公开(公告)号：WO2012160393A1

公开(公告)日：2012-11-29

申请号：PCT/GB2012/051196

申请日：2012-05-25

Applicant: MICROVISK LIMITED ,  DJAKOV, Vladislav ,  DUNN, Richard

Inventor： DJAKOV, Vladislav ,  DUNN, Richard

IPC: G01N27/12 ,  C12Q1/00 ,  G01N33/543 ,  B82Y15/00

CPC classification number: G01N33/5304 ,  G01N27/128 ,  G01N29/022 ,  G01N33/54373 ,  G01N33/5438

Abstract: There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterise a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample. There is also provided a method for measuring at least one thermal property of a fluid medium sample, and a fluid medium sample reaction detection apparatus.

Abstract translation: 提供了一种使用热特征来监测流体介质样品中的一个或多个指定反应的方法，包括提供至少一个微悬臂传感器，所述微悬臂传感器包括具有不同热膨胀系数的至少两种材料，以及 具有集成在其中的加热器和压阻传感器，校准至少一个微悬臂响应于热变化以形成校准的微悬臂梁响应特性，启动流体介质样品中的指定反应，将加热器与一个或多个 电脉冲以在微悬臂中引起发热，对集成的压阻传感器的输出进行采样，以在流体介质中指定的反应期间表征微悬臂梁的响应，并从校准的微悬臂梁响应特性中减去 采样输出以确定t中的一个或多个指定反应的特性 他流体介质样品。 还提供了一种用于测量流体介质样品的至少一种热性质和流体介质样品反应检测装置的方法。

公开(公告)号：WO2014083300A1

公开(公告)日：2014-06-05

申请号：PCT/GB2013/050607

申请日：2013-03-12

Applicant: MICROVISK LIMITED

Inventor： DUNN, Richard John ,  BELLO FERNANDEZ DE SANMAMED, Lois ,  IBBOTSON, Robert Henry ,  DJAKOV, Vladislav

IPC: G01N33/49 ,  G01N15/05

CPC classification number: G01N15/05 ,  G01N15/04 ,  G01N15/06 ,  G01N15/0606 ,  G01N29/022 ,  G01N29/036 ,  G01N33/491 ,  G01N2015/055

Abstract: There is provided a method of measuring a sedimentation parameter of suspensions or precipitants in a fluid medium sample, said method compromising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterise a response of the micro-cantilever during sedimentation in the fluid medium sample, and determining a value of the sedimentation parameter from the characterised response. There is also provided an apparatus arranged to carry out the method.

Abstract translation: 提供了一种测量流体介质样品中悬浮液或沉淀剂的沉降参数的方法，所述方法损害提供至少一个微悬臂传感器，所述微悬臂传感器包括具有不同热膨胀系数的至少两种材料，以及 具有集成在其中的加热器和压阻传感器，用一个或多个电脉冲脉冲加热器以在微悬臂中引起发热，对集成压阻式传感器的输出进行采样，以表征微悬臂梁的响应 在流体介质样品中沉淀，并根据特征响应确定沉降参数的值。 还提供了一种用于执行该方法的设备。

公开(公告)号：WO2013121211A1

公开(公告)日：2013-08-22

申请号：PCT/GB2013/050360

申请日：2013-02-15

Applicant: MICROVISK LIMITED

Inventor： IBBOTSON, Robert ,  DJAKOV, Vladislav ,  DUNN, Richard

IPC: G01N33/543

CPC classification number: G01N33/54373 ,  G01N33/86

Abstract: There is provided a fluidics test strip, comprising a micro-sensor (e.g. a micro-cantilever) formed on a substrate surface and a reagent deposition site formed on the substrate surface, operable to control the size and location of a reagent deposition. There is also provided a method of forming fluidics test strip, comprising forming a micro-sensor on a substrate surface and forming a reagent deposition site on the substrate surface, operable to control the size and location of a reagent deposition. Preferably the reagent deposition site comprises a central island portion surrounded by one or more moats and optionally fences in the surface material. An apparatus and computer readable medium for carrying out the method of manufacture of the test strip are also provided.

Abstract translation: 提供了流体测试条，其包括形成在基板表面上的微传感器（例如微悬臂梁）和形成在基板表面上的试剂沉积位置，可操作以控制试剂沉积的尺寸和位置。 还提供了形成流体测试条的方法，包括在衬底表面上形成微传感器，并在衬底表面上形成试剂沉积位置，可操作以控制试剂沉积的尺寸和位置。 优选地，试剂沉积位置包括由表面材料中的一个或多个护城河和任选的栅栏围绕的中心岛部分。 还提供了一种用于执行测试条的制造方法的设备和计算机可读介质。

公开(公告)号：WO2009022121A3

公开(公告)日：2009-02-19

申请号：PCT/GB2008/002717

申请日：2008-08-08

Applicant: MICROVISK LIMITED ,  DJAKOV, Vladislav

Inventor： DJAKOV, Vladislav

IPC: G01N11/00

Abstract: Device and associated methods for detecting a property of a fluid. The device includes a body region and a first flexible element having a first end and a second end. The first end is fixedly located on the body region. The flexible element includes at least a first layer having a first coefficient of thermal expansion and a second layer having a second, different coefficient of thermal expansion. An electrical heater element can be arranged to heat the flexible element to induce bending of said flexible element. The resistance of a first portion of the electrical heater element adjacent the first end can be greater than the resistance of a second portion of the electrical heater element further from the first end. The device can include a heater controller arranged to supply an electrical pulse having a duration less than 5ms to the electrical heater. The device can include a second, reference flexible element having a first end and a second end, with the first end fixedly located on the body region. Each flexible element can include a respective sensor arranged to provide a signal indicative of the movement of that flexible element. The sensor of the reference flexible element has a different configuration than the sensor of the first flexible element, with at least one of the flexible elements including at least one additional portion of material for equalising the thermal conductivity distribution of the two flexible elements.