公开(公告)号：WO2018226104A2

公开(公告)日：2018-12-13

申请号：PCT/NO2018/050148

申请日：2018-06-06

Applicant: LIFECARE AS

Inventor： FRISVOLD, Rune ,  PFÜTZNER, Andreas

Abstract: Interstitial fluid glucose measuring device, system and method, the device comprising first and second cavities (10, 20), both configured for being in fluid communication with interstitial fluid outside the cavities, wherein the first and second pressure sensors (12, 22) are configured for sensing the pressure in said first and second cavities (10, 20), respectively. The first cavity (10) comprises an active solution and is defined in part by a first glucose porous membrane (11) interfacing on one side the interior of said first cavity (10) and on the other side configured for interfacing the interstitial body fluid. The active solution (13) is a composition comprising a lectin and a polysaccharide.

公开(公告)号：WO2008108663A1

公开(公告)日：2008-09-12

申请号：PCT/NO2008/000085

申请日：2008-03-07

Applicant: LIFECARE AS ,  HOOSERWERF, Arno ,  OVERSTOLZ, Thomas

Inventor： OVERSTOLZ, Thomas

IPC: B01D69/10 ,  B01D67/00 ,  H01L21/027 ,  H01L21/00

CPC classification number: B01D67/0062 ,  B01D67/0072 ,  B01D69/10 ,  B01D71/02 ,  B01D2325/028 ,  B81B3/007 ,  B81B2203/0127

Abstract: The present invention disclose a method for manufacturing ultra-thin reinforced membranes from a SOI wafer having a front side and a back side, the front side having a etch stop layer buried under a device layer, provided for by forming reinforcement bars by etching openings in the device layer down to the etch stop layer, filling the openings at least partially by deposition of a first filler, and then polishing the top surface to the silicon surface before depositing a membrane material.

Abstract translation: 本发明公开了一种从具有正面和背面的SOI晶片制造超薄增强膜的方法，其前侧具有埋在器件层下面的蚀刻停止层，该蚀刻停止层通过在 该器件层直到蚀刻停止层，至少部分地通过沉积第一填料填充开口，然后在沉积膜材料之前将顶表面抛光到硅表面。

公开(公告)号：WO1998034659A1

公开(公告)日：1998-08-13

申请号：PCT/NO1998000042

申请日：1998-02-06

Applicant: LIFECARE AS ,  ELLINGSEN, Olav

Inventor： LIFECARE AS

IPC: A61M05/50

CPC classification number: A61M5/3234

Abstract: A self-destructing disposable syringe comprising a syringe housing (1), a plunger with plunger rod (2) and plunger head (3) with seal (3'), and an injection needle (4), an extension (7) running from the external end wall (5) of the housing (1) and equipped with inwardly bendable flaps (6); a holder (8) located centrally in the housing (1) having a central bore (9) and having a flange (10) formed at the end facing the plunger head (3) having a liquid-tight seal (11) against the liquid chamber (12) of the housing (1); and having a wholly or partly tapered part (15) extending inside the flapped extension (7) of the housing (1) and having an end bead (16) with an inverted collar (17) for interaction with and retention (21) of the inwardly bent flaps (20) on the extension (7) of the housing (1); having an injection needle (4) running through the bore (9) of the holder (8), an end sleeve (22) which is coaxial with and intimately surrounds the flapped extension (7), which extension and end sleeve can be made in one piece; and means (18, 13, 14, 20) for retracting the hypodermic needle (4) inside the syringe housing (1) after use.

Abstract translation: 一种自毁式一次性注射器，包括注射器壳体（1），具有柱塞杆（2）的柱塞和具有密封件（3'）的柱塞头（3），以及注射针（4），延伸部 壳体（1）的外端壁（5）并且具有可向内弯曲的翼片（6）; 位于壳体（1）中心的具有中心孔（9）并具有形成在面向柱塞头（3）的端部处的凸缘（10）的保持器（8）具有抵靠液体的液密密封件（11） 壳体（1）的腔室（12）; 并且具有在所述壳体（1）的所述翘起的延伸部（7）的内部延伸的全部或部分锥形部分（15），并且具有带有倒置套环（17）的端部凸缘（16），用于与所述壳体（1）相互作用并保持（21） 在壳体（1）的延伸部（7）上的向内弯曲的翼片（20）; 具有穿过保持器（8）的孔（9）的注射针（4），与套管延伸部（7）同轴并紧密地围绕的端套（22），该延伸部和端套可以制成 一块; 以及用于在使用后使注射器外壳（1）内的皮下注射针（4）缩回的装置（18,13,14,20）。

公开(公告)号：WO2018169408A1

公开(公告)日：2018-09-20

申请号：PCT/NO2018/050055

申请日：2018-03-01

Applicant: LIFECARE AS

Inventor： FRISVOLD, Rune

IPC: G01N33/66

Abstract: Present invention relates to a composition comprising a carbohydrate-binding molecule, the carbohydrate-binding molecule being a lectin; a lectin-binding molecule, the lectin-binding molecule being a polysaccharide; at least one chloride salt of a divalent metal ion, wherein the lectin to polysaccharide molar ratio is from 3:1 to 1:1. Present invention also relates to a method of preparing the above composition, and the usage of the composition in carbohydrate sensing systems.

公开(公告)号：WO2008108663A8

公开(公告)日：2009-10-22

申请号：PCT/NO2008000085

申请日：2008-03-07

Applicant: LIFECARE AS ,  HOOSERWERF ARNO ,  OVERSTOLZ THOMAS

Inventor： HOOSERWERF ARNO ,  OVERSTOLZ THOMAS

IPC: B01D69/10 ,  B01D67/00 ,  H01L21/00 ,  H01L21/027

CPC classification number: B01D67/0062 ,  B01D67/0072 ,  B01D69/10 ,  B01D71/02 ,  B01D2325/028 ,  B81B3/007 ,  B81B2203/0127

Abstract: The present invention disclose a method for manufacturing ultra-thin reinforced membranes from a SOI wafer having a front side and a back side, the front side having a etch stop layer buried under a device layer, provided for by forming reinforcement bars by etching openings in the device layer down to the etch stop layer, filling the openings at least partially by deposition of a first filler, and then polishing the top surface to the silicon surface before depositing a membrane material.

Abstract translation: 本发明公开了一种从具有正面和背面的SOI晶片制造超薄增强膜的方法，其前侧具有埋在器件层下面的蚀刻停止层，该蚀刻停止层通过在 该器件层直到蚀刻停止层，至少部分地通过沉积第一填料填充开口，然后在沉积膜材料之前将顶表面抛光到硅表面。

公开(公告)号：WO2018226104A3

公开(公告)日：2018-12-13

申请号：PCT/NO2018/050148

申请日：2018-06-06

Applicant: LIFECARE AS

Inventor： FRISVOLD, Rune ,  PFÜTZNER, Andreas

IPC: A61B5/00 ,  A61B5/145

Abstract: Interstitial fluid glucose measuring device, system and method, the device comprising first and second cavities (10, 20), both configured for being in fluid communication with interstitial fluid outside the cavities, wherein the first and second pressure sensors (12, 22) are configured for sensing the pressure in said first and second cavities (10, 20), respectively. The first cavity (10) comprises an active solution and is defined in part by a first glucose porous membrane (11) interfacing on one side the interior of said first cavity (10) and on the other side configured for interfacing the interstitial body fluid. The active solution (13) is a composition comprising a lectin and a polysaccharide.

公开(公告)号：WO2009025563A1

公开(公告)日：2009-02-26

申请号：PCT/NO2008/000295

申请日：2008-08-20

Applicant: LIFECARE AS ,  JOHANNESSEN, Erik

Inventor： JOHANNESSEN, Erik

IPC: G01N13/04 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/14503

Abstract: An apparatus and method for measuring augmented osmotic pressure in a reference cavity is provided, in which the device comprise a substrate frame (4) attached to a support structure (1) in which a plurality of transducer devices (2) are buried. An array of osmotic membranes (3) is integrated by the support structure and which acts to facilitate a trans-membrane pressure gradient as a function of the osmotic pressure change in a sealed cavity (7). The sealed cavity is formed by rigid substrate materials (5,6) in which the membranes, support structure and transducer devices only will be subject to induced stress in response to augmented osmotic pressure and thereby generate a pressure induced signal change observed from the transducer devices. The transducer devices may be arranged as piezoresistive elements,, as micromechanical switches, as variable capacitive elements or as an optical light source and detector. The device can be used to monitor changes in osmotic pressure in response to a concentration change of a specified dissolved solute particle.

Abstract translation: 提供了一种用于测量参考腔中的增强渗透压的装置和方法，其中该装置包括附接到多个换能器装置（2）的支撑结构（1）的衬底框架（4）。 渗透膜（3）的阵列由支撑结构整合，其作用是促进作为密封空腔（7）中的渗透压变化的函数的跨膜压力梯度。 密封空腔由刚性基材（5,6）形成，其中膜，支撑结构和换能器装置仅响应于增加的渗透压而受到诱发应力，从而产生从换能器装置观察到的压力感应信号变化 。 换能器装置可以被设置为压电元件，作为微机械开关，可变电容元件或者作为光学光源和检测器。 该装置可以用于监测渗透压变化，以响应于指定溶解的溶质颗粒的浓度变化。

公开(公告)号：WO2004107972A1

公开(公告)日：2004-12-16

申请号：PCT/NO2004/000166

申请日：2004-06-09

Applicant: LIFECARE AS ,  ELLINGSEN, Olav ,  KULSENG, Bård, Erik ,  KRISTIANSEN, Helge

Inventor： ELLINGSEN, Olav ,  KULSENG, Bård, Erik ,  KRISTIANSEN, Helge

IPC: A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14532 ,  A61B2560/0219 ,  A61B2562/028

Abstract: The present invention teaches a method, system and units for measuring changes in blood during a longer period of time in vivo with a patient by measuring diffusivity of solvent. A differential pressure sensor is arranged on a silicon wafer or beam comprising resistors being in communication with fluids in two chambers via semipermable membranes enabling measuring of two components in said blood by tracking changes over time.

Abstract translation: 本发明教导了通过测量溶剂的扩散性来测量患者体内较长时间内血液变化的方法，系统和单元。 差压传感器布置在硅晶片或光束上，该晶片或光束包括通过半可编程膜在两个腔室中与流体连通的电阻器，能够通过跟踪随时间的变化来测量所述血液中的两个部件。