公开(公告)号：WO2012160393A1

公开(公告)日：2012-11-29

申请号：PCT/GB2012/051196

申请日：2012-05-25

Applicant: MICROVISK LIMITED ,  DJAKOV, Vladislav ,  DUNN, Richard

Inventor： DJAKOV, Vladislav ,  DUNN, Richard

IPC: G01N27/12 ,  C12Q1/00 ,  G01N33/543 ,  B82Y15/00

CPC classification number: G01N33/5304 ,  G01N27/128 ,  G01N29/022 ,  G01N33/54373 ,  G01N33/5438

Abstract: There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterise a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample. There is also provided a method for measuring at least one thermal property of a fluid medium sample, and a fluid medium sample reaction detection apparatus.

Abstract translation: 提供了一种使用热特征来监测流体介质样品中的一个或多个指定反应的方法，包括提供至少一个微悬臂传感器，所述微悬臂传感器包括具有不同热膨胀系数的至少两种材料，以及 具有集成在其中的加热器和压阻传感器，校准至少一个微悬臂响应于热变化以形成校准的微悬臂梁响应特性，启动流体介质样品中的指定反应，将加热器与一个或多个 电脉冲以在微悬臂中引起发热，对集成的压阻传感器的输出进行采样，以在流体介质中指定的反应期间表征微悬臂梁的响应，并从校准的微悬臂梁响应特性中减去 采样输出以确定t中的一个或多个指定反应的特性 他流体介质样品。 还提供了一种用于测量流体介质样品的至少一种热性质和流体介质样品反应检测装置的方法。

公开(公告)号：WO2007104978A1

公开(公告)日：2007-09-20

申请号：PCT/GB2007/000887

申请日：2007-03-14

Applicant: THE SCIENCE AND TECHNOLOGY FACILITIES COUNCIL ,  DJAKOV, Vladislav ,  HUQ, Ejaz ,  DUNN, Richard, John

Inventor： DJAKOV, Vladislav ,  HUQ, Ejaz ,  DUNN, Richard, John

IPC: G01N9/00 ,  G01N11/16 ,  B06B1/06

CPC classification number: G01N9/002 ,  G01N11/16 ,  Y10T29/49002

Abstract: A device for measuring the properties of a fluid, a method of manufacture, and a method of operation is described. The device includes a body region, a first flexible element and a second flexible element. Each flexible element has a first end and a second end, the first end being fixedly located on the body region. Each flexible element is moveable from at least a first respective configuration to a second respective configuration via bending of the element. The first flexible element includes an actuating portion arranged to move the flexible element between the first configuration and the second configuration. The second flexible element includes an integral movement sensor for sensing movement of the flexible element. The first flexible element is coupled to the second flexible element at a position distant from the body region. Only the actuating portion of the first flexible element is operable to move the first and second flexible elements.

Abstract translation: 描述了用于测量流体性质的装置，制造方法和操作方法。 该装置包括主体区域，第一柔性元件和第二柔性元件。 每个柔性元件具有第一端和第二端，第一端固定地位于身体区域上。 每个柔性元件可以通过元件的弯曲从至少第一相应构造移动到第二相应构造。 第一柔性元件包括致动部分，其被布置成在第一构造和第二构造之间移动柔性元件。 第二柔性元件包括用于感测柔性元件的移动的整体运动传感器。 第一柔性元件在远离身体区域的位置处联接到第二柔性元件。 只有第一柔性元件的致动部分可操作以移动第一和第二柔性元件。

公开(公告)号：WO2005054817A1

公开(公告)日：2005-06-16

申请号：PCT/GB2004/005079

申请日：2004-12-03

Applicant: COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS ,  DJAKOV, Vladislav ,  HUQ, Ejaz ,  VERNON, Paul

Inventor： DJAKOV, Vladislav ,  HUQ, Ejaz ,  VERNON, Paul

IPC: G01N11/16

CPC classification number: G01N11/16

Abstract: A device for detecting a property of a fluid includes a body region and a flexible element having a first end and a second end. The first end is fixedly located on the body region. The flexible element is arranged to move from at least a first configuration to a second configuration via bending of the flexible element. The flexible element includes an actuating portion arranged to move the flexible element between the first configuration and the second configuration. The device also includes a movement detector for detecting movement of the flexible element.

Abstract translation: 用于检测流体性质的装置包括主体区域和具有第一端和第二端的柔性元件。 第一端固定在身体区域上。 柔性元件布置成通过柔性元件的弯曲从至少第一构型移动到第二构型。 柔性元件包括致动部分，其被布置成在第一配置和第二配置之间移动柔性元件。 该装置还包括用于检测柔性元件的移动的移动检测器。

公开(公告)号：WO2009022121A3

公开(公告)日：2009-02-19

申请号：PCT/GB2008/002717

申请日：2008-08-08

Applicant: MICROVISK LIMITED ,  DJAKOV, Vladislav

Inventor： DJAKOV, Vladislav

IPC: G01N11/00

Abstract: Device and associated methods for detecting a property of a fluid. The device includes a body region and a first flexible element having a first end and a second end. The first end is fixedly located on the body region. The flexible element includes at least a first layer having a first coefficient of thermal expansion and a second layer having a second, different coefficient of thermal expansion. An electrical heater element can be arranged to heat the flexible element to induce bending of said flexible element. The resistance of a first portion of the electrical heater element adjacent the first end can be greater than the resistance of a second portion of the electrical heater element further from the first end. The device can include a heater controller arranged to supply an electrical pulse having a duration less than 5ms to the electrical heater. The device can include a second, reference flexible element having a first end and a second end, with the first end fixedly located on the body region. Each flexible element can include a respective sensor arranged to provide a signal indicative of the movement of that flexible element. The sensor of the reference flexible element has a different configuration than the sensor of the first flexible element, with at least one of the flexible elements including at least one additional portion of material for equalising the thermal conductivity distribution of the two flexible elements.

公开(公告)号：WO2009022121A2

公开(公告)日：2009-02-19

申请号：PCT/GB2008002717

申请日：2008-08-08

Applicant: MICROVISK LTD ,  DJAKOV VLADISLAV

Inventor： DJAKOV VLADISLAV

IPC: G01N11/00

CPC classification number: G01N11/16

Abstract: Device and associated methods for detecting a property of a fluid. The device includes a body region and a first flexible element having a first end and a second end. The first end is fixedly located on the body region. The flexible element includes at least a first layer having a first coefficient of thermal expansion and a second layer having a second, different coefficient of thermal expansion. An electrical heater element can be arranged to heat the flexible element to induce bending of said flexible element. The resistance of a first portion of the electrical heater element adjacent the first end can be greater than the resistance of a second portion of the electrical heater element further from the first end. The device can include a heater controller arranged to supply an electrical pulse having a duration less than 5ms to the electrical heater. The device can include a second, reference flexible element having a first end and a second end, with the first end fixedly located on the body region. Each flexible element can include a respective sensor arranged to provide a signal indicative of the movement of that flexible element. The sensor of the reference flexible element has a different configuration than the sensor of the first flexible element, with at least one of the flexible elements including at least one additional portion of material for equalising the thermal conductivity distribution of the two flexible elements.

Abstract translation: 用于检测流体性质的装置和相关方法。 该装置包括主体区域和具有第一端部和第二端部的第一柔性元件。 第一端固定在身体区域上。 柔性元件至少包括具有第一热膨胀系数的第一层和具有第二不同热膨胀系数的第二层。 可以布置电加热器元件以加热柔性元件以引起所述柔性元件的弯曲。 与第一端相邻的电加热器元件的第一部分的电阻可以大于电加热器元件的远离第一端的第二部分的电阻。 该装置可以包括加热器控制器，其布置成向电加热器提供持续时间小于5ms的电脉冲。 该装置可以包括具有第一端和第二端的第二参考柔性元件，第一端固定地位于身体区域上。 每个柔性元件可以包括布置成提供指示该柔性元件的运动的信号的相应传感器。 参考柔性元件的传感器具有与第一柔性元件的传感器不同的构造，其中至少一个柔性元件包括用于均衡两个柔性元件的热导率分布的材料的至少一个附加部分。