公开(公告)号：WO2007054128A1

公开(公告)日：2007-05-18

申请号：PCT/EP2005/055948

申请日：2005-11-14

申请人： DOMINION PHARMAKINE S.L. ,  UNIVERSIDAD DEL PAIS VASCO ,  GALLOT ESCOBAL, Natalia ,  VIDAL VANACLOCHA, Fernando ,  COSSÍO MORA, Fernando Pedro ,  MENDOZA ARTECHE, Miren Lorea ,  ZUBIA OLASCOAGA, Aizpea ,  VALCÁRCEL CUESTA, María ,  VARA SALAZAR, Yosu Ion ,  SOLAUN AGUIRRE, Miren Sorne ,  LÓPEZ PESTAÑA, José Javier ,  SAN SEBASTIAN LARZABAL, Eider

发明人： COSSÍO MORA, Fernando Pedro ,  MENDOZA ARTECHE, Miren Lorea ,  ZUBIA OLASCOAGA, Aizpea ,  VALCÁRCEL CUESTA, María ,  VARA SALAZAR, Yosu Ion ,  SOLAUN AGUIRRE, Miren Sorne ,  LÓPEZ PESTAÑA, José Javier ,  SAN SEBASTIAN LARZABAL, Eider

IPC分类号： C07D207/16 ,  C07D409/04 ,  C07D401/04 ,  C07D405/04 ,  A61K31/401 ,  A61P35/04

CPC分类号： C07D409/04 ,  C07D207/16 ,  C07D401/04 ,  C07D405/04

摘要： The invention relates to the treatment of disorders or diseases mediated by LFA-1/ ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.

摘要翻译： 本发明涉及由LFA-1 / ICAM-1分子相互作用介导的疾病或疾病的治疗。 这是基于能够抑制所述相互作用的新型化合物的使用，更具体地说，涉及含有这些化合物的药物组合物。

公开(公告)号：WO2006108864A3

公开(公告)日：2007-03-29

申请号：PCT/EP2006061565

申请日：2006-04-12

申请人： DOMINION PHARMAKINE S L ,  UNIV PAIS VASCO ,  COSSIO FERNANDO PEDRO ,  ALDABA AREVALO ENEKO ,  VARA SALAZAR YOSU ION ,  ZUBIA OLASCOAGA AIZPEA ,  VIVANCO AMATO SILVIA ,  MENDOZA ARTECHE MIREN LOREA ,  SALADO POGONZA CLARISA ,  GALLOT ESCOBAL NATALIA ,  VIDAL VANACLOCHA FERNANDO

发明人： COSSIO FERNANDO PEDRO ,  ALDABA AREVALO ENEKO ,  VARA SALAZAR YOSU ION ,  ZUBIA OLASCOAGA AIZPEA ,  VIVANCO AMATO SILVIA ,  MENDOZA ARTECHE MIREN LOREA ,  SALADO POGONZA CLARISA ,  GALLOT ESCOBAL NATALIA ,  VIDAL VANACLOCHA FERNANDO

IPC分类号： C07C251/24 ,  A61K31/13 ,  A61K31/40 ,  A61K31/404 ,  A61P35/00 ,  C07D207/40 ,  C07D207/42 ,  C07D209/12

CPC分类号： C07D207/416 ,  C07C251/24 ,  C07D207/42 ,  C07D209/12

摘要： This invention is related to new nitrogenated trans-stilbene analog compounds, more specifically, imine, pyrrol and Índole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cáncer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.

摘要翻译： 本发明涉及新的氮化反式二烯烃类似物，更具体地涉及亚胺，吡咯和铱醇衍生物，其制备方法和用作药物组合物，用于治疗和/或化学预防哺乳动物疾病如cer cer，纤维硬化 和急性/慢性炎症，移植物抗宿主反应，中风和心脏病发作中缺血再灌注组织损伤，神经变性和器官移植期间，其病理和病理生理机制依赖于或由不希望的氧化应激，血管生成和增殖 响应。

公开(公告)号：WO2006108864A2

公开(公告)日：2006-10-19

申请号：PCT/EP2006/061565

申请日：2006-04-12

申请人： Dominion Pharmakine S.L. ,  Universidad del País Vasco ,  COSSÍO, Fernando Pedro ,  ALDABA ARÉVALO, Eneko ,  VARA SALAZAR, Yosu Ion ,  ZUBIA OLASCOAGA, Aizpea ,  VIVANCO AMATO, Silvia ,  MENDOZA ARTECHE, Miren Lorea ,  SALADO POGONZA, Clarisa ,  GALLOT ESCOBAL, Natalia ,  VIDAL VANACLOCHA, Fernando

发明人： COSSÍO, Fernando Pedro ,  ALDABA ARÉVALO, Eneko ,  VARA SALAZAR, Yosu Ion ,  ZUBIA OLASCOAGA, Aizpea ,  VIVANCO AMATO, Silvia ,  MENDOZA ARTECHE, Miren Lorea ,  SALADO POGONZA, Clarisa ,  GALLOT ESCOBAL, Natalia ,  VIDAL VANACLOCHA, Fernando

CPC分类号： C07D207/416 ,  C07C251/24 ,  C07D207/42 ,  C07D209/12

摘要： This invention is related to new nitrogenated trans-stilbene analog compounds, more specifically, imine, pyrrol and Índole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cáncer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.

摘要翻译： 本发明涉及新的氮化反式 - 二苯乙烯类似物，更具体而言，涉及亚胺，吡咯和Índole衍生物，其制备方法和用作药物组合物，用于治疗和/或化学预处理那些哺乳动物疾病例如cáncer，fibrosclerosis 和急性/慢性炎症，移植物抗宿主反应，中风和心脏病发作中的缺血再灌注组织损伤，神经变性和器官移植期间，其病理和病理生理机制依赖于或由不希望的氧化应激，血管生成和增殖 响应。