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1.发明申请ALPHA-GALACTOSYLCERAMIDE ANALOGS, THEIR METHODS OF MANUFACTURE, INTERMEDIATE COMPOUNDS USEFUL IN THESE METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开ALPHA-GALACTOSYLCERAMIDE ANALOGS，他们的制造方法，这些方法中有用的中间体化合物和含有它们的药物组合物
公开(公告)号：WO2008047249A3
公开(公告)日：2010-02-11
申请号：PCT/IB2007004270
申请日：2007-10-18
Applicant: CENTRE NAT RECH SCIENT , UNIV PARIS DESCARTES , INST NAT SANTE RECH MED , DUBREUIL DIDIER , PIPELIER MURIEL , MICOUIN LAURENT , LECOURT THOMAS , LACONE VIVIEN , BONNEVILLE MARC , LEPENDU JACQUES , TURCOT-DUBOIS ANNE-LAURE
Inventor： DUBREUIL DIDIER , PIPELIER MURIEL , MICOUIN LAURENT , LECOURT THOMAS , LACONE VIVIEN , BONNEVILLE MARC , LEPENDU JACQUES , TURCOT-DUBOIS ANNE-LAURE
IPC: C07H15/06 , A61K31/7032 , C07H15/14
Abstract: The invention relates to a -galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the a-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize a-galactoceramide analogs by a mere metathesis reaction. The a -galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
Abstract translation: 本发明涉及β-半乳甘油酰胺类似物，其制备方法，可用于这些方法的中间体化合物。 它还涉及含有α-半乳糖苷类似物的药物组合物。 本发明的制造方法涉及使用不纯中间体化合物，其通过仅仅通过复分解反应合成α-半乳甘露聚糖类似物。 本发明的α-半乳糖苷类似物可用作药物组合物的活性成分，特别是在具有抗癌性质的药物组合物中。
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2.发明申请ALPHA-GALACTOCERAMIDE ANALOGS, THEIR METHODS OF MANUFACTURE, INTERMEDIATE COMPOUNDS USEFUL IN THESE METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开ALPHA-GALACTOCERAMIDE ANALOGS，他们的制造方法，这些方法中有用的中间体化合物和含有它们的药物组合物
公开(公告)号：WO2008047249A2
公开(公告)日：2008-04-24
申请号：PCT/IB2007004270
申请日：2007-10-18
Applicant: CENTRE NAT RECH SCIENT , UNIV PARIS DESCARTES , INST NAT SANTE RECH MED , DUBREUIL DIDIER , PIPELIER MURIEL , MICOUIN LAURENT , LECOURT THOMAS , LACONE VIVIEN , BONNEVILLE MARC , LEPENDU JACQUES , TURCOT-DUBOIS ANNE-LAURE
Inventor： DUBREUIL DIDIER , PIPELIER MURIEL , MICOUIN LAURENT , LECOURT THOMAS , LACONE VIVIEN , BONNEVILLE MARC , LEPENDU JACQUES , TURCOT-DUBOIS ANNE-LAURE
Abstract: The invention relates to a -galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the a-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize a-galactoceramide analogs by a mere metathesis reaction. The a -galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
Abstract translation: 本发明涉及β-半乳甘油酰胺类似物，其制备方法，可用于这些方法的中间体化合物。 它还涉及含有α-半乳糖苷类似物的药物组合物。 本发明的制造方法涉及使用不纯中间体化合物，其通过仅仅通过复分解反应合成α-半乳甘露聚糖类似物。 本发明的α-半乳糖苷类似物可用作药物组合物的活性成分，特别是在具有抗癌性质的药物组合物中。
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Patent Agency Ranking
公开(公告)号：WO2008047249A9
公开(公告)日：2008-04-24
申请号：PCT/IB2007/004270
申请日：2007-10-18
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PARIS DESCARTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , DUBREUIL, Didier , PIPELIER, Muriel , MICOUIN, Laurent , LECOURT, Thomas , LACONE, Vivien , BONNEVILLE, Marc , LEPENDU, Jacques , TURCOT-DUBOIS, Anne-Laure
Inventor： DUBREUIL, Didier , PIPELIER, Muriel , MICOUIN, Laurent , LECOURT, Thomas , LACONE, Vivien , BONNEVILLE, Marc , LEPENDU, Jacques , TURCOT-DUBOIS, Anne-Laure
IPC: C07H15/06 , C07H15/14 , A61K31/7032
Abstract: The invention relates to α -galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α -galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
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4.发明申请NOUVEAU PROCEDE DE PREPARATION D'ALPHA-GLYCOSYLCERAMIDES, NOUVEAUX DERIVES ALPHA-GLYCOSYLCERAMIDE ET LEURS APPLICATIONS. 审中-公开制备α-淀粉样蛋白的新方法，新型α-淀粉样蛋白衍生物及其用途
公开(公告)号：WO2003093287A1
公开(公告)日：2003-11-13
申请号：PCT/FR2003/001362
申请日：2003-04-30
Applicant: INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , VO-HOANG, Yen , BONIN, Martine , MICOUIN, Laurent , GACHELIN, Gabriel
Inventor： VO-HOANG, Yen , BONIN, Martine , MICOUIN, Laurent , GACHELIN, Gabriel
IPC: C07H15/10
CPC classification number: C07H15/10 , C07C271/22 , C07H15/04
Abstract: L'invention concerne de nouveaux dérivés alpha-glycosylcéramide répondant ô la formule générale (S-I), un procédé pour leur préparation ainsi que les compositions pharmaceutiques les comprenant et leurs utilisations.
Abstract translation: 本发明涉及通式（S-1）的新型α-糖基神经酰胺衍生物，其制备方法以及包含其的药物组合物及其应用。
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5.发明申请ALPHA-GALACTOSYLCERAMIDE ANALOGS, THEIR METHODS OF MANUFACTURE, INTERMEDIATE COMPOUNDS USEFUL IN THESE METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开ALPHA-GALACTOSYLCERAMIDE ANALOGS，他们的制造方法，这些方法中有用的中间体化合物和含有它们的药物组合物
公开(公告)号：WO2008047174A1
公开(公告)日：2008-04-24
申请号：PCT/IB2006/003929
申请日：2006-10-18
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE RENE DESCARTES (PARIS V) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , DUBREUIL, Didier , PIPELIER, Muriel , MICOUIN, Laurent , LECOURT, Thomas , LACONE, Vivien , BONNEVILLE, Marc , LEPENDU, Jacques , TURCOT-DUBOIS, Anne-Laure
Inventor： DUBREUIL, Didier , PIPELIER, Muriel , MICOUIN, Laurent , LECOURT, Thomas , LACONE, Vivien , BONNEVILLE, Marc , LEPENDU, Jacques , TURCOT-DUBOIS, Anne-Laure
IPC: C07H15/06 , C07H15/14 , A61K31/7032
Abstract: The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
Abstract translation: 本发明涉及α-半乳聚糖类似物，其制备方法，可用于这些方法的中间体化合物。 它还涉及含有α-半乳糖苷类似物的药物组合物。 本发明的制造方法涉及使用不纯中间体化合物，其通过仅仅通过复分解反应合成α-半乳甘露聚糖类似物。 本发明的α-半乳糖苷类似物可用作药物组合物的活性成分，特别是在具有抗癌性质的药物组合物中。
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6.发明申请AMINOGLYCOSIDE ANALOGUES, USES THEREOF FOR TREATING MICROBIAL DISEASES AND SYNTHESIS THEREOF 审中-公开氨基丁糖类似物，用于治疗微生物疾病及其合成
公开(公告)号：WO2006024784A3
公开(公告)日：2006-06-29
申请号：PCT/FR2005002025
申请日：2005-08-03
Applicant: UNIV PARIS DESCARTES , CT NAT DE LA RECH SCENTIFIQUE , MICOUIN LAURENT , DARDEL FREDERIC FRANCOIS PIERR , TISNE-VICROBECK CARINE , MAURICE FREDERIQUE , BONIN MARTINE , PEREZ LUNA ALEJANDRO , BOURNAUD CHLOEE JULIE , BEGIS GUILLAUME
Inventor： MICOUIN LAURENT , DARDEL FREDERIC FRANCOIS PIERR , TISNE-VICROBECK CARINE , MAURICE FREDERIQUE , BONIN MARTINE , PEREZ LUNA ALEJANDRO , BOURNAUD CHLOEE JULIE , BEGIS GUILLAUME
IPC: C07C271/22 , A61K31/132 , A61K31/133 , A61K31/16 , A61K31/325 , A61P31/04 , A61P31/10 , A61P31/12 , C07C215/44 , C07C229/08 , C07C235/74
CPC classification number: C07C215/44 , A61K31/132 , A61K31/133 , A61K31/16 , A61K31/195 , A61K31/255 , A61K31/325 , A61K31/351 , C07C229/08 , C07C235/74 , C07C271/22 , C07C2601/08 , C07H15/224 , Y02P20/55
Abstract: The invention concerns the use of compounds comprising a cyclopentane cycle, substituted in positions (1) and (3) by primary, secondary or tertiary amino groups, identical or different, optionally protected by a protecting group, said amino groups being in cis configuration, for preparing a medicine for treating microbial diseases, such as bacterial infections, viral infections or mycoses.
Abstract translation: 本发明涉及包含环戊烷循环的化合物在位置（1）和（3）中被通过保护基团任选保护的相同或不同的伯，仲或叔氨基取代的所述化合物的用途，所述氨基为顺式构型， 用于制备用于治疗微生物疾病的药物，例如细菌感染，病毒感染或真菌病。
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公开(公告)号：WO2006024784A2
公开(公告)日：2006-03-09
申请号：PCT/FR2005/002025
申请日：2005-08-03
Applicant: UNIVERSITE RENE DESCARTES-PARIS 5 , CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE , MICOUIN, Laurent , DARDEL, Fréderic, François, Pierre, Marie , TISNE-VICROBECK, Carine , MAURICE, Frédérique , BONIN, Martine , PEREZ LUNA, Alejandro , BOURNAUD, Chloée, Julie , BEGIS, Guillaume
Inventor： MICOUIN, Laurent , DARDEL, Fréderic, François, Pierre, Marie , TISNE-VICROBECK, Carine , MAURICE, Frédérique , BONIN, Martine , PEREZ LUNA, Alejandro , BOURNAUD, Chloée, Julie , BEGIS, Guillaume
IPC: A61K31/132 , A61K31/133 , A61K31/16 , A61K31/325 , C07C215/44 , C07C229/08 , C07C235/74 , C07C271/22
CPC classification number: C07C215/44 , A61K31/132 , A61K31/133 , A61K31/16 , A61K31/195 , A61K31/255 , A61K31/325 , A61K31/351 , C07C229/08 , C07C235/74 , C07C271/22 , C07C2601/08 , C07H15/224 , Y02P20/55
Abstract: La présente invention concerne l'utilisation de composés comprenant un cycle cyclopentane, substitué en positions (1) et (3) par des groupements aminés, primaires, secondaires ou tertiaires, identiques ou différents, éventuellement protégés par un groupement protecteur, lesdits groupements aminés étant en configuration cis, pour la préparation d'un médicament destiné au traitement des maladies microbiennes, telle que les infections bactériennes, les viroses ou les mycoses.
Abstract translation: 本发明涉及包含环戊烷循环的化合物在位置（1）和（3）中被通过保护基团任选保护的相同或不同的伯，仲或叔氨基取代的所述化合物的用途，所述氨基为顺式构型， 用于制备用于治疗微生物疾病的药物，例如细菌感染，病毒感染或真菌病。
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