症，过敏和自身免疫性疾病的治疗以及药物开发的合适靶标。
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