Abstract:
In one aspect, this invention is directed to prodrugs of ion channel modulating compounds, wherein the prodrug comprises an ion channel modulating compound attached to one or more prodrug moieties. In another aspect, this invention is directed to pharmaceutical compositions comprising prodrugs of ion channel modulating compounds and pharmaceutically acceptable excipients. In another aspect, this invention is directed to methods of treating arrhythmia in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a prodrug of an ion channel modulating compound or a pharmaceutical composition comprising an ion channel modulating compound and a pharmaceutically acceptable excipient. In another aspect, this invention is directed to method for modulating ion channel activity in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a prodrug of an ion channel modulating compound or a pharmaceutical composition comprising an ion channel modulating compound and a pharmaceutically acceptable excipient.
Abstract:
This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed
Abstract:
Various olefins may be polymerized using a catalyst system containing selected alpha -diimine, urethane or urea ligands, some of them novel, complexed to nickel, palladium or other selected transition metals. The polymers are useful as molding resins and elastomers.
Abstract:
The present invention relates to novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.
Abstract:
Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.
Abstract:
Novel insecticides have formula (I) in which R1 is hydrogen, halogen, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or C1-C4 haloalkylthio; R2 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or C1-C4 haloalkylthio; R3 is hydrogen, halogen or C1-C4 haloalkyl; or R1 and R2 taken together are C1-C4 alkyleneoxy or halo-C1-C3 alkyleneoxy; provided that R1, R2 and R3 are not all hydrogen; R4 is methyl, ethyl, n-propyl, C3-C7 branched alkyl, C1-C6 haloalkyl, C2-C4 alkenyl; or cyclopropyl, optionally substituted by up to 4 methyl groups or up to 2 halogens; R5 is: (a); (b); (c) or (d); R6 is phenyl, benzyl, C3-C4 alkenyl, or C3 alkynyl; R7, R8, R10 and R11 are each halogen; and R9 is methyl, methoxymethyl, methylthio, methylthiomethyl, hydroxymethyl, cyanomethyl, benzyl, C3-C4 alkenyl, C3 alkynyl or propargylamino.
Abstract:
Various olefins may be polymerized using a catalyst system containing selected alpha -diimine, urethane or urea ligands, some of them novel, complexed to nickel, palladium or other selected transition metals. The polymers are useful as molding resins and elastomers.
Abstract:
The invention relates to phenoxyacetic acid derivatives of formula (I), wherein R1, R2, Xn and A are as defined in the description, A represents a halogen atom, hydroxy, OR3, S(O)kR3, or a group of formula (A-1) or (A-2), wherein R3-R5 and k have the meanings given in the description, and to their use as herbicides.
Abstract translation:本发明涉及式(I)的苯氧基乙酸衍生物,其中R1,R2,Xn和A如说明书中所定义,A表示卤素原子,羟基,OR 3,S(O)k R 3或式 A-1)或(A-2),其中R3-R5和k具有说明书中给出的含义,以及它们作为除草剂的用途。
Abstract:
There are provided novel 1,4-diamine-2,3-dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.