公开(公告)号：WO2003062943A2

公开(公告)日：2003-07-31

申请号：PCT/IL2003/000053

申请日：2003-01-22

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  ALON, Uri ,  SHEN-ORR, Shai, S. ,  MILO, Ron

Inventor： ALON, Uri ,  SHEN-ORR, Shai, S. ,  MILO, Ron

IPC: G06F

CPC classification number: G06F19/12

Abstract: A method for analyzing data, such as biological data for example, for identifying one or more network motifs, or recurring patterns of relationships and/or behavioral connections between the components of a complex system. The method of the present invention is optionally and preferably applied to biological systems, such as gene regulatory systems for example.

Abstract translation: 用于分析数据的方法，例如用于识别一个或多个网络图案的生物数据，或复合系统的组件之间的关系和/或行为连接的重复模式。 本发明的方法任选地优选地应用于生物系统，例如基因调控系统。

公开(公告)号：WO2011099006A3

公开(公告)日：2011-11-10

申请号：PCT/IL2011000145

申请日：2011-02-10

Applicant: YEDA RES & DEV ,  MILO RON ,  BAR-EVEN ARREN ,  NOOR ELAD

Inventor： MILO RON ,  BAR-EVEN ARREN ,  NOOR ELAD

IPC: C12N15/82 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/18 ,  C12N9/88 ,  C12N9/90 ,  G06F19/12

CPC classification number: C12N9/93 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1018 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/18 ,  C12N9/88 ,  C12N9/90 ,  C12N15/70 ,  C12N15/8245 ,  C12N15/8247 ,  C12N15/8269 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P11/00 ,  C12Y101/01059 ,  C12Y102/01018 ,  C12Y201/03001 ,  C12Y208/03001 ,  C12Y401/01031 ,  C12Y402/01017 ,  C12Y402/01054 ,  C12Y604/01001 ,  C12Y604/01002 ,  G06F19/12 ,  Y02P20/52

Abstract: A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein an enzyme which performs the carboxylation reaction is selected from the group consisting of phophoenolpyruvate (PEP) carboxlase, pyruvate carboxylase and acetyl-CoA carboxylase and wherein an export product of the carbon fixation pathway is glyoxylate. Additional carbon fixation pathways are also provided and methods of generating same.

Abstract translation: 提供了一种用于碳固定的系统。 该系统包括催化碳固定通道的反应的酶，其中碳固定通路的至少一个反应是羧化反应，其中碳固定路径的反应产物包括草酰乙酸和丙二酰辅酶A，其中酶 进行羧化反应的选自苯丙醇丙酮酸（PEP）羧基酶，丙酮酸羧化酶和乙酰​​辅酶A羧化酶，其中碳固定路径的出口产物是乙醛酸盐。 还提供了另外的碳固定路径和产生它们的方法。

公开(公告)号：WO2009093242A2

公开(公告)日：2009-07-30

申请号：PCT/IL2009000089

申请日：2009-01-22

Applicant: YEDA RES & DEV ,  ALON URI ,  SIGAL ALEX ,  MILO RON ,  DANON TAMAR ,  COHEN ARIEL ,  GEVA-ZATORSKY NAAMA ,  FRENKEL-MORGENSTERN MILANA ,  COHEN LYDIA ,  PERZOV NATALIE ,  EDEN ERAN

Inventor： ALON URI ,  SIGAL ALEX ,  MILO RON ,  DANON TAMAR ,  COHEN ARIEL ,  GEVA-ZATORSKY NAAMA ,  FRENKEL-MORGENSTERN MILANA ,  COHEN LYDIA ,  PERZOV NATALIE ,  EDEN ERAN

IPC: C12N15/09

CPC classification number: A61K31/4745 ,  C07K2319/60 ,  C12N15/62

Abstract: Nucleic acid construct systems are disclosed. The constructs comprise: (i) a first nucleic acid construct comprising a first nucleic acid sequence encoding a first reporter polypeptide linked to an additional nucleic acid sequence capable of inserting the first nucleic acid construct into a genome of a host cell such that an endogenous polypeptide covalently attached to the first reporter polypeptide is expressed in the cell; and (ii) a second nucleic acid construct comprising a second nucleic acid sequence encoding a second reporter polypeptide, linked to an additional nucleic acid sequence capable of inserting in a non-directed manner the second nucleic acid construct into a genome of a host cell such that an endogenous polypeptide covalently attached to the second reporter polypeptide is expressed in the cell, wherein the first reporter polypeptide and the second reporter polypeptide are distinguishable. Cells and cell populations comprising same as well as methods of generating same are also disclosed. In addition, use of the novel construct systems are disclosed for identifying target agents are also disclosed.

Abstract translation: 公开了核酸构建体系。 所述构建体包含：（i）第一核酸构建体，其包含编码与能够将第一核酸构建体插入宿主细胞的基因组的另外的核酸序列连接的第一报道多肽的第一核酸序列， 共价连接到第一报道多肽在细胞中表达; 和（ii）第二核酸构建体，其包含编码第二报告多肽的第二核酸序列，其与能够以非定向方式将第二核酸构建体插入宿主细胞基因组的另外的核酸序列连接， 共价连接到第二报道多肽的内源多肽在细胞中表达，其中第一报告多肽和第二报道多肽是可区分的。 还公开了包含相同的细胞和细胞群以及产生它们的方法。 此外，还公开了用于鉴定目标试剂的新型构建体系的使用。

公开(公告)号：WO2009093242A3

公开(公告)日：2009-07-30

申请号：PCT/IL2009/000089

申请日：2009-01-22

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  ALON, Uri ,  SIGAL, Alex ,  MILO, Ron ,  DANON, Tamar ,  COHEN, Ariel ,  GEVA-ZATORSKY, Naama ,  FRENKEL-MORGENSTERN, Milana ,  COHEN, Lydia ,  PERZOV, Natalie ,  EDEN, Eran

Inventor： ALON, Uri ,  SIGAL, Alex ,  MILO, Ron ,  DANON, Tamar ,  COHEN, Ariel ,  GEVA-ZATORSKY, Naama ,  FRENKEL-MORGENSTERN, Milana ,  COHEN, Lydia ,  PERZOV, Natalie ,  EDEN, Eran

IPC: C12N15/62 ,  A61K31/4745

Abstract: Nucleic acid construct systems are disclosed. The constructs comprise: (i) a first nucleic acid construct comprising a first nucleic acid sequence encoding a first reporter polypeptide linked to an additional nucleic acid sequence capable of inserting the first nucleic acid construct into a genome of a host cell such that an endogenous polypeptide covalently attached to the first reporter polypeptide is expressed in the cell; and (ii) a second nucleic acid construct comprising a second nucleic acid sequence encoding a second reporter polypeptide, linked to an additional nucleic acid sequence capable of inserting in a non-directed manner the second nucleic acid construct into a genome of a host cell such that an endogenous polypeptide covalently attached to the second reporter polypeptide is expressed in the cell, wherein the first reporter polypeptide and the second reporter polypeptide are distinguishable. Cells and cell populations comprising same as well as methods of generating same are also disclosed. In addition, use of the novel construct systems are disclosed for identifying target agents are also disclosed.

公开(公告)号：WO2011099006A2

公开(公告)日：2011-08-18

申请号：PCT/IL2011/000145

申请日：2011-02-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  MILO, Ron ,  BAR-EVEN, Arren ,  NOOR, Elad

Inventor： MILO, Ron ,  BAR-EVEN, Arren ,  NOOR, Elad

IPC: C12N15/82 ,  C12N9/00 ,  C12N9/88 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/18 ,  C12N9/90 ,  G06F19/12

CPC classification number: C12N9/93 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1018 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/18 ,  C12N9/88 ,  C12N9/90 ,  C12N15/70 ,  C12N15/8245 ,  C12N15/8247 ,  C12N15/8269 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P11/00 ,  C12Y101/01059 ,  C12Y102/01018 ,  C12Y201/03001 ,  C12Y208/03001 ,  C12Y401/01031 ,  C12Y402/01017 ,  C12Y402/01054 ,  C12Y604/01001 ,  C12Y604/01002 ,  G06F19/12 ,  Y02P20/52

Abstract: A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein an enzyme which performs the carboxylation reaction is selected from the group consisting of phophoenolpyruvate (PEP) carboxlase, pyruvate carboxylase and acetyl-CoA carboxylase and wherein an export product of the carbon fixation pathway is glyoxylate. Additional carbon fixation pathways are also provided and methods of generating same.

Abstract translation: 提供了一种用于碳固定的系统。 该系统包含催化碳固定途径的反应的酶，其中碳固定途径的至少一个反应是羧化反应，其中碳固定途径的反应产物包含草酰乙酸和丙二酰-CoA，其中酶 其中进行羧化反应的酶选自磷酸烯醇式丙酮酸（PEP）羧化酶，丙酮酸羧化酶和乙酰​​-CoA羧化酶，并且其中碳固定途径的出口产物是乙醛酸盐。 还提供了额外的碳固定途径和产生同样的方法。

公开(公告)号：WO2003062943A3

公开(公告)日：2003-07-31

申请号：PCT/IL2003/000053

申请日：2003-01-22

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  ALON, Uri ,  SHEN-ORR, Shai, S. ,  MILO, Ron

Inventor： ALON, Uri ,  SHEN-ORR, Shai, S. ,  MILO, Ron

IPC: G06F19/00

Abstract: A method for analyzing data, such as biological data for example, for identifying one or more network motifs, or recurring patterns of relationships and/or behavioral connections between the components of a complex system. The method of the present invention is optionally and preferably applied to biological systems, such as gene regulatory systems for example.