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公开(公告)号：WO2022090801A2
公开(公告)日：2022-05-05
申请号：PCT/IB2021/000745
申请日：2021-10-26
申请人： COMPUGEN LTD. , COJOCARU, Gad, S. , KFIR, Tal, Fridman , WEYL, Emmanuel , NOVIK, Amit , KLIGER, Yossef , SABATH, Niv , OPHIR, Eran , ALTEBER, Zoya , FRENKEL, Masha
发明人： COJOCARU, Gad, S. , KFIR, Tal, Fridman , WEYL, Emmanuel , NOVIK, Amit , KLIGER, Yossef , SABATH, Niv , OPHIR, Eran , ALTEBER, Zoya , FRENKEL, Masha
IPC分类号： G01N33/574 , G01N2800/52 , G01N33/57492
摘要： The present invention provides biomarkers for use in determining populations for treatment with anti-PVRIG antibodies and such biomarkers include, for example PVRIG and/or PVRL2 expression.
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公开(公告)号：WO2021021837A2
公开(公告)日：2021-02-04
申请号：PCT/US2020/043921
申请日：2020-07-28
申请人： COMPUGEN LTD. , WHITE, Mark
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , A61K39/3955
摘要： The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof.
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公开(公告)号：WO2016134335A3
公开(公告)日：2016-11-03
申请号：PCT/US2016018811
申请日：2016-02-19
申请人： COMPUGEN LTD
发明人： WHITE MARK , KUMAR SANDEEP , CHAN CHRISTOPHER , LIANG SPENCER , STAPLETON LANCE , DRAKE ANDREW W , GOZLAN YOSI , VAKNIN IIAN , SAMEAH-GREENWALD SHIRLEY , DASSA LIAT , TIRAN ZOHAR , COJOCARU GAD S , LEVY OFER , MACHLENKIN ARTHUR , TOPORIK AMIR , KLIGER YOSSEF , NEMZER SERGEY , NOVIK AMIT , BENITA YAIR
CPC分类号： C07K16/1009 , A61K2039/507 , C07K7/06 , C07K14/70503 , C07K16/2803 , C07K16/2818 , C07K2317/74 , C07K2319/30 , C12N15/1138 , C12N2310/14 , G01N33/5011 , G01N33/502 , G01N33/505 , G01N33/574 , G01N2333/70596 , G01N2500/02 , G01N2500/10
摘要： The present invention is directed to PVRIG polypeptides and their uses.
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公开(公告)号：WO2016134335A2
公开(公告)日：2016-08-25
申请号：PCT/US2016/018811
申请日：2016-02-19
申请人： COMPUGEN LTD.
发明人： WHITE, Mark , KUMAR, Sandeep , CHAN, Christopher , LIANG, Spencer , STAPLETON, Lance , DRAKE, Andrew W. , GOZLAN, Yosi , VAKNIN, Iian , SAMEAH-GREENWALD, Shirley , DASSA, Liat , TIRAN, Zohar , COJOCARU, Gad, S. , LEVY, Ofer , MACHLENKIN, Arthur , TOPORIK, Amir , KLIGER, Yossef , NEMZER, Sergey , NOVIK, Amit , BENITA, Yair
IPC分类号： G01N33/574
CPC分类号： C07K16/1009 , A61K2039/507 , C07K7/06 , C07K14/70503 , C07K16/2803 , C07K16/2818 , C07K2317/74 , C07K2319/30 , C12N15/1138 , C12N2310/14 , G01N33/5011 , G01N33/502 , G01N33/505 , G01N33/574 , G01N2333/70596 , G01N2500/02 , G01N2500/10 , Y02A50/466
摘要： The present invention is directed to PVRIG polypeptides and their uses.
摘要翻译： 本发明涉及PVRIG多肽及其用途。
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5.发明申请
公开(公告)号：WO2015037000A8
公开(公告)日：2015-03-19
申请号：PCT/IL2014/050809
申请日：2014-09-11
申请人： COMPUGEN LTD
发明人： LEVINE, Zurit , ROTMAN, Galit , DASSA, Liat , LEVY, Ofer , COJOCARU, Gad S. , TOPORIK, Amir , KLIGER, Yossef , VAKNIN, Ilan , HECHT, Iris
IPC分类号： A61K38/17 , G01N33/50 , G01N33/564 , G01N33/574 , C07K14/435 , C07K7/00 , G01N33/569 , C07K19/00
摘要： This invention relates to VSTM5 proteins, soluble molecules and fusions thereof which are suitable targets for drug development and for treatment of immune related disorders, immunotherapy, treatment of cancer, infectious disorders and/or sepsis.
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6.发明申请
公开(公告)号：WO2012035518A1
公开(公告)日：2012-03-22
申请号：PCT/IB2011/054060
申请日：2011-09-16
IPC分类号： A61K39/395 , C07K16/30 , A61K31/704 , C07K14/47 , G01N33/574
CPC分类号： C07K16/3061 , A61K31/713 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/30 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2319/30 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2320/10 , C12N2320/30 , C12Q1/6886 , G01N33/57407 , G01N33/57426 , G01N33/6893 , G01N2333/705 , A61K2300/00
摘要： This disclosure relates to a novel target for production of immune and non- immune based therapeutics and for disease diagnosis. More particularly, the disclosure provides therapeutic antibodies against TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages, wherein the cancer is relates to multiple myeloma, including multiple myeloma precursor diseases. This disclosure further relates to extracellular domains of TMEM154 proteins and variants, and therapeutic usages thereof.
摘要翻译： 本公开涉及用于产生免疫和非免疫的治疗剂和用于疾病诊断的新靶标。 更具体地，本公开提供了针对TMEM154抗原的治疗性抗体，其在癌症中差异表达，以及诊断和治疗用途，其中所述癌症涉及多发性骨髓瘤，包括多发性骨髓瘤前体疾病。 本公开还涉及TMEM154蛋白和变体的细胞外结构域及其治疗用途。
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公开(公告)号：WO2010100633A1
公开(公告)日：2010-09-10
申请号：PCT/IL2009/000235
申请日：2009-03-01
申请人： COMPUGEN LTD. , KINAR, Yaron , BEIMAN, Merav , MONTIA, Eve , WALLACH, Shira , PERGAM, Tania , NOVIK, Amit , SAMEAH-GREENWALD, Shirley , COJOCARU, Gad S. , COHEN-DAYAG, Anat , FURMAN, Yael
发明人： KINAR, Yaron , BEIMAN, Merav , MONTIA, Eve , WALLACH, Shira , PERGAM, Tania , NOVIK, Amit , SAMEAH-GREENWALD, Shirley , COJOCARU, Gad S. , COHEN-DAYAG, Anat , FURMAN, Yael
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158 , C12Q2600/16 , G01N33/6893 , G01N2800/347 , G01N2800/52 , Y10T436/143333
摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of polynucelotides and/or proteins, and to kits utilizing same. The present invention discloses novel polynucleotide varinats and proteins encoded therefrom, and sets comprising the novel polynucleotides, and known genes the expression of which is indicative of renal injury.
摘要翻译： 本发明涉及用于基于测量多核苷酸和蛋白质的表达来预测肾损伤发作的方法和方法，特别是关于测量多聚核苷酸和/或蛋白质组的表达，以及使用它们的试剂盒。 本发明公开了新颖的多核苷酸变种蛋白和由其编码的蛋白质，以及包含新型多核苷酸的组以及其表达指示肾损伤的已知基因。
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8.发明申请
公开(公告)号：WO2010067308A3
公开(公告)日：2010-06-17
申请号：PCT/IB2009/055585
申请日：2009-12-08
申请人： COMPUGEN LTD. , LEVINE, Zurit , ROSENBERG, Avi Yeshah , ROTMAN, Galit , TOPORIK, Amir , KINAR, Yaron , NEMZAR, Sergey , COHEN-DAYAG, Anat , WALACH, Shira , SAMEACH-GREENWALD, Shirley , DASSA, Liat , BEIMAN, Merav , MONTIA, Eve , NOVIK, Amit , LEVY, Ofer
发明人： LEVINE, Zurit , ROSENBERG, Avi Yeshah , ROTMAN, Galit , TOPORIK, Amir , KINAR, Yaron , NEMZAR, Sergey , COHEN-DAYAG, Anat , WALACH, Shira , SAMEACH-GREENWALD, Shirley , DASSA, Liat , BEIMAN, Merav , MONTIA, Eve , LEVY, Ofer
IPC分类号： C07K16/28 , C07K14/705
摘要： This invention relates to a novel target for production of immune and non¬ immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTC AP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.
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公开(公告)号：WO2010010551A2
公开(公告)日：2010-01-28
申请号：PCT/IL2009/000709
申请日：2009-07-20
申请人： COMPUGEN LTD. , KLIGER, Yossef , BORUKHOV, Itamar , LEVY, Ofer , TIRAN, Zohar , WOOL, Assaf , SCHREIBER, Ehud , AMIR, Anat , LEVINE, Zurit , TOPORIK, Amir
发明人： KLIGER, Yossef , BORUKHOV, Itamar , LEVY, Ofer , TIRAN, Zohar , WOOL, Assaf , SCHREIBER, Ehud , AMIR, Anat , LEVINE, Zurit , TOPORIK, Amir
IPC分类号： C07K14/515
CPC分类号： C07K14/515 , A61K38/14 , A61K38/1891 , A61K45/06 , C07K9/00 , C07K9/001
摘要： In at least some embodiments, the subject invention provides angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition comprising them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins comprising them.
摘要翻译： 在至少一些实施方案中，本发明提供血管生成素衍生的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和用于制备药物的用途，治疗广泛的病症，病症和 疾病，编码它们的核苷酸序列，针对其表位的抗体和包含它们的融合蛋白。
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公开(公告)号：WO2009083950A3
公开(公告)日：2009-09-03
申请号：PCT/IL2008001561
申请日：2008-12-01
申请人： COMPUGEN LTD , KINAR YARON , BEIMAN MERAV , MONTIA EVE , WALLACH SHIRA , PERGAM TANIA , NOVIK AMIT , SAMEAH-GREENWALD SHIRLEY , COJOCARU GAD S , COHEN-DAYAG ANAT , FURMAN YAEL
发明人： KINAR YARON , BEIMAN MERAV , MONTIA EVE , WALLACH SHIRA , PERGAM TANIA , NOVIK AMIT , SAMEAH-GREENWALD SHIRLEY , COJOCARU GAD S , COHEN-DAYAG ANAT , FURMAN YAEL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/347 , G01N2800/60
摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucelotides and proteins, and to kits utilizing same.
摘要翻译： 本发明涉及用于通过测量多核苷酸和蛋白质的表达来预测肾损伤发作的方法和方法，特别是关于测量新颖和已知的多肽酶和蛋白质的组合的表达，以及使用它们的试剂盒。
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