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    XANTHAN-ESTER AND ACRIDAN SUBSTRATES FOR HORSERADISH PEROXIDASE
    2.
    发明申请
    XANTHAN-ESTER AND ACRIDAN SUBSTRATES FOR HORSERADISH PEROXIDASE 审中-公开
    用于马尾松过氧化物的XANTHAN-ESTER和ACRIDAN底物

    公开(公告)号：WO00015618A1

    公开(公告)日：2000-03-23

    申请号：PCT/US1999/020635

    申请日：1999-09-10

    IPC: G01N33/53 ,  C07D219/06 ,  C07D311/84 ,  C09K11/07 ,  C12Q1/28 ,  G01N21/76 ,  G01N33/535 ,  G01N33/577 ,  C07D219/04 ,  C07D311/82 ,  C07D335/12 ,  C12N9/96 ,  G01N33/533 ,  G01N33/573 ,  G01N33/74

    CPC classification number: C07D219/06 ,  C07D311/84 ,  C12Q1/28 ,  G01N2333/59 ,  Y10S435/968

    Abstract: Xanthan-esters and acridans are substrates for horseradish peroxidase. These stable, enzymatically cleavable chemiluminescent esters are substrates for horseradish peroxidase which, together with peroxide is among the extensively used enzyme in enzyme-linked detection methods, including immunoassays, oligonucleotide detection and nucleic acid hybridization. The novel compounds are used, together with peroxide, alkali and the peroxidase, to indicate the presence and/or concentration of target compounds. The assays may be enhanced by the use of polymeric quaternary onium enhancement compounds or similar compounds selected to enhance the chemiluminescence emitted.

    Abstract translation: 黄原酸酯和吖啶是辣根过氧化物酶的底物。 这些稳定的，酶促切割的化学发光酯是辣根过氧化物酶的底物，与过氧化物一起是酶联检测方法中广泛使用的酶，包括免疫测定，寡核苷酸检测和核酸杂交。 这些新型化合物与过氧化物，碱和过氧化物酶一起使用，以表明目标化合物的存在和/或浓度。 可以通过使用选择用于增强所发射的化学发光的聚合季铵增强化合物或类似化合物来增强测定。

    MECHANICAL OPENING OF LIPID BILAYERS BY MOLECULAR NANOMACHINES
    4.
    发明申请
    MECHANICAL OPENING OF LIPID BILAYERS BY MOLECULAR NANOMACHINES 审中-公开
    用分子纳米粒子机械打开脂双层膜

    公开(公告)号：WO2018013930A1

    公开(公告)日：2018-01-18

    申请号：PCT/US2017/042148

    申请日：2017-07-14

    Applicant: WILLIAM MARSH RICE UNIVERSITY ,  DURHAM UNIVERSITY

    Inventor： TOUR, James M. ,  PAL, Robert ,  GARCIA, Victor ,  NILEWSKI, Lizanne

    IPC: A61K51/04 ,  C07D335/12

    Abstract: Embodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo . The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide -based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.

    Abstract translation: 本公开的实施方式涉及通过将脂质双分子层与包括能够响应于外部刺激而移动（例如，旋转）的移动部件的分子相关联而打开脂质双层的方法; 并且在将分子与脂质双层结合之前，期间或之后将分子暴露于外部刺激。 暴露导致分子的移动组分移动并由此打开脂质双分子层（例如通过孔形成）。 外部刺激可能包括能源，如紫外线。 打开的脂双层可能是体内或体外细胞膜的组分。 脂双层的打开可允许各种材料（例如活性剂，例如基于肽的药物）通过脂质双层并进入细胞。 本公开的另外的实施方式涉及用于打开脂质双层的上述分子。

    TRICYCLIC ENERGY QUENCHER COMPOUNDS FOR REDUCING SINGLET OXYGEN GENERATION
    5.
    发明申请
    TRICYCLIC ENERGY QUENCHER COMPOUNDS FOR REDUCING SINGLET OXYGEN GENERATION 审中-公开
    用于减少单氧发生的三元能量探针化合物

    公开(公告)号：WO2014025370A1

    公开(公告)日：2014-02-13

    申请号：PCT/US2012/067519

    申请日：2012-12-03

    Applicant: HALLSTAR INNOVATIONS CORP.

    Inventor： BONDA, Craig, A. ,  HU, Shengkui

    IPC: A61K8/49 ,  A61K8/40 ,  A61K31/382 ,  A61K31/35 ,  A61K31/277 ,  A61Q1/00 ,  A61Q17/04 ,  C07C255/41 ,  C07C255/34 ,  C07D311/82 ,  C07D335/12

    CPC classification number: A61K31/277 ,  A61K8/40 ,  A61K8/46 ,  A61K8/494 ,  A61K8/498 ,  A61K8/4986 ,  A61K31/216 ,  A61K31/352 ,  A61K31/382 ,  A61K45/06 ,  A61Q17/04 ,  C07C255/41 ,  C07C325/02 ,  C07C2603/18 ,  C07C2603/24 ,  C07D311/82 ,  C07D335/12 ,  C09B11/28 ,  C09B23/005 ,  C09B23/0058 ,  C09B23/04 ,  C09B23/105 ,  C09B23/107

    Abstract: A method of quenching excited state energy from a photodegradable pigment that has been excited by absorption of light having a wavelength in the wavelength range of 290 - 800 nm, comprising reacting a pigment with a conjugated fused tricyclic compound having electron withdrawing groups of Formula (II) or a salt thereof: formula (II) wherein: A is selected from the group consisting of O, S, C=0, C=S, formula (III) and (IV); B 1 , B 2 , D 1 , and D 2 are each independently selected from the group consisting of F, Cl, Br, I, CF 3 , CCl 3 , NR 3 3 +, NO 2 ,CN, C(=O)R 4 , C(=O)OR 1 , SO 2 R 5 , aryl, and — C=CHR 6 ; each m independently is 0, 1, 2, 3, or 4; n is 0 or 1; each R 1 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and aryl; R 2 is selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, alkynyl, and aryl; each R 3 is independently selected from the group consisting of H and C 1 -C 6 alkyl; each R 4 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and aryl; each R 5 is independently selected from the group consisting of H, O - , OH, NH 2 , and CI; and, each R 6 is independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and aryl.

    Abstract translation: 一种通过吸收波长范围为290〜800nm的光而激发的可光降解颜料的激发态能量的方法，包括使颜料与具有式（II）的吸电子基团的共轭稠合三环化合物反应 ）或其盐：式（II）其中：A选自O，S，C = O，C = S，式（III）和（IV）; B1，B2，D1和D2各自独立地选自F，Cl，Br，I，CF3，CCl3，NR3 3+，NO2，CN，C（= O）R4，C（= O）OR1 ，SO 2 R 5，芳基和-C = CHR 6; 每个m独立地为0,1,2,3或4; n为0或1; 每个R 1独立地选自H，烷基，烯基，炔基，环烷基，环烯基和芳基; R2选自H，烷基，环烷基，烯基，炔基和芳基; 每个R 3独立地选自H和C 1 -C 6烷基; 每个R 4独立地选自H，烷基，烯基，炔基，环烷基，环烯基和芳基; 每个R 5独立地选自H，O-，OH，NH 2和Cl; 并且每个R 6独立地选自烷基，烯基，炔基，环烷基，环烯基和芳基。

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