公开(公告)号：WO2021222849A2

公开(公告)日：2021-11-04

申请号：PCT/US2021/030322

申请日：2021-04-30

申请人： CEDARS-SINAI MEDICAL CENTER ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  STRIPP, Barry R. ,  MULAY, Apoorva ,  KONDA, Bindu ,  SHARMA, Arun ,  SVENDSEN, Clive ,  ARUMUGASWAMI, Vaithilingaraja ,  SAREEN, Dhruv ,  SHAHARUDDIN, Hanan ,  WANG, Victoria ,  SANTOS, Roberta S.

发明人： STRIPP, Barry R. ,  MULAY, Apoorva ,  KONDA, Bindu ,  SHARMA, Arun ,  SVENDSEN, Clive ,  ARUMUGASWAMI, Vaithilingaraja ,  SAREEN, Dhruv ,  SHAHARUDDIN, Hanan ,  WANG, Victoria ,  SANTOS, Roberta S.

IPC分类号： A61K35/12 ,  A61K35/36 ,  A61K35/545 ,  C12N15/09 ,  C12N5/10 ,  C12N2503/02 ,  C12N2506/45 ,  C12N2510/00 ,  C12N5/0676

摘要： Described herein are particular infection model systems, methods of studying infection, and method of screening compounds in various model systems. Particularly, SARS-CoV-2 is studied in these organ and infection models.

公开(公告)号：WO2021222816A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/030280

申请日：2021-04-30

申请人： CEDARS-SINAI MEDICAL CENTER ,  STRIPP, Barry R. ,  KONDA, Bindu ,  MULAY, Apoorva

发明人： STRIPP, Barry R. ,  KONDA, Bindu ,  MULAY, Apoorva

IPC分类号： A61L27/36

摘要： The in vitro organoid model is a major technological breakthrough and an essential tool to study the basic biology of an organ system and for the development of various clinical applications for disease intervention. Organoids can self-renew and exhibit similarities in function as of their tissue of origin. Here, a step-by-step protocol is described to isolate region-specific progenitors from the human lung and generate 3D organoid cultures as an experimental and validation tool.