公开(公告)号：WO2018154075A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054578

申请日：2018-02-23

Applicant: HVIVO SERVICES LIMITED

Inventor： MANN, Alexander James ,  EVANS, Gareth Lyndon ,  ESTELLES LOPEZ, Lucia Teresa

IPC: C12Q1/68 ,  G06F19/18 ,  C12Q1/6883 ,  G06F19/24

CPC classification number: C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  G16B25/00 ,  G16B40/00 ,  G16H20/10 ,  G16H50/20 ,  G16H50/30

Abstract: The present invention provides methods for classifying subjects exposed to viral infection, in particular influenza. The methods may be used to classify subjects before they show symptoms of infection. The methods may also be used to classify subjects who are infected but are asymptomatic. The present invention also provides an apparatus for performing the methods of the invention as well as related methods for controlling the spread of viral infections and/or secondary bacterial infections.

公开(公告)号：WO2016193977A2

公开(公告)日：2016-12-08

申请号：PCT/IL2016/050566

申请日：2016-06-02

Applicant: NEVIAH GENOMICS LTD. ,  COMPUGEN LTD.

Inventor： YARDEN, Ganit ,  WOOL, Assaf

IPC: G01N33/50 ,  C12Q1/68

CPC classification number: G01N33/5067 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N33/5014 ,  G01N33/5023

Abstract: Methods of predicting hepatotoxicity of a compound by providing an in vitro hepatocyte culture system capable of expressing a panel of genes, wherein the culture may be incubated with the compound or compounds to be screened and the expression level of the panel of genes measured is described herein. By comparing the expression level of the panel of genes in the culture system exposed to the compound(s) being screened with the gene expression of the same panel of genes in a control culture system, hepatotoxicity of the compound(s) is able to be predicted.

Abstract translation: 通过提供能够表达一组基因的体外肝细胞培养系统来预测化合物的肝毒性的方法，其中可以将培养物与待筛选的化合物或化合物孵育，并且本文描述测量的基因组的表达水平 。 通过比较暴露于被筛选的化合物的培养系统中的基因组的表达水平与对照培养系统中同一组基因的基因表达，化合物的肝毒性能够 预料到的。

公开(公告)号：WO2015069883A8

公开(公告)日：2016-04-14

申请号：PCT/US2014064331

申请日：2014-11-06

Applicant: BARANOVA ANNA ,  KOSTYUK SVETLANA ,  VEIKO NATALYA

Inventor： BARANOVA ANNA ,  KOSTYUK SVETLANA ,  VEIKO NATALYA

IPC: A61K39/44

CPC classification number: C12Q1/6876 ,  C07K16/44 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/142

Abstract: The present invention relates to methods of treating and diagnosing oxidative damage in a subject comprising administering an agent that binds oxidized extracellular nucleic acid, and methods of treating diseases and conditions in a subject comprising administering an adjuvant therapy comprising an agent that binds oxidized extracellular nucleic acid. The oxidized fraction of extracellular DNA can also be detected through electrochemical methods or by mass- spectrometry.

Abstract translation: 本发明涉及治疗和诊断受试者的氧化损伤的方法，包括施用结合氧化的细胞外核酸的试剂，以及治疗受试者疾病和病症的方法，包括施用辅助治疗，其包括结合氧化细胞外核酸的试剂 。 细胞外DNA的氧化部分也可以通过电化学方法或质谱法检测。

公开(公告)号：WO2015183173A1

公开(公告)日：2015-12-03

申请号：PCT/SE2015/050617

申请日：2015-05-28

Applicant: GRAFSTRÖM, Roland ,  KOHONEN, Pekka ,  PARKKINEN, Juuso ,  KASKI, Samuel

Inventor： GRAFSTRÖM, Roland ,  KOHONEN, Pekka ,  PARKKINEN, Juuso ,  KASKI, Samuel

IPC: C12Q1/68 ,  G06F19/12

CPC classification number: G06F19/12 ,  C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158 ,  G06F19/18 ,  G06F19/20 ,  G06F19/702 ,  G06F19/704 ,  G06F19/707

Abstract: A novel method to predict toxicity and dose-dependent effects of an agent based on transcriptomic data analysis, by determining a predictive toxicogenomics space (PTGS) score. The PTGS score helps to predict and model the toxicity of compounds typically consisting of chemicals, pharmaceuticals, cosmetics and agrochemicals. The invention further comprises methods of deriving the PTGS score, as well as computer programs to calculate PTGS scores.

Abstract translation: 通过确定预测毒性基因组学空间（PTGS）评分，基于转录组学数据分析预测药物的毒性和剂量依赖性作用的新方法。 PTGS分数有助于预测和模拟通常由化学品，药物，化妆品和农用化学品组成的化合物的毒性。 本发明还包括导出PTGS分数的方法以及计算PTGS评分的计算机程序。

公开(公告)号：WO2014127258A3

公开(公告)日：2014-10-23

申请号：PCT/US2014016522

申请日：2014-02-14

Applicant: UNIV CORNELL ,  UNIV ROCKEFELLER

Inventor： VARTANIAN TIMOTHY ,  RUMAH KAREEM RASHID ,  FISCHETTI VINCENT A

IPC: A61K39/395 ,  A61P25/00 ,  A61P25/28

CPC classification number: C07K16/1282 ,  A61K31/7048 ,  A61K35/741 ,  A61K35/742 ,  A61K38/47 ,  A61K39/00 ,  A61K2039/505 ,  C07K2317/76 ,  C12Q1/689 ,  C12Q2600/118 ,  C12Q2600/142 ,  C12Y302/01017 ,  G01N33/56911 ,  G01N2333/33 ,  G01N2469/20 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/285

Abstract: The invention provides epsilon toxin (ETX) produced by Clostridium perfringens type B or type D as a causative toxin for human multiple sclerosis (MS). The invention further identifies ETX binding receptor MAL for ETX mediated cell death and other toxin- logical activities in MS. Methods and compositions to prevent humans from multiple sclerosis (MS) and/or treating MS by directly or indirectly interfering with epsilon toxin (ETX), its binding receptor (e.g., MAL), or ETX-receptor interactions so as to inhibit or suppress downstream ETX mediated receptor signaling activities are provided. Also provided are various methods to detect, diagnose, monitor, assess multiple sclerosis (MS) by determining an expression level of ETX gene or its encoding protein in human patient suspected for and/or at risk for multiple sclerosis (MS).

Abstract translation: 本发明提供由产气荚膜梭状芽孢杆菌B型或D型作为人多发性硬化症（MS）致病毒素产生的ε毒素（ETX）。 本发明进一步鉴定ETX结合受体MAL用于ETX介导的细胞死亡和MS中的其他毒素活性。 通过直接或间接干扰ε-毒素（ETX），其结合受体（例如MAL）或ETX-受体相互作用来抑制或抑制多发性硬化（MS）和/或治疗MS以抑制或抑制下游的方法和组合物 提供了ETX介导的受体信号传导活性。 还提供了通过确定怀疑为和/或具有多发性硬化（MS）风险的人类患者中ETX基因或其编码蛋白的表达水平来检测，诊断，监测，评估多发性硬化（MS）的各种方法。

公开(公告)号：WO2014035065A1

公开(公告)日：2014-03-06

申请号：PCT/KR2013/006848

申请日：2013-07-30

Applicant: 동국대학교 산학협력단

Inventor： 서영록 ,  이상민 ,  김혜림 ,  쾨드리드프리야폰 ,  권지영 ,  원종일

IPC: C12Q1/68 ,  C12N15/11

CPC classification number: C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158

Abstract: 본 발명은 카드뮴 노출 여부 확인용 마이크로어레이 칩 및 이를 이용하여 카드뮴 노출 여부를 확인하는 방법을 제공한다. 본 발명의 카드뮴 노출 여부 확인용 마이크로어레이 칩은 카드뮴 노출 여부 모니터링 및 위해성 판정에 유용하게 이용될 수 있으며, 아울러 카드뮴에 의해 야기되는 독성 작용 기작을 규명하는 도구로 활용될 수 있다.

Abstract translation: 本发明提供了一种用于检查镉暴露的微阵列芯片，以及通过使用它来检查镉暴露的方法。 用于检查本发明的镉暴露的微阵列芯片可用于镉暴露监测和风险测定中的优点，并且可以用作阐明镉引起的毒性作用机理的工具。

公开(公告)号：WO2014035063A1

公开(公告)日：2014-03-06

申请号：PCT/KR2013/006840

申请日：2013-07-30

Applicant: 동국대학교 산학협력단

Inventor： 서영록 ,  이상민 ,  김혜림 ,  원종일 ,  권지영 ,  정석원 ,  쾨드리드프리야폰

IPC: C12Q1/68 ,  C12N15/11

CPC classification number: C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158

Abstract: 본 발명은 니켈 노출 여부 확인용 마이크로어레이 칩 및 이를 이용하여 니켈 노출 여부를 확인하는 방법을 제공한다. 본 발명의 니켈 노출 여부 확인용 마이크로어레이 칩은 니켈 노출 여부 모니터링 및 위해성 판정에 유용하게 이용될 수 있으며, 아울러 니켈에 의해 야기되는 독성 작용 기작을 규명하는 도구로 활용될 수 있다.

Abstract translation: 本发明提供了一种用于检查镍暴露的微阵列芯片，以及通过使用它来检查镍暴露的方法。 用于检查本发明的镍暴露的微阵列芯片可以用于镍暴露监测和风险测定中的优点，并且可以用作阐明镍产生的毒性作用机理的工具。

公开(公告)号：WO2013162133A1

公开(公告)日：2013-10-31

申请号：PCT/KR2012/008923

申请日：2012-10-29

Applicant: 서울시립대학교산학협력단

Inventor： 최진희 ,  노지연 ,  조기종 ,  손진오

IPC: C12Q1/68 ,  C12N15/11 ,  G01N33/20

CPC classification number: C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158

Abstract: 본 발명은 서열번호 1의 염기서열로 이루어진 예쁜꼬마선충 ( Caenorhabditis elegans ) 유래 mtl-2 ( metallothionein-2 ) 유전자를 포함하는 광산 토양 중의 중금속 검출용 키트, 중금속으로 오염된 것으로 추정되는 광산 토양 시료에 노출시킨 예쁜꼬마선충으로부터 mtl-2 유전자의 발현 수준을 측정하는 단계를 포함하는 광산 토양 중의 중금속의 존재 여부를 검출하는 방법 및 예쁜꼬마선충 유래 mtl-2 유전자를 포함하는 광산 토양 중의 중금속 검출용 조성물을 제공한다.

Abstract translation: 本发明涉及一种用于检测矿区土壤重金属的试剂盒，其中包含秀丽隐杆线杆菌来源的金属硫蛋白-2（mtl-2）基因，其碱基序列为序列号 本发明还涉及一种用于检测矿物土壤中重金属存在的方法，包括测量暴露于被认为被污染的矿山土壤样品的秀丽隐杆线虫的mt1-2基因的表达水平的步骤 与重金属。 本发明还涉及一种用于检测矿土中重金属的组合物，其包含秀丽隐杆线虫来源的mt1-2基因。

公开(公告)号：WO2013151440A2

公开(公告)日：2013-10-10

申请号：PCT/NL2013/050256

申请日：2013-04-05

Applicant: STICHTING VU-VUMC

Inventor： VAN STRAALEN, Nicolaas, Maria ,  ROELOFS, Theodorus, Frank, Maria

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q2600/142 ,  C12Q2600/158

Abstract: A method for determining toxicity of a sample, particularly a soil sample suspected of containing polycyclic aromatic hydrocarbon pollutants, is provided. The method allows for quantification of toxicity levels based on gene expression profiling of a test organism, for example Folsomia candida,exposed to the sample.

Abstract translation: 提供了一种确定样品毒性的方法，特别是怀疑含有多环芳烃污染物的土壤样品。 该方法允许基于暴露于样品的测试生物（例如，假丝酵母​​菌）的基因表达谱来定量毒性水平。

公开(公告)号：WO2013122816A1

公开(公告)日：2013-08-22

申请号：PCT/US2013/025215

申请日：2013-02-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： KAMPMANN, Martin ,  BASSIK, Michael ,  WEISSMAN, Jonathan

IPC: C12Q1/68 ,  C12N15/11 ,  G01N33/50 ,  G01N33/58

CPC classification number: C12N15/1075 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/12 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/142 ,  G01N33/502 ,  G06F19/18 ,  C12Q2525/207 ,  C12Q2525/301 ,  C12Q2535/122

Abstract: The present invention provides methods for conducting screens using nucleic acid elements (e.g., interfering RNAs) to confidently identify hit genetic elements. The present invention further comprises constructing vectors that contain two or more nucleic acid elements to knock down all pairwise combinations of the hit genetic elements identified from the screen. Following quantitation of the single and double-knockdown phenotypes, genetic interactions between all gene pairs can be calculated. Genes can then be clustered according to the similarity of the pattern of their interactions with all of the other genes to obtain a genetic interaction map, which can advantageously be used to predict functional associations between genes and identify drug targets for therapy such as combination cancer therapy.

Abstract translation: 本发明提供了使用核酸元件（例如干扰RNA）进行筛选以自信地鉴定命中遗传元件的方法。 本发明还包括构建含有两个或多个核酸元件的载体，以敲除从筛选鉴定的命中遗传元件的所有成对组合。 在单次和双重敲低表型的定量之后，可以计算所有基因对之间的遗传相互作用。 然后可以根据其与所有其他基因的相互作用模式的相似性将基因聚类，以获得遗传相互作用图，其可有利地用于预测基因之间的功能关联并鉴定用于治疗的药物靶标，例如组合癌症治疗 。