公开(公告)号：WO2022165249A1

公开(公告)日：2022-08-04

申请号：PCT/US2022/014411

申请日：2022-01-28

Applicant: MICROVASCULAR HEALTH SOLUTIONS, LLC ,  OMNI IMAGING, INC.

Inventor： WANG, Yongping

IPC: A61B5/026 ,  A61B5/145 ,  A61B10/00 ,  G01N21/17 ,  G01N21/27

Abstract: Disclosed are methods and apparatuses for microvascular system imaging. In some embodiments, an apparatus for microvascular system imaging is a probe including at least one high-resolution image sensor module, at least one lens set, one or more optical filters, an illumination source, and a housing. In some embodiments, the lens set may be a miniature lens set. In some embodiments, the housing may be a tube structure. In some embodiments, the tube may be covered with a protective and/or sterile cover. The cover may be optically non-distorting. The imaging probe may additionally include a removable cap.

公开(公告)号：WO2018208846A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/031686

申请日：2018-05-08

Applicant: MICROVASCULAR HEALTH SOLUTIONS, LLC

Inventor： LONG, Robert Maxfield ,  VINK, Hans

IPC: A61K38/44 ,  A61K31/05 ,  A61K31/7008 ,  A61K31/728 ,  A61K31/737 ,  A61K35/744 ,  A61K36/03 ,  G01N33/68

CPC classification number: G01N33/5064 ,  A61K31/05 ,  A61K31/7008 ,  A61K31/728 ,  A61K31/737 ,  A61K38/44 ,  C12Y111/01006 ,  C12Y115/01001 ,  G01N2800/50 ,  A61K2300/00

Abstract: Compositions, systems, and methods for assessing or improving vascular health, treatments or treatment methods involving the same, systems and methods for diagnosing vascular health or impairment, and compositions and methods for use in treating endothelial glycocalyx to improving vascular health or treat a (vascular health-associated) disease or other condition, in human and non-human mammals are disclosed. Computer systems, hardware storage devices, and methods used to determine glycocalyx impairment using a dynamically extrapolated characterization of a plurality of microvascular vessels, diagnose a subject as suffering from glycocalyx dysfunction or impairment, and assess or determine the health, functionality, or impairment of the glycocalyx as a function of blood flow. Compositions comprising glucosamine, hyaluronan, fucoidan, and antioxidants improve vascular health by enhance synthesis of new glycocalyx, protecting existing glycocalyx against damage, and enhancing repair of damaged glycocalyx.

公开(公告)号：WO2016164787A3

公开(公告)日：2016-11-10

申请号：PCT/US2016026739

申请日：2016-04-08

Applicant: MICROVASCULAR HEALTH SOLUTIONS LLC

Inventor： LONG ROBERT MAXFIELD ,  VINK HANS

IPC: A61K31/728 ,  A61K31/737 ,  A61K35/66 ,  A61K36/03 ,  A61P9/00

CPC classification number: A61K38/446 ,  A61K31/05 ,  A61K31/7008 ,  A61K31/728 ,  A61K31/737 ,  A61K35/744 ,  A61K36/03 ,  C12Y111/01006 ,  C12Y115/01001 ,  A61K2300/00

Abstract: Compositions and methods for treating endothelial glycocalyx include glucosamine, hyaluronan and/or fucoidan, and one or more antioxidants, such as superoxide dismutase, catalase, and/or polyphenol. The compositions improve vascular health by exhibiting beneficial synergistic effects on endothelial glycocalyx over the benefits of taking any single component alone or the sum of reported effects of the individual components. Specifically, components of the composition (1) enhance synthesis of new glycocalyx by (a) providing and (b) increasing production of glycocalyx precursors, (2) protecting existing glycocalyx against damage, such as by oxidation degradation, by (a) providing and (b) increasing production of antioxidants, some of which associate with endothelial glycocalyx, and (3) enhance repair of damaged glycocalyx by (a) providing glycocalyx mimetics and (b) increasing the prevalence of glycocalyx scaffold for association and incorporation thereof.

Abstract translation: 用于治疗内皮糖萼的组合物和方法包括葡糖胺，透明质酸和/或岩藻依聚糖，以及一种或多种抗氧化剂，例如超氧化物歧化酶，过氧化氢酶和/或多酚。 该组合物通过对内皮糖萼具有有益的协同效应而超过单独服用任何单一组分的益处或单独组分的报告效果总和来改善血管健康。 具体而言，组合物（1）的组分通过（a）提供和（b）增加糖萼前体的生产，（2）通过（例如）氧化降解保护现有的糖萼免受损害，通过以下方式来增强新的糖萼的合成： （b）增加抗氧化剂的产生，其中一些抗氧化剂与内皮糖萼相关联，和（3）通过（a）提供糖萼模拟物和（b）增加糖萼支架的结合和掺入来增强受损的糖萼的修复。

公开(公告)号：WO2016164787A2

公开(公告)日：2016-10-13

申请号：PCT/US2016/026739

申请日：2016-04-08

Applicant: MICROVASCULAR HEALTH SOLUTIONS, LLC

Inventor： LONG, Robert Maxfield ,  VINK, Hans

IPC: A61K31/728 ,  A61K31/737 ,  A61K35/66 ,  A61K36/03 ,  A61P9/00

CPC classification number: A61K38/446 ,  A61K31/05 ,  A61K31/7008 ,  A61K31/728 ,  A61K31/737 ,  A61K35/744 ,  A61K36/03 ,  C12Y111/01006 ,  C12Y115/01001 ,  A61K2300/00

Abstract: Compositions and methods for treating endothelial glycocalyx include glucosamine, hyaluronan and/or fucoidan, and one or more antioxidants, such as superoxide dismutase, catalase, and/or polyphenol. The compositions improve vascular health by exhibiting beneficial synergistic effects on endothelial glycocalyx over the benefits of taking any single component alone or the sum of reported effects of the individual components. Specifically, components of the composition (1) enhance synthesis of new glycocalyx by (a) providing and (b) increasing production of glycocalyx precursors, (2) protecting existing glycocalyx against damage, such as by oxidation degradation, by (a) providing and (b) increasing production of antioxidants, some of which associate with endothelial glycocalyx, and (3) enhance repair of damaged glycocalyx by (a) providing glycocalyx mimetics and (b) increasing the prevalence of glycocalyx scaffold for association and incorporation thereof.

Abstract translation: 用于治疗内皮糖萼的组合物和方法包括葡糖胺，透明质酸和/或岩藻依聚糖，以及一种或多种抗氧化剂，例如超氧化物歧化酶，过氧化氢酶和/或多酚。 该组合物通过对内皮糖萼片具有有益的协同作用而改善血管健康，而不仅仅是单独使用任何单一组分或单独组分的报道效应的总和。 具体地，组合物（1）的组分通过（a）提供和（b）增加糖萼前体的产生来增强新糖萼骨的合成，（2）通过（a）提供和（b）保护现有的糖萼不受诸如氧化降解的损伤， （b）增加抗氧化剂的生产，其中一些与内皮糖萼结合，和（3）通过（a）提供糖萼模拟物和（b）增加糖萼骨架的结合和结合的流行性来增强损伤的糖萼的修复。