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公开(公告)号：WO2014078082A2
公开(公告)日：2014-05-22
申请号：PCT/US2013/067623
申请日：2013-10-30
Applicant: MIMEDX GROUP, INC. , KOOB, Thomas J.
Inventor： KOOB, Thomas J.
IPC: A61K47/42
CPC classification number: A61K47/42 , A61K9/0024 , A61K33/00 , A61K33/34
Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods. Also described is a novel vacuum drying device and the use thereof.
Abstract translation: 本公开描述了包含抗真菌剂，优选铜的胶原构建体和相关方法。 还描述了一种新颖的真空干燥装置及其用途。
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公开(公告)号：WO2014078081A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/067622
申请日：2013-10-30
Applicant: MIMEDX GROUP, INC. , KOOB, Thomas J.
Inventor： KOOB, Thomas J.
CPC classification number: A61K47/48292 , A61K31/282 , A61K31/555 , A61K33/24 , A61K47/6435 , A61K47/6953 , C07K14/78 , C12N2533/54
Abstract: The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods. Also described is a novel vacuum drying device and the use thereof.
Abstract translation: 本公开描述了包含抗癌剂，优选铂的胶原构建体和相关方法。 还描述了一种新颖的真空干燥装置及其用途。
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3.发明申请METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING TUBES FOR AUTO AND/OR ALLO-GRAFTS 审中-公开制造胶原纤维医疗结构和相关医疗结构的方法，包括用于自动和/或合成纤维的管
公开(公告)号：WO2011156319A3
公开(公告)日：2012-04-12
申请号：PCT/US2011039375
申请日：2011-06-07
Applicant: MIMEDX INC , PAULOS LEON , LI MENGYAN , HERNANDEZ DANIEL , KOOB THOMAS J
Inventor： PAULOS LEON , LI MENGYAN , HERNANDEZ DANIEL , KOOB THOMAS J
CPC classification number: A61L27/46 , A61B17/00491 , A61B17/0401 , A61B17/06166 , A61B17/1128 , A61B17/1146 , A61B50/30 , A61B2017/00526 , A61B2017/06052 , A61B2017/06071 , A61B2017/0608 , A61B2050/314 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/82 , A61F2210/0004 , A61F2210/0076 , A61F2230/0067 , A61F2230/0069 , A61F2240/00 , A61F2240/001 , A61L15/325 , A61L27/14 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/507 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/044 , A61L2420/04 , A61L2420/08 , A61L2430/10 , A61L2430/32 , B29C53/58 , B29C53/66 , B32B37/142 , B32B37/20 , B32B38/08 , B32B2535/00 , Y10T428/249921 , Y10T428/2938 , Y10T442/3065 , C08L89/06
Abstract: The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.
Abstract translation: 本公开描述了缠绕胶原纤维以制造医疗构造物和相关胶原纤维管和贴片装置的方法。
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4.发明申请COMPRESSIBLE TUBES FOR PLACING IMPLANTS AND RELATED MEDICAL KITS AND METHODS OF USING SAME 审中-公开用于植入植入物和相关医疗工具的可压缩管及其使用方法
公开(公告)号：WO2011146292A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/036042
申请日：2011-05-11
Applicant: MIMEDX, INC. , NIU, Mei , HERNANDEZ, Daniel , KOOB, Thomas J.
Inventor： NIU, Mei , HERNANDEZ, Daniel , KOOB, Thomas J.
CPC classification number: A61F2/0805 , A61B17/06 , A61B17/06004 , A61B17/06066 , A61B17/06166 , A61B17/1146 , A61B17/3468 , A61B2017/00336 , A61B2017/00902 , A61B2017/00942 , A61B2017/06052 , A61F2002/825 , A61L27/24 , A61L27/3666
Abstract: Medical delivery devices include a needle and a flexible compressible impermeable tube attached to the needle. The compressible tube has an open interior channel. The device is adapted to releasably hold a length of a medical implant in the open interior channel of the tube. The medical implant can be slidably inserted into the interior channel of the tube and is loosely held by the tube.
Abstract translation: 医疗输送装置包括针和连接到针的柔性可压缩不渗透管。 可压缩管具有开放的内部通道。 该装置适于将医疗植入物的一定长度可释放地保持在管的敞开的内部通道中。 医疗植入物可以可滑动地插入管的内部通道并被管松散地保持。
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5.发明申请WOVEN AND/OR BRAIDED FIBER IMPLANTS AND METHODS OF MAKING SAME 审中-公开WOVEN和/或BRAIDED FIBER IMPLANTS及其制造方法
公开(公告)号：WO2008082588A3
公开(公告)日：2009-06-04
申请号：PCT/US2007026381
申请日：2007-12-27
Applicant: SHRINERS HOSPITALS CHILDREN , KOOB THOMAS J , DAVIS TIAN , PRINGLE DOUGLAS
Inventor： KOOB THOMAS J , DAVIS TIAN , PRINGLE DOUGLAS
IPC: A61L27/24
CPC classification number: C07K14/78 , A61L27/24 , D06M13/152 , D06M2101/14
Abstract: The disclosure describes implantable bioprosthesis having an implantable braided or woven construct with a plurality of fibers interlocked or interlaced together.
Abstract translation: 本公开描述了具有植入式编织或编织构造物的可植入生物假体，其具有互锁或交织在一起的多个纤维。
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Patent Agency Ranking
公开(公告)号：WO2014193468A1
公开(公告)日：2014-12-04
申请号：PCT/US2013/067620
申请日：2013-10-30
Applicant: MIMEDX GROUP, INC. , KOOB, Thomas J.
Inventor： KOOB, Thomas J.
IPC: A61K31/785 , A61K38/17 , A61P35/04
CPC classification number: A61K47/48292 , A61K47/48776 , A61K47/6435 , A61K47/6901
Abstract: Provided herein are biocompatible polymer conjugates comprising a biologically compatible polymer covalently bound to a biologically compatible chelator moiety, which in turn are optionally bound, reversibly, to pharmacologically active metal ions. The biologically compatible polymer may comprise of modified biomaterial or tissue grafts composed of at least one membrane, capable of recruiting stem cells in vivo and in vitro. Also described is a novel vacuum drying device and the use thereof.
Abstract translation: 本文提供了生物相容性聚合物缀合物，其包含与生物相容的螯合剂部分共价结合的生物相容性聚合物，其又可选地结合到药理活性金属离子上。 生物相容性聚合物可包含由能够在体内和体外募集干细胞的由至少一个膜组成的修饰的生物材料或组织移植物。 还描述了一种新颖的真空干燥装置及其用途。
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7.发明申请CROSS-LINKED DEHYDRATED PLACENTAL TISSUE GRAFTS AND METHODS FOR MAKING AND USING THE SAME 审中-公开交联脱水的普通组织织物及其制造和使用方法
公开(公告)号：WO2013095830A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/065672
申请日：2012-11-16
Applicant: MIMEDX GROUP INC. , KOOB, Thomas J. , DANIEL, John , SPENCER, Randall
Inventor： KOOB, Thomas J. , DANIEL, John , SPENCER, Randall
IPC: A61F2/02
CPC classification number: A61L27/3604 , A61K35/50 , A61L15/40 , A61L27/3687 , A61L27/50 , A61L27/54 , A61L27/60 , A61L2430/40
Abstract: Described herein are tissue grafts produced by contacting dehydrated placental tissue grafts with a cross-linking agent. The tissue grafts described herein provide barrier and prevent the migration of a bioactive agent from the wound. Thus, the tissue grafts enhance wound healing while preventing the undesirable migration of a bioactive agent from the wound. Methods for making and using the cross-linked grafts are also described herein.
Abstract translation: 这里描述的是通过使脱水的胎盘组织移植物与交联剂接触而产生的组织移植物。 本文所述的组织移植物提供屏障并防止生物活性剂从伤口迁移。 因此，组织移植物增强伤口愈合，同时防止生物活性剂从伤口的不希望的迁移。 本文还描述了制备和使用交联移植物的方法。
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8.发明申请BIOSTAPLES SUITABLE FOR WRIST, HAND AND OTHER LIGAMENT REPLACEMENTS OR REPAIRS 审中-公开适用于手表，手提和其他重要的替代品或维修的生物标签
公开(公告)号：WO2009105246A3
公开(公告)日：2009-12-03
申请号：PCT/US2009001087
申请日：2009-02-20
Applicant: MIMEDX INC , WIEDRICH THOMAS , DAVIS TIAN , KOOB THOMAS J
Inventor： WIEDRICH THOMAS , DAVIS TIAN , KOOB THOMAS J
IPC: A61B17/064 , A61B17/03
CPC classification number: A61F2/08 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00084 , A61B2017/00526 , A61F2/0095 , A61F2240/001 , A61L31/044 , B29C70/20 , B29K2311/00 , B29L2031/7546
Abstract: The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible biostaples suitable for ligament repairs or replacements comprising collagen fibers that may be configured to expand in situ after implantation to frictionally engage a bone tunnel wall or bone sleeve to thereby affix the construct in the bone tunnel.
Abstract translation: 本公开描述了可植入医疗产品，其包括适于韧带修复或替代的干性或部分水合的生物相容性生物载体，其包括胶原纤维，其可被配置为在植入之后原位扩张以摩擦接合骨隧道壁或骨套，从而将构建体固定在 骨隧道。
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9.发明申请IN VIVO HYDRAULIC FIXATION INCLUDING BIO-RIVETS USING BIOCOMPATIBLE EXPANDABLE FIBERS 审中-公开血液液压固定包括使用生物可扩增纤维的生物圈
公开(公告)号：WO2008103377A3
公开(公告)日：2009-09-17
申请号：PCT/US2008002230
申请日：2008-02-20
Applicant: SHRINERS HOSPITALS CHILDREN , KOOB THOMAS J , PRINGLE DOUGLAS
Inventor： KOOB THOMAS J , PRINGLE DOUGLAS
CPC classification number: A61F2/08 , A61B2090/064 , A61F2/0811 , A61F2002/0817 , A61F2002/0835 , A61F2002/087 , A61F2002/0876 , A61F2002/0882 , A61F2002/0888 , A61F2210/0061 , A61F2250/001 , A61L27/24 , A61L27/50 , A61L2430/10
Abstract: The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel.
Abstract translation: 本公开描述了可植入医疗产品，其包括干燥或部分水合的生物相容性构建体，其包含胶原纤维，其构造成在植入后原位膨胀以摩擦接合骨隧道壁，从而将构建体固定在骨隧道中。
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10.发明申请TENDON OR LIGAMENT BIOPROSTHESES AND METHODS OF MAKING SAME 审中-公开TENDON或LIGAMENT BIOPROSTHESES及其制造方法
公开(公告)号：WO2008085493A3
公开(公告)日：2009-06-04
申请号：PCT/US2007026365
申请日：2007-12-27
Applicant: SHRINERS HOSPITALS CHILDREN , KOOB THOMAS J , PRINGLE DOUGLAS
Inventor： KOOB THOMAS J , PRINGLE DOUGLAS
CPC classification number: C07K14/78 , A61L27/24 , D06M13/152 , D06M2101/14
Abstract: The disclosure describes implantable bioprosthesis having an implantable construct with a multi-fiber array of collagen fibers attached together.
Abstract translation: 本公开描述了具有可植入构造物的可植入生物假体，其具有附着在一起的胶原纤维的多纤维阵列。
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