公开(公告)号：WO2013040494A1

公开(公告)日：2013-03-21

申请号：PCT/US2012/055627

申请日：2012-09-14

Applicant: UNIVERSITY OF FLORIDA ,  DENNIS, Donn, M. ,  MELKER, Richard, J.

Inventor： DENNIS, Donn, M. ,  MELKER, Richard, J.

IPC: A61J3/07 ,  A61K47/10 ,  A61K47/08 ,  A61K49/00 ,  A61B5/083 ,  A61B5/08 ,  A61K9/48

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/083 ,  A61B5/4833 ,  A61B5/4839 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/0095 ,  A61K9/2013 ,  A61K9/4858 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K49/00 ,  G01N2033/4975 ,  Y10T436/13

Abstract: Solid Oral Dosage Forms (SODFs) comprising Self Monitoring and Reporting Therapeutics (SMART™) adherence technology are provided which require no or minimal modification of clinical trial materials (CTMs) or marketed drug while providing tamper resistant (literally foolproof) measurement of adherence that is highly accurate and without altering the chemical, manufacturing, and controls (CMC) of the CTM or marketed drug.

Abstract translation: 提供了包括自我监测和报告治疗（SMART TM））粘附技术的固体口服剂型（SODF），其不需要或仅对临床试验材料（CTM）或市售药物进行最小的修改，同时提供抗篡改（字面上的笨重）测量的依从性 这是高度准确的，而不改变CTM或市售药物的化学，制造和控制（CMC）。

公开(公告)号：WO2008033978A3

公开(公告)日：2008-12-11

申请号：PCT/US2007078362

申请日：2007-09-13

Applicant: UNIV FLORIDA ,  ROSS EDWARD ALLAN ,  MELKER RICHARD J

Inventor： ROSS EDWARD ALLAN ,  MELKER RICHARD J

IPC: F03G7/04 ,  F03G7/06 ,  F25D23/12

CPC classification number: A61M1/34 ,  A61B5/02007 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/6819 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3609 ,  A61M2205/3306 ,  A61M2205/50

Abstract: Disclosed herein are methods, systems and devices to monitor vascular volume status during renal replacement therapy utilizing at least one oximetry/photoplethysmography sensor. The methods, systems and devices provide an alternative to conventional vascular volume monitoring methods during renal replacement therapy while enabling reliable, non-invasive, and automatic monitoring of vascular volume to avert patient hypotension. The methods, systems and devices may be employed in the context of both inpatient and outpatient dialysis facilities and may also be incorporated into conventional hemodialysis and hemo filtration techniques and equipment.

Abstract translation: 本文公开了利用至少一个血氧定量/光电容积脉搏波传感器来监测肾替代治疗期间的血管容量状态的方法，系统和装置。 该方法，系统和装置提供了肾替代疗法期间常规血管容量监测方法的替代方案，同时实现血管容量的可靠，非侵入性和自动监测以防止患者血压过低。 该方法，系统和装置可以用于住院和门诊透析设施的背景下，并且也可以结合到常规的血液透析和血液过滤技术和设备中。

公开(公告)号：WO2008021617A8

公开(公告)日：2008-04-24

申请号：PCT/US2007071469

申请日：2007-06-18

Applicant: UNIV FLORIDA ,  MELKER RICHARD J ,  BJORAKER DAVID G ,  DENNIS DONN MICHAEL ,  STEWART JON DALE ,  BATICH CHRISTOPHER D ,  BOOTH MATTHEW M ,  HORN JOHN FREDERICK ,  YOUNGBLOOD RONALD ,  MOREY TIMOTHY E

Inventor： MELKER RICHARD J ,  BJORAKER DAVID G ,  DENNIS DONN MICHAEL ,  STEWART JON DALE ,  BATICH CHRISTOPHER D ,  BOOTH MATTHEW M ,  HORN JOHN FREDERICK ,  YOUNGBLOOD RONALD ,  MOREY TIMOTHY E

IPC: A61B5/00 ,  A61B5/083

CPC classification number: A61B5/083 ,  A61B5/1486 ,  A61B5/413 ,  Y10T436/144444

Abstract: Systems and methods for analyzing glucose present m exhaled breath condensate (EBC). Electr

Abstract translation: 用于分析葡萄糖的系统和方法，用于呼出呼气浓缩物（EBC）。 ELECTR

公开(公告)号：WO2008020845A2

公开(公告)日：2008-02-21

申请号：PCT/US2006/031980

申请日：2006-08-15

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  MELKER, Richard, J. ,  EULIANO, Neil, R.

Inventor： MELKER, Richard, J. ,  EULIANO, Neil, R.

IPC: A61B5/1455 ,  A62B18/02 ,  G05D1/00 ,  G08B21/02

CPC classification number: A61B5/0295 ,  A61B5/02 ,  A61B5/02416 ,  A61B5/0261 ,  A61B5/14552 ,  A61B5/6803 ,  A61B5/6815 ,  A61B5/6817 ,  A61B5/6819 ,  A61B5/6838 ,  A61M16/0051 ,  A61M16/06 ,  A61M16/0627 ,  A61M16/0683 ,  A61M2230/205 ,  A61M2230/432

Abstract: Disclosed herein are methods and devices for delivering gas to a subject and obtaining plethysmograph readings from a subject. Specifically disclosed herein are masks and helmets which comprise one or more pulse oximeter probes associated therewith. The masks and helmets may be used in particular contexts, including, but not limited to, emergency responder personnel, pilots or subjects of medical attention.

Abstract translation: 本文公开了用于将气体输送至受试者并从受试者获得体积描记器读数的方法和装置。 本文具体公开了包含与其相关的一个或多个脉搏血氧计探头的面罩和头盔。 面罩和头盔可用于特定情况下，包括但不限于应急响应人员，飞行员或医疗关注对象。

公开(公告)号：WO2007089328A3

公开(公告)日：2007-12-13

申请号：PCT/US2006046660

申请日：2006-12-06

Applicant: UNIV FLORIDA ,  MELKER RICHARD J ,  DENNIS DONN MICHAEL ,  BJORAKER DAVID G ,  GOLD MARK S

Inventor： MELKER RICHARD J ,  DENNIS DONN MICHAEL ,  BJORAKER DAVID G ,  GOLD MARK S

IPC: G01N33/497

CPC classification number: A61M16/01 ,  A61B5/082 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/411 ,  A61B5/4821 ,  A61B5/7267 ,  A61M16/0051 ,  A61M16/026 ,  A61M16/0808 ,  A61M16/0841 ,  A61M16/1045 ,  A61M16/18 ,  A61M16/22 ,  A61M2016/0036 ,  A61M2016/1035 ,  A61M2202/0275 ,  A61M2202/0486 ,  A61M2205/18 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/52 ,  A61M2205/80 ,  A61M2230/43 ,  A61M2230/432 ,  A61M2230/435 ,  A61M2230/437 ,  G01N33/497

Abstract: The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as "artificial" or "electronic" noses or tongues, to non-invasively monitor endogenous compound level s in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.

Abstract translation: 本发明包括用于通过在患者呼气时检测诸如气味的标记物来监测血液中内源性化合物浓度的系统和方法，其中这样的标记物是内源性化合物本身或来自内源性化合物的结果。 就嗅觉标记而​​言，本发明优选利用电子传感器技术，例如被称为“人造”或“电子”鼻或舌的商业装置，以无创地监测血液中的内源性化合物水平。 本发明进一步包括能够追踪血液中（远程或邻近位置）的内源性化合物浓度并且提供关于患者中出现的或有害的病症的必要警报的报告系统。

公开(公告)号：WO2006116469A3

公开(公告)日：2007-07-05

申请号：PCT/US2006015763

申请日：2006-04-25

Applicant: UNIV FLORIDA ,  MELKER RICHARD J ,  EULIANO NEIL R

Inventor： MELKER RICHARD J ,  EULIANO NEIL R

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/08

CPC classification number: A61B5/4884 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/08 ,  A61B5/085 ,  A61B5/1073 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/411 ,  A61B5/4836 ,  A61B2560/0223 ,  A61M16/0069 ,  A61M16/1005 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/502 ,  A61M2230/205

Abstract: Disclosed herein are apparatuses and methods to monitor respiration and abnormal respiration events utilizing plethysmography. The apparatuses and methods provide an alternative to conventional respiration monitoring methods while enabling accurate yet minimally interruptive and invasive monitoring of respiration. The methods and apparatuses may be employed in the context of sleep studies to determine respiratory related sleep disorders.

Abstract translation: 本文公开了利用体积描记法监测呼吸和异常呼吸事件的装置和方法。 这些装置和方法提供了常规呼吸监测方法的替代方案，同时能够进行精确的，最小的中断和有创性的呼吸监测。 可以在睡眠研究的上下文中使用方法和装置来确定呼吸相关的睡眠障碍。

公开(公告)号：WO2006121590A1

公开(公告)日：2006-11-16

申请号：PCT/US2006/014895

申请日：2006-04-21

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  BJORAKER, David, G. ,  MELKER, Richard, J. ,  DENNIS, Donn, Michael ,  MARTIN, Charles, R. ,  STEWART, Jon, D.

Inventor： BJORAKER, David, G. ,  MELKER, Richard, J. ,  DENNIS, Donn, Michael ,  MARTIN, Charles, R. ,  STEWART, Jon, D.

IPC: G01N33/49

CPC classification number: G01N33/54373 ,  G01N33/54346 ,  G01N33/86 ,  Y02A50/58

Abstract: Systems and methods for the diagnostic analysis of blood samples. The present invention uses sensor technology useful in the analysis of headspace sample from blood to provide an efficient and accurate means for identifying the presence of a volatile marker associated with hematological diseases or conditions. In a preferred embodiment, the sensor technology of the present invention includes detecting means such as RNA oligonucleotide chains or aptamers.

Abstract translation: 血液样本诊断分析的系统和方法。 本发明使用用于分析来自血液的顶空样品的传感器技术，以提供用于鉴定与血液疾病或病症相关的挥发性标记的存在的有效且准确的方法。 在优选实施方案中，本发明的传感器技术包括检测手段，如RNA寡核苷酸链或适体。

公开(公告)号：WO2004000400A2

公开(公告)日：2003-12-31

申请号：PCT/US2003/015700

申请日：2003-05-16

Applicant: UNIVERSITY OF FLORIDA ,  MELKER, Richard, J.

Inventor： MELKER, Richard, J.

IPC: A61M16/01

CPC classification number: A61B5/4821 ,  A61B5/08 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/7267 ,  A61M5/142 ,  A61M5/1723 ,  A61M16/0051 ,  A61M16/01 ,  A61M16/026 ,  A61M2016/1035 ,  A61M2230/437

Abstract: A method and system is provided for monitoring delivery of anesthesia (inhalational and intravenous) and detecting the depth of anesthesia wherein at least one anesthetic agent is absorbed in a patient's bloodstream during the administration of anesthesia, which includes sampling inspired and expired gas; analyzing the gas for concentration of at least one substance indicative of the anesthetic agent using sensor technology such as free (unmetabolized) anesthetic agent or its metabolites; determining the effect of the agent based on that concentration; and determining depth of anesthesia based thereon.

Abstract translation: 提供了一种用于监测麻醉（吸入和静脉内）输送和检测麻醉深度的方法和系统，其中在麻醉施用期间至少一种麻醉剂被吸收在患者的血液中，其包括取样启动和呼气。 使用诸如游离（未代谢的）麻醉剂或其代谢物的传感器技术来分析用于浓度指示麻醉剂的至少一种物质的气体; 基于该浓度确定试剂的作用; 并基于此确定麻醉深度。

公开(公告)号：WO2012024106A2

公开(公告)日：2012-02-23

申请号：PCT/US2011/046943

申请日：2011-08-08

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  XHALE, INC. ,  MELKER, Richard, J. ,  DENNIS, Donn, M. ,  MELKER, Jeremy ,  RICE, Mark ,  HURLEY, Robert ,  GOLD, Mark ,  ALLEN, Richard

Inventor： MELKER, Richard, J. ,  DENNIS, Donn, M. ,  MELKER, Jeremy ,  RICE, Mark ,  HURLEY, Robert ,  GOLD, Mark ,  ALLEN, Richard

IPC: A61B5/02 ,  A61B5/0205 ,  A61B5/087 ,  A61B5/145

CPC classification number: A61M5/1723 ,  A61B5/002 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/0836 ,  A61B5/14551 ,  A61B5/4818 ,  A61B5/4821 ,  A61B5/4839 ,  A61B5/6803 ,  A61B5/7246 ,  A61M16/00 ,  A61M16/0051 ,  A61M16/026 ,  A61M16/0666 ,  A61M16/0677 ,  A61M16/10 ,  A61M16/161 ,  A61M2005/16863 ,  A61M2016/0027 ,  A61M2205/3368 ,  A61M2230/04 ,  A61M2230/205 ,  A61M2230/432 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3468

Abstract: A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.

Abstract translation: 用于安全施用，减少或停止施用至少一种药物，液体或两者的监测和控制系统，设备和方法，其包括至少一个中央源位点（CSS）光电容积描记术（PPG） ）传感器，其耦合到用于控制至少一种药物，流体或两者的递送的装置。

公开(公告)号：WO2007103474A2

公开(公告)日：2007-09-13

申请号：PCT/US2007/005890

申请日：2007-03-07

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  DENNIS, Donn, Michael ,  MELKER, Richard, J. ,  BOOTH, Matthew, M. ,  PROKAI, Laszlo

Inventor： DENNIS, Donn, Michael ,  MELKER, Richard, J. ,  BOOTH, Matthew, M. ,  PROKAI, Laszlo

IPC: A61K49/00 ,  G01N33/497

CPC classification number: A61B5/082 ,  A61B5/0022 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/746 ,  A61B2562/028 ,  A61K49/0002 ,  A61K49/0004

Abstract: The present invention provides novel methods for monitoring subject adherence in taking prescribed drugs by detecting markers in exhaled breath after a subject takes the prescribed drug. In particular, the present invention provides novel methods for making additives that are combined with the drug(s). Upon biological breakdown of the drug/additive formulation in a subject's body, markers resulting directly from the biological breakdown of the additives are detected in exhaled breath using sensor technology. In certain embodiments of the invention, the drug adherence monitoring systems and methods include a reporting system capable of tracking subject compliance (either remotely or proximately) and of providing necessary alerts to the subject, caregiver, healthcare provider, and the like.

Abstract translation: 本发明提供了在受试者服用规定的药物后通过检测呼出呼吸中的标记物来监测受试者依从性的新方法。 特别地，本发明提供了制备与药物组合的添加剂的新方法。 在受试者的身体中药物/添加剂制剂的生物分解时，直接由添加剂的生物分解产生的标记物使用传感器技术在呼气中检测。 在本发明的某些实施方案中，药物依从性监测系统和方法包括能够跟踪受试者遵从性（远程或近似）并向对象，看护者，医疗保健提供者等提供必要的警报的报告系统。