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    LIGATIONAL ENCODING USING BUILDING BLOCK OLIGONUCLEOTIDES
    6.
    发明申请
    LIGATIONAL ENCODING USING BUILDING BLOCK OLIGONUCLEOTIDES 审中-公开
    使用建筑物块编码的编码

    公开(公告)号：WO2005090566A2

    公开(公告)日：2005-09-29

    申请号：PCT/DK2005/000199

    申请日：2005-03-22

    Applicant: NUEVOLUTION A/S ,  GOULIAEV, Alex, Haahr ,  PEDERSEN, Henrik

    Inventor： GOULIAEV, Alex, Haahr ,  PEDERSEN, Henrik

    IPC: C12N15/10

    CPC classification number: C12N15/1068

    Abstract: The present invention in one aspect relates to a method for synthesizing a bifunctional complex comprising a molecule and an identifier polynucleotide identifying at least some of the chemical entities which have participated in the synthesis of the molecule in accordance with the methods of the present invention. The invention also relates to a library of different bifunctional complexes. The library of the invention can be used e.g. for identifying drug leads. Furthermore, the present invention is based on the principle that chemical entities initially provided on a building block oligonucleotide (i.e. a building block having an oligonucleotide part which is linked to a chemical entity) can be brought into reactive proximity without the use of a template comprising a set of covalently linked codons. Also, the present invention allows reaction of chemical entities when the chemical entities are linked to a single stranded identifier polynucleotide obtained by covalently linking the oligonucleotide parts (oligonucleotide identifiers) of the building blocks. The single stranded identifier polynucleotides differs from template directed synthesis methods employing codon and anti-codon hybridisation between a template and one or more transfer units, i.e. methods wherein e.g. reactive units on transfer units are reacted while the anti-codon of the transfer units are hybridised to template codons.

    Abstract translation: 本发明一方面涉及一种用于合成双功能复合物的方法，所述双功能复合物包含分子和标识物多核苷酸，其鉴定了根据本发明的方法参与分子合成的至少一些化学实体。 本发明还涉及不同双功能复合物的文库。 本发明的文库可以例如使用。 用于鉴定药物的潜在客户。 此外，本发明是基于以下原则：最初提供在构建单元寡核苷酸上的化学实体（即具有与化学实体连接的寡核苷酸部分的构建单元）可以进行反应性接近而不使用包含 一套共价连锁的密码子。 此外，当化学实体与通过共价连接构建单元的寡核苷酸部分（寡核苷酸标识符）获得的单链标识符多核苷酸连接时，本发明允许化学实体的反应。 单链标识符多核苷酸与模板定向合成方法的不同之处在于使用模板和一个或多个转移单元之间的密码子和抗 - 密码子杂交， 转移单元上的反应单元反应，同时转移单元的反密码子与模板密码子杂交。

    METHOD FOR PRODUCING SECOND-GENERATION LIBRARY
    7.
    发明申请
    METHOD FOR PRODUCING SECOND-GENERATION LIBRARY 审中-公开
    生成第二代库的方法

    公开(公告)号：WO2004074429A3

    公开(公告)日：2004-09-30

    申请号：PCT/DK2004000117

    申请日：2004-02-23

    Applicant: NUEVOLUTION AS ,  FRESKGAARD PER-OLA ,  GOULIAEV ALEX HAAHR ,  THISTED THOMAS ,  OLSEN EVA KAMPMANN

    Inventor： FRESKGAARD PER-OLA ,  GOULIAEV ALEX HAAHR ,  THISTED THOMAS ,  OLSEN EVA KAMPMANN

    IPC: C12N15/10 ,  C12Q1/68 ,  C07B61/00 ,  C12P1/00

    CPC classification number: C40B40/08 ,  B01J19/0046 ,  B01J2219/00592 ,  C12N15/1068 ,  C12Q1/6811 ,  C40B50/04 ,  C40B50/06 ,  C40B50/10 ,  C12Q2565/501 ,  C12Q2531/113

    Abstract: The present invention relates to a method for generating a second-generation library. In a first step, a library of encoded molecules associated with an identifier nucleic acid comprising codons identifying chemical entities that have participated in the formation of the encoded molecule is provided. In a second step, the library is partitioned and encoded molecules having a certain property are selected. Codons of identifiers of selected encoded molecules are subsequently identified, and a second-generation library is prepared using at least some of the chemical entities coded for by the identified codons. The new focussed library may be used for another partition step to select encoded molecules with a certain property.

    Abstract translation: 本发明涉及用于生成第二代库的方法。 在第一步中，提供了与识别核酸相关的编码分子文库，其包含识别已参与编码分子形成的化学实体的密码子。 第二步，将文库分区并选择具有某种特性的编码分子。 随后鉴定所选编码分子的标识符密码子，并使用至少一些由所鉴定的密码子编码的化学实体制备第二代文库。 新聚焦库可用于另一个分区步骤来选择具有某种属性的编码分子。

    AN IMPROVED METHOD FOR SYNTHESISING TEMPLATED MOLECULES
    9.
    发明申请
    AN IMPROVED METHOD FOR SYNTHESISING TEMPLATED MOLECULES 审中-公开
    用于合成模板分子的改进方法

    公开(公告)号：WO2003078625A2

    公开(公告)日：2003-09-25

    申请号：PCT/DK2003/000172

    申请日：2003-03-14

    Applicant: NUEVOLUTION A/S ,  PEDERSEN, Henrik ,  HOLTMANN, Anette ,  FRANCH, Thomas ,  GOULIAEV, Alex, Haahr ,  FELDING, Jakob

    Inventor： PEDERSEN, Henrik ,  HOLTMANN, Anette ,  FRANCH, Thomas ,  GOULIAEV, Alex, Haahr ,  FELDING, Jakob

    IPC: C12N15/10

    CPC classification number: C12N15/1068 ,  C07B2200/11 ,  C07D405/04 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/6816 ,  C40B40/06 ,  C40B40/14

    Abstract: The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.

    Abstract translation: 本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。 该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。 支架功能实体和构建单元的功能性实体均具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体可以接近。 该方法可以用于产生可以选择用于生物活性的模板分子的文库。

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