公开(公告)号：WO2005113478A3

公开(公告)日：2008-12-18

申请号：PCT/US2005016501

申请日：2005-05-11

Applicant: UNIV MICHIGAN STATE ,  NAIR MURALEEDHARAN G ,  DHANANJEYAN MUGUNTHU R ,  KRON MICHAEL A ,  MILEV YOULI

Inventor： NAIR MURALEEDHARAN G ,  DHANANJEYAN MUGUNTHU R ,  KRON MICHAEL A ,  MILEV YOULI

IPC: A61K31/545 ,  A61K31/52 ,  A61K31/70 ,  C07C46/00 ,  C07C50/18 ,  C07C50/34

CPC classification number: C07C50/34 ,  C07C46/00

Abstract: A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.

Abstract translation: 描述了制备羟基取代的蒽醌的方法。 该方法将邻苯二甲酸酐（取代或未取代的）与至少两个羟基取代的苯环部分结合。 剩余的羟基在一些蒽醌中转化为甲氧基。 该化合物特别可用于治疗寄生虫病。 另外，使用蒽醌治疗或预防疟疾，丝虫病血吸虫病和其他寄生虫病的方法。

公开(公告)号：WO2005113478A9

公开(公告)日：2005-12-01

申请号：PCT/US2005/016501

申请日：2005-05-11

Applicant: MICHIGAN STATE UNIVERSITY ,  NAIR, Muraleedharan, G. ,  DHANANJEYAN, Mugunthu, R. ,  KRON, Michael, A. ,  MILEV, Youli

Inventor： NAIR, Muraleedharan, G. ,  DHANANJEYAN, Mugunthu, R. ,  KRON, Michael, A. ,  MILEV, Youli

IPC: C07C45/27 ,  A01N47/00

Abstract: A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.

公开(公告)号：WO2005113478A2

公开(公告)日：2005-12-01

申请号：PCT/US2005016501

申请日：2005-05-11

Applicant: UNIV MICHIGAN STATE ,  NAIR MURALEEDHARAN G ,  DHANANJEYAN MUGUNTHU R ,  KRON MICHAEL A ,  MILEV YOULI

Inventor： NAIR MURALEEDHARAN G ,  DHANANJEYAN MUGUNTHU R ,  KRON MICHAEL A ,  MILEV YOULI

IPC: C07C46/00 ,  C07C50/18 ,  C07C50/34

CPC classification number: C07C50/34 ,  C07C46/00

Abstract: A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.

Abstract translation: 描述了制备羟基取代的蒽醌的方法。 该方法将邻苯二甲酸酐（取代或未取代的）与至少两个羟基取代的苯环部分结合。 剩余的羟基在一些蒽醌中转化为甲氧基。 该化合物特别可用于治疗寄生虫病。 另外，使用蒽醌治疗或预防疟疾，丝虫病血吸虫病和其他寄生虫病的方法。