公开(公告)号：WO2006014626A3

公开(公告)日：2006-10-05

申请号：PCT/US2005025549

申请日：2005-07-19

Applicant: CELATOR PHARMACEUTICALS INC ,  UNIV PRINCETON ,  MAYER LAWRENCE D ,  PRUD HOMME ROBERT K ,  ALLEN CHRISTINE J ,  SAAD WALID S

Inventor： MAYER LAWRENCE D ,  PRUD HOMME ROBERT K ,  ALLEN CHRISTINE J ,  SAAD WALID S

IPC: A61K31/74 ,  A61K31/77

CPC classification number: A61K47/482 ,  A61K8/85 ,  A61K9/5153 ,  A61K45/06 ,  A61K47/22 ,  A61K47/48107 ,  A61K47/48192 ,  A61K47/551 ,  A61K47/552 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6935 ,  A61K2800/57 ,  A61Q17/04 ,  B82Y5/00

Abstract: Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.

Abstract translation: 通过两亲性共聚物稳定并且包含至少一个与疏水部分结合的活性物质的颗粒构建物在体外和体内环境中均提供活性物质的持续释放。

公开(公告)号：WO2006014626A2

公开(公告)日：2006-02-09

申请号：PCT/US2005/025549

申请日：2005-07-19

Applicant: CELATOR PHARMACEUTICALS, INC. ,  THE TRUSTEES OF PRINCETON UNIVERSITY ,  MAYER, Lawrence, D. ,  PRUD'HOMME, Robert, K. ,  ALLEN, Christine, J. ,  SAAD, Walid, S.

Inventor： MAYER, Lawrence, D. ,  PRUD'HOMME, Robert, K. ,  ALLEN, Christine, J. ,  SAAD, Walid, S.

IPC: A61K9/14

CPC classification number: A61K47/482 ,  A61K8/85 ,  A61K9/5153 ,  A61K45/06 ,  A61K47/22 ,  A61K47/48107 ,  A61K47/48192 ,  A61K47/551 ,  A61K47/552 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6935 ,  A61K2800/57 ,  A61Q17/04 ,  B82Y5/00

Abstract: Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.

Abstract translation: 通过两亲性共聚物稳定并且包含至少一种与疏水部分偶联的活性物质的微粒构建体在体内和体外都提供了活性物质的持续释放， I>的环境。

公开(公告)号：WO03041681A3

公开(公告)日：2003-09-18

申请号：PCT/CA0201726

申请日：2002-11-13

Applicant: CELATOR TECHNOLOGIES INC ,  WEBB MURRAY ,  TARDI PAUL ,  MAYER LAWRENCE D ,  ICKENSTEIN LUDGER M

Inventor： WEBB MURRAY ,  TARDI PAUL ,  MAYER LAWRENCE D ,  ICKENSTEIN LUDGER M

IPC: A61K9/127 ,  A61K9/19 ,  A61K31/704 ,  A61K31/7072 ,  A61K33/24 ,  A61K9/00

CPC classification number: A61K9/1271 ,  A61K9/127 ,  A61K9/1278

Abstract: Liposomes that contain at least 10 mol % of a negatively charged lipid coupled to an non-zwitterionic moiety are stable in the blood. Liposomes containing at least 1 mol % of such lipids may be frozen safely.

Abstract translation: 含有至少10mol％与非两性离子部分偶联的负电荷脂质的脂质体在血液中是稳定的。 含有至少1摩尔％这种脂质的脂质体可以安全冷冻。

公开(公告)号：WO2003041681A2

公开(公告)日：2003-05-22

申请号：PCT/CA2002/001726

申请日：2002-11-13

Applicant: CELATOR TECHNOLOGIES, INC. ,  WEBB, Murray ,  TARDI, Paul ,  MAYER, Lawrence, D. ,  ICKENSTEIN, Ludger, M.

Inventor： WEBB, Murray ,  TARDI, Paul ,  MAYER, Lawrence, D. ,  ICKENSTEIN, Ludger, M.

IPC: A61K9/00

CPC classification number: A61K9/1271 ,  A61K9/127 ,  A61K9/1278

Abstract: Liposomes that contain at least 10 mol % of a negatively charged lipid coupled to an non-zwitterionic moiety are stable in the blood. Liposomes containing at least 1 mol % of such lipids may be frozen safely.

Abstract translation: 含有至少10摩尔％的与非两性离子部分偶联的带负电荷的脂质的脂质体在血液中是稳定的。 含有至少1摩尔％的这种脂质的脂质体可以安全地冷冻。

公开(公告)号：WO0141738A3

公开(公告)日：2001-11-29

申请号：PCT/CA0001494

申请日：2000-12-11

Applicant: CELATOR TECHNOLOGIES INC ,  MAYER LAWRENCE D ,  CHIU GIGI ,  BALLY MARCEL B

Inventor： MAYER LAWRENCE D ,  CHIU GIGI ,  BALLY MARCEL B

IPC: A61K9/127

CPC classification number: A61K9/1271

Abstract: The liposomes of the invention have a reactive surface that demonstrates reduced interaction with macromolecules and increased blood circulation time. The reactive surface may comprise phosphatidylserine. The liposomes are protected by the presence of high levels of a hydrophilic polymer conjugated to a lipid. The invention further provides means for adjusting the appropriate ratio of hydrophilic polymer to a reactive lipid by a) determining the reactivity of the lipid; b) determining the time required for the carrier to reach its desired target location; c) determining the affinity of desired interactions with the reactive surface; and d) incorporating in the liposome or lipid carrier the amount of polyethylene glycol required to protect the reactive surface.

Abstract translation: 本发明的脂质体具有反应性表面，其表现出与大分子减少的相互作用和增加的血液循环时间。 反应性表面可以包含磷脂酰丝氨酸。 通过存在高水平的与脂质缀合的亲水性聚合物来保护脂质体。 本发明还提供了通过以下方法来调节亲水性聚合物与活性脂质的适当比例：a）确定脂质的反应性; b）确定承运人达到其所需目标位置所需的时间; c）确定与反应性表面的所需相互作用的亲和力; 和d）在脂质体或脂质载体中掺入保护反应性表面所需的聚乙二醇的量。