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1.发明申请BIOSTAPLES SUITABLE FOR WRIST, HAND AND OTHER LIGAMENT REPLACEMENTS OR REPAIRS 审中-公开适用于手表，手提和其他重要的替代品或维修的生物标签
公开(公告)号：WO2009105246A3
公开(公告)日：2009-12-03
申请号：PCT/US2009001087
申请日：2009-02-20
Applicant: MIMEDX INC , WIEDRICH THOMAS , DAVIS TIAN , KOOB THOMAS J
Inventor： WIEDRICH THOMAS , DAVIS TIAN , KOOB THOMAS J
IPC: A61B17/064 , A61B17/03
CPC classification number: A61F2/08 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00084 , A61B2017/00526 , A61F2/0095 , A61F2240/001 , A61L31/044 , B29C70/20 , B29K2311/00 , B29L2031/7546
Abstract: The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible biostaples suitable for ligament repairs or replacements comprising collagen fibers that may be configured to expand in situ after implantation to frictionally engage a bone tunnel wall or bone sleeve to thereby affix the construct in the bone tunnel.
Abstract translation: 本公开描述了可植入医疗产品，其包括适于韧带修复或替代的干性或部分水合的生物相容性生物载体，其包括胶原纤维，其可被配置为在植入之后原位扩张以摩擦接合骨隧道壁或骨套，从而将构建体固定在 骨隧道。
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2.发明申请MEDICAL CONSTRUCTS OF TWISTED LENGTHS OF COLLAGEN FIBERS AND METHODS OF MAKING SAME 审中-公开胶原纤维缠绕长度的医学结构及其制备方法
公开(公告)号：WO2009139871A3
公开(公告)日：2010-04-01
申请号：PCT/US2009002971
申请日：2009-05-13
Applicant: MIMEDX INC , DAVIS TIAN , KOOB THOMAS J
Inventor： DAVIS TIAN , KOOB THOMAS J
CPC classification number: A61L17/08 , A61B17/06166 , A61B2017/00526 , A61F2/08 , A61F2210/0004 , A61F2210/0057 , A61F2240/001 , A61F2250/0017 , A61F2250/0028 , A61F2250/0036 , A61F2250/0039 , A61L17/145 , A61L27/24 , A61L27/58 , A61L2430/10 , D02G3/10 , D02G3/448
Abstract: The disclosure describes medical constructs with a plurality of collagen fibers twisted together and methods of twisting the collagen fibers to form the medical constructs.
Abstract translation: 本公开描述了具有扭转在一起的多个胶原纤维的医学构造物和扭转胶原纤维以形成医学构造物的方法。
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3.发明申请WOVEN AND/OR BRAIDED FIBER IMPLANTS AND METHODS OF MAKING SAME 审中-公开WOVEN和/或BRAIDED FIBER IMPLANTS及其制造方法
公开(公告)号：WO2008082588A3
公开(公告)日：2009-06-04
申请号：PCT/US2007026381
申请日：2007-12-27
Applicant: SHRINERS HOSPITALS CHILDREN , KOOB THOMAS J , DAVIS TIAN , PRINGLE DOUGLAS
Inventor： KOOB THOMAS J , DAVIS TIAN , PRINGLE DOUGLAS
IPC: A61L27/24
CPC classification number: C07K14/78 , A61L27/24 , D06M13/152 , D06M2101/14
Abstract: The disclosure describes implantable bioprosthesis having an implantable braided or woven construct with a plurality of fibers interlocked or interlaced together.
Abstract translation: 本公开描述了具有植入式编织或编织构造物的可植入生物假体，其具有互锁或交织在一起的多个纤维。
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4.发明申请METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING TUBES FOR AUTO AND/OR ALLO-GRAFTS 审中-公开制造胶原纤维医疗结构和相关医疗结构的方法，包括用于自动和/或合成纤维的管
公开(公告)号：WO2011156319A3
公开(公告)日：2012-04-12
申请号：PCT/US2011039375
申请日：2011-06-07
Applicant: MIMEDX INC , PAULOS LEON , LI MENGYAN , HERNANDEZ DANIEL , KOOB THOMAS J
Inventor： PAULOS LEON , LI MENGYAN , HERNANDEZ DANIEL , KOOB THOMAS J
CPC classification number: A61L27/46 , A61B17/00491 , A61B17/0401 , A61B17/06166 , A61B17/1128 , A61B17/1146 , A61B50/30 , A61B2017/00526 , A61B2017/06052 , A61B2017/06071 , A61B2017/0608 , A61B2050/314 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/82 , A61F2210/0004 , A61F2210/0076 , A61F2230/0067 , A61F2230/0069 , A61F2240/00 , A61F2240/001 , A61L15/325 , A61L27/14 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/507 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/044 , A61L2420/04 , A61L2420/08 , A61L2430/10 , A61L2430/32 , B29C53/58 , B29C53/66 , B32B37/142 , B32B37/20 , B32B38/08 , B32B2535/00 , Y10T428/249921 , Y10T428/2938 , Y10T442/3065 , C08L89/06
Abstract: The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.
Abstract translation: 本公开描述了缠绕胶原纤维以制造医疗构造物和相关胶原纤维管和贴片装置的方法。
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5.发明申请COLLAGEN FIBER RIBBONS WITH INTEGRATED FIXATION SUTURES AND METHODS OF MAKING THE SAME 审中-公开具有整合固定缝的胶原纤维支架及其制造方法
公开(公告)号：WO2012121986A3
公开(公告)日：2012-12-06
申请号：PCT/US2012027366
申请日：2012-03-02
Applicant: MIMEDX INC , KOOB THOMAS J , LI MENGYAN
Inventor： KOOB THOMAS J , LI MENGYAN
CPC classification number: A61F2/08 , A61B17/06166 , A61B2017/00867 , A61B2017/00893 , A61B2017/00964 , A61L17/08 , D01F4/00 , D03D3/005 , D03D15/00 , D04C1/12 , D04C3/00 , D10B2403/0311 , D10B2509/04 , F04C2270/0421
Abstract: The disclosure describes implantable bioprosthesis and constructs having an implantable woven ribbon with at least one integrated suture.
Abstract translation: 本公开描述了具有带有至少一个整合缝合线的可植入编织带的可植入生物假体和构造物。
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Patent Agency Ranking6.发明申请COMPRESSIBLE TUBES FOR PLACING IMPLANTS AND RELATED MEDICAL KITS AND METHODS OF USING SAME 审中-公开用于植入植入物和相关医疗工具的可压缩管及其使用方法
公开(公告)号：WO2011146292A3
公开(公告)日：2012-03-15
申请号：PCT/US2011036042
申请日：2011-05-11
Applicant: MIMEDX INC , NIU MEI , HERNANDEZ DANIEL , KOOB THOMAS J
Inventor： NIU MEI , HERNANDEZ DANIEL , KOOB THOMAS J
CPC classification number: A61F2/0805 , A61B17/06 , A61B17/06004 , A61B17/06066 , A61B17/06166 , A61B17/1146 , A61B17/3468 , A61B2017/00336 , A61B2017/00902 , A61B2017/00942 , A61B2017/06052 , A61F2002/825 , A61L27/24 , A61L27/3666
Abstract: Medical delivery devices include a needle and a flexible compressible impermeable tube attached to the needle. The compressible tube has an open interior channel. The device is adapted to releasably hold a length of a medical implant in the open interior channel of the tube. The medical implant can be slidably inserted into the interior channel of the tube and is loosely held by the tube.
Abstract translation: 医疗输送装置包括针和连接到针的柔性可压缩不渗透管。 可压缩管具有开放的内部通道。 该装置适于将医疗植入物的一定长度可释放地保持在管的敞开的内部通道中。 医疗植入物可以可滑动地插入管的内部通道并被管松散地保持。
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7.发明申请METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING NERVE GUIDES AND PATCHES 审中-公开制造胶原纤维医疗结构及相关医疗结构的方法，包括神经指导和护理
公开(公告)号：WO2010042207A3
公开(公告)日：2010-07-08
申请号：PCT/US2009005542
申请日：2009-10-09
Applicant: MIMEDX INC , LI MENGYAN , KOOB THOMAS J
Inventor： LI MENGYAN , KOOB THOMAS J
CPC classification number: A61L27/46 , A61B17/00491 , A61B17/0401 , A61B17/06166 , A61B17/1128 , A61B17/1146 , A61B50/30 , A61B2017/00526 , A61B2017/06052 , A61B2017/06071 , A61B2017/0608 , A61B2050/314 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/82 , A61F2210/0004 , A61F2210/0076 , A61F2230/0067 , A61F2230/0069 , A61F2240/00 , A61F2240/001 , A61L15/325 , A61L27/14 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/507 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/044 , A61L2420/04 , A61L2420/08 , A61L2430/10 , A61L2430/32 , B29C53/58 , B29C53/66 , B32B37/142 , B32B37/20 , B32B38/08 , B32B2535/00 , Y10T428/249921 , Y10T428/2938 , Y10T442/3065 , C08L89/06
Abstract: The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.
Abstract translation: 本公开描述了缠绕胶原纤维以制造医疗构造物和相关胶原纤维管和贴片装置的方法。
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8.发明申请METHODS OF MAKING BIOCOMPOSITE MEDICAL CONSTRUCTS AND RELATED CONSTRUCTS INCLUDING ARTIFICIAL TISSUES, VESSELS AND PATCHES 审中-公开制造生物复合材料医疗建筑物的方法及相关建筑物，包括人造组织，血管和皮瓣
公开(公告)号：WO2010042205A2
公开(公告)日：2010-04-15
申请号：PCT/US2009005540
申请日：2009-10-09
Applicant: MIMEDX INC , GREENHALGH KERRIANN , LI MENGYAN , KOOB THOMAS J
Inventor： GREENHALGH KERRIANN , LI MENGYAN , KOOB THOMAS J
CPC classification number: A61L27/46 , A61B17/00491 , A61B17/0401 , A61B17/06166 , A61B17/1128 , A61B17/1146 , A61B50/30 , A61B2017/00526 , A61B2017/06052 , A61B2017/06071 , A61B2017/0608 , A61B2050/314 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/82 , A61F2210/0004 , A61F2210/0076 , A61F2230/0067 , A61F2230/0069 , A61F2240/00 , A61F2240/001 , A61L15/325 , A61L27/14 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/507 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/044 , A61L2420/04 , A61L2420/08 , A61L2430/10 , A61L2430/32 , B29C53/58 , B29C53/66 , B32B37/142 , B32B37/20 , B32B38/08 , B32B2535/00 , Y10T428/249921 , Y10T428/2938 , Y10T442/3065 , C08L89/06
Abstract: The disclosure describes methods of making collagen based biocomposite constructs and related devices. The methods include: (a) winding at least one collagen fiber a number of revolutions about a length of a support member having a long axis, the winding having at least one defined pitch and/or fiber angle relative to the long axis of the support member to form an elongate construct; and (b) applying a fluid polymeric material, such as, for example, an acrylate emulsion and/or other thermoplastic material, onto the collagen fiber during the winding step. Optionally, the fluid polymeric material can include antibiotics and/or other therapeutic agents for additional function/utility.
Abstract translation: 本公开描述了制备基于胶原的生物复合构建体和相关装置的方法。 所述方法包括：（a）绕具有长轴的支撑构件的长度缠绕至少一个胶原纤维，所述绕组具有相对于支撑体的长轴具有至少一个限定的间距和/或纤维角度 构件以形成细长结构; 和（b）在卷绕步骤期间将诸如例如丙烯酸酯乳液和/或其它热塑性材料的流体聚合物材料施加到胶原纤维上。 任选地，流体聚合物材料可以包括用于附加功能/效用的抗生素和/或其它治疗剂。
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公开(公告)号：WO2014078082A3
公开(公告)日：2014-07-17
申请号：PCT/US2013067623
申请日：2013-10-30
Applicant: MIMEDX GROUP INC , KOOB THOMAS J
Inventor： KOOB THOMAS J
CPC classification number: A61K47/42 , A61K9/0024 , A61K33/00 , A61K33/34
Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods. Also described is a novel vacuum drying device and the use thereof.
Abstract translation: 本公开描述了包含抗真菌剂（优选铜）的胶原构建体以及相关方法。 还描述了一种新颖的真空干燥装置及其用途。
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10.发明申请IN VIVO HYDRAULIC FIXATION INCLUDING BIO-RIVETS USING BIOCOMPATIBLE EXPANDABLE FIBERS 审中-公开血液液压固定包括使用生物可扩增纤维的生物圈
公开(公告)号：WO2008103377A3
公开(公告)日：2009-09-17
申请号：PCT/US2008002230
申请日：2008-02-20
Applicant: SHRINERS HOSPITALS CHILDREN , KOOB THOMAS J , PRINGLE DOUGLAS
Inventor： KOOB THOMAS J , PRINGLE DOUGLAS
CPC classification number: A61F2/08 , A61B2090/064 , A61F2/0811 , A61F2002/0817 , A61F2002/0835 , A61F2002/087 , A61F2002/0876 , A61F2002/0882 , A61F2002/0888 , A61F2210/0061 , A61F2250/001 , A61L27/24 , A61L27/50 , A61L2430/10
Abstract: The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel.
Abstract translation: 本公开描述了可植入医疗产品，其包括干燥或部分水合的生物相容性构建体，其包含胶原纤维，其构造成在植入后原位膨胀以摩擦接合骨隧道壁，从而将构建体固定在骨隧道中。
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