公开(公告)号：WO2008051285A2

公开(公告)日：2008-05-02

申请号：PCT/US2007/008249

申请日：2007-03-30

Applicant: MEDICAL SERVICE CONSULTATION INTERNATIONAL, LLC ,  HOOPER, Dennis, G.

Inventor： HOOPER, Dennis, G.

IPC: C07H19/00 ,  C12Q1/68

CPC classification number: G01N33/56961 ,  C12Q1/6895 ,  C12Q2600/142 ,  G01N2469/10 ,  G01N2800/26 ,  G01N2800/50

Abstract: The invention relates to a method of identifying a specific fungal species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the fungal species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically identify the fungal species, and specifically identifying the fungal species. The invention also relates to a method of identifying a mycotoxin in patient tissue or body fluid. The method comprises the steps of extracting and recovering the mycotoxin from the patient tissue or body fluid, contacting the mycotoxin with an antibody directed against the mycotoxin, and identifying the myocotoxin. Both of these methods can be used to determine if a patient is at risk for or has developed a disease state related to a fungal infection, and to develop an effective treatment regimen for the patient.

Abstract translation: 本发明涉及鉴定患者组织或体液中的特定真菌种类的方法。 该方法包括从患者组织或体液中提取和回收真菌种类的DNA，扩增DNA，将探针与DNA杂交以特异性鉴定真菌物种，并具体鉴定真菌物种。 本发明还涉及鉴定患者组织或体液中霉菌毒素的方法。 该方法包括以下步骤：从患者组织或体液中提取和回收霉菌毒素，使真菌毒素与针对真菌毒素的抗体接触，并鉴定肌球蛋白。 这两种方法都可用于确定患者是否处于与真菌感染相关的疾病状态或已经发展的风险，并为患者开发有效的治疗方案。

公开(公告)号：WO2017049120A1

公开(公告)日：2017-03-23

申请号：PCT/US2016/052189

申请日：2016-09-16

Applicant: MEDICAL SERVICE CONSULTATION INTERNATIONAL LLC

Inventor： HOOPER, Dennis G.

IPC: C12Q1/02 ,  C12Q1/04 ,  G01N33/569

CPC classification number: G01N33/56961 ,  G01N2333/37 ,  G01N2333/385

Abstract: This invention relates to methods and compositions for detecting, quantifying, or identifying mycotoxins. More particularly, the invention relates to methods and compositions for detecting, quantifying, or identifying a gliotoxin, or a derivative thereof, a mycotoxin of a Penicillium species, or a mycotoxin of a Chaetomium species, in the tissues or body fluid samples of patients.

Abstract translation: 本发明涉及用于检测，定量或鉴定真菌毒素的方法和组合物。 更具体地说，本发明涉及在患者的组织或体液样品中检测，定量或鉴定青霉属物质或毛壳菌属的真菌毒素的霉菌毒素或其衍生物的方法和组合物。