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公开(公告)号：WO2009149218A3
公开(公告)日：2012-01-19
申请号：PCT/US2009046185
申请日：2009-06-03
Applicant: CELEXION LLC , BAYNES BRIAN , LIPOVSEK DASA , LIPPOW SHAUN
Inventor： BAYNES BRIAN , LIPOVSEK DASA , LIPPOW SHAUN
CPC classification number: C12N15/1093 , C40B30/02 , G06F19/16 , G06F19/18
Abstract: Aspects of the invention relate to variant proteins and methods for designing and using the same. In some embodiments, the invention relates to methods for determining a functional variant of a protein that is restricted by one or more known legal rights, such as patent rights. Functional variants according to this invention are free of such restrictions.
Abstract translation: 本发明的方面涉及变体蛋白及其设计和使用的方法。 在一些实施方案中，本发明涉及用于确定由一种或多种已知合法权利（例如专利权）限制的蛋白质的功能性变体的方法。 根据本发明的功能变体没有这样的限制。
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2.发明申请BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL HEXANES AND PENTANES FROM CARBOHYDRATE FEEDSTOCKS 审中-公开来自碳氢化合物饲料的二官能和香精的生物合成
公开(公告)号：WO2014028026A1
公开(公告)日：2014-02-20
申请号：PCT/US2012/051274
申请日：2012-08-17
Applicant: CELEXION, LLC , BAYNES, Brian M. , GEREMIA, John Michael , LIPPOW, Shaun
Inventor： BAYNES, Brian M. , GEREMIA, John Michael , LIPPOW, Shaun
IPC: C12N1/21 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/88 , C12N9/90 , C12P13/00 , C12P7/44 , C12P7/42 , C12P7/18
CPC classification number: C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/0022 , C12N9/0026 , C12N9/0032 , C12N9/1025 , C12N9/1096 , C12N9/13 , C12N9/88 , C12N9/90 , C12N9/93 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
Abstract: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
Abstract translation: 本文提供了在微生物中生产双官能烷烃的方法。 还提供了编码这些酶的酶和核酸，其与来自微生物中的碳水化合物原料的双官能烷烃生产有关。 本发明还提供用于生产双官能烷烃的重组微生物和代谢途径。
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公开(公告)号：WO2011146902A9
公开(公告)日：2011-11-24
申请号：PCT/US2011/037459
申请日：2011-05-20
Applicant: MERRIMACK PHARMACEUTICALS, INC. , NIELSEN, Ulrik , WICKHAM, Thomas , SCHOEBERL, Birgit , HARMS, Brian , LINGGI, Bryan , ONSUM, Matthew , DELABARRE, Byron , LIPPOW, Shaun, M.
Inventor： NIELSEN, Ulrik , WICKHAM, Thomas , SCHOEBERL, Birgit , HARMS, Brian , LINGGI, Bryan , ONSUM, Matthew , DELABARRE, Byron , LIPPOW, Shaun, M.
IPC: C12N15/62
Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.
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公开(公告)号：WO2009149218A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046185
申请日：2009-06-03
Applicant: CODON DEVICES, INC. , BAYNES, Brian , LIPOVSEK, Dasa , LIPPOW, Shaun
Inventor： BAYNES, Brian , LIPOVSEK, Dasa , LIPPOW, Shaun
CPC classification number: C12N15/1093 , C40B30/02 , G06F19/16 , G06F19/18
Abstract: Aspects of the invention relate to variant proteins and methods for designing and using the same. In some embodiments, the invention relates to methods for determining a functional variant of a protein that is restricted by one or more known legal rights, such as patent rights. Functional variants according to this invention are free of such restrictions.
Abstract translation: 本发明的方面涉及变体蛋白及其设计和使用的方法。 在一些实施方案中，本发明涉及用于确定由一种或多种已知合法权利（例如专利权）限制的蛋白质的功能性变体的方法。 根据本发明的功能变体没有这样的限制。
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Patent Agency Ranking5.发明申请BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL HEXANES AND PENTANES FROM CARBOHYDRATE FEEDSTOCKS 审中-公开来自碳氢化合物饲料的二官能和香精的生物合成
公开(公告)号：WO2014028026A9
公开(公告)日：2015-03-26
申请号：PCT/US2012051274
申请日：2012-08-17
Applicant: CELEXION LLC , BAYNES BRIAN M , GEREMIA JOHN MICHAEL , LIPPOW SHAUN
Inventor： BAYNES BRIAN M , GEREMIA JOHN MICHAEL , LIPPOW SHAUN
IPC: C12N1/21 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/88 , C12N9/90 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/00
CPC classification number: C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/0022 , C12N9/0026 , C12N9/0032 , C12N9/1025 , C12N9/1096 , C12N9/13 , C12N9/88 , C12N9/90 , C12N9/93 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
Abstract: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
Abstract translation: 本文提供了在微生物中生产双官能烷烃的方法。 还提供了编码这些酶的酶和核酸，其与来自微生物中的碳水化合物原料的双官能烷烃生产有关。 本发明还提供用于生产双官能烷烃的重组微生物和代谢途径。
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公开(公告)号：WO2008130629A3
公开(公告)日：2009-04-23
申请号：PCT/US2008005021
申请日：2008-04-19
Applicant: CODON DEVICES INC , LIPPOW SHAUN , LIPOVSEK DASA , AHA PATRICIA M
Inventor： LIPPOW SHAUN , LIPOVSEK DASA , AHA PATRICIA M
Abstract: Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases of the invention are useful for manipulating long pieces of DNA.
Abstract translation: 本发明的方面提供了工程化内切核酸酶，其特征在于识别位点之外的长识别序列和特异性切割。 本发明的工程化内切核酸酶可用于操作长的DNA片段。
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公开(公告)号：WO2008130629A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/005021
申请日：2008-04-19
Applicant: CODON DEVICES, INC. , LIPPOW, Shaun , LIPOVSEK, Dasa , AHA, Patricia, M.
Inventor： LIPPOW, Shaun , LIPOVSEK, Dasa , AHA, Patricia, M.
Abstract: Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases of the invention are useful for manipulating long pieces of DNA.
Abstract translation: 本发明的方面提供了工程化内切核酸酶，其特征在于识别位点之外的长识别序列和特异性切割。 本发明的工程化内切核酸酶可用于操作长的DNA片段。
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公开(公告)号：WO2022087484A1
公开(公告)日：2022-04-28
申请号：PCT/US2021/056348
申请日：2021-10-22
Applicant: WILLIAMS, Katherine, L. , EMERLING, Daniel, Eric , LIPPOW, Shaun, M. , ATKINS, Ngan, Nguyen
Inventor： WILLIAMS, Katherine, L. , EMERLING, Daniel, Eric , LIPPOW, Shaun, M. , ATKINS, Ngan, Nguyen
IPC: C07K16/10 , A61P31/14 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Described herein are antibodies or variants thereof that specifically bind to coronavirus antigens, such as SARS-CoV-2 antigens. The antibodies can be neutralizing antibodies. Also provided are methods of using the antibodies, including methods of treating a subject infected with SARS-CoV-2, and methods of diagnosing a subject infected with SARS-CoV-2.
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公开(公告)号：WO2011146902A1
公开(公告)日：2011-11-24
申请号：PCT/US2011037459
申请日：2011-05-20
Applicant: MERRIMACK PHARMACEUTICALS INC , NIELSEN ULRIK , WICKHAM THOMAS , SCHOEBERL BIRGIT , HARMS BRIAN , LINGGI BRYAN , ONSUM MATTHEW , DELABARRE BYRON , LIPPOW SHAUN M
Inventor： NIELSEN ULRIK , WICKHAM THOMAS , SCHOEBERL BIRGIT , HARMS BRIAN , LINGGI BRYAN , ONSUM MATTHEW , DELABARRE BYRON , LIPPOW SHAUN M
IPC: C12N15/62
CPC classification number: C07K16/44 , A61K38/00 , A61K45/06 , A61K47/48538 , A61K47/66 , A61K47/6811 , A61K47/6891 , B82Y5/00 , C07K14/47 , C07K14/475 , C07K14/485 , C07K14/65 , C07K16/46 , C07K2317/31 , C07K2317/76 , C07K2319/00 , C07K2319/80 , C12N15/62
Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.
Abstract translation: 提供了具有治疗用途的双特异性融合蛋白，以及包含这种融合蛋白的药物组合物，以及使用这种融合蛋白修复或再生受损或患病组织的方法。 双特异性融合蛋白通常包含：（a）靶向靶分子结合的靶向多肽结构域; 和（b）可检测地调节组织再生的活化剂结构域。
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