Abstract:
An apparatus is provided for intended use in agitating a fluid under cryogenic conditions. In one embodiment, the apparatus includes a fluid-agitating element for placement in contact with the fluid. The fluid-agitating element includes a superconductor, and a motive device is provided for causing the fluid-agitating element to agitate the fluid. In the case where fluid pumping is the desired outcome, an associated vessel may be provided including an inlet for receiving the fluid and an outlet for discharging the fluid as a result of the action of the fluid- agitating element. Related methods are also described, as is an impeller for use in connection with fluids under cryogenic conditions.
Abstract:
A vessel in which a fluid is received and agitated using an internal fluidagitating element driven by an external motive device is disclosed. In one aspect, the vessel is a bag including a first receiver for receiving and holding a fluid-agitating element at a home location. The first receiver may be in the form of an inwardly projecting post having an oversized portion for capturing the fluid-agitating element, but various other forms are disclosed. Use of this feature in completely rigid vessels where the fluid-agitating element is free of direct attachment from a first receiver having an oversized portion is also disclosed. In another aspect, the vessel or bag further includes a second receiver for receiving a portion of an external structure, such as a motive device, and aligning the vessel relative thereto. Related methods are also disclosed.
Abstract:
An apparatus detects a leak of an electrically conductive fluid from a disposable plastic bag used in mixing applications, such as during bioprocessing in a sterile environment. In one embodiment, the bag is associated with a sensor for detecting a leak from an interior compartment. The sensor may be arranged to detect either a leak internal to the at least two material layers of the bag or external to the outer layer, or both. Related methods are also disclosed.
Abstract:
An apparatus is provided for intended use in pumping a fluid under sterile conditions. In one embodiment, a first rigid container is internally pressurized to pump fluid through a first flexible vessel within the rigid container. In another embodiment, first and second containers are provided, each for receiving flexible vessels that create independent pumping chambers upon the selective or periodic internal pressurization of the containers. Related aspects and methods are also provided.
Abstract:
Various alignment systems, devices, and related methods are for use in associated with the mixing of fluid in a vessel, such as a flexible bag, using an internal fluid-agitating element driven by an external motive device.
Abstract:
An apparatus is provided for intended use in agitating a fluid under cryogenic conditions. In one embodiment, the apparatus includes a fluid-agitating element for placement in contact with the fluid. The fluid-agitating element includes a superconductor, and a motive device is provided for causing the fluid-agitating element to agitate the fluid. In the case where fluid pumping is the desired outcome, an associated vessel may be provided including an inlet for receiving the fluid and an outlet for discharging the fluid as a result of the action of the fluid- agitating element. Related methods are also described, as is an impeller for use in connection with fluids under cryogenic conditions.
Abstract:
An apparatus is provided for intended use in pumping a fluid under sterile conditions. In one embodiment, a first rigid container is internally pressurized to pump fluid through a first flexible vessel within the rigid container. In another embodiment, first and second containers are provided, each for receiving flexible vessels that create independent pumping chambers upon the selective or periodic internal pressurization of the containers. Related aspects and methods are also provided.
Abstract:
In a vessel, such as a collapsible bag, a fluid is received and agitated using a fluid-agitating element driven by an external motive device, such as a motor, and supported by a bearing, such as a roller bearing.
Abstract:
Various alignment systems, devices, and related methods are for use in associated with the mixing of fluid in a vessel, such as a flexible bag, using an internal fluid-agitating element driven by an external motive device.
Abstract:
A drain connector arranged for mounting to a tank or bag having an interior volume includes a drain flange defining a bore having an inner diameter, and a hollow body having at least an upper portion with a maximum outer diameter that is no greater than the inner diameter of the bore and arranged to convey fluid to the interior volume, with at least one circumferential sealing element between the drain flange and hollow body, with the drain flange including a body extending outside the interior volume and including at least one retaining element arranged to retain the hollow body in a position. A drain flange may include multiple bores for receiving multiple hollow bodies, with each hollow body including at least one circumferential sealing element. One or more drain flanges may be generic for use with hollow bodies of different characteristics to enable fabrication of a processing container or bag by affixing one or more drain flanges, and then selecting among the plurality of different hollow bodies for insertion into the drain flange(s).