公开(公告)号：WO2002083714A3

公开(公告)日：2002-10-24

申请号：PCT/US2002/009877

申请日：2002-03-28

Applicant: EPIMMUNE INC. ,  SETTE, Alessandro ,  CHESNUT, Robert ,  LIVINGSTON, Brian, D. ,  BAKER, Denise, Marie ,  NEWMAN, Mark, J. ,  BROWN, David, H.

Inventor： SETTE, Alessandro ,  CHESNUT, Robert ,  LIVINGSTON, Brian, D. ,  BAKER, Denise, Marie ,  NEWMAN, Mark, J. ,  BROWN, David, H.

IPC: G01N33/53

Abstract: The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of spacer nucleic acid at the junctions of the multi-epitope constructs encoding a plurality of CTL and/or HTL eoutioe oeotudes so as to minimize the number of junciontal epitopes and provide vaccines with increased immunogenicity.

公开(公告)号：WO1995004542A1

公开(公告)日：1995-02-16

申请号：PCT/US1994008721

申请日：1994-08-02

Applicant: CYTEL CORPORATION ,  FIKES, John, D. ,  LIVINGSTON, Brian, D. ,  SETTE, Alessandro, D. ,  SIDNEY, John, C.

Inventor： CYTEL CORPORATION

IPC: A61K38/00

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K39/00

Abstract: The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C-terminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.

Abstract translation: 提供了人MAGE-1抗原的完整核苷酸和氨基酸序列。 来自C末端残基的肽用于定义刺激针对MAGE-1抗原的HLA限制性细胞毒性T淋巴细胞活性的表位。 这些肽特别可用于刺激个体对与黑素瘤相关的MAGE-1抗原的免疫应答的方法。

公开(公告)号：WO2005033265A3

公开(公告)日：2005-09-09

申请号：PCT/US2004012732

申请日：2004-04-26

Applicant: EPIMMUNE INC ,  SETTE ALESSANDRO ,  CHESNUT ROBERT W ,  NEWMAN MARK J ,  LIVINGSTON BRIAN D

Inventor： SETTE ALESSANDRO ,  CHESNUT ROBERT W ,  NEWMAN MARK J ,  LIVINGSTON BRIAN D

IPC: A61K39/21 ,  A61K39/29 ,  C07H21/04 ,  C07K14/02 ,  C07K14/16 ,  C12N20060101

CPC classification number: A61K39/292 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/627 ,  A61K2039/645 ,  C07K14/005 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/04 ,  C07K2319/06 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2740/16022 ,  C12N2740/16034

Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.

Abstract translation: 本发明涉及生物学领域。 特别地，其涉及多表位核酸和肽疫苗以及设计这种疫苗以提供增加的免疫原性的方法。

公开(公告)号：WO2017184456A1

公开(公告)日：2017-10-26

申请号：PCT/US2017/027675

申请日：2017-04-14

Applicant: MCLEOD, Rima ,  EL BISSATI, Kamal ,  ZHOU, Ying ,  ALEXANDER, Jeff ,  VANG, Lo ,  REED, Steve ,  PAULILLO, Sara, M. ,  RAMAN, Senthil, K. ,  BURKHARD, Peter ,  MELO, Mariane ,  IRVINE, Darrel ,  WEISS, Ron ,  ZHANG, Yuan ,  SETTE, Alessandro ,  SIDNEY, John ,  LIVINGSTON, Brian, D. ,  LORENZI, Hernan

Inventor： MCLEOD, Rima ,  EL BISSATI, Kamal ,  ZHOU, Ying ,  ALEXANDER, Jeff ,  VANG, Lo ,  REED, Steve ,  PAULILLO, Sara, M. ,  RAMAN, Senthil, K. ,  BURKHARD, Peter ,  MELO, Mariane ,  IRVINE, Darrel ,  WEISS, Ron ,  ZHANG, Yuan ,  SETTE, Alessandro ,  SIDNEY, John ,  LIVINGSTON, Brian, D. ,  LORENZI, Hernan

IPC: A61K31/7088 ,  A61K38/17 ,  A61K39/012 ,  A61P33/02 ,  A61P37/04 ,  C12N15/11 ,  C12N15/12 ,  C12N15/63

Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

Abstract translation: 本文公开了编码多表位多肽及其组装体的多核苷酸，以及它们用于治疗或限制弓形虫感染的用途。

公开(公告)号：WO2009026465A2

公开(公告)日：2009-02-26

申请号：PCT/US2008/073921

申请日：2008-08-21

Applicant: DYNAVAX TECHNOLOGIES CORPORATION ,  VAN NEST, Gary ,  LIVINGSTON, Brian, D. ,  ROTH, Georg ,  HIGGINS, Deborah, A.

Inventor： VAN NEST, Gary ,  LIVINGSTON, Brian, D. ,  ROTH, Georg ,  HIGGINS, Deborah, A.

IPC: A61K39/145 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/6025 ,  A61K2039/622 ,  A61K2039/70 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2760/16022 ,  C12N2760/16034

Abstract: The invention provides compositions of influenza proteins, such as matrix and nucleoprotein, that are presented to an individual's immune system as multimeric displays to induce an immune response. The compositions are optionally associated with any type of immunomodulatory compound (IMC) comprising an immunostimutatory sequences (ISS). The invention further provides compositions of influenza matrix and nucleoproteins that can induce cellular and/or humoral immune response. The invention also provides methods of making and using these compositions, e.g, as a vaccine, for ameliorating symptoms associated with infection with influenza virus or for reducing the risk of infection with influenza virus.

Abstract translation: 本发明提供了作为多聚体显示物呈递给个体的免疫系统以诱导免疫应答的流感蛋白（例如基质和核蛋白）的组合物。 组合物任选地与包含免疫刺激性序列（ISS）的任何类型的免疫调节化合物（IMC）相关联。 本发明还提供可诱导细胞和/或体液免疫应答的流感基因和核蛋白的组合物。 本发明还提供了制备和使用这些组合物例如疫苗用于改善与流感病毒感染相关的症状或降低流感病毒感染风险的方法。

公开(公告)号：WO2005012502A3

公开(公告)日：2005-07-14

申请号：PCT/US2004009510

申请日：2004-03-29

Applicant: EPIMMUNE INC ,  BAKER DENISE M ,  LIVINGSTON BRIAN D ,  CHESNUT ROBERT W ,  SETTE ALESSANDRO ,  NEWMAN MARK J

Inventor： BAKER DENISE M ,  LIVINGSTON BRIAN D ,  CHESNUT ROBERT W ,  SETTE ALESSANDRO ,  NEWMAN MARK J

IPC: C07K7/06 ,  C07K7/08 ,  C12N20060101 ,  G01N33/68 ,  G06F19/00 ,  C06F19/00

CPC classification number: C07K7/06 ,  C07K7/08 ,  C12N2740/16211 ,  C12N2740/16311 ,  C12N2770/24211 ,  G01N33/569 ,  G01N33/6878 ,  G01N2333/70539 ,  Y02A90/26

Abstract: The present invention is directed to methods for selecting a variant of a peptide epitope which induces a CTL response against another variant(s) of the peptide epitope, by determining whether the variant comprises only conserved residues, as defined herein, at non-anchor positions in comparison to the other variant(s). The present invention is also directed to variants identified by the methods above; peptides comprising such variants; nucleic acids encoding such variants and peptides; cells comprising such variants, and/or peptides, and/or nucleic acids; compositions comprising such variants, and/or peptides, and/or nucleic acids, and/or cells; as well as therapeutic and diagnostic methods for using such variants, peptides, nucleic acids, cells, and compositions.

Abstract translation: 本发明涉及用于选择肽表位变体的方法，所述肽表位的诱变针对肽表位的另一个变体的CTL应答，通过确定该变体是否仅包含如本文定义的保守残基在非锚定位置 与其他变体相比。 本发明还涉及通过上述方法鉴定的变体; 包含这些变体的肽; 编码这种变体和肽的核酸; 包含这些变体的细胞和/或肽和/或核酸; 包含这些变体的组合物和/或肽，和/或核酸和/或细胞; 以及使用这些变体，肽，核酸，细胞和组合物的治疗和诊断方法。

公开(公告)号：WO2005033265A2

公开(公告)日：2005-04-14

申请号：PCT/US2004/012732

申请日：2004-04-26

Applicant: EPIMMUNE INC. ,  SETTE, Alessandro ,  CHESNUT, Robert, W. ,  NEWMAN, Mark, J. ,  LIVINGSTON, Brian, D.

Inventor： SETTE, Alessandro ,  CHESNUT, Robert, W. ,  NEWMAN, Mark, J. ,  LIVINGSTON, Brian, D.

IPC: C12N

CPC classification number: A61K39/292 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/627 ,  A61K2039/645 ,  C07K14/005 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/04 ,  C07K2319/06 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2740/16022 ,  C12N2740/16034

Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.

Abstract translation: 本发明涉及生物学领域。 具体而言，它涉及多表位核酸和肽疫苗以及设计这种疫苗以提供增加的免疫原性的方法。

公开(公告)号：WO2005012502A2

公开(公告)日：2005-02-10

申请号：PCT/US2004/009510

申请日：2004-03-29

Applicant: EPIMMUNE INC. ,  BAKER, Denise, M. ,  LIVINGSTON, Brian, D. ,  CHESNUT, Robert, W. ,  SETTE, Alessandro ,  NEWMAN, Mark, J.

Inventor： BAKER, Denise, M. ,  LIVINGSTON, Brian, D. ,  CHESNUT, Robert, W. ,  SETTE, Alessandro ,  NEWMAN, Mark, J.

IPC: C12N

CPC classification number: C07K7/06 ,  C07K7/08 ,  C12N2740/16211 ,  C12N2740/16311 ,  C12N2770/24211 ,  G01N33/569 ,  G01N33/6878 ,  G01N2333/70539 ,  Y02A50/53 ,  Y02A50/55 ,  Y02A50/58 ,  Y02A90/26

Abstract: The present invention is directed to methods for selecting a variant of a peptide epitope which induces a CTL response against another variant(s) of the peptide epitope, by determining whether the variant comprises only conserved residues, as defined herein, at non-anchor positions in comparison to the other variant(s). The present invention is also directed to variants identified by the methods above; peptides comprising such variants; nucleic acids encoding such variants and peptides; cells comprising such variants, and/or peptides, and/or nucleic acids; compositions comprising such variants, and/or peptides, and/or nucleic acids, and/or cells; as well as therapeutic and diagnostic methods for using such variants, peptides, nucleic acids, cells, and compositions.

Abstract translation: 本发明涉及通过确定变体是否仅包含保守残基来选择诱导针对肽表位的另一变体的CTL应答的肽表位变体的方法， 本文定义的非锚定位置与其他变体相比较。 本发明还涉及通过上述方法鉴定的变体; 包含此类变体的肽; 编码这种变体和肽的核酸; 包含此类变体和/或肽和/或核酸的细胞; 包含此类变体和/或肽，和/或核酸和/或细胞的组合物; 以及使用这些变体，肽，核酸，细胞和组合物的治疗和诊断方法。

公开(公告)号：WO2009026465A3

公开(公告)日：2009-04-09

申请号：PCT/US2008073921

申请日：2008-08-21

Applicant: DYNAVAX TECH CORP ,  VAN NEST GARY ,  LIVINGSTON BRIAN D ,  ROTH GEORG ,  HIGGINS DEBORAH A

Inventor： VAN NEST GARY ,  LIVINGSTON BRIAN D ,  ROTH GEORG ,  HIGGINS DEBORAH A

IPC: A61K39/145 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/6025 ,  A61K2039/622 ,  A61K2039/70 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2760/16022 ,  C12N2760/16034

Abstract: The invention provides compositions of influenza proteins, such as matrix and nucleoprotein, that are presented to an individual's immune system as multimeric displays to induce an immune response. The compositions are optionally associated with any type of immunomodulatory compound (IMC) comprising an immunostimutatory sequences (ISS). The invention further provides compositions of influenza matrix and nucleoproteins that can induce cellular and/or humoral immune response. The invention also provides methods of making and using these compositions, e.g, as a vaccine, for ameliorating symptoms associated with infection with influenza virus or for reducing the risk of infection with influenza virus.

Abstract translation: 本发明提供流感蛋白质的组合物，例如基质和核蛋白质，其作为多聚体展示呈递给个体的免疫系统以诱导免疫应答。 该组合物任选地与包含免疫刺激性序列（ISS）的任何类型的免疫调节化合物（IMC）相关联。 本发明进一步提供了可诱导细胞和/或体液免疫应答的流感基质和核蛋白的组合物。 本发明还提供了制备和使用这些组合物（例如作为疫苗）以改善与流感病毒感染相关的症状或降低流感病毒感染风险的方法。

公开(公告)号：WO2005033265A9

公开(公告)日：2005-06-02

申请号：PCT/US2004012732

申请日：2004-04-26

Applicant: EPIMMUNE INC ,  SETTE ALESSANDRO ,  CHESNUT ROBERT W ,  NEWMAN MARK J ,  LIVINGSTON BRIAN D

Inventor： SETTE ALESSANDRO ,  CHESNUT ROBERT W ,  NEWMAN MARK J ,  LIVINGSTON BRIAN D

IPC: A61K39/21 ,  A61K39/29 ,  C07H21/04 ,  C07K14/02 ,  C07K14/16 ,  C12N20060101 ,  C12N

CPC classification number: A61K39/292 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/627 ,  A61K2039/645 ,  C07K14/005 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/04 ,  C07K2319/06 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2740/16022 ,  C12N2740/16034

Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.