公开(公告)号：WO2009070738A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084986

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC. ,  CAULLER, Lawrence ,  WEINER, Richard

Inventor： CAULLER, Lawrence ,  WEINER, Richard

IPC: H04B1/04 ,  A61F2/02

CPC classification number: A61N1/37229 ,  A61B5/6849 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/36071 ,  A61N1/36125 ,  A61N1/37205 ,  A61N1/3756

Abstract: A stimulation system and method includes a stimulation driver which drives bio-interface electrodes with a pulse shape which transmits more than 2/3 of the pulse's total energy before 1/3 of the pulse's total duration has elapsed.

Abstract translation: 刺激系统和方法包括刺激驱动器，所述刺激驱动器驱动具有脉冲形状的生物界面电极，该脉冲形状在脉冲的总持续时间的1/3已经过去之前传输脉冲总能量的2/3以上。

公开(公告)号：WO2010002936A2

公开(公告)日：2010-01-07

申请号：PCT/US2009049321

申请日：2009-06-30

Applicant: MICRO TRANSPONDER INC ,  UNIV TEXAS ,  KILGARD MICHAEL ,  CAULLER LARRY ,  ENGINEER NAZER ,  MCINTYRE CHRISTA ,  ROSELLINI WILL

Inventor： KILGARD MICHAEL ,  CAULLER LARRY ,  ENGINEER NAZER ,  MCINTYRE CHRISTA ,  ROSELLINI WILL

IPC: A61H1/00 ,  A61M21/00 ,  A61N1/36

CPC classification number: A61N1/36167 ,  A61F11/00 ,  A61M21/00 ,  A61M21/02 ,  A61M2021/0016 ,  A61M2021/0022 ,  A61M2021/0027 ,  A61M2021/0044 ,  A61M2021/0072 ,  A61M2021/0077 ,  A61M2205/3515 ,  A61M2230/06 ,  A61M2230/08 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/432 ,  A61M2230/50 ,  A61M2230/60 ,  A61M2230/65 ,  A61N1/36014 ,  A61N1/36053 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36092 ,  A61N1/361 ,  A61N1/36103 ,  A61N1/36139 ,  A61N5/0618 ,  A61N5/0622 ,  G09B19/00 ,  G09B19/003 ,  G09B23/28 ,  H04R25/75

Abstract: The present application claims priority benefits under 35 U.S. C. § 119(e) from U.S. Provisional Application No. 61/077,648, filed on July 2, 2008 and entitled "Treatment of Tinnitus with Vagus Nerve Stimulation"; U.S. Provisional Application No. 61/078,954, filed on July 8, 2008 and entitled "Neuroplasticity Enhancement"; U.S. Provisional Application No. 61/086, 116, filed on August 4, 2008 and entitled "Tinnitus Treatment Methods and Apparatus"; and U.S. Provisional Application No. 61/149,387, filed on February 3, 2009 and entitled "Healing the Human Brain: The Next Medical Revolution." The present application incorporates the foregoing disclosures herein by reference. Background: The present disclosure relates generally to therapy, rehabilitation and training including induced plasticity. More particularly, the disclosure relates to methods and systems of enhancing therapy, rehabilitation and training using nerve stimulation paired with training experiences.

Abstract translation: 本申请要求2008年7月2日提交的题为“治疗耳鸣与迷走神经刺激”的美国临时申请No.61 / 077,648的美国专利第35条第119（e）条的优先权。 2008年7月8日提交的题为“神经可塑性增强”的美国临时申请No.61 / 078,954; 2008年8月4日提交的题为“耳鸣治疗方法和装置”的美国临时申请No.61 / 086,116; 和2009年2月3日提交的题为“治愈人脑：下一届医学革命”的美国临时申请No.61 / 149,387。 本申请将上述公开内容并入本文作为参考。 背景技术本公开一般涉及包括诱导可塑性在内的治疗，康复和训练。 更具体地，本公开涉及使用与训练经验配对的神经刺激来增强治疗，康复和训练的方法和系统。

公开(公告)号：WO2009070697A3

公开(公告)日：2009-07-16

申请号：PCT/US2008084898

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC ,  CAULLER LAWRENCE ,  WEINER RICHARD

Inventor： CAULLER LAWRENCE ,  WEINER RICHARD

IPC: A61N1/06

CPC classification number: A61N1/37229 ,  A61B5/6849 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/36071 ,  A61N1/36125 ,  A61N1/37205 ,  A61N1/3756

Abstract: A method and system for providing electrical stimulation to tissue includes implanting one or more battery-free microtransponders having spiral antennas into tissue. Energy is provided wirelessly to the plurality of microtransponders. Tissue is stimulated using the energy.

Abstract translation: 用于向组织提供电刺激的方法和系统包括将具有螺旋天线的一个或多个无电池微转发器植入组织中。 能量被无线地提供给多个微转发器。 使用能量刺激组织。

公开(公告)号：WO2010002936A3

公开(公告)日：2010-01-07

申请号：PCT/US2009/049321

申请日：2009-06-30

Applicant: MICRO TRANSPONDER INC. ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  KILGARD, Michael ,  CAULLER, Larry ,  ENGINEER, Nazer ,  MCINTYRE, Christa ,  ROSELLINI, Will

Inventor： KILGARD, Michael ,  CAULLER, Larry ,  ENGINEER, Nazer ,  MCINTYRE, Christa ,  ROSELLINI, Will

IPC: A61H1/00 ,  A61N1/36 ,  A61M21/00

Abstract: The present application claims priority benefits under 35 U.S. C. § 119(e) from U.S. Provisional Application No. 61/077,648, filed on July 2, 2008 and entitled "Treatment of Tinnitus with Vagus Nerve Stimulation"; U.S. Provisional Application No. 61/078,954, filed on July 8, 2008 and entitled "Neuroplasticity Enhancement"; U.S. Provisional Application No. 61/086, 116, filed on August 4, 2008 and entitled "Tinnitus Treatment Methods and Apparatus"; and U.S. Provisional Application No. 61/149,387, filed on February 3, 2009 and entitled "Healing the Human Brain: The Next Medical Revolution." The present application incorporates the foregoing disclosures herein by reference. Background: The present disclosure relates generally to therapy, rehabilitation and training including induced plasticity. More particularly, the disclosure relates to methods and systems of enhancing therapy, rehabilitation and training using nerve stimulation paired with training experiences.

公开(公告)号：WO2009110935A1

公开(公告)日：2009-09-11

申请号：PCT/US2008/084972

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC. ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CAULLER, Lawrence ,  WEINER, Richard

Inventor： CAULLER, Lawrence ,  WEINER, Richard

IPC: A61N1/06

CPC classification number: A61N1/3605 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/6846 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3787

Abstract: A wireless microtransponder array constructed as a single structure of joined microtransponders. The microtransponders can be configured as a linear array strip with connective material in between. The microtransponders can also be entirely embedded within a strip of material, or joined by a single, common substrate structure.

Abstract translation: 无线微应答器阵列构造为连接的微转发器的单一结构。 微转发器可以被配置为在其间具有连接材料的线性阵列条。 微型应答器也可以完全嵌入在材料条中，或者通过单个公共基板结构连接。

公开(公告)号：WO2009070715A2

公开(公告)日：2009-06-04

申请号：PCT/US2008084941

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC ,  CAULLER LAWRENCE ,  WEINER RICHARD

Inventor： CAULLER LAWRENCE ,  WEINER RICHARD

IPC: A61M5/32 ,  A61M5/158

CPC classification number: A61N1/37229 ,  A61B5/6849 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/36071 ,  A61N1/36125 ,  A61N1/37205 ,  A61N1/3756

Abstract: Methods and devices for hypodermic implanting micro- transponders into a body. The method includes preassembling an array of micro-transponders into a cannula which is configured for tissue penetration and injection.

Abstract translation: 将微发射器植入体内的皮下植入方法和装置。 该方法包括将一组微型发射应答器预先组装到套管中，该套管配置用于组织穿透和注射。

公开(公告)号：WO2009070697A2

公开(公告)日：2009-06-04

申请号：PCT/US2008/084898

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC. ,  CAULLER, Lawrence ,  WEINER, Richard

Inventor： CAULLER, Lawrence ,  WEINER, Richard

IPC: A61N1/06

CPC classification number: A61N1/37229 ,  A61B5/6849 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/36071 ,  A61N1/36125 ,  A61N1/37205 ,  A61N1/3756

Abstract: A method and system for providing electrical stimulation to tissue includes implanting one or more battery-free microtransponders having spiral antennas into tissue. Energy is provided wirelessly to the plurality of microtransponders. Tissue is stimulated using the energy.

Abstract translation: 用于向组织提供电刺激的方法和系统包括将具有螺旋天线的一个或多个无电池微转发器植入组织中。 能量被无线地提供给多个微转发器。 使用能量刺激组织。

公开(公告)号：WO2009070719A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084951

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC. ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CAULLER, Lawrence

Inventor： CAULLER, Lawrence

IPC: H04B1/04 ,  A61F2/02

CPC classification number: A61N1/37229 ,  A61B5/6849 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/36071 ,  A61N1/36125 ,  A61N1/37205 ,  A61N1/3756

Abstract: A transponder includes a stimulus driver configured to discharge an electrical stimulus when a trigger signal is received. A first conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus discharged by the stimulus driver. A second conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus conducted by the first conducting electrode. A depolarization resistance connects the first conducting electrode to the second conducting electrode in response to the trigger signal.

Abstract translation: 应答器包括被配置为当接收到触发信号时放电电刺激的激励驱动器。 第一导电电极耦合到刺激驱动器并且传导由刺激驱动器释放的电刺激。 第二导电电极耦合到刺激驱动器并且传导由第一导电电极传导的电刺激。 去极化电阻响应于触发信号将第一导电电极连接到第二导电电极。

公开(公告)号：WO2009070715A3

公开(公告)日：2009-06-04

申请号：PCT/US2008/084941

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC. ,  CAULLER, Lawrence ,  WEINER, Richard

Inventor： CAULLER, Lawrence ,  WEINER, Richard

IPC: A61M5/32 ,  A61M5/158

Abstract: Methods and devices for hypodermic implanting micro- transponders into a body. The method includes preassembling an array of micro-transponders into a cannula which is configured for tissue penetration and injection.

公开(公告)号：WO2009070709A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084926

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC. ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CAULLER, Lawrence

Inventor： CAULLER, Lawrence

IPC: H04B1/04 ,  A61F2/02

CPC classification number: A61N1/37229 ,  A61B5/6849 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/36071 ,  A61N1/36125 ,  A61N1/37205 ,  A61N1/3756

Abstract: A transponder includes a stimulus driver configured to discharge an electrical stimulus when a trigger signal is received. A first conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus discharged by the stimulus driver. A second conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus conducted by the first conducting electrode. A depolarization switch is gated by the trigger signal and connects the first conducting electrode to the second conducting electrode in response to the trigger signal.

Abstract translation: 应答器包括被配置为当接收到触发信号时放电电刺激的激励驱动器。 第一导电电极耦合到刺激驱动器并且传导由刺激驱动器释放的电刺激。 第二导电电极耦合到刺激驱动器并且传导由第一导电电极传导的电刺激。 去极化开关由触发信号选通，并响应于触发信号将第一导电电极连接到第二导电电极。