公开(公告)号：WO2018083635A3

公开(公告)日：2018-05-11

申请号：PCT/IB2017/056848

申请日：2017-11-03

Applicant: AUCKLAND UNISERVICES LIMITED ,  MARSHALL, Andrew James ,  BUCHANAN, Christina Maree ,  REWCASTLE, Gordon William ,  LU, Guo-Liang ,  FLANAGAN, Jack Urquhart ,  BONNET, Muriel ,  SHEPHERD, Peter Robin ,  JAMIESON, Stephen Michael Frazer ,  GAMAGE, Swarnalatha Akuratiya ,  DENNY, William Alexander

Inventor： MARSHALL, Andrew James ,  BUCHANAN, Christina Maree ,  REWCASTLE, Gordon William ,  LU, Guo-Liang ,  FLANAGAN, Jack Urquhart ,  BONNET, Muriel ,  SHEPHERD, Peter Robin ,  JAMIESON, Stephen Michael Frazer ,  GAMAGE, Swarnalatha Akuratiya ,  DENNY, William Alexander

IPC: C07D219/06 ,  C07D311/86 ,  C07D219/14 ,  C07D335/12 ,  A61K31/435 ,  A61K31/35 ,  A61P35/00 ,  A61P19/02

Abstract: Disclosed are tricyclic heterocyclic compounds having kinase inhibitory activity, pharmaceutical compositions and kits comprising the compounds, and use of the compounds in the treatment of or in medicaments for the treatment of various diseases and conditions. In particular, disclosed are tricyclic heterocyclic compounds of the formula (I) having CSF-1R (c-FMS kinase) inhibitory activity and their use in the treatment of various diseases and conditions, such as those mediated by CSF-1R, including proliferative or neoplastic diseases and conditions, including cancers, and bone, inflammatory, and autoimmune diseases and conditions.

公开(公告)号：WO2012146740A1

公开(公告)日：2012-11-01

申请号：PCT/EP2012/057810

申请日：2012-04-27

Applicant: ISTAR MEDICAL ,  MARSHALL, Andrew ,  MAGINNESS, Max ,  ALVAREZ, Michel

Inventor： MARSHALL, Andrew ,  MAGINNESS, Max ,  ALVAREZ, Michel

IPC: A61B3/16 ,  A61B5/00 ,  A61F9/007

CPC classification number: A61B3/16 ,  A61B5/0031 ,  A61F9/00781

Abstract: Described herein is a device (400) for glaucoma treatment and monitoring that comprises a combination of an intraocular pressure (iOP) sensor and a glaucoma drainage device. The device (400) comprises an IOP sensor (410) and an inductive antenna (420) mounted within a porous biocompatible material (430) that forms the drainage path. The IOP sensor (410) is mounted in a footplate portion (450) of the device (400) and is mountable in the anterior chamber of an eye. The footplate portion (450) is connected to a body portion (440) that houses the spiral antenna (420) by means of a neck portion (460) which locates the footplate portion (450) in a suitable position within the anterior chamber. Due to its size, the footplate portion (450) housing the IOP sensor (410) can readily be inserted into the anterior chamber with the body portion (440) housing the spiral antenna (420) located outside of the anterior chamber in a sub-scleral space to disperse the aqueous humour. Readings can be taken from the device (400) by an inductive coupling link between the antenna (420) and an external detector device.

Abstract translation: 本文描述了一种用于青光眼治疗和监测的装置（400），其包括眼内压（iOP）传感器和青光眼引流装置的组合。 装置（400）包括安装在形成排水路径的多孔生物相容性材料（430）内的IOP传感器（410）和感应天线（420）。 IOP传感器（410）安装在装置（400）的脚板部分（450）中并且可安装在眼睛的前房中。 脚踏板部分（450）通过颈部（460）连接到容纳螺旋形天线（420）的主体部分（440），颈部部分将脚板部分（450）定位在前房内的合适位置。 由于其尺寸，容纳IOP传感器（410）的脚板部分（450）可以容易地插入前房，其中主体部分（440）容纳位于前房的外侧的螺旋天线（420） 巩膜空间分散房水。 可以通过天线（420）和外部检测器设备之间的感应耦合链路从设备（400）读取数据。

公开(公告)号：WO2011127395A1

公开(公告)日：2011-10-13

申请号：PCT/US2011/031764

申请日：2011-04-08

Applicant: HEALIONICS CORPORATION ,  MARSHALL, Andrew, J. ,  ALVAREZ, Michel ,  MAGINNESS, Max, G.

Inventor： MARSHALL, Andrew, J. ,  ALVAREZ, Michel ,  MAGINNESS, Max, G.

IPC: A61L27/52 ,  A61L27/56 ,  A61L27/16 ,  A61L27/02

CPC classification number: A61L29/146 ,  A61F2/02 ,  A61L27/56 ,  A61L2400/18 ,  Y10T428/12479 ,  Y10T428/24355 ,  Y10T428/249979

Abstract: This disclosure provides implantable devices coated with microporous surface layers with macrotopographic features that improve bio-integration at the interface of the implantable devices and the surrounding tissue.

Abstract translation: 本公开提供了涂覆有微孔表面层的可植入装置，其具有改善在可植入装置和周围组织的界面处的生物整合的宏观特征。

公开(公告)号：WO2011091008A1

公开(公告)日：2011-07-28

申请号：PCT/US2011/021677

申请日：2011-01-19

Applicant: SWAGELOK COMPANY ,  ARSTEIN, Dale, C. ,  BENNETT, Mark, A. ,  BEARER, Mark, D. ,  BERRY, Tobin, P. ,  BROWN, Cal, R. ,  CLASON, Mark, A. ,  CLARK, Ross, A. ,  FOTTA, Robert, A. ,  HAMILTON, Justin ,  KALATA, Gregory, S. ,  KARKOSIAK, John, D. ,  MALEC, Kennan, Joseph ,  MARSHALL, Andrew, P. ,  MOHLENKAMP, Michael, J. ,  RAYLE, Jeffrey, S. ,  SCHIROKY, Gerhard, H. ,  SLAVEN, Harry ,  WELCH, Douglas, S. ,  WILLIAMS, Peter, C.

Inventor： ARSTEIN, Dale, C. ,  BENNETT, Mark, A. ,  BEARER, Mark, D. ,  BERRY, Tobin, P. ,  BROWN, Cal, R. ,  CLASON, Mark, A. ,  CLARK, Ross, A. ,  FOTTA, Robert, A. ,  HAMILTON, Justin ,  KALATA, Gregory, S. ,  KARKOSIAK, John, D. ,  MALEC, Kennan, Joseph ,  MARSHALL, Andrew, P. ,  MOHLENKAMP, Michael, J. ,  RAYLE, Jeffrey, S. ,  SCHIROKY, Gerhard, H. ,  SLAVEN, Harry ,  WELCH, Douglas, S. ,  WILLIAMS, Peter, C.

IPC: F16L19/10

CPC classification number: F16L33/2071 ,  F16L19/083 ,  F16L19/103 ,  Y10T29/49826

Abstract: The disclosure presents exemplary embodiments of a cartridge nut concept for conduit fittings. The cartridge nut concept may include the feature of loosely retaining one or more conduit gripping devices with a fitting component such as a male or female threaded nut. The cartridge nut concept may be realized using one or more geometry or shape features or characteristics of one or more conduit gripping devices. Still further, the cartridge nut concept may be realized in combination with a ferrule cartridge concept.

Abstract translation: 本公开提供了用于导管配件的盒螺母概念的示例性实施例。 墨盒螺母概念可以包括松散地保持一个或多个导管夹持装置的特征，其具有诸如公螺纹或阴螺纹螺母的装配部件。 墨盒螺母概念可以使用一个或多个导管夹持装置的一个或多个几何形状特征或特征来实现。 此外，盒螺母概念可以与套圈盒概念一起实现。

公开(公告)号：WO2011065987A1

公开(公告)日：2011-06-03

申请号：PCT/US2010/026107

申请日：2010-03-03

Applicant: HEALIONICS CORPORATION ,  MAGINNESS, Max ,  MARSHALL, Andrew ,  GLAISTER, Christine L. ,  ALVAREZ, Michel

Inventor： MAGINNESS, Max ,  MARSHALL, Andrew ,  GLAISTER, Christine L. ,  ALVAREZ, Michel

IPC: A61L27/14 ,  A61L27/52 ,  A61L27/56 ,  A61L27/58

CPC classification number: A61L27/58 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2400/10

Abstract: The disclosure provides granular forms of porous biomaterials and methods for forming and applying these biomaterials, including uses to promote vascularization and tissue ingrowth.

Abstract translation: 本公开提供了多孔生物材料的颗粒形式和形成和应用这些生物材料的方法，包括促进血管形成和组织向内生长的用途。

公开(公告)号：WO2005032418A2

公开(公告)日：2005-04-14

申请号：PCT/US2004/032639

申请日：2004-10-01

Applicant: UNIVERSITY OF WASHINGTON ,  RATNER, Buddy, D. ,  MARSHALL, Andrew

Inventor： RATNER, Buddy, D. ,  MARSHALL, Andrew

IPC: A61F

CPC classification number: A61F2/0077 ,  A61F2/06 ,  A61L27/14 ,  A61L27/56

Abstract: The invention provides porous biomaterials and methods for forming porous bioniaterials. The porous bioniaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15 % and about 40 % of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.

Abstract translation: 本发明提供用于形成多孔生物材料的多孔生物材料和方法。 本发明的多孔生物材料包括限定孔阵列的生物相容性聚合物支架，其中基本上所有的孔具有相似的直径，其中孔的平均直径在约20和约90微米之间，其中基本上所有的孔各自 连接到至少4个其它孔，并且其中孔之间的基本上所有连接的直径在孔的平均直径的约15％至约40％之间。 本发明还提供了包括生物材料层的可植入装置，以及用于在可植入生物材料内和周围促进血管生成的方法。

公开(公告)号：WO2009023505A1

公开(公告)日：2009-02-19

申请号：PCT/US2008/072427

申请日：2008-08-07

Applicant: SWAGELOK COMPANY ,  MARSHALL, Andrew, P. ,  WILLIAMS, Peter, C. ,  CLASON, Mark, A.

Inventor： MARSHALL, Andrew, P. ,  WILLIAMS, Peter, C. ,  CLASON, Mark, A.

IPC: F16L19/06 ,  F16L19/10

CPC classification number: F16L19/103

Abstract: A ferrule type, flareless fitting is provided that includes a first fitting component (12), a second fitting component (16), a front ferrule (20), and a rear ferrule (22). The first fitting component comprises a rear ferrule recess and a front ferrule recess. The second fitting component includes a ferrule camming surface. The front ferrule is disposed between the first fitting component and the second fitting component such that a portion of the front ferrule engages the front ferrule camming surface. The front ferrule includes a flange that extends radially outward from a portion of the front ferrule that engages the front ferrule camming surface. A difference angle is defined between the front ferrule recess and an outer surface of the flange when the fitting is in a finger tight condition. The difference angle diminishes during pull up of the fitting. A rear ferrule is disposed between the front ferrule and the first fitting component such that a rear ferrule drive surface of the rear ferrule recess engages the rear ferrule when the fitting is pulled up.

Abstract translation: 提供了一种套圈型的防爆配件，其包括第一配件部件（12），第二配件部件（16），前套圈（20）和后套圈（22）。 第一配件部件包括后套圈凹部和前套圈凹部。 第二配件部件包括套圈凸轮表面。 前套圈设置在第一配件部件和第二配件部件之间，使得前套圈的一部分接合前套圈凸轮表面。 前套圈包括从前套圈的与前套圈凸轮表面接合的部分径向向外延伸的凸缘。 当配件处于手指紧密状态时，在前套圈凹部和凸缘的外表面之间限定差角。 配件上拉时差角度减小。 后套圈设置在前套圈和第一配件部件之间，使得后套圈凹部的后套圈驱动表面在配件被拉起时与后套圈接合。

公开(公告)号：WO2009003016A1

公开(公告)日：2008-12-31

申请号：PCT/US2008/068147

申请日：2008-06-25

Applicant: SWAGELOK COMPANY ,  ANTON, Arthur, Frank ,  BUTKOVIC, Michael, Ray ,  GOEMANS, Johan, Jan ,  MRACEK, Kevin ,  ARSTEIN, Dale, C. ,  DACEK, Franziska, H. ,  KARKOSIAK, John, D. ,  RUBINSKI, Jeffrey, Michael ,  O'CONNOR, David, Bryan ,  O'CONNOR, David, E. ,  LUBAR, Nicholas, Raney ,  SCHIROKY, Gerhard, H. ,  BENNETT, Mark, A. ,  GAUSMAN, Theodore, J. ,  MARSHALL, Andrew, P. ,  VANDENDRIESSCHE, Larry, Dean ,  BON, Sylvia, Antoinette ,  GLIME, William, H., III ,  MOHLENKAMP, Michael, Jerome ,  WILLIAMS, Peter, C. ,  ALES, Richard, A. ,  MOORE, Stephen, W. ,  COLLINS, Sunniva, R.

Inventor： ANTON, Arthur, Frank ,  BUTKOVIC, Michael, Ray ,  GOEMANS, Johan, Jan ,  MRACEK, Kevin ,  ARSTEIN, Dale, C. ,  DACEK, Franziska, H. ,  KARKOSIAK, John, D. ,  RUBINSKI, Jeffrey, Michael ,  O'CONNOR, David, Bryan ,  O'CONNOR, David, E. ,  LUBAR, Nicholas, Raney ,  SCHIROKY, Gerhard, H. ,  BENNETT, Mark, A. ,  GAUSMAN, Theodore, J. ,  MARSHALL, Andrew, P. ,  VANDENDRIESSCHE, Larry, Dean ,  BON, Sylvia, Antoinette ,  GLIME, William, H., III ,  MOHLENKAMP, Michael, Jerome ,  WILLIAMS, Peter, C. ,  ALES, Richard, A. ,  MOORE, Stephen, W. ,  COLLINS, Sunniva, R.

IPC: F16L19/12 ,  F16L19/05 ,  F16J15/06

CPC classification number: F16L15/08 ,  F16J15/064 ,  F16L15/04 ,  F16L19/0283 ,  F16L19/05 ,  F16L19/103 ,  F16L19/12

Abstract: Apparatus and method for mechanically attached connections of conduits may include a conduit gripping member (34), a drive member (36), and a seal member (48), the drive member causing axial movement of the conduit gripping member to indent into an outer surface of the conduit when the assembly is pulled-up, the drive member causing the seal member to form a zero clearance seal at a location that is axially spaced from the conduit gripping member. The zero clearance seal may comprise a face seal arrangement including a gasket (48), and the conduit gripping member may be a ferrule, ring or other device that can grip and optionally seal against the conduit outer surface. The assembly may include 'a sensing function for detecting or sensing a characteristic or condition of an assembly component or the fluid or both, hi one embodiment, a body coupling member has a two piece construction of a main body and a conduit socket insert. A flared fitting embodiment is also provided. Sensing functions are also incorporated into fittings other than just zero clearance fittings.

Abstract translation: 用于机械连接导管的装置和方法可以包括导管夹持构件（34），驱动构件（36）和密封构件（48），所述驱动构件使得导管夹持构件轴向移动以缩进到外部 当组件被拉起时，导管的表面，导致密封构件的驱动构件在与导管夹持构件轴向间隔开的位置处形成零间隙密封。 零间隙密封可以包括包括垫圈（48）的面密封装置，并且导管夹持构件可以是可以夹持并任选地密封导管外表面的套圈，环或其它装置。 组件可以包括用于检测或感测组件部件或流体或两者的特性或状态的感测功能。在一个实施例中，主体联接构件具有主体和导管插座插入件的两件式结构。 还提供了一种扩口配套实施例。 感应功能也被并入除了零间隙配件之外的配件中。

公开(公告)号：WO2008030375A3

公开(公告)日：2008-07-10

申请号：PCT/US2007019025

申请日：2007-08-30

Applicant: SWAGELOK CO ,  BEARER MARK D ,  GAUSMAN THEODORE J ,  KARKOSIAK JOHN D ,  WILLIAMS PETER C ,  BERRY TOBIN ,  MARSHALL ANDREW P

Inventor： BEARER MARK D ,  GAUSMAN THEODORE J ,  KARKOSIAK JOHN D ,  WILLIAMS PETER C ,  BERRY TOBIN ,  MARSHALL ANDREW P

IPC: F16L19/10 ,  F16L19/065

CPC classification number: F16L19/10 ,  F16L19/065 ,  F16L19/103

Abstract: A fitting for a conduit (9) is provided with first and second fitting components (4,6), a gripping member (2), and a live-loading mechanism (3). The first fitting component is adapted to receive a conduit along a central axis. The gripping member includes a gripping portion adapted to engage the conduit when the gripping member is tightened to the conduit. The second fitting component is adapted to be joined to the first fitting component to provide a seal between the gripping member and at least one of the first and second fitting components. The live-loading mechanism is adapted to hold the gripping portion in live-loaded engagement with the conduit when the first fitting component is separated from the second fitting component.

Abstract translation: 用于管道（9）的配件设置有第一和第二装配部件（4,6），夹紧构件（2）和活载装置（3）。 第一装配部件适于沿着中心轴线容纳导管。 夹持构件包括当把持构件紧固到导管时适于接合导管的夹持部分。 第二装配部件适于连接到第一装配部件，以在夹持部件与第一和第二装配部件中的至少一个之间提供密封。 活动装载机构适于在第一装配部件与第二装配部件分离时将抓握部分保持与导管的活动接合。

公开(公告)号：WO2008057983A1

公开(公告)日：2008-05-15

申请号：PCT/US2007/083416

申请日：2007-11-02

Applicant: SWAGELOK COMPANY ,  BENNETT, Mark, A. ,  BERRY, Tobin ,  CLASON, Mark, A. ,  KARKOSIAK, John, D. ,  LIPPUCCI, Thomas, A. ,  MARSHALL, Andrew, P. ,  RUBINSKI, Jeffrey, Michael ,  STROBERG, Edward, A. ,  WILLIAMS, Peter, C.

Inventor： BENNETT, Mark, A. ,  BERRY, Tobin ,  CLASON, Mark, A. ,  KARKOSIAK, John, D. ,  LIPPUCCI, Thomas, A. ,  MARSHALL, Andrew, P. ,  RUBINSKI, Jeffrey, Michael ,  STROBERG, Edward, A. ,  WILLIAMS, Peter, C.

IPC: F16L19/08 ,  F16L19/10

CPC classification number: F16L19/103 ,  F16L19/065 ,  F16L19/083 ,  F16L25/00 ,  F16L2201/10

Abstract: A fitting is provided that may optionally be pulled-up to its final assembled condition by torque rather than by turns. At least one fitting component includes a structure that facilitates pull-up by torque. The structure may take a wide variety of different forms. In one embodiment, at least one of the external surface of the first threaded fitting component (112) and the outer position of the nut (116) includes an incline (145) in an engagement area.

Abstract translation: 提供了可以通过扭矩而不是轮流将其可选地上拉到最终组装状态的配件。 至少一个配件部件包括便于通过转矩上拉的结构。 该结构可能采取各种不同的形式。 在一个实施例中，第一螺纹配件部件（112）的外表面和螺母（116）的外部位置中的至少一个在接合区域中包括倾斜（145）。