公开(公告)号：WO2007062664A2

公开(公告)日：2007-06-07

申请号：PCT/DK2006000685

申请日：2006-12-01

Applicant: NUEVOLUTION AS ,  FRANCH THOMAS ,  LUNDORF MIKKEL DYBRO ,  JAKOBSEN SOEREN NYBOE ,  OLSEN EVA KAMPMANN ,  ANDERSEN ANNE LEE ,  HOLTMANN ANETTE ,  HANSEN ANDERS HOLM ,  SOERENSEN ANDERS MALLING ,  GOLDBECH ANNE ,  DE LEON DAEN ,  KALDOR DITTE KIVSMOSE ,  SLOEK FRANK ABILGAARD ,  HUSEMOEN GITTE NYSTRUP ,  DOLBERG JOHANNES ,  JENSEN KIM BIRKEBAEK ,  PETERSEN LENE ,  NOERREGAARD-MADSEN MADS ,  GODSKESEN MICHAEL ANDERS ,  GLAD SANNE SCHROEDER ,  NEVE SOEREN ,  THISTED THOMAS ,  KRONBORG TINE TITILOLA AKINLEM ,  SAMS CHRISTIAN ,  FELDING JAKOB ,  FRESKGAARD PER-OLA ,  GOULIAEV ALEX HAAHR ,  PEDERSEN HENRIK

Inventor： FRANCH THOMAS ,  LUNDORF MIKKEL DYBRO ,  JAKOBSEN SOEREN NYBOE ,  OLSEN EVA KAMPMANN ,  ANDERSEN ANNE LEE ,  HOLTMANN ANETTE ,  HANSEN ANDERS HOLM ,  SOERENSEN ANDERS MALLING ,  GOLDBECH ANNE ,  DE LEON DAEN ,  KALDOR DITTE KIVSMOSE ,  SLOEK FRANK ABILGAARD ,  HUSEMOEN GITTE NYSTRUP ,  DOLBERG JOHANNES ,  JENSEN KIM BIRKEBAEK ,  PETERSEN LENE ,  NOERREGAARD-MADSEN MADS ,  GODSKESEN MICHAEL ANDERS ,  GLAD SANNE SCHROEDER ,  NEVE SOEREN ,  THISTED THOMAS ,  KRONBORG TINE TITILOLA AKINLEM ,  SAMS CHRISTIAN ,  FELDING JAKOB ,  FRESKGAARD PER-OLA ,  GOULIAEV ALEX HAAHR ,  PEDERSEN HENRIK

IPC: C12N15/10 ,  C12Q1/68 ,  C40B40/06 ,  C40B50/06

CPC classification number: C12N15/1068 ,  C12N15/1089 ,  C40B40/08 ,  C40B50/04 ,  C40B50/06

Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

Abstract translation: 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。

公开(公告)号：WO03078445A2

公开(公告)日：2003-09-25

申请号：PCT/DK0300173

申请日：2003-03-14

Applicant: NUEVOLUTION AS ,  GOULIAEV ALEX HAAHR ,  PEDERSEN HENRIK ,  GODSKESEN MICHAEL ANDERS ,  KRONBORG TINE TITILOLA AKINLEM ,  HUSEMOEN GITTE NYSTRUP ,  HO JUSTIN ,  FELDING JAKOB ,  SAMS CHRISTIAN

Inventor： GOULIAEV ALEX HAAHR ,  PEDERSEN HENRIK ,  GODSKESEN MICHAEL ANDERS ,  KRONBORG TINE TITILOLA AKINLEM ,  HUSEMOEN GITTE NYSTRUP ,  HO JUSTIN ,  FELDING JAKOB ,  SAMS CHRISTIAN

IPC: C07B61/00 ,  C07D405/04 ,  C07H21/00 ,  C12N15/10

CPC classification number: C07D405/04 ,  C07H21/00 ,  C12N15/1068 ,  C40B40/00

Abstract: A building block having the dual capabilities of recognising an encoding element and transferring a Functional Entity Precursor to a recipient reactive group is disclosed. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.

Abstract translation: 公开了具有识别编码元件并将功能实体前体传送到接收者反应组的双重能力的构建块。 构建单元可以用于生成单个复合体或不同复合物的文库，其中复合物包含与编码元件连接的编码分子。 复合物库可用于寻求药物活性化合物。