公开(公告)号：WO2007059065A3

公开(公告)日：2007-07-26

申请号：PCT/US2006044059

申请日：2006-11-14

Applicant: ABBOTT LAB ,  SOGIN DAVID C ,  LAIRD DONALD M ,  YU ZHIGUANG ,  DOSS ROBERT C

Inventor： SOGIN DAVID C ,  LAIRD DONALD M ,  YU ZHIGUANG ,  DOSS ROBERT C

IPC: G01N33/566 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  G01N33/74

CPC classification number: G01N33/566 ,  G01N33/689 ,  G01N33/74 ,  G01N2800/368

Abstract: Method of measuring the quantity of a first proteinaceous specific binding partner (sbp) in a biological sample comprising detecting the binding of the first proteinaceous sbp with a labeled second proteinaceous sbp, wherein neither the first or second sbp is an antibody or fragment thereof, which is preferably a method of determining the amount of sFlt-1, particularly free sFlt-1, and the amount of PlGF, particularly free PlGF, in a sample, which is preferably used in a method of predicting risk of preeclampsia comprising comparing free PlGF to free sFlt-1.

Abstract translation: 测量生物样品中第一蛋白质特异性结合配偶体（sbp）的量的方法，包括检测第一蛋白质sbp与标记的第二蛋白质sbp的结合，其中第一或第二sbp都不是抗体或其片段，其 优选是确定优选用于预测先兆子痫风险的方法中的样品中sFlt-1，特别是游离sFlt-1的量和PlGF，尤其是游离PlGF的量的方法，其包括将游离PlGF与 免费sFlt-1。

公开(公告)号：WO2007059065A2

公开(公告)日：2007-05-24

申请号：PCT/US2006/044059

申请日：2006-11-14

Applicant: ABBOTT LABORATORIES ,  SOGIN, David, C. ,  LAIRD, Donald, M. ,  YU, Zhiguang ,  DOSS, Robert, C.

Inventor： SOGIN, David, C. ,  LAIRD, Donald, M. ,  YU, Zhiguang ,  DOSS, Robert, C.

IPC: G01N33/566 ,  G01N33/74 ,  G01N33/53 ,  G01N33/50

CPC classification number: G01N33/566 ,  G01N33/689 ,  G01N33/74 ,  G01N2800/368

Abstract: Method of measuring the quantity of a first proteinaceous specific binding partner (sbp) in a biological sample comprising detecting the binding of the first proteinaceous sbp with a labeled second proteinaceous sbp, wherein neither the first or second sbp is an antibody or fragment thereof, which is preferably a method of determining the amount of sFlt-1, particularly free sFlt-1, and the amount of PlGF, particularly free PlGF, in a sample, which is preferably used in a method of predicting risk of preeclampsia comprising comparing free PlGF to free sFlt-1.

Abstract translation: 测量生物样品中第一蛋白质特异性结合配偶体（sbp）的量的方法，包括检测第一蛋白质sbp与标记的第二蛋白质sbp的结合，其中第一或第二sbp 是抗体或其片段，其优选是测定样品中sFlt-1，特别是游离sFlt-1的量和PlGF，尤其是游离PlGF的量的方法，其优选用于预测 先兆子痫的风险包括将游离PlGF与游离sFlt-1进行比较。

公开(公告)号：WO2007059065B1

公开(公告)日：2007-09-13

申请号：PCT/US2006044059

申请日：2006-11-14

Applicant: ABBOTT LAB ,  SOGIN DAVID C ,  LAIRD DONALD M ,  YU ZHIGUANG ,  DOSS ROBERT C

Inventor： SOGIN DAVID C ,  LAIRD DONALD M ,  YU ZHIGUANG ,  DOSS ROBERT C

IPC: G01N33/566 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  G01N33/74

CPC classification number: G01N33/566 ,  G01N33/689 ,  G01N33/74 ,  G01N2800/368

Abstract: Method of measuring the quantity of a first proteinaceous specific binding partner (sbp) in a biological sample comprising detecting the binding of the first proteinaceous sbp with a labeled second proteinaceous sbp, wherein neither the first or second sbp is an antibody or fragment thereof, which is preferably a method of determining the amount of sFlt-1, particularly free sFlt-1, and the amount of PlGF, particularly free PlGF, in a sample, which is preferably used in a method of predicting risk of preeclampsia comprising comparing free PlGF to free sFlt-1.

Abstract translation: 测量生物样品中第一蛋白质特异性结合配偶体（sbp）的量的方法，包括检测第一蛋白质sbp与标记的第二蛋白质sbp的结合，其中第一或第二sbp都不是抗体或其片段，其中 优选地是测定样品中sFlt-1的量，特别是游离的sFlt-1以及PlGF的量，特别是游离PlGF的量，其优选用于预测先兆子痫风险的方法中，其包括将游离PlGF与 免费sFlt-1。