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    ATRIAL PEPTIDE DERIVATIVES
    3.
    发明申请
    ATRIAL PEPTIDE DERIVATIVES 审中-公开
    ATRIAL肽衍生物

    公开(公告)号：WO1989010935A1

    公开(公告)日：1989-11-16

    申请号：PCT/US1989001928

    申请日：1989-05-05

    Applicant: ABBOTT LABORATORIES ,  ROCKWAY, Todd, W. ,  KISO, Yoshiaki ,  DAVIDSEN, Steven, K. ,  LUCAS, Scott, D. ,  THOMAS, A., Mitchell ,  VON GELDERN, Thomas, W.

    Inventor： ABBOTT LABORATORIES

    IPC: C07K07/08

    CPC classification number: C07K14/582 ,  A61K38/00

    Abstract: Atrial peptides comprising the amino acid sequence (I), wherein R1 is hydrogen, Ser, Cit, SerSer, Arg, Carbamoyl Ser, Guanido-Ser-Ser, Amcca, Guanido-Amcca, Lys, ArgArg, Ser-Arg, Ser-Lys, Acetyl-Ser-Ser, D-Ser-Ser, Ser-D-Ser, Guanido-Aocta, Aunda, Aocta, Ahexa, HSer, Apenta, Papaa, Abuta, Mamba, Orn, D-Orn or Acetyl-apenta, Acetyl-Ahexa, Guanido; R2 is Cys, D-Cys or Pen; R3 is L-Phe, D-Ala, L-Ala, D-Val, D-Cha, Sar, D-Phg, Aib, beta-Ala or Gly; R4 is Phe, Trp, D-Tic, L-Tic, N-MePhe, D-Ala, Tyr, 2-Thi, DimeDOPA or DOPA; R5 is Gly-Gly, Ala-Gly, D-Ala-Gly, Gly-Ala, Amcca, Mapaa or Papaa; R6 is Arg, D-Arg or Cit; R7 is Ile, Leu, D-Leu or Met; R8 is Asp, Asn, beta-methylAsp, cycloAsp, Gly or Ser; R9 is Arg, D-Arg or Ala; R10 is Ile, Leu or Phe; R11 is Cys, D-Cys, HCys, Cys-4-thiomethylproline, or trans-4-thiomethylproline; R12 is absent, Phe, D-Ala-Phe, D-Phe, Cha, Pro, D-Pro, 2-Thi, Aic, D-Tic, trans-4-FPro, L-Tic, Leu, Ile or beta-NA1; R13 is OH, Arg, Arg-NH2, D-Arg, Gln, Lys, HomoArg, or Gly; or pharmaceutically acceptable salts, esters or amides thereof.

    PARTICLE-TOUGHENED FIBER-REINFORCED POLYMER COMPOSITES
    5.
    发明申请
    PARTICLE-TOUGHENED FIBER-REINFORCED POLYMER COMPOSITES 审中-公开
    颗粒增韧纤维增强聚合物复合材料

    公开(公告)号：WO2010138546A1

    公开(公告)日：2010-12-02

    申请号：PCT/US2010/036142

    申请日：2010-05-26

    Applicant: CYTEC TECHNOLOGY CORP. ,  BONNEAU, Mark, Richard ,  BOYD, Jack, Douglas ,  EMMERSON, Gordon, Thomas ,  LUCAS, Scott, D. ,  HOWARD, Stephen, Jacob ,  JACOBS, Spencer, Donald

    Inventor： BONNEAU, Mark, Richard ,  BOYD, Jack, Douglas ,  EMMERSON, Gordon, Thomas ,  LUCAS, Scott, D. ,  HOWARD, Stephen, Jacob ,  JACOBS, Spencer, Donald

    IPC: C08J5/24 ,  C08L79/08

    CPC classification number: C08L79/04 ,  C08G73/06 ,  C08G73/10 ,  C08G73/12 ,  C08J5/24 ,  C08J2379/08 ,  C08K7/02 ,  C08L79/08 ,  Y10T428/249924 ,  Y10T428/24994 ,  Y10T428/254

    Abstract: Particle toughened, fiber-reinforced composites include a fiber region and an interlayer region between the fibers. The fiber region includes a plurality of fibers at least partially within a first polymer composition including a first base polymer formulation and a first plurality of toughening particles. The interlayer region includes a second polymer composition including a second base polymer formulation and at least one of the first plurality of toughening particles and a second plurality of toughening particles. Examples of first and second pluralities of toughening particles, respectively, may include core shell rubbers and polyimides. Increasing concentration of the first plurality of toughening particles may improve the composite toughness while preserving thermal properties of the composite, such as weight loss after extended duration exposure to elevated temperature. It is further discovered that the relative placement of the toughening particles influences composite mechanical properties, such as compression after impact (CAI) strength.

    Abstract translation: 纤维增强纤维增强复合材料包括纤维区域和纤维之间的层间区域。 纤维区域包括至少部分地在包含第一基础聚合物配方和第一多个增韧颗粒的第一聚合物组合物内的多个纤维。 层间区域包括第二聚合物组合物，其包括第二基础聚合物配制剂和第一多个增韧颗粒中的至少一个和第二多个增韧颗粒。 第一和第二多个增韧颗粒的实例可分别包括核壳橡胶和聚酰亚胺。 增加第一多个增韧颗粒的浓度可以提高复合材料韧性，同时保持复合材料的热性能，例如长时间暴露于高温下的重量损失。 进一步发现，增韧颗粒的相对位置影响复合机械性能，例如冲击后的压缩（CAI）强度。

    ATRIAL PEPTIDE DERIVATIVES
    6.
    发明申请
    ATRIAL PEPTIDE DERIVATIVES 审中-公开
    ATRIAL肽衍生物

    公开(公告)号：WO1990014362A1

    公开(公告)日：1990-11-29

    申请号：PCT/US1990002917

    申请日：1990-05-23

    Applicant: ABBOTT LABORATORIES ,  LUCAS, Scott, D. ,  ROCKWAY, Todd, W. ,  DAVIDSEN, Steven, K. ,  THOMAS, A., Mitchell ,  VON GELDERN, Thomas, W.

    Inventor： ABBOTT LABORATORIES

    IPC: C07K07/08

    CPC classification number: C07K14/58 ,  A61K38/00

    Abstract: The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.

    Abstract translation: 本发明提供了具有有用的低血压，利尿钠，利尿剂，改善释放，肾保护，平滑肌松弛剂和血管舒张活性的新型肽。 本发明的新型心房肽包括式（I）或其药学上可接受的盐，酯或酰胺，其中R 1选自氢，乙酰基氨基，氨基，Arg，Cit，His，Lys，Orn和 丝氨酸 - 丝氨酸; R 2是含硫基团; R 3是疏水性氨基酸或二肽; R 4是二肽间隔物或式X-Y的三肽，其中X是二肽间隔物，Y是碱性氨基酸; R 5是疏水性氨基酸; R 6是多至三个氨基酸的肽; R 7选自Cha，Phe，Cha-Arg，Phe-Arg，（D）Phe-Arg，Phe-（D）Arg，Phe> Arg，Leu-Arg，Ala-Arg，Arg和Gly -翼; R 8为含硫基团。

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