-
公开(公告)号：WO2004015130A3
公开(公告)日：2004-10-14
申请号：PCT/US0325001
申请日：2003-08-07
申请人： EXELIXIS , SQUIBB BRISTOL MYERS CO , MANNE VEERASWAMY , LYNCH MARK , ROSS-MACDONALD PETRA B , STOUCH TERRY , LAING NAOMI , CARROLL PAMELA , FITZGERALD KEVIN , COSTA MICHAEL R , MAXWELL MARK E , KINDT RACHEL M , LACKNER MARK R , HUNG TAK , O'BRIEN CAROL L , ZHANG HAI GUANG , BROWN KATHERINE S , LEE JAE MOON , LOMBARDO LOUIS J
发明人： MANNE VEERASWAMY , LYNCH MARK , ROSS-MACDONALD PETRA B , STOUCH TERRY , LAING NAOMI , CARROLL PAMELA , FITZGERALD KEVIN , COSTA MICHAEL R , MAXWELL MARK E , KINDT RACHEL M , LACKNER MARK R , HUNG TAK , O'BRIEN CAROL L , ZHANG HAI GUANG , BROWN KATHERINE S , LEE JAE MOON , LOMBARDO LOUIS J
CPC分类号： C07K14/4747 , A61K31/00 , C12N9/1085 , C12N15/1137 , C12N2310/14 , C12Y205/0106 , G01N33/5011 , G01N2510/00 , G01N2800/52
摘要： The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein. The present invention further provides a 3-dimensional structure of RabGGT, and methods of use of the structure to identify compounds that modulate RabGGT activity.
摘要翻译： 本发明提供诱导细胞凋亡的方法，所述方法通常涉及使细胞与降低RabGGT的水平和/或活性的试剂接触。 本发明还提供了治疗与个体中不需要的细胞增殖有关的病症的方法，所述方法通常涉及向个体施用降低RabGGT的水平和/或活性的药剂。 本发明还提供减少细胞凋亡的方法，所述方法通常涉及增加细胞中RabGGT的水平和/或活性。 本发明还提供了治疗与过度凋亡相关的疾病的方法。 本发明还提供了用于鉴定可用本发明的方法治疗的细胞的方法。 本发明还提供了调节RabGGT和RabGGT相互作用蛋白之间的结合事件的方法。 本发明还提供了RabGGT的3维结构，以及使用该结构鉴定调节RabGGT活性的化合物的方法。
-
公开(公告)号：WO2004024881A3
公开(公告)日：2004-07-01
申请号：PCT/US0328902
申请日：2003-09-15
申请人： EXELIXIS INC , COSTA MICHAEL , MAXWELL MARK E , LACKNER MARK R , HUNG TAK , O'BRIEN CAROL L , LICKTEIG KIM
发明人： COSTA MICHAEL , MAXWELL MARK E , LACKNER MARK R , HUNG TAK , O'BRIEN CAROL L , LICKTEIG KIM
IPC分类号： C07K14/47 , G01N33/50 , A61K39/395 , A61K38/00 , A61K39/00 , A61K48/00 , G01N33/53 , G01N33/566
CPC分类号： G01N33/5011 , C07K14/4702 , G01N2510/00
摘要： Human LDLR genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LDLR are provided.
摘要翻译： 人类LDLR基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶标。 提供了鉴定p53调节剂的方法，包括筛选调节LDLR活性的试剂。
-
公开(公告)号：WO2004024881A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028902
申请日：2003-09-15
申请人： EXELIXIS, INC. , COSTA, Michael , MAXWELL, Mark, E. , LACKNER, Mark, R. , HUNG, Tak , O'BRIEN, Carol, L. , LICKTEIG, Kim
发明人： COSTA, Michael , MAXWELL, Mark, E. , LACKNER, Mark, R. , HUNG, Tak , O'BRIEN, Carol, L. , LICKTEIG, Kim
IPC分类号： C12N
CPC分类号： G01N33/5011 , C07K14/4702 , G01N2510/00
摘要： Human LDLR genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LDLR are provided.
摘要翻译： 人LDLR基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节LDLR活性的试剂。
-
公开(公告)号：WO2004004766A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021378
申请日：2003-07-09
申请人： EXELIXIS, INC. , COSTA, Michael, A. , MAXWELL, Mark, E. , LACKNER, Mark, R. , HUNG, Tak , O'BRIEN, Carol, L. , JIN, Yisheng , NICOLL, Monique , HAI, Bing , ZHANG, HaiGuang , LICKTEIG, Kim , AMUNDSEN, Craig, D.
发明人： COSTA, Michael, A. , MAXWELL, Mark, E. , LACKNER, Mark, R. , HUNG, Tak , O'BRIEN, Carol, L. , JIN, Yisheng , NICOLL, Monique , HAI, Bing , ZHANG, HaiGuang , LICKTEIG, Kim , AMUNDSEN, Craig, D.
IPC分类号： A61K39/395
CPC分类号： C12N15/111 , A61K31/00 , C07K14/4702 , C12N2310/14 , C12N2320/12 , G01N33/5011 , G01N2510/00
摘要： Human MP53 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MP53 are provided.
摘要翻译： 人MP53基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MP53活性的试剂。
-
公开(公告)号：WO2006009950A2
公开(公告)日：2006-01-26
申请号：PCT/US2005/021653
申请日：2005-06-20
申请人： EXELIXIS, INC. , MAXWELL, Mark, E. , OLLMANN, Michael, Martin , HEUER, Timothy, S. , HITZ, Benjamin, C.
IPC分类号： C12N9/12
CPC分类号： G01N33/573 , C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , G01N33/57438 , G01N33/6872 , G01N2500/00 , Y10T436/143333
摘要： Human ALDO genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of ALDO are provided.
摘要翻译： 人ALDO基因被鉴定为IGF途径的调节剂，因此是与缺陷IGF功能相关的病症的治疗靶标。 提供了鉴定IGF调节剂的方法，包括筛选调节ALDO活性的试剂。
-
公开(公告)号：WO2004015130A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/025001
申请日：2003-08-07
申请人： EXELIXIS , BRISTOL-MYERS SQUIBB COMPANY , MANNE, Veeraswamy , LYNCH, Mark , ROSS-MACDONALD, Petra B. , STOUCH, Terry , LANGE, Naomi , CARROLL, Pamela , FITZGERALD, Kevin , COSTA, Michael, R. , MAXWELL, Mark E. , KINDT, Rachel M. , LACKNER, Mark R. , HUNG, Tak , O'BRIEN, Carol, L. , ZHANG, Hai Guang , BROWN, Katherine, S. , LEE, Jae Moon , LOMBARDO, Louis J.
发明人： MANNE, Veeraswamy , LYNCH, Mark , ROSS-MACDONALD, Petra B. , STOUCH, Terry , LANGE, Naomi , CARROLL, Pamela , FITZGERALD, Kevin , COSTA, Michael, R. , MAXWELL, Mark E. , KINDT, Rachel M. , LACKNER, Mark R. , HUNG, Tak , O'BRIEN, Carol, L. , ZHANG, Hai Guang , BROWN, Katherine, S. , LEE, Jae Moon , LOMBARDO, Louis J.
IPC分类号： C12Q
CPC分类号： C07K14/4747 , A61K31/00 , C12N9/1085 , C12N15/1137 , C12N2310/14 , C12Y205/0106 , G01N33/5011 , G01N2510/00 , G01N2800/52
摘要： The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein. The present invention further provides a 3-dimensional structure of RabGGT, and methods of use of the structure to identify compounds that modulate RabGGT activity.
摘要翻译： 本发明提供了诱导细胞凋亡的方法，所述方法通常包括使细胞与降低RabGGT水平和/或活性的试剂接触。 本发明进一步提供了用于治疗个体中与有害细胞增殖有关的病症的方法，所述方法通常包括向个体施用降低RabGGT水平和/或活性的药剂。 本发明还提供了减少细胞凋亡的方法，所述方法通常涉及提高细胞中RabGGT的水平和/或活性。 本发明还提供了治疗与过度凋亡相关的疾病的方法。 本发明进一步提供了用于鉴定可以用本发明的方法治疗的细胞的方法。 本发明还提供了用于调节RabGGT和RabGGT相互作用蛋白之间的结合事件的方法。 本发明进一步提供了RabGGT的三维结构，以及使用该结构鉴定调节RabGGT活性的化合物的方法。
-
公开(公告)号：WO2006009962A2
公开(公告)日：2006-01-26
申请号：PCT/US2005021682
申请日：2005-06-20
申请人： EXELIXIS INC , MAXWELL MARK E , OLLMANN MICHAEL MARTIN , HEUER TIMOTHY S , BJERKE LYNN MARGARET
IPC分类号： C12Q1/68
CPC分类号： G01N33/573 , C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , G01N33/57438 , G01N33/6872 , G01N2500/00 , Y10T436/143333
摘要： Human ACAC genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of ACAC are provided.
摘要翻译： 人ACAC基因被鉴定为IGF途径的调节剂，因此是与缺陷性IGF功能相关的病症的治疗靶点。 提供了用于鉴定IGF调节剂的方法，包括筛选调节ACAC活性的试剂。
-
公开(公告)号：WO2006009947A3
公开(公告)日：2006-01-26
申请号：PCT/US2005/021650
申请日：2005-06-20
申请人： EXELIXIS, INC. , MAXWELL, Mark, E. , OLLMANN, Michael, Martin , BJERKE, Lynn, Margaret , HITZ, Benjamin, C. , ZHANG, Haiguang , LICKTEIG, Kim
发明人： MAXWELL, Mark, E. , OLLMANN, Michael, Martin , BJERKE, Lynn, Margaret , HITZ, Benjamin, C. , ZHANG, Haiguang , LICKTEIG, Kim
摘要： Human MIGF genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of MIGF are provided.
-
公开(公告)号：WO2006009947A2
公开(公告)日：2006-01-26
申请号：PCT/US2005021650
申请日：2005-06-20
申请人： EXELIXIS INC , MAXWELL MARK E , OLLMANN MICHAEL MARTIN , BJERKE LYNN MARGARET , HITZ BENJAMIN C , ZHANG HAIGUANG , LICKTEIG KIM
发明人： MAXWELL MARK E , OLLMANN MICHAEL MARTIN , BJERKE LYNN MARGARET , HITZ BENJAMIN C , ZHANG HAIGUANG , LICKTEIG KIM
IPC分类号： C12Q1/68
CPC分类号： G01N33/573 , C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , G01N33/57438 , G01N33/6872 , G01N2500/00 , Y10T436/143333
摘要： Human MIGF genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of MIGF are provided.
摘要翻译： 人MIGF基因被鉴定为IGF途径的调节剂，因此是与缺陷型IGF功能相关的病症的治疗靶点。 提供了用于鉴定IGF调节剂的方法，包括筛选调节MIGF活性的试剂。
-
公开(公告)号：WO2004048537A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/037544
申请日：2003-11-24
申请人： EXELIXIS, INC. , COSTA, Michael, R. , MAXWELL, Mark, E. , LACKNER, Mark, R. , HUNG, Tak , O'BRIEN, Carol, L. , LICKTEIG, Kim
发明人： COSTA, Michael, R. , MAXWELL, Mark, E. , LACKNER, Mark, R. , HUNG, Tak , O'BRIEN, Carol, L. , LICKTEIG, Kim
IPC分类号： C12N
CPC分类号： C07K14/705
摘要： Human LAMP genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LAMP are provided.
摘要翻译： 人LAMP基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节LAMP活性的试剂。
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.018 秒)
