公开(公告)号：WO2011099006A3

公开(公告)日：2011-11-10

申请号：PCT/IL2011000145

申请日：2011-02-10

Applicant: YEDA RES & DEV ,  MILO RON ,  BAR-EVEN ARREN ,  NOOR ELAD

Inventor： MILO RON ,  BAR-EVEN ARREN ,  NOOR ELAD

IPC: C12N15/82 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/18 ,  C12N9/88 ,  C12N9/90 ,  G06F19/12

CPC classification number: C12N9/93 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1018 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/18 ,  C12N9/88 ,  C12N9/90 ,  C12N15/70 ,  C12N15/8245 ,  C12N15/8247 ,  C12N15/8269 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P11/00 ,  C12Y101/01059 ,  C12Y102/01018 ,  C12Y201/03001 ,  C12Y208/03001 ,  C12Y401/01031 ,  C12Y402/01017 ,  C12Y402/01054 ,  C12Y604/01001 ,  C12Y604/01002 ,  G06F19/12 ,  Y02P20/52

Abstract: A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein an enzyme which performs the carboxylation reaction is selected from the group consisting of phophoenolpyruvate (PEP) carboxlase, pyruvate carboxylase and acetyl-CoA carboxylase and wherein an export product of the carbon fixation pathway is glyoxylate. Additional carbon fixation pathways are also provided and methods of generating same.

Abstract translation: 提供了一种用于碳固定的系统。 该系统包括催化碳固定通道的反应的酶，其中碳固定通路的至少一个反应是羧化反应，其中碳固定路径的反应产物包括草酰乙酸和丙二酰辅酶A，其中酶 进行羧化反应的选自苯丙醇丙酮酸（PEP）羧基酶，丙酮酸羧化酶和乙酰​​辅酶A羧化酶，其中碳固定路径的出口产物是乙醛酸盐。 还提供了另外的碳固定路径和产生它们的方法。

公开(公告)号：WO2015177800A3

公开(公告)日：2016-03-24

申请号：PCT/IL2015050540

申请日：2015-05-21

Applicant: YEDA RES & DEV

Inventor： MILO RON ,  ANTONOVSKY NIV ,  NOOR ELAD ,  BAR-EVEN ARREN ,  ZOHAR YEHUDIT ,  ZELCBUCH LIOR ,  GLEIZER SHMUEL ,  AMRAM SHIRA

IPC: C07K14/195

CPC classification number: C12N15/70 ,  C07K14/195 ,  C07K14/245 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/90 ,  C12Y101/01049 ,  C12Y203/03009 ,  C12Y207/01011 ,  C12Y207/01019 ,  C12Y401/01039 ,  C12Y402/01011 ,  C12Y504/02

Abstract: A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing C02 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing C02. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.

Abstract translation: 公开了一种经遗传修饰的微生物，以便通过使用重组碳固定酶代谢CO 2来产生第一基本生物质前体。 微生物通过代谢有机碳源而不是通过代谢CO 2来产生第二生物质前体。 微生物不使用有机碳源来生产第一种基本生物质前体。